LOCUS       NM_146229               2046 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dynein cytoplasmic 1 light intermediate chain 1
            (Dync1li1), mRNA.
ACCESSION   NM_146229
VERSION     NM_146229.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2046)
  AUTHORS   Zhang,Y., Zhang,S., Zhou,H., Ma,X., Wu,L., Tian,M., Li,S., Qian,X.,
            Gao,X. and Chai,R.
  TITLE     Dync1li1 is required for the survival of mammalian cochlear hair
            cells by regulating the transportation of autophagosomes
  JOURNAL   PLoS Genet 18 (6), e1010232 (2022)
   PUBMED   35727824
  REMARK    GeneRIF: Dync1li1 is required for the survival of mammalian
            cochlear hair cells by regulating the transportation of
            autophagosomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2046)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2046)
  AUTHORS   Leca,I., Phillips,A.W., Hofer,I., Landler,L., Ushakova,L.,
            Cushion,T.D., Durnberger,G., Stejskal,K., Mechtler,K. and
            Keays,D.A.
  TITLE     A proteomic survey of microtubule-associated proteins in a R402H
            TUBA1A mutant mouse
  JOURNAL   PLoS Genet 16 (11), e1009104 (2020)
   PUBMED   33137126
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2046)
  AUTHORS   Liu,Z.D., Zhang,S., Hao,J.J., Xie,T.R. and Kang,J.S.
  TITLE     Cellular model of neuronal atrophy induced by DYNC1I1 deficiency
            reveals protective roles of RAS-RAF-MEK signaling
  JOURNAL   Protein Cell 7 (9), 638-650 (2016)
   PUBMED   27510948
  REMARK    GeneRIF: the DYNC1I1 deficiency, a neuron-specific dynein
            intermediate chain, causes neuronal atrophy in primary hippocampal
            neurons.
REFERENCE   6  (bases 1 to 2046)
  AUTHORS   Pfister,K.K., Fisher,E.M., Gibbons,I.R., Hays,T.S., Holzbaur,E.L.,
            McIntosh,J.R., Porter,M.E., Schroer,T.A., Vaughan,K.T.,
            Witman,G.B., King,S.M. and Vallee,R.B.
  TITLE     Cytoplasmic dynein nomenclature
  JOURNAL   J Cell Biol 171 (3), 411-413 (2005)
   PUBMED   16260502
REFERENCE   7  (bases 1 to 2046)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 2046)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2046)
  AUTHORS   Bielli,A., Thornqvist,P.O., Hendrick,A.G., Finn,R., Fitzgerald,K.
            and McCaffrey,M.W.
  TITLE     The small GTPase Rab4A interacts with the central region of
            cytoplasmic dynein light intermediate chain-1
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1141-1153 (2001)
   PUBMED   11243854
REFERENCE   10 (bases 1 to 2046)
  AUTHORS   Nolan,P.M., Peters,J., Strivens,M., Rogers,D., Hagan,J., Spurr,N.,
            Gray,I.C., Vizor,L., Brooker,D., Whitehill,E., Washbourne,R.,
            Hough,T., Greenaway,S., Hewitt,M., Liu,X., McCormack,S.,
            Pickford,K., Selley,R., Wells,C., Tymowska-Lalanne,Z., Roby,P.,
            Glenister,P., Thornton,C., Thaung,C., Stevenson,J.A., Arkell,R.,
            Mburu,P., Hardisty,R., Kiernan,A., Erven,A., Steel,K.P.,
            Voegeling,S., Guenet,J.L., Nickols,C., Sadri,R., Nasse,M.,
            Isaacs,A., Davies,K., Browne,M., Fisher,E.M., Martin,J., Rastan,S.,
            Brown,S.D. and Hunter,J.
  TITLE     A systematic, genome-wide, phenotype-driven mutagenesis programme
            for gene function studies in the mouse
  JOURNAL   Nat Genet 25 (4), 440-443 (2000)
   PUBMED   10932191
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161419.2.
            
            On Nov 17, 2006 this sequence version replaced NM_146229.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023347.1, AK159702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC161419.2         150912-151108
            198-271             AC161419.2         151290-151363
            272-388             AC161419.2         167135-167251
            389-619             AC161419.2         168088-168318
            620-789             AC161419.2         171226-171395
            790-883             AC161419.2         175591-175684
            884-1019            AC161419.2         177175-177310
            1020-1131           AC161419.2         177681-177792
            1132-1191           AC161419.2         179944-180003
            1192-1236           AC161419.2         181939-181983
            1237-1357           AC161419.2         182630-182750
            1358-1510           AC161419.2         183786-183938
            1511-2046           AC161419.2         185334-185869
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 64.96 cM"
     gene            1..2046
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /note="dynein cytoplasmic 1 light intermediate chain 1"
                     /db_xref="GeneID:235661"
                     /db_xref="MGI:MGI:2135610"
     exon            1..197
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1623
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /note="dynein, cytoplasmic, light intermediate chain 1;
                     DLC-A; dynein light chain A; dynein light intermediate
                     chain 1, cytosolic"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 light intermediate chain 1"
                     /protein_id="NP_666341.1"
                     /db_xref="CCDS:CCDS23595.1"
                     /db_xref="GeneID:235661"
                     /db_xref="MGI:MGI:2135610"
                     /translation="MAAVGRVGSFGSSPPGLASTYASGPLANELASGSGGPAAGDDED
                     GQNLWSCILSEVSTRSRSKLPTGKNVLLLGEDGAGKTSLIRRIQGIEEYKKGRGLEYL
                     YLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDALSLRDTLVMLVVDMSKPWTALD
                     SLQKWASVVREHVDKLKIPPEEMKEMEQKLIRDFQEYVEPGEDFPASPQRRTTGAQED
                     RGDSVVLPLGADTLTHNLGLPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCL
                     QYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIG
                     ILHENFQTLKVEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAG
                     RPVDASPRVPGGSPRTPNRSVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNS
                     LLSKKTGSPGGPGVGGSPGGGAAGASPSLPPSAKKSGQKPVLSDVHAELDRITRKPAS
                     VSPTTPTSPTEGEAS"
     exon            198..271
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..388
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..619
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..789
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..883
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1019
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1131
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1191
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1236
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1357
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1510
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..2046
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2013
                     /gene="Dync1li1"
                     /gene_synonym="1110053F02Rik; Dlic1; Dnclic1; LIC-1"
                     /note="major polyA site"
ORIGIN      
        1 cgccgcttcg ttcttccagc cctgtcagga gtggtgtgat tcccgaccaa gatggcggcc
       61 gtggggcgag tcggctcgtt cggttcatct ccacccgggc tagcctcgac ctacgccagc
      121 ggacccctag ccaacgagct agcgtcgggc agcggcggcc ccgcggcggg cgacgatgag
      181 gacgggcaga acctttggtc ctgcatcctc agcgaggtct ccacgcgctc gcgctccaag
      241 ctcccgaccg ggaagaacgt gctgctgctg ggtgaagatg gagctgggaa gacaagcctc
      301 ataagaagaa ttcagggcat agaggagtac aagaagggaa gaggactgga gtacctgtac
      361 ttaaatgtgc acgacgaaga cagggatgat caaacaagat gtaatgtatg gatcttagat
      421 ggagatctgt accacaaagg gctactcaag ttctctctgg atgccctttc tctgagggac
      481 actctggtca tgttggttgt tgatatgtca aagccttgga ctgctttgga ttccttacag
      541 aaatgggcaa gtgtggtgag agaacatgtc gacaagctga aaatcccccc tgaagagatg
      601 aaggaaatgg agcagaagtt gattagagac ttccaagagt acgtggagcc aggagaagac
      661 ttcccagcct cccctcagcg aagaaccact ggtgcgcagg aggacagagg tgacagtgtt
      721 gtcctgcccc tgggtgcaga cacactcaca cacaacctgg gcctaccagt gctcgtagtc
      781 tgtacgaagt gtgatgccat tagtgtattg gagaaagagc atgactacag agatgaacac
      841 ttcgatttta tccagtctca catccgcaag ttctgtttac agtatggcgc agcgctgatt
      901 tacacttcag taaaagagaa caagaacata gacttagttt ataaatacat cgtccagaag
      961 ctgtacgggt tcccgtacaa gatccctgcg gtggtggtgg agaaggacgc agtgtttatt
     1021 ccagcagggt gggataatga taagaaaata ggaatattac atgaaaattt tcagactttg
     1081 aaagtagaag ataattttga agacatcata accaaacctc ctgtcagaaa gttcgtgcat
     1141 gagaaggaga tcatggcaga agatgaccaa gtgtttctga tgaagctaca gtctctttta
     1201 gcaaagcaac ctccaactgc agctggaagg cctgtggatg catcaccaag agtccctgga
     1261 ggctcccctc gaacaccaaa cagatctgtg tcatccaatg ttgccagtgt gtcccccatc
     1321 cctgctggat ccaaaaaaat tgatccaaac atgaaagctg gagcgaccag cgaaggggtc
     1381 ctggcgaatt tcttcaacag tctgttgagt aagaagactg gctctcctgg aggccccggg
     1441 gtcggcggca gtcctggagg aggggctgca ggtgcaagcc ccagtttgcc accgtccgcc
     1501 aaaaagtcag gccagaaacc tgtgctttca gatgttcacg cagagctaga cagaatcaca
     1561 cggaaacctg cttctgtttc tcctacaaca cctacatctc ctacggaagg agaagcctcc
     1621 tgaagatacc aaacaaagcc atttgttcat tcttctgggt aatgacagct tgcctctgcc
     1681 ctgcccttcc aagttggaac tacgatgggg ccggaagctt ttacaaacag acaaagttta
     1741 tgtccttatg tccttttttt tttttttttg gtggctgccc atttttaaaa gaggaactac
     1801 acagaagaaa gacaggtttt tttttttttt tggtttttcg agacaggatt tctctgtata
     1861 gccctggctg tcccagaact cactttgtag accaggctgg cctcaaactc agaaatcctc
     1921 ctgcctctgc ctccggtgtg cgccaccagg accggctaag aaagacaatt ttacattatg
     1981 tagaataact gtttgcattg ccattctgca aaatgaagaa attttgattt ttgaaaaaaa
     2041 aaaaaa
//
