LOCUS       NM_010064               2534 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2),
            transcript variant 8, mRNA.
ACCESSION   NM_010064
VERSION     NM_010064.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2534)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2534)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2534)
  AUTHORS   Verdile,V., Svetoni,F., La Rosa,P., Ferrante,G., Cesari,E.,
            Sette,C. and Paronetto,M.P.
  TITLE     EWS splicing regulation contributes to balancing Foxp1 isoforms
            required for neuronal differentiation
  JOURNAL   Nucleic Acids Res 50 (6), 3362-3378 (2022)
   PUBMED   35253879
REFERENCE   4  (bases 1 to 2534)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 2534)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2534)
  AUTHORS   Shibata,M., Hattori,H., Sasaki,T., Gotoh,J., Hamada,J. and
            Fukuuchi,Y.
  TITLE     Temporal profiles of the subcellular localization of Bim, a
            BH3-only protein, during middle cerebral artery occlusion in mice
  JOURNAL   J Cereb Blood Flow Metab 22 (7), 810-820 (2002)
   PUBMED   12142566
REFERENCE   7  (bases 1 to 2534)
  AUTHORS   Sasaki,S., Shionoya,A., Ishida,M., Gambello,M.J., Yingling,J.,
            Wynshaw-Boris,A. and Hirotsune,S.
  TITLE     A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the
            developing and adult nervous system
  JOURNAL   Neuron 28 (3), 681-696 (2000)
   PUBMED   11163259
REFERENCE   8  (bases 1 to 2534)
  AUTHORS   Crackower,M.A., Sinasac,D.S., Xia,J., Motoyama,J., Prochazka,M.,
            Rommens,J.M., Scherer,S.W. and Tsui,L.C.
  TITLE     Cloning and characterization of two cytoplasmic dynein intermediate
            chain genes in mouse and human
  JOURNAL   Genomics 55 (3), 257-267 (1999)
   PUBMED   10049579
REFERENCE   9  (bases 1 to 2534)
  AUTHORS   Suzuki,K. and Mansson,J.E.
  TITLE     Animal models of lysosomal disease: an overview
  JOURNAL   J Inherit Metab Dis 21 (5), 540-547 (1998)
   PUBMED   9728334
  REMARK    Review article
REFERENCE   10 (bases 1 to 2534)
  AUTHORS   Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M.,
            Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Vallee,R.B.
  TITLE     Multiple mouse chromosomal loci for dynein-based motility
  JOURNAL   Genomics 36 (1), 29-38 (1996)
   PUBMED   8812413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY226221.1, AK168730.1, GU992210.1 and BQ174310.1.
            
            On Nov 11, 2010 this sequence version replaced NM_010064.3.
            
            Transcript Variant: This variant (8; also called 1b.C) differs in
            the 5' UTR and lacks multiple exons in the 5' coding region,
            compared to variant 1. Variant 8 encodes a shorter isoform (5),
            compared to isoform 1. Variants 5 and 8 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168730.1, AK088015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY226221.1         2-27
            27-1028             AK168730.1         2-1003
            1029-2462           GU992210.1         949-2382
            2463-2534           BQ174310.1         1-72                c
FEATURES             Location/Qualifiers
     source          1..2534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 42.38 cM"
     gene            1..2534
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /note="dynein cytoplasmic 1 intermediate chain 2"
                     /db_xref="GeneID:13427"
                     /db_xref="MGI:MGI:107750"
     exon            1..129
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            130..246
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1977
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /note="isoform 5 is encoded by transcript variant 8;
                     cytoplasmic dynein 1 intermediate chain 2; DH IC-2; dynein
                     intermediate chain 2, cytosolic; dynein, cytoplasmic,
                     intermediate chain 2"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 intermediate chain 2
                     isoform 5"
                     /protein_id="NP_034194.1"
                     /db_xref="CCDS:CCDS16112.1"
                     /db_xref="GeneID:13427"
                     /db_xref="MGI:MGI:107750"
                     /translation="MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAA
                     VSVQEESDLEKKRREAEALLQSMGLTTDSPIVPPPMSPSSKSVSTPSEAGSQDSGDGA
                     VGSRRGPIKLGMAKITQVDFPPREIVTYTKETQTPVTAQPKEDEEEEDDVATPKPPVE
                     PEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIF
                     FDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNN
                     EEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
                     DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHP
                     QDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQ
                     GPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSP
                     THPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEG
                     QIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA"
     exon            247..364
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..455
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..571
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..667
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..830
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..930
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1056
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1203
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1317
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1451
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1596
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1737
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1863
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2519
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2489..2494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /note="hexamer: AATAAA"
     regulatory      2499..2504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /note="hexamer: AATATA"
     polyA_site      2510
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /note="major polyA site"
     polyA_site      2519
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
ORIGIN      
        1 gtagcggccg ccgcccatcc ctctttgtgt gcttgggacg ccgcggatct gcggcggcga
       61 cagttggaga gggacgttcc cgggaagtta ccggccagag aaagcgatct ccactccgcc
      121 acctgacagg tcacaaccat gtcggacaaa agtgatttaa aagctgagtt ggaacgtaag
      181 aagcaacggt tggcccaaat cagagaagaa aagaagagga aagaagagga aaggaaaaaa
      241 aaggaaactg atcagaagaa ggaagctgct gtttctgtac aagaagagtc tgatcttgaa
      301 aaaaaaagaa gagaagctga ggcattgctt caaagcatgg gactaactac ggactcccct
      361 attgtccctc ctcctatgtc tccatcctcc aagtcggtga gcacgccaag tgaagctgga
      421 agccaggatt ctggagatgg cgccgtggga tctagacgag gacctattaa acttggaatg
      481 gccaaaatta ctcaagttga ctttccccct cgagaaatcg tcacatacac aaaggaaact
      541 cagaccccgg ttacagctca acccaaagaa gatgaggagg aggaagatga tgtagcaact
      601 cctaaacctc ctgttgaacc tgaagaagag aaaactttga aaaaagacga agagaatgat
      661 agcaaagctc cacctcatga actaactgaa gaagaaaagc aacagatttt acactcagaa
      721 gaatttttaa gtttctttga ccattctacg agaattgtag aaagagccct ttctgagcag
      781 attaacatct tctttgacta cagtgggaga gacttggaag acaaagaagg ggagattcaa
      841 gcaggtgcta agctgtcatt aaatcgacag ttctttgatg agcgttggtc aaagcatcga
      901 gttgttagtt gtttggattg gtcatcccag tatccagaat tacttgtggc ttcctataat
      961 aacaatgaag aggctcctca tgagcctgat ggtgtggccc tcgtgtggaa tatgaagtac
     1021 aaaaaaacta ccccagagta tgtgttccac tgccagtcag ctgtaatgtc tgctacattt
     1081 gcaaaatttc atccgaatct tgttgttgga ggtacatatt caggccagat tgtgctttgg
     1141 gataaccgca gcaataaaag aactcctgtc cagagaacgc cgctgtcagc tgctgcacac
     1201 acacaccctg tctactgtgt aaatgttgtt ggaacacaaa atgctcacaa tctgattagc
     1261 atctctactg atggaaaaat ttgttcctgg agtttggaca tgctttccca tccacaggat
     1321 agcatggagt tggttcataa acagtcaaag gcagtagctg taacatctat gtctttccct
     1381 gttggagacg tcaacaactt tgttgtgggc agtgaagaag gttctgtgta tacagcatgc
     1441 cgccatggca gcaaagctgg aatcagtgag atgtttgagg gacaccaggg acccatcact
     1501 ggaatccact gtcacgcggc tgttggagca gtagacttct cacatctgtt tgtcacttcg
     1561 tcttttgact ggacagttaa actttggaca actaagaata acaagccttt gtactcattt
     1621 gaagataatt cagactatgt ctatgatgtt atgtggtcac ccacccaccc agccctgttt
     1681 gcctgtgtgg acggcatggg gagactggat ctatggaatc tcaacaatga cacagaggta
     1741 ccaactgcca gcatttctgt ggagggcaac cctgctctta accgtgtgag atggacccac
     1801 tcaggaagag aaattgccgt gggtgattct gaaggacaga ttgtcatcta tgatgtggga
     1861 gagcagatcg ctgttccccg aaatgatgaa tgggcaagat ttggccgaac actcgcagaa
     1921 attaacgcaa accgagctga cgcagaggag gaggcagcta cccgaatccc tgcctagcct
     1981 gaaaagcggc tgtagcctta gcaaatttgg caaaaatgat taagtagatc tcaaactatt
     2041 tgcatgcttc tgattaaatg agtgttaaaa gaaaatgcca tggataatct gggtttaata
     2101 caggaagcaa agcttacaat gcctttttat attatattca ctttgttttg gattggtgtc
     2161 atttttaata cagctgacaa ctttacagaa tgcagccttt tctgaattct aacacttggg
     2221 tgtatattgt taattattct tttggattct tttgaacttg taatactata tataattatt
     2281 tctaaagcac agattaagta agttctgcat atttctaagt agccacaatt ccttattccg
     2341 cactaagtac atacctccgt gtcagtggtg ttcttcctgt ccaagtgtat aggaatattg
     2401 ttccctcccc gcatgccgtc gcctacctgt tgtaagtttc atgttgatgc catttccctt
     2461 ctcgatagtt ctatggtagt tatctataaa taaaaacaaa tatatgctaa cttctcaaaa
     2521 aaaaaaaaaa aaaa
//
