LOCUS       NP_034194                612 aa            linear   ROD 30-APR-2024
DEFINITION  cytoplasmic dynein 1 intermediate chain 2 isoform 5 [Mus musculus].
ACCESSION   NP_034194
VERSION     NP_034194.1
DBSOURCE    REFSEQ: accession NM_010064.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 612)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 612)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 612)
  AUTHORS   Verdile,V., Svetoni,F., La Rosa,P., Ferrante,G., Cesari,E.,
            Sette,C. and Paronetto,M.P.
  TITLE     EWS splicing regulation contributes to balancing Foxp1 isoforms
            required for neuronal differentiation
  JOURNAL   Nucleic Acids Res 50 (6), 3362-3378 (2022)
   PUBMED   35253879
REFERENCE   4  (residues 1 to 612)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (residues 1 to 612)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 612)
  AUTHORS   Shibata,M., Hattori,H., Sasaki,T., Gotoh,J., Hamada,J. and
            Fukuuchi,Y.
  TITLE     Temporal profiles of the subcellular localization of Bim, a
            BH3-only protein, during middle cerebral artery occlusion in mice
  JOURNAL   J Cereb Blood Flow Metab 22 (7), 810-820 (2002)
   PUBMED   12142566
REFERENCE   7  (residues 1 to 612)
  AUTHORS   Sasaki,S., Shionoya,A., Ishida,M., Gambello,M.J., Yingling,J.,
            Wynshaw-Boris,A. and Hirotsune,S.
  TITLE     A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the
            developing and adult nervous system
  JOURNAL   Neuron 28 (3), 681-696 (2000)
   PUBMED   11163259
REFERENCE   8  (residues 1 to 612)
  AUTHORS   Crackower,M.A., Sinasac,D.S., Xia,J., Motoyama,J., Prochazka,M.,
            Rommens,J.M., Scherer,S.W. and Tsui,L.C.
  TITLE     Cloning and characterization of two cytoplasmic dynein intermediate
            chain genes in mouse and human
  JOURNAL   Genomics 55 (3), 257-267 (1999)
   PUBMED   10049579
REFERENCE   9  (residues 1 to 612)
  AUTHORS   Suzuki,K. and Mansson,J.E.
  TITLE     Animal models of lysosomal disease: an overview
  JOURNAL   J Inherit Metab Dis 21 (5), 540-547 (1998)
   PUBMED   9728334
  REMARK    Review article
REFERENCE   10 (residues 1 to 612)
  AUTHORS   Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M.,
            Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Vallee,R.B.
  TITLE     Multiple mouse chromosomal loci for dynein-based motility
  JOURNAL   Genomics 36 (1), 29-38 (1996)
   PUBMED   8812413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY226221.1, AK168730.1, GU992210.1 and BQ174310.1.
            
            Transcript Variant: This variant (8; also called 1b.C) differs in
            the 5' UTR and lacks multiple exons in the 5' coding region,
            compared to variant 1. Variant 8 encodes a shorter isoform (5),
            compared to isoform 1. Variants 5 and 8 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168730.1, AK088015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..612
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 42.38 cM"
     Protein         1..612
                     /product="cytoplasmic dynein 1 intermediate chain 2
                     isoform 5"
                     /note="cytoplasmic dynein 1 intermediate chain 2; DH IC-2;
                     dynein intermediate chain 2, cytosolic; dynein,
                     cytoplasmic, intermediate chain 2"
                     /calculated_mol_wt=68263
     Region          1..188
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88487.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q13409; propagated from
                     UniProtKB/Swiss-Prot (O88487.1)"
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:27474409; propagated from
                     UniProtKB/Swiss-Prot (O88487.1)"
     Site            84
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62871; propagated from
                     UniProtKB/Swiss-Prot (O88487.1)"
     Site            89
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88487.1)"
     Site            91
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88487.1)"
     Site            95
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88487.1)"
     Site            98
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88487.1)"
     Region          107..137
                     /region_name="Dynein_IC2"
                     /note="Cytoplasmic dynein 1 intermediate chain 2;
                     pfam11540"
                     /db_xref="CDD:463291"
     Region          251..300
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O88487.1)"
     Region          253..572
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(253,270,284,290..291,303..304,323,328,334..335,
                     353..354,373,378,384..385,414,431,436,448..449,473,477,
                     483..484,496..497,515,520,526..527,542..543,561,565,
                     571..572)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          256..305
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          304..344
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O88487.1)"
     Region          313..351
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          353..394
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O88487.1)"
     Region          359..400
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          403..443
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (O88487.1)"
     Region          408..455
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          448..493
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (O88487.1)"
     Region          463..495
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          496..536
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (O88487.1)"
     Region          501..539
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          542..581
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (O88487.1)"
     Region          547..573
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..612
                     /gene="Dync1i2"
                     /gene_synonym="3110079H08Rik; Dncic2"
                     /coded_by="NM_010064.4:139..1977"
                     /note="isoform 5 is encoded by transcript variant 8"
                     /db_xref="CCDS:CCDS16112.1"
                     /db_xref="GeneID:13427"
                     /db_xref="MGI:MGI:107750"
ORIGIN      
        1 msdksdlkae lerkkqrlaq ireekkrkee erkkketdqk keaavsvqee sdlekkrrea
       61 eallqsmglt tdspivpppm spssksvstp seagsqdsgd gavgsrrgpi klgmakitqv
      121 dfppreivty tketqtpvta qpkedeeeed dvatpkppve peeektlkkd eendskapph
      181 elteeekqqi lhseeflsff dhstrivera lseqiniffd ysgrdledke geiqagakls
      241 lnrqffderw skhrvvscld wssqypellv asynnneeap hepdgvalvw nmkykkttpe
      301 yvfhcqsavm satfakfhpn lvvggtysgq ivlwdnrsnk rtpvqrtpls aaahthpvyc
      361 vnvvgtqnah nlisistdgk icswsldmls hpqdsmelvh kqskavavts msfpvgdvnn
      421 fvvgseegsv ytacrhgska gisemfeghq gpitgihcha avgavdfshl fvtssfdwtv
      481 klwttknnkp lysfednsdy vydvmwspth palfacvdgm grldlwnlnn dtevptasis
      541 vegnpalnrv rwthsgreia vgdsegqivi ydvgeqiavp rndewarfgr tlaeinanra
      601 daeeeaatri pa
//
