LOCUS       NM_001409611            2660 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus dynein cytoplasmic 1 intermediate chain 1 (Dync1i1),
            transcript variant 9, mRNA.
ACCESSION   NM_001409611 XM_006504982
VERSION     NM_001409611.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   He,S., Gillies,J.P., Zang,J.L., Cordoba-Beldad,C.M., Yamamoto,I.,
            Fujiwara,Y., Grantham,J., DeSantis,M.E. and Shibuya,H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Du,H., Wang,Z., Guo,R., Yang,L., Liu,G., Zhang,Z., Xu,Z., Tian,Y.,
            Yang,Z., Li,X. and Chen,B.
  TITLE     Transcription factors Bcl11a and Bcl11b are required for the
            production and differentiation of cortical projection neurons
  JOURNAL   Cereb Cortex 32 (17), 3611-3632 (2022)
   PUBMED   34963132
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Doyle,D.Z., Lam,M.M., Qalieh,A., Qalieh,Y., Sorel,A., Funk,O.H. and
            Kwan,K.Y.
  TITLE     Chromatin remodeler Arid1a regulates subplate neuron identity and
            wiring of cortical connectivity
  JOURNAL   Proc Natl Acad Sci U S A 118 (21) (2021)
   PUBMED   34011608
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Lau,E.O., Damiani,D., Chehade,G., Ruiz-Reig,N., Saade,R.,
            Jossin,Y., Aittaleb,M., Schakman,O., Tajeddine,N., Gailly,P. and
            Tissir,F.
  TITLE     DIAPH3 deficiency links microtubules to mitotic errors, defective
            neurogenesis, and brain dysfunction
  JOURNAL   Elife 10, e61974 (2021)
   PUBMED   33899739
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2660)
  AUTHORS   Puthalakath,H., Huang,D.C., O'Reilly,L.A., King,S.M. and
            Strasser,A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   7  (bases 1 to 2660)
  AUTHORS   Crackower,M.A., Sinasac,D.S., Xia,J., Motoyama,J., Prochazka,M.,
            Rommens,J.M., Scherer,S.W. and Tsui,L.C.
  TITLE     Cloning and characterization of two cytoplasmic dynein intermediate
            chain genes in mouse and human
  JOURNAL   Genomics 55 (3), 257-267 (1999)
   PUBMED   10049579
REFERENCE   8  (bases 1 to 2660)
  AUTHORS   Suzuki,K. and Mansson,J.E.
  TITLE     Animal models of lysosomal disease: an overview
  JOURNAL   J Inherit Metab Dis 21 (5), 540-547 (1998)
   PUBMED   9728334
  REMARK    Review article
REFERENCE   9  (bases 1 to 2660)
  AUTHORS   Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M.,
            Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Vallee,R.B.
  TITLE     Multiple mouse chromosomal loci for dynein-based motility
  JOURNAL   Genomics 36 (1), 29-38 (1996)
   PUBMED   8812413
REFERENCE   10 (bases 1 to 2660)
  AUTHORS   King,S.M., Barbarese,E., Dillman,J.F. 3rd, Patel-King,R.S.,
            Carson,J.H. and Pfister,K.K.
  TITLE     Brain cytoplasmic and flagellar outer arm dyneins share a highly
            conserved Mr 8,000 light chain
  JOURNAL   J Biol Chem 271 (32), 19358-19366 (1996)
   PUBMED   8702622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034254.4, AC162178.2, AC023286.4 and AC023175.4.
            
            On Jul 21, 2022 this sequence version replaced XM_006504982.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784645.1126125.1,
                                           SRR17784650.631453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC034254.4         84214-84378
            166-282             AC034254.4         115820-115936
            283-397             AC162178.2         122536-122650
            398-539             AC162178.2         125156-125297
            540-599             AC162178.2         139945-140004
            600-715             AC162178.2         156281-156396
            716-805             AC023286.4         139475-139564
            806-968             AC023286.4         147686-147848
            969-1068            AC023286.4         150200-150299
            1069-1194           AC023286.4         157535-157660
            1195-1341           AC023175.4         52732-52878
            1342-1455           AC023175.4         57594-57707
            1456-1589           AC023175.4         60265-60398
            1590-1734           AC023175.4         62956-63100
            1735-1875           AC023175.4         97161-97301
            1876-2001           AC023175.4         101346-101471
            2002-2660           AC023175.4         118263-118921
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 2.26 cM"
     gene            1..2660
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /note="dynein cytoplasmic 1 intermediate chain 1"
                     /db_xref="GeneID:13426"
                     /db_xref="MGI:MGI:107743"
     exon            1..165
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            166..282
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2112
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /note="isoform 6 is encoded by transcript variant 9;
                     dynein, cytoplasmic, intermediate chain 1; Dynein
                     intermediate chain 1, cytosolic (DH IC-1) (Cytoplasmic
                     dynein intermediate chain 1)"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 intermediate chain 1
                     isoform 6"
                     /protein_id="NP_001396540.1"
                     /db_xref="GeneID:13426"
                     /db_xref="MGI:MGI:107743"
                     /translation="MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKE
                     PVQDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKS
                     VSTPSDAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLP
                     REVVSYSKETQTPLATHQSEEDEEDEEMVEPKIGHDSELENQEKKQETKEAPPRELTE
                     EEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFN
                     RQFYDEHWSKHRVVTCMDWSLQYPELMVASYSNNEDAPHEPDGVALVWNMKFKKTTPE
                     YVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPV
                     YCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTG
                     DVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTS
                     SFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNSDT
                     EVPTASVAIEGASALNRVRWAQGGKEVAVGDSEGRIWIYDVGELAVPHNDEWTRFART
                     LVEIRANRADSEEEGAVELAA"
     exon            283..397
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            398..539
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            540..599
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            600..715
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            716..805
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            806..968
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1068
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1194
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1341
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1455
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1589
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1734
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1875
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2001
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2660
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /note="hexamer: AATAAA"
     polyA_site      2660
                     /gene="Dync1i1"
                     /gene_synonym="DH IC-1; DHIC-1; DIC; Dncic1; IC74"
                     /note="major polyA site"
ORIGIN      
        1 agctgtcagt gtcaggctca ggagagagga agtgatcgct ccgggaggag cgctagccta
       61 gccgcgcagc gtgagacagc acatcctgct ggcgcgggcc cgctgctctc cgtcctcccg
      121 cgcctcctcc acgacctcca gtgagcctcc gcgtacagca ttcaggaagc aaacatgtct
      181 gacaagagcg acctaaaggc cgagctggag cgcaaaaagc agcgcttagc acagataaga
      241 gaggagaaga aacggaagga agaggagagg aagaagaaag aggcagatat gcagcaaaag
      301 aaagagcccg ttcaagatga ctccgatctg gatcgcaaac gacgggagac agaagctttg
      361 cttcagagca ttggcatatc accggagccc cctctagtgc agccgttgca ttttttaaca
      421 tgggatacct gttattttca ttatttagtc ccaaccccta tgtctccctc ttcgaaatca
      481 gtgagcactc ccagtgatgc tggaagccaa gactcgggcg atctggggcc attaacaagg
      541 accctgcagt gggacacaga cccctcagtg ctccagctgc agtcagactc agaacttggg
      601 agacgactgc acaagctggg cgtgtcaaag gtgacccagg tggatttcct gcctagggaa
      661 gtagtatcct actccaagga gacacagact cctcttgcaa cacatcagtc tgaagaggat
      721 gaggaagatg aggagatggt agaacccaaa attggtcatg attctgaact ggagaatcaa
      781 gaaaaaaagc aggagacaaa ggaagcccct ccaagagagt tgacggagga agaaaaacag
      841 cagatcctgc actcagaaga attcctcatc ttctttgacc ggacaatccg agtaattgaa
      901 agagctcttg cagaggactc ggacatcttt tttgactaca gcggtcgaga gctggaggag
      961 aaagatgggg atgtgcaggc tggagccaac ctgtctttca accgtcagtt ctacgatgaa
     1021 cattggtcta agcatcgggt ggtcacatgt atggactggt ctctccagta ccctgagctg
     1081 atggttgctt cttatagcaa caacgaagat gctccccacg agccagatgg agtggccttg
     1141 gtttggaaca tgaagttcaa gaaaaccaca ccagaatatg tcttccactg tcagtcttct
     1201 gtgatgtcag tctgctttgc ccgttttcat cctaatttgg tggttggtgg cacctattca
     1261 ggccagattg tcctctggga caatcgcagt catcgaagaa cgcctgtcca gaggaccccc
     1321 ttgtcagccg ctgcacatac acatcctgtg tactgtgtca atgttgttgg gacccagaat
     1381 gctcacaacc tgatcactgt ctctaccgat ggcaaaatgt gttcctggag cttggacatg
     1441 ctctcaaccc cacaggagag catggagctg gtgtataata agtccaagcc tgtggctgtg
     1501 acgggaatgg ctttcccaac gggagacgtc aacaacttcg tggttggcag tgaggaaggg
     1561 accgtctaca cggcttgtcg tcatggaagc aaagcaggca tcggtgaggt ctttgaaggt
     1621 caccaagggc cagtgacagg cattaactgc cacatggcag tgggtcccat cgacttttct
     1681 catctgtttg tcacgtcatc atttgactgg actgtcaaac tgtggaccac gaagcacaac
     1741 aagccgctct actcctttga agacaatgca gactatgtgt acgatgtcat gtggtccccc
     1801 gtgcatcccg cgctctttgc ctgcgtggac gggatggggc gcttggacct ctggaacctc
     1861 aacagtgaca ccgaggtgcc aacagcaagt gtggccattg aaggagcatc tgccctaaac
     1921 cgagttcgtt gggcacaggg tggcaaggaa gttgcggtag gggactcaga aggccgcatt
     1981 tggatctacg atgttggaga gcttgccgtt ccacacaatg atgaatggac acgatttgcc
     2041 cggaccctgg tggagatccg cgccaacagg gctgacagcg aggaggaagg ggctgttgag
     2101 ttagctgcct agacatgaga tgagtctgcc cactctggcg cccacccttc catgctagaa
     2161 ctcagtctgc agtcaaggcc cccgtgcagt gtttggcgtt ctttctgtat cagtatcccc
     2221 gtggcatctt gggtgccata ttgtgcagtg tttccccata ttctccacgt gtacctactc
     2281 actcgaaatc caccccagcg tttctacctt tgtgtccccg tctcaaaaac aaatggggga
     2341 gggaaccctt aggggtttag ttgttgcctt ttaactactt ggtagctgta tttaatagct
     2401 ggaaacctct ggttgaattt gtgcttacat gtacttctgg cgtagtccta ttaaatccat
     2461 atgaagccag atatgattgg gtgcagatgt ggtgtgcctc atgatatggt acagggccaa
     2521 agacttgaga tgtggtgttt tacatggtga ttcgcattat gaatggattt actacaagaa
     2581 cattgctgct ccttatttat tgtaatgtgc tgcatggaac atatttattt gaaagcatta
     2641 aaataaacga tcttagagca
//
