LOCUS       NM_001403761            2644 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus dymeclin (Dym), transcript variant 1, mRNA.
ACCESSION   NM_001403761 XM_030250594
VERSION     NM_001403761.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Zhou,Z., Ye,Q., Ren,H., Zhang,Y., Han,B., Yao,H. and Bai,Y.
  TITLE     CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in
            LPS-induced mouse model of depression
  JOURNAL   Int J Biol Macromol 254 (Pt 3), 127922 (2024)
   PUBMED   37944732
  REMARK    GeneRIF: CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4
            axis in LPS-induced mouse model of depression.
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Dupuis,N., Fafouri,A., Bayot,A., Kumar,M., Lecharpentier,T.,
            Ball,G., Edwards,D., Bernard,V., Dournaud,P., Drunat,S.,
            Vermelle-Andrzejewski,M., Vilain,C., Abramowicz,M., Desir,J.,
            Bonaventure,J., Gareil,N., Boncompain,G., Csaba,Z., Perez,F.,
            Passemard,S., Gressens,P. and El Ghouzzi,V.
  TITLE     Dymeclin deficiency causes postnatal microcephaly, hypomyelination
            and reticulum-to-Golgi trafficking defects in mice and humans
  JOURNAL   Hum Mol Genet 24 (10), 2771-2783 (2015)
   PUBMED   25652408
  REMARK    GeneRIF: Dymeclin is crucial for proper myelination and anterograde
            neuronal trafficking, two processes that are highly active during
            postnatal brain maturation.
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Osipovich,A.B., Jennings,J.L., Lin,Q., Link,A.J. and Ruley,H.E.
  TITLE     Dyggve-Melchior-Clausen syndrome: chondrodysplasia resulting from
            defects in intracellular vesicle traffic
  JOURNAL   Proc Natl Acad Sci U S A 105 (42), 16171-16176 (2008)
   PUBMED   18852472
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Cohn,D.H., Ehtesham,N., Krakow,D., Unger,S., Shanske,A.,
            Reinker,K., Powell,B.R. and Rimoin,D.L.
  TITLE     Mental retardation and abnormal skeletal development
            (Dyggve-Melchior-Clausen dysplasia) due to mutations in a novel,
            evolutionarily conserved gene
  JOURNAL   Am J Hum Genet 72 (2), 419-428 (2003)
   PUBMED   12491225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125122.4, AC132385.5 and AC121511.12.
            
            On Apr 4, 2022 this sequence version replaced XM_030250594.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.353931.1,
                                           SRR17784651.843262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC125122.4         32366-32586         c
            222-412             AC125122.4         8081-8271           c
            413-465             AC132385.5         37677-37729
            466-559             AC132385.5         39977-40070
            560-693             AC132385.5         41326-41459
            694-766             AC132385.5         47797-47869
            767-892             AC132385.5         64899-65024
            893-1035            AC132385.5         67061-67203
            1036-1218           AC132385.5         99486-99668
            1219-1397           AC132385.5         103807-103985
            1398-1523           AC132385.5         108154-108279
            1524-1637           AC132385.5         110120-110233
            1638-1732           AC132385.5         111521-111615
            1733-1897           AC132385.5         147163-147327
            1898-2000           AC132385.5         183859-183961
            2001-2183           AC121511.12        64060-64242
            2184-2297           AC121511.12        77355-77468
            2298-2644           AC121511.12        120690-121036
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.97 cM"
     gene            1..2644
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /note="dymeclin"
                     /db_xref="GeneID:69190"
                     /db_xref="MGI:MGI:1918480"
     exon            1..221
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            222..412
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2447
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="dymeclin isoform 1"
                     /protein_id="NP_001390690.1"
                     /db_xref="GeneID:69190"
                     /db_xref="MGI:MGI:1918480"
                     /translation="MGSNSSKISDLPKNEYLKKLSGPESISENDPFWNQLFSFSFPAP
                     TSSSELKLLEEATISVCKSLVENNPRTGNLAALTKVFLSRTRELRLSAECQNHIFIWQ
                     THNALFIICCLLKVFIRELSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCSLVQLIT
                     DTPLLDITYEIAVEAISAMVVFLSCQLFHKEVLRQSISHKYLMQGPCLPYTSKLVKTL
                     LYNFIRQEKPPPPGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGAGSKAAASPEL
                     TSPLANQSLLLLLVLVNLTDAPDIPNPYRQAVSSFKNTQDSSPFPSSIPHTFQINFNS
                     LYTALCEQQTSDQATLLLYTLLHQNSNVRTYVLARTDMENLVLPILEILYHVEERNSH
                     HVYMALIILLILTEDDGFNRSIHEVILRNITWYSERVLTEISLGSLLILVVIRTIQYN
                     MTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIISYTCRHLRRYVYVLDRLYSPRS
                     PCSARQRCFSAPSDNGEELLSLTCSHILRSYASSLFSLLSKKHNKVLEQATQSLRGPL
                     SSSDVPLPDYAQDLSVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRT
                     HPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFPELKF
                     KYVEEEQPEEFFIPYVWSLVYNSAVGLYWNPQDIQLFAMDSD"
     exon            413..465
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            466..559
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            560..693
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..766
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            767..892
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1035
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1218
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1397
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1523
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1637
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1732
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1897
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2000
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2183
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2297
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2644
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2620..2625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="Dym"
                     /gene_synonym="1810041M12Rik; 4933427L07Rik;
                     C030019K18Rik"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgtcc tccgtctctt cccccttctc accccaactc ctcctgcgtc tccgcacgga
       61 cagccgctgg ggctggaacg cggtgggaac cggagcccct gacctacgga accatggagg
      121 cctaagccgc cgtgcacacc cgggcccctg tgcgcccgcg ctcccgttcc cttgctgcct
      181 gccggccgcg gctggaagcg gagtccgcgc cgctgaccca ggttgtcttg tggaaatgcc
      241 cgtgtgagga cgagctgcct accacgtaga agatgggatc gaacagcagc aagatcagtg
      301 atcttccgaa aaacgagtac ttaaaaaagc tgtcaggccc cgagtctata tctgaaaacg
      361 accccttctg gaatcagctc ttttcatttt ctttccccgc accaaccagc agttctgagt
      421 tgaagctatt ggaagaggca accatttcag tttgcaagtc tttggttgaa aacaaccctc
      481 gaacaggaaa tcttgctgcg ctaactaagg tcttcctatc tagaaccagg gagctcaggc
      541 tctcagccga gtgtcagaac cacatcttca tctggcagac acacaatgct ctgtttatta
      601 tttgctgctt gctgaaagtg ttcatccgtg agctgtctga ggaagagctg cagcttcatt
      661 ttacatatga agaaaagtcc cccggcagct acagttctga ctctgaagac cttctggaag
      721 agttgctctg cagcttggta cagttaatca ctgatactcc actcttggat atcacgtatg
      781 agatagcagt ggaggccatc tcggcaatgg ttgtcttcct ttcctgccaa ctcttccaca
      841 aggaggttct gcgacagagc atcagtcaca agtacctgat gcaaggccca tgtcttccct
      901 acaccagtaa acttgtgaaa accttattgt ataactttat cagacaagaa aagccacctc
      961 cgcccggaac ccatgtcttc cctcagcagt cggatggggg aggactgctg tatggactgg
     1021 catcaggagt agcaactggt ctctggactg tcttcacgct aggcggggca ggcagcaaag
     1081 cagctgcgtc cccagaactt acatctcctc tggccaacca gagtctcctg ctgctgctgg
     1141 tgctggtgaa cctgacggat gccccagaca tacccaaccc ctacaggcaa gctgtctcgt
     1201 catttaagaa cacgcaagac agcagtccgt tcccatcatc aattcctcat accttccaga
     1261 ttaactttaa cagtttgtac acagccctgt gtgagcagca gacgtctgat caggcaacgc
     1321 tgctcctgta cacgctgctc caccagaaca gcaatgtcag gacgtacgtg ctggcccgga
     1381 cggatatgga aaatcttgtt ttaccaattc ttgagatttt gtatcatgtt gaggaaagaa
     1441 actcacacca tgtctatatg gcccttataa tcctgttgat ccttacagaa gacgatggct
     1501 tcaatcggtc cattcatgaa gtgatattaa gaaacattac ttggtattca gaaagagtct
     1561 taactgagat ttccctgggg agcctcctaa ttctggtggt aataagaacc atccagtaca
     1621 atatgaccag gactcgagac aagtacctgc acacaaactg cctggcggct ttagcaaaca
     1681 tgtcagcgca gttccgctcc ctccaccagt acgctgccca gaggatcatc agttatacct
     1741 gccgccactt gcggagatat gtttatgtgt tggacagatt gtattccccc cgctctccct
     1801 gttccgcacg tcagcgttgc ttctcggccc ccagtgacaa tggagaggaa ctcttgtctc
     1861 taacttgctc tcacattctc agatcctatg cctccagttt gttttctttg ctgtctaaaa
     1921 aacacaacaa ggtcctggag caagccacgc agtccttgag aggtcccctg agctccagcg
     1981 atgtccctct cccagattat gcacaggacc tcagtgtcat tgaagaagtg attcggatga
     2041 tgctggagat catcaactcc tgcctgacaa attctcttca ccacaaccca aacttggtgt
     2101 acgccttgct ttacaaacgg gacctctttg agcaattccg aactcatccc tcattccagg
     2161 acataatgca aaacattgac ctggtgatct ccttctttag ctcaagactt ctacaagctg
     2221 gagctgagct gtcggtggaa agggtcttgg aaatcattaa acaaggggtt gtggcgctgc
     2281 ccaaagacag actaaagaag tttccagaac tgaagttcaa atacgtggag gaagagcagc
     2341 ctgaggagtt cttcatcccg tacgtctggt ccctggtcta caactcagcg gtcggcttgt
     2401 actggaaccc gcaggacatc cagctgtttg ccatggactc ggactgaagc aggacacagc
     2461 cacgcccacc ccagccacgc ccaggagcag aggcagacag actgaggcac cacagagggt
     2521 caaacaagcg tgcttccctc acacactgtg actattggga gactgcgcca gttagcagta
     2581 gttcactcag ccttgattgt actgcaaggg cgagacaaaa ataaacggga aacgtgctgt
     2641 tcaa
//
