LOCUS       NM_033613               1456 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus decapping exoribonuclease (Dxo), transcript variant 1,
            mRNA.
ACCESSION   NM_033613
VERSION     NM_033613.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1456)
  AUTHORS   Doamekpor,S.K., Grudzien-Nogalska,E., Mlynarska-Cieslak,A.,
            Kowalska,J., Kiledjian,M. and Tong,L.
  TITLE     DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs
  JOURNAL   Nucleic Acids Res 48 (11), 6136-6148 (2020)
   PUBMED   32374864
  REMARK    GeneRIF: DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps
            on RNAs.
REFERENCE   2  (bases 1 to 1456)
  AUTHORS   Doamekpor,S.K., Gozdek,A., Kwasnik,A., Kufel,J. and Tong,L.
  TITLE     A novel 5'-hydroxyl dinucleotide hydrolase activity for the
            DXO/Rai1 family of enzymes
  JOURNAL   Nucleic Acids Res 48 (1), 349-358 (2020)
   PUBMED   31777937
  REMARK    GeneRIF: A novel 5'-hydroxyl dinucleotide hydrolase activity for
            the DXO/Rai1 family of enzymes has been reported.
            Erratum:[Nucleic Acids Res. 2021 Jul 21;49(13):7806. doi:
            10.1093/nar/gkab570.. PMID: 34165569]
REFERENCE   3  (bases 1 to 1456)
  AUTHORS   Yun,J.S., Yoon,J.H., Choi,Y.J., Son,Y.J., Kim,S., Tong,L. and
            Chang,J.H.
  TITLE     Molecular mechanism for the inhibition of DXO by adenosine
            3',5'-bisphosphate
  JOURNAL   Biochem Biophys Res Commun 504 (1), 89-95 (2018)
   PUBMED   30180947
REFERENCE   4  (bases 1 to 1456)
  AUTHORS   Jiao,X., Doamekpor,S.K., Bird,J.G., Nickels,B.E., Tong,L.,
            Hart,R.P. and Kiledjian,M.
  TITLE     5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells
            Promotes RNA Decay through DXO-Mediated deNADding
  JOURNAL   Cell 168 (6), 1015-1027 (2017)
   PUBMED   28283058
REFERENCE   5  (bases 1 to 1456)
  AUTHORS   Jiao,X., Chang,J.H., Kilic,T., Tong,L. and Kiledjian,M.
  TITLE     A mammalian pre-mRNA 5' end capping quality control mechanism and
            an unexpected link of capping to pre-mRNA processing
  JOURNAL   Mol Cell 50 (1), 104-115 (2013)
   PUBMED   23523372
  REMARK    GeneRIF: Report Dom3Z has role in pre-mRNA 5' end capping quality
            control mechanism and suggest link between proper 5' end capping
            and subsequent pre-mRNA processing.
REFERENCE   6  (bases 1 to 1456)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   7  (bases 1 to 1456)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   8  (bases 1 to 1456)
  AUTHORS   Yang,Z. and Yu,C.Y.
  TITLE     Organizations and gene duplications of the human and mouse MHC
            complement gene clusters
  JOURNAL   Exp Clin Immunogenet 17 (1), 1-17 (2000)
   PUBMED   10686478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT573030.3.
            
            On Nov 3, 2022 this sequence version replaced NM_033613.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004713.1, SRR13422597.1318359.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               CT573030.3         199027-199238
            213-574             CT573030.3         199390-199751
            575-810             CT573030.3         199898-200133
            811-1030            CT573030.3         200223-200442
            1031-1166           CT573030.3         200545-200680
            1167-1261           CT573030.3         200810-200904
            1262-1456           CT573030.3         200984-201178
FEATURES             Location/Qualifiers
     source          1..1456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.39 cM"
     gene            1..1456
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /note="decapping exoribonuclease"
                     /db_xref="GeneID:112403"
                     /db_xref="MGI:MGI:1890444"
     exon            1..212
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /inference="alignment:Splign:2.1.0"
     exon            213..574
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1412
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Dom3Z; decapping and exoribonuclease protein;
                     deNADding enzyme DXO; 5'-3' exoribonuclease DXO;
                     NAD-capped RNA hydrolase DXO"
                     /codon_start=1
                     /product="decapping and exoribonuclease protein isoform 1"
                     /protein_id="NP_291091.2"
                     /db_xref="CCDS:CCDS28660.1"
                     /db_xref="GeneID:112403"
                     /db_xref="MGI:MGI:1890444"
                     /translation="MEPRGTKRKAEKTEVEKPLHKLPRAVPLLRTQPSLYSGPFPFYR
                     RPSELGCFSLDAQRQYHGDARALRYYSPPPINGPGPDFDLRDGYPDRYQPRDEEVQER
                     LDHLLRWVLEHRNQLEGGPGWLAGATVTWRGHLTKLLTTPYERQEGWQLAASRFQGTL
                     YLSEVETPAARAQRLARPPLLRELMYMGYKFEQYMCADKPGGSPDPSGEVNTNVAYCS
                     VLRSRLGNHPLLFSGEVDCLNPQAPCTQPPSCYVELKTSKEMHSPGQWRSFYRHKLLK
                     WWAQSFLPGVPHVVAGFRNPEGFVCSLKTFPTMEMFENVRNDREGWNPSVCMNFCAAF
                     LSFAQSTVVQDDPRLVHLFSWEPGGPVTVSVHRDAPYAFLPSWYVETMTQDLPPLSKT
                     PSPKD"
     exon            575..810
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1030
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1166
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1261
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1456
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1438..1443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /note="hexamer: AATAAA"
     polyA_site      1456
                     /gene="Dxo"
                     /gene_synonym="Dom3z; NG6"
                     /note="major polyA site"
ORIGIN      
        1 agagcgctca ctggggcgcg ccgaggcgcg agtggcccgc ctgggttccc gctccggtgc
       61 agacggacct cgcccactcc gacgctgagg gcggatgaga gcgtcatcag aaacagcaac
      121 tccgtgtttg catccttctc cggcttctga cgtgcggccc tgacgccgta gcctcgagga
      181 ggtggaggtc ggtcagggtg gggagctttg aggacctcat ggaacccaga gggactaaga
      241 gaaaagcgga gaagacagag gtggaaaagc ctttgcacaa actcccccgg gcagtccctt
      301 tactgcggac acagccctct ctgtactcgg gacccttccc gttctaccgg cgtccatccg
      361 aactgggctg cttctccctg gacgcacaac gccagtacca tggagatgcc cgagccctcc
      421 gctactacag cccccctccc atcaacggcc caggcccgga ctttgacctc agagatggat
      481 accctgaccg ataccagccc cgggacgagg aagtccaaga gaggttggac catttgctgc
      541 gctgggtcct ggaacaccgg aaccagctgg aggggggtcc cggctggctg gcaggggcca
      601 cggtgacatg gagagggcac ctgacaaaat tgctgaccac gccgtatgag cggcaggagg
      661 gctggcagct ggcagcctcc cggttccaag ggacactgta cctaagtgag gtggagaccc
      721 cggctgctcg ggcccagagg cttgcacggc cacccctcct ccgggagctc atgtacatgg
      781 gctacaaatt tgagcagtac atgtgcgcag acaaacccgg aggctcccca gacccctctg
      841 gggaagttaa caccaacgtg gcctactgct ctgtgctacg cagccgcctg ggaaaccacc
      901 ctctcctgtt ctccggggag gtagactgcc tgaaccccca ggctccttgc acacagcctc
      961 cctcctgcta cgtggagctc aagacatcca aggagatgca cagccctggc cagtggagga
     1021 gcttttacag acacaagttg ctgaaatggt gggctcagtc gttcctcccg ggggtcccac
     1081 atgttgttgc cggcttccgg aacccagaag gtttcgtctg ttccttaaag acctttccta
     1141 ccatggagat gtttgaaaat gtcaggaatg accgagaagg ctggaatccc tctgtgtgca
     1201 tgaacttctg tgctgccttc cttagctttg cccagagcac agtagtccag gacgatccca
     1261 ggcttgtcca cctcttctcc tgggaacctg gtggccctgt cactgtgtct gtccatcgtg
     1321 acgcacccta tgccttcctg ccctcatggt atgtggagac tatgacccaa gacctcccac
     1381 cactctcaaa gactccctct cccaaggact gaggacaagt ctgggctccg tgcagataat
     1441 aaaggcgtgt ttctaa
//
