LOCUS       NM_001347176            3955 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus dishevelled segment polarity protein 3 (Dvl3),
            transcript variant 2, mRNA.
ACCESSION   NM_001347176 XM_006521779
VERSION     NM_001347176.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3955)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3955)
  AUTHORS   Dias,A.P., Rehmani,T., Applin,B.D., Salih,M. and Tuana,B.
  TITLE     SLMAP3 is crucial for organogenesis through mechanisms involving
            primary cilia formation
  JOURNAL   Open Biol 14 (10), rsob240206 (2024)
   PUBMED   39417621
REFERENCE   3  (bases 1 to 3955)
  AUTHORS   Yoo,S.S., Lee,D.W., Ham,H.J., Yeo,I.J., Chang,J.Y., Yun,J.,
            Son,D.J., Han,S.B. and Hong,J.T.
  TITLE     Presenilin-2 knock-In mice show severe depressive behavior via DVL3
            downregulation
  JOURNAL   CNS Neurosci Ther 30 (2), e14370 (2024)
   PUBMED   37501340
  REMARK    GeneRIF: Presenilin-2 knock-In mice show severe depressive behavior
            via DVL3 downregulation.
REFERENCE   4  (bases 1 to 3955)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3955)
  AUTHORS   Ru,J., Guo,D., Fan,J., Zhang,J., Ju,R., Ouyang,H., Wei,L., Liu,Y.
            and Liu,C.
  TITLE     Malformation of Tear Ducts Underlies the Epiphora and Precocious
            Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for
            Tear Duct Genesis
  JOURNAL   Invest Ophthalmol Vis Sci 61 (13), 6 (2020)
   PUBMED   33141892
REFERENCE   6  (bases 1 to 3955)
  AUTHORS   Luo,Z.G., Wang,Q., Zhou,J.Z., Wang,J., Luo,Z., Liu,M., He,X.,
            Wynshaw-Boris,A., Xiong,W.C., Lu,B. and Mei,L.
  TITLE     Regulation of AChR clustering by Dishevelled interacting with MuSK
            and PAK1
  JOURNAL   Neuron 35 (3), 489-505 (2002)
   PUBMED   12165471
REFERENCE   7  (bases 1 to 3955)
  AUTHORS   Yan,D., Wallingford,J.B., Sun,T.Q., Nelson,A.M., Sakanaka,C.,
            Reinhard,C., Harland,R.M., Fantl,W.J. and Williams,L.T.
  TITLE     Cell autonomous regulation of multiple Dishevelled-dependent
            pathways by mammalian Nkd
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 3802-3807 (2001)
   PUBMED   11274398
REFERENCE   8  (bases 1 to 3955)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   9  (bases 1 to 3955)
  AUTHORS   Yang,Y., Lijam,N., Sussman,D.J. and Tsang,M.
  TITLE     Genomic organization of mouse Dishevelled genes
  JOURNAL   Gene 180 (1-2), 121-123 (1996)
   PUBMED   8973355
REFERENCE   10 (bases 1 to 3955)
  AUTHORS   Tsang,M., Lijam,N., Yang,Y., Beier,D.R., Wynshaw-Boris,A. and
            Sussman,D.J.
  TITLE     Isolation and characterization of mouse dishevelled-3
  JOURNAL   Dev Dyn 207 (3), 253-262 (1996)
   PUBMED   8922524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087898.19.
            
            On Feb 16, 2023 this sequence version replaced NM_001347176.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052151.1, SRR9219380.91308.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AC087898.19        187759-188022       c
            265-334             AC087898.19        182789-182858       c
            335-456             AC087898.19        181583-181704       c
            457-566             AC087898.19        181353-181462       c
            567-702             AC087898.19        181039-181174       c
            703-796             AC087898.19        180769-180862       c
            797-866             AC087898.19        180526-180595       c
            867-1006            AC087898.19        179336-179475       c
            1007-1083           AC087898.19        179132-179208       c
            1084-1151           AC087898.19        178958-179025       c
            1152-1301           AC087898.19        178698-178847       c
            1302-1433           AC087898.19        178034-178165       c
            1434-1601           AC087898.19        177695-177862       c
            1602-1817           AC087898.19        174122-174337       c
            1818-2228           AC087898.19        173624-174034       c
            2229-3955           AC087898.19        171104-172830       c
FEATURES             Location/Qualifiers
     source          1..3955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.46 cM"
     gene            1..3955
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /note="dishevelled segment polarity protein 3"
                     /db_xref="GeneID:13544"
                     /db_xref="MGI:MGI:108100"
     exon            1..264
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2260
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /note="isoform 2 is encoded by transcript variant 2;
                     segment polarity protein dishevelled homolog DVL-3;
                     dishevelled 3, dsh homolog"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-3 isoform 2"
                     /protein_id="NP_001334105.1"
                     /db_xref="CCDS:CCDS84210.1"
                     /db_xref="GeneID:13544"
                     /db_xref="MGI:MGI:108100"
                     /translation="MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKF
                     FFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPS
                     MERTGGIGDSRPPSFHPHASGGSQENLDNDTETDSLVSAQRERPRRRDGPEHAARLNG
                     TTKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHK
                     RRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGI
                     YIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVA
                     KCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSIT
                     SSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDW
                     LYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHD
                     HDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSAS
                     SQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSER
                     SGPAASEHSHRSHHSLTSSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAP
                     PGRDLASVPPELTASRQSFRMAMGNPTKNFGLFDFL"
     exon            265..334
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            335..456
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            457..566
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            567..702
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            703..796
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            797..866
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1006
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1083
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1151
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1301
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1433
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1601
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1817
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2228
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..3955
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3932..3937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /note="hexamer: AATAAA"
     polyA_site      3955
                     /gene="Dvl3"
                     /gene_synonym="b2b2866Clo"
                     /note="major polyA site"
ORIGIN      
        1 gagtggggct gagcagcggg ccgcgccgag cgccgagctc tgccggagag gcccggcccc
       61 gctgcccaag caggccgcgc gccgcggggc cgaggccgga gccatgggcg agaccaagat
      121 catctaccac ctggacggcc aggagacgcc gtacctggtg aagctgcccc tgcccgccga
      181 gcgcgtcacc ttggcggact ttaagggcgt tctgcagcgg cccagctata agttcttctt
      241 caagtctatg gacgacgatt ttggggtggt gaaggaagag atctcggacg acaatgccaa
      301 gctaccctgc ttcaatggcc gggtggtgtc ctggctggta tctgccgagg gctcacaccc
      361 agagccggcc cctttctgtg ctgacaaccc gtcagagctg ccaccttcga tggaacgcac
      421 aggaggcatt ggggactctc gacccccctc cttccaccct catgctagtg ggggcagcca
      481 ggagaatctg gacaatgaca cggagaccga ctccttggtg tctgcccaac gagagcggcc
      541 ccgacggagg gatggcccgg agcacgcagc ccgactcaat ggaaccacaa agggtgagcg
      601 gcgacgggag ccaggcggct atgacagttc atctaccctc atgagcagcg agctggagac
      661 taccagtttc tttgattccg atgaggatga ttccaccagc aggttcagca gctccacaga
      721 acagagcagt gcctcacgcc tcatgagaag acacaagcgg cggcggcgga agcagaaggt
      781 ctcccggatt gagcggtcct cgtctttcag cagcatcaca gactccacta tgtctctcaa
      841 catcatcacc gtcactctca acatggaaaa gtataacttc ttgggcatct ccattgtggg
      901 ccaaagcaat gagcgaggtg atgggggcat ctacattggc tccatcatga agggtggggc
      961 tgtggcagct gatggacgca ttgagccagg agatatgcta ctgcaggtaa atgagatcaa
     1021 cttcgagaac atgagcaacg atgacgcagt ccgagtcctt cgggagattg tgcacaagcc
     1081 agggcccatc actctgactg tagccaagtg ctgggaccca agtcctcgcg gctgcttcac
     1141 attaccccgg agcgagccca tccgtcccat tgaccctgca gcctgggtct ctcacacggc
     1201 agccatgaca ggcaccttcc ccgcctatgg catgagcccc tccttaagca ccatcacctc
     1261 taccagctcc tccatcacca gctccatccc tgatacagag cgcctagatg atttccacct
     1321 ctccatccac agtgacatgg cggccatcgt aaaagccatg gcctcccctg agtcagggtt
     1381 ggaggtccga gaccgcatgt ggctcaagat taccattccc aatgctttca tcggctcgga
     1441 tgtggtggac tggctgtacc acaacgtgga agggttcacc gaccgtcggg aggcccgcaa
     1501 gtatgctagc aacctgctga aagctggttt catccgccat accgtcaaca agatcacgtt
     1561 ctccgagcag tgctactaca tctttggcga cctctgtggt aacatggcca acctatcgct
     1621 tcacgaccat gatggctcca gtggcgcctc tgaccaggac acactggctc ctttgccgca
     1681 cccaggagct gccccttggc ctatggcttt cccttaccag tacccaccac ctccgcatcc
     1741 ctacaaccca cacccaggct tcccagaact gggctacagc tacggtgggg gcagcgccag
     1801 cagtcagcac agtgaaggca gtcggagcag tggctccaac cgaagtggca gcgaccggcg
     1861 caaggagaag gacccaaaag ctggggactc caagtcaggt ggtagcggca gcgagtcaga
     1921 ccacactaca cgcagcagtc tgagggggcc acgggagcgg gcaccaagcg agcgatcagg
     1981 cccagcggcc agcgagcaca gccaccgcag tcaccattcg ctgaccagca gcctgcgcag
     2041 ccaccacaca cacccaagct atggcccacc cggagtgccc cctctctatg gtcccccgat
     2101 gctgatgatg accccgccgc cggcagccat gggtccccca ggagcccctc cagggcgtga
     2161 cctggcctcg gtgcccccgg aactgacggc cagcagacag tccttccgca tggcaatggg
     2221 aaaccccacc aagaatttcg ggctctttga ctttctgtga gtccccagga aggggaggcc
     2281 cagcctccaa ggagaccagg aactctgctt cagcagcccc tcagggcttc ccaaggatgt
     2341 ccaaccctca cacccacact acaaggtcac taggcttctg ggaaggacct cagcttcccc
     2401 caggtgtaag actgttcttc tcagagagaa gtagagaagt ttgcttccct ccacctcgta
     2461 cacatagata tatacataca cgtgagtctc tctctctctc tctctctctc tctctctctc
     2521 tctctctctc tctctctctc tccgtacaca tagatatata cacacacgtg agtctctctc
     2581 tctctctctc tctctctctc tctctctctc tctctcacac acacacacac acacacacac
     2641 acacacacac acacacacac acacacacac acacacacac acgcctcagg gctggtccct
     2701 gaccggaggg ctggaccctt cttccaagtc atccctagat atggggctgg tccgtgactg
     2761 ccctctcctc ttcctgctag cccttacgct tcccatacat gttcccaatg tctttgtact
     2821 tggataaagc ccaaaagatg ggctccacag agggctgtcc aggtgactga caggccattc
     2881 tctacttccc tcctacaccc ccaccccacc cccatatcct tataactgtt ctgttttcat
     2941 cttctccatg agacctggga acacaggcca gttggagctt aagcagacaa ctgggacttc
     3001 caaacagctc cagttatttt gaaaattgtt ttctacctta aatcacaaat ttctctttaa
     3061 aactctgcta tataaactct gacttatcca gactcttaac tcttcagggc aagggtgtca
     3121 gctgggaaca tagctctgta gtgtctgcct agcatgcccc agcaaatgtc tccccccatc
     3181 aggatgtcct tagtccaggt ttgggggcaa cttgaagtag ggctgttttg ccattcattc
     3241 atccgtttaa caccttttct gggattttaa tgaacaaagg gctatgttag aagcatgatt
     3301 tgatcttagc tgtcttcggt tctctctaac tctgcctttt cctgtgatct tgagaatccc
     3361 tcgtcagtgc tcacttgtgc gctggacgcc agtacccttg tcatcctgtc tttggctcac
     3421 atctcctcct ttcccactcc catgatagtg tcagccattc tcttcttaag ctgttgatat
     3481 gctggccact tctaaatctg gatctccaac cccagcttcc cctctcttta gacctgtttt
     3541 tattacccac tggacatctc cacaggcatg tccataatag tcaagcatta ttcctcttga
     3601 attcctgtcc tggtgacctt cgttacaagc tacacctaca tggtattagt cagcatcaca
     3661 cacccttcta ctcttgacac tctgaagttc agctgttcct ctccctttct taatttacag
     3721 agcatgggat ttggagtcaa gttggtttgg gcttgaattc cagctctcat ttttggttgt
     3781 gtaaaagagt tatttaacct ctctggagcc tcagtcctcc catatgtaaa atgatgataa
     3841 taatacctac ctcacagggt tgttgtgagg aattagatat tgtacgaaaa gtgcctagca
     3901 cagtgcctgg cacacaatag agtaggtgct caataaatgg tagctattat tatta
//
