LOCUS       NM_007888               2969 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus dishevelled segment polarity protein 2 (Dvl2), mRNA.
ACCESSION   NM_007888
VERSION     NM_007888.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2969)
  AUTHORS   Qu,X., Xu,D., Yang,T., Tian,Y., King,C.T., Wang,X., Sheng,M.,
            Lin,Y., Bian,X., Li,C., Jiang,L., Xia,Q., Farmer,D.G. and Ke,B.
  TITLE     Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and
            exacerbates inflammatory liver injury
  JOURNAL   Redox Biol 79, 103455 (2025)
   PUBMED   39644526
REFERENCE   2  (bases 1 to 2969)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2969)
  AUTHORS   Shen,J., Zha,Q., Yang,Q.H., Zhou,Y.Q., Liang,X., Chen,Y.J.,
            Qi,G.X., Zhang,X.J., Yao,W.B., Gao,X.D. and Chen,S.
  TITLE     Inhibiting von Hippel-Lindau protein-mediated Dishevelled
            ubiquitination protects against experimental parkinsonism
  JOURNAL   Acta Pharmacol Sin 44 (5), 940-953 (2023)
   PUBMED   36357669
  REMARK    GeneRIF: Inhibiting von Hippel-Lindau protein-mediated Dishevelled
            ubiquitination protects against experimental parkinsonism.
REFERENCE   4  (bases 1 to 2969)
  AUTHORS   Hummel,D., Becks,A., Men,H., Bryda,E.C., Glasco,D.M. and
            Chandrasekhar,A.
  TITLE     Celsr1 suppresses Wnt5a-mediated chemoattraction to prevent
            incorrect rostral migration of facial branchiomotor neurons
  JOURNAL   Development 149 (22) (2022)
   PUBMED   36325991
REFERENCE   5  (bases 1 to 2969)
  AUTHORS   Zhao,T., McMahon,M., Reynolds,K., Saha,S.K., Stokes,A. and
            Zhou,C.J.
  TITLE     The role of Lrp6-mediated Wnt/beta-catenin signaling in the
            development and intervention of spinal neural tube defects in mice
  JOURNAL   Dis Model Mech 15 (6) (2022)
   PUBMED   35514236
REFERENCE   6  (bases 1 to 2969)
  AUTHORS   Cox,K.B., Johnson,K.R. and Wood,P.A.
  TITLE     Chromosomal locations of the mouse fatty acid oxidation genes
            Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene
  JOURNAL   Mamm Genome 9 (8), 608-610 (1998)
   PUBMED   9680378
REFERENCE   7  (bases 1 to 2969)
  AUTHORS   Yang,Y., Lijam,N., Sussman,D.J. and Tsang,M.
  TITLE     Genomic organization of mouse Dishevelled genes
  JOURNAL   Gene 180 (1-2), 121-123 (1996)
   PUBMED   8973355
REFERENCE   8  (bases 1 to 2969)
  AUTHORS   Klingensmith,J., Yang,Y., Axelrod,J.D., Beier,D.R., Perrimon,N. and
            Sussman,D.J.
  TITLE     Conservation of dishevelled structure and function between flies
            and mice: isolation and characterization of Dvl2
  JOURNAL   Mech Dev 58 (1-2), 15-26 (1996)
   PUBMED   8887313
REFERENCE   9  (bases 1 to 2969)
  AUTHORS   Steitz,S.A., Tsang,M. and Sussman,D.J.
  TITLE     Wnt-mediated relocalization of dishevelled proteins
  JOURNAL   In Vitro Cell Dev Biol Anim 32 (7), 441-445 (1996)
   PUBMED   8856345
REFERENCE   10 (bases 1 to 2969)
  AUTHORS   Greco,T.L., Sussman,D.J. and Camper,S.A.
  TITLE     Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and
            vestigial tail (vt) on mouse chromosome 11
  JOURNAL   Mamm Genome 7 (6), 475-476 (1996)
   PUBMED   8662242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596185.12.
            
            On Aug 21, 2018 this sequence version replaced NM_007888.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146822.1, AK168376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               AL596185.12        112237-112671
            436-505             AL596185.12        116450-116519
            506-651             AL596185.12        116800-116945
            652-761             AL596185.12        117082-117191
            762-897             AL596185.12        117307-117442
            898-988             AL596185.12        117583-117673
            989-1058            AL596185.12        117781-117850
            1059-1198           AL596185.12        117936-118075
            1199-1275           AL596185.12        118159-118235
            1276-1343           AL596185.12        119098-119165
            1344-1472           AL596185.12        119460-119588
            1473-1604           AL596185.12        119665-119796
            1605-1784           AL596185.12        119926-120105
            1785-2003           AL596185.12        120422-120640
            2004-2969           AL596185.12        120789-121754
FEATURES             Location/Qualifiers
     source          1..2969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.96 cM"
     gene            1..2969
                     /gene="Dvl2"
                     /note="dishevelled segment polarity protein 2"
                     /db_xref="GeneID:13543"
                     /db_xref="MGI:MGI:106613"
     exon            1..435
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2452
                     /gene="Dvl2"
                     /note="DSH homolog 2; dishevelled-2; dishevelled 2, dsh
                     homolog"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-2"
                     /protein_id="NP_031914.3"
                     /db_xref="CCDS:CCDS24930.1"
                     /db_xref="GeneID:13543"
                     /db_xref="MGI:MGI:106613"
                     /translation="MAGSSAGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFK
                     SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDTPQPEVAPP
                     AHESRTELVPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLR
                     RDRPRRRDSSEHGAGGHRPGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMS
                     RFSSSTEQSSASRLLKRHRRRRKQRPPRMERTSSFSSVTDSTMSLNIITVTLNMEKYN
                     FLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAV
                     RVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPA
                     YPGSSSMSTITSGSSLPDGCEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIP
                     NAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDL
                     SGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPP
                     PYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEL
                     SSRGGSLRRGGEPGGTGDGGPPPSRGSTGAPPNLRALPGLHPYGAPSGMALPYNPMMV
                     VMMPPPPPPVSTAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM"
     exon            436..505
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..651
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..761
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..897
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..988
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1058
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1198
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1275
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1343
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1472
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1604
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1784
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..2003
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2969
                     /gene="Dvl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgctgctc gcgacgtccg tggagctagt ggccctcgac tgtgcggtct aggttttgag
       61 tctcgccaca cagctcttcc cgatcagccc gctggtcccc gccatcctcc ttgggcacgt
      121 cttccgcact ggccctgcgc tgttggcgct agcgcgtcag tttgcgggtg tgcgcaggcg
      181 cggcgggggc gcttagtcct gttgggtggg cggctgagcc cgggagcgcg cgagcgagac
      241 catggcgggc agcagcgcgg ggggcggtgg tgtaggcgag acgaaggtga tttaccatct
      301 ggatgaagaa gagactcctt acctggtgaa gatccctgtc ccggcggagc gcatcacgct
      361 cggcgatttc aagagcgttt tgcagcggcc cgcgggcgcc aagtactttt tcaagtccat
      421 ggatcaggat tttggggtgg tgaaggaaga gatctccgat gacaatgccc gcctaccttg
      481 cttcaatgga agggttgtct cctggcttgt gtcgtcagat accccacagc ctgaggtggc
      541 tcccccagcc catgagtctc ggacagaact ggttcctccg cctccaccct tacccccttt
      601 gccaccagaa aggaccagtg gaattgggga ctcaaggcct ccatccttcc accctaatgt
      661 atccagcagc catgaaaatc tagagcctga gacagagacc gaatctgtcg tatcactgag
      721 gcgagaccga cctaggagga gagacagcag tgaacatggc gctggtggcc acaggcctgg
      781 tggcccctcg aggctggagc gccacctggc tggctacgag agctcttcca ccctcatgac
      841 cagtgagctg gagagtacca gcctaggaga ctcggatgag gatgacacca tgagtaggtt
      901 cagcagctcc actgagcaga gcagtgcctc ccgcctcctc aagcgccacc gaaggcgaag
      961 gaagcagcgg ccgccacgca tggagaggac ctcatccttc agcagtgtca ccgattccac
     1021 aatgtctctc aacatcatca cggtcacgct caacatggag aagtacaact tcctgggcat
     1081 ctccattgtg ggccaaagta acgagcgtgg tgatgggggc atctacatcg gctccatcat
     1141 gaaagggggc gcggtggctg cggacgggcg gatcgagcct ggagacatgc ttttgcaggt
     1201 aaatgatatg aactttgaga acatgagcaa cgacgatgct gtacgagtgc tgagagacat
     1261 cgtgcacaag ccaggcccca tcgtgctgac cgtggccaag tgttgggacc cgtctcccca
     1321 ggcctacttc accctccctc gaaatgagcc catccagccc atcgacccag ccgcctgggt
     1381 gtcgcactcg gctgcgctga ctggcgcctt ccctgcttac cctggctcct catctatgag
     1441 cactatcaca tctggctcct ctctgcctga tggctgcgaa ggccggggtc tctctgtcca
     1501 catggacatg gcctctgtca ccaaggccat ggcagcccca gagtctgggc tcgaagtccg
     1561 ggaccgcatg tggctcaaga tcaccatccc aaacgccttt ctaggctccg atgtggtgga
     1621 ctggctgtac catcacgtgg aaggttttcc tgagcgccgg gaggcccgca agtatgccag
     1681 tgggctgttg aaggcgggac tcatccggca caccgtcaac aagattactt tctctgagca
     1741 gtgctattat gtcttcgggg acctcagtgg tggctgtgag agttacctag ttaacctctc
     1801 tctgaatgac aatgacggtt ccagtggggc ttcagaccag gataccctgg cacctctgcc
     1861 tggagctact ccctggcccc tgctgcccac cttctcctac cagtatccag cgccacaccc
     1921 ctacagcccc cagcctccac cctaccacga gctttcttcg tacacctatg gtggaggcag
     1981 tgccagcagc cagcacagtg aggggagccg gagcagcggg tcgacaagaa gcgatggggg
     2041 ggctgggcgc acaggcaggc ctgaggaacg ggcccctgag tccaagtccg gcagtggcag
     2101 tgagtcagaa ctctccagcc ggggaggcag ccttcggcgg ggtggggagc ctggtgggac
     2161 tggtgatggc ggccctcctc catccagggg ctcgacaggc gctcctccta atctccgagc
     2221 tcttcccggg ctccatccct atggagcccc atctggcatg gctctcccct ataaccccat
     2281 gatggtagtt atgatgcctc cacccccacc ccctgtctcc acagcagtgc agccccctgg
     2341 tgcccctcca gtcagagacc tgggctccgt gcccccagaa ctgacagcta gccgtcagag
     2401 cttccacatg gccatgggca accccagtga gttttttgtg gatgttatgt agggacccat
     2461 cttgaggcca cattgggtct gtgcccttgg cctggcaagt ttcagcctgg tgcccttcat
     2521 agtgcctggg ctcagcctgg cggctggtgc ctaccaaaac gtttttgcca ctgtgactct
     2581 caccagcagt gcctggtcct tccccctctt cctcgggggt agatggggac ctttggttat
     2641 ttttagcttt attttttata agctttttgg ggggttaaaa tagactttct tatatttggg
     2701 ggagtatttt tttaaataga cagttcctct tttatatgga gaatcccttc taaccccaga
     2761 atatgaccgc cacctccagg tgcctagtca gctctcatgt tgagggtggg tggtggtcag
     2821 tggtaccctg ggaagaagaa ggtgtgggct gggtacccca gacagcagtc caaggaggct
     2881 ggtggtgtgt tggggactgt gtagctgcct ttgttactct atttatttta gtcacttgta
     2941 caaaacacca aataaagcaa atagaggcc
//
