LOCUS       NM_010091               3374 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dishevelled segment polarity protein 1 (Dvl1),
            transcript variant 1, mRNA.
ACCESSION   NM_010091
VERSION     NM_010091.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3374)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3374)
  AUTHORS   Verdile,V., Svetoni,F., La Rosa,P., Ferrante,G., Cesari,E.,
            Sette,C. and Paronetto,M.P.
  TITLE     EWS splicing regulation contributes to balancing Foxp1 isoforms
            required for neuronal differentiation
  JOURNAL   Nucleic Acids Res 50 (6), 3362-3378 (2022)
   PUBMED   35253879
REFERENCE   3  (bases 1 to 3374)
  AUTHORS   Wu,Y., Zhou,Y., Huang,J., Ma,K., Yuan,T., Jiang,Y., Ye,M. and Li,J.
  TITLE     The Role of Sorting Nexin 17 in Cardiac Development
  JOURNAL   Front Cardiovasc Med 8, 748891 (2021)
   PUBMED   34988124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3374)
  AUTHORS   Ru,J., Guo,D., Fan,J., Zhang,J., Ju,R., Ouyang,H., Wei,L., Liu,Y.
            and Liu,C.
  TITLE     Malformation of Tear Ducts Underlies the Epiphora and Precocious
            Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for
            Tear Duct Genesis
  JOURNAL   Invest Ophthalmol Vis Sci 61 (13), 6 (2020)
   PUBMED   33141892
REFERENCE   5  (bases 1 to 3374)
  AUTHORS   Lijam,N., Paylor,R., McDonald,M.P., Crawley,J.N., Deng,C.X.,
            Herrup,K., Stevens,K.E., Maccaferri,G., McBain,C.J., Sussman,D.J.
            and Wynshaw-Boris,A.
  TITLE     Social interaction and sensorimotor gating abnormalities in mice
            lacking Dvl1
  JOURNAL   Cell 90 (5), 895-905 (1997)
   PUBMED   9298901
REFERENCE   6  (bases 1 to 3374)
  AUTHORS   Pizzuti,A., Novelli,G., Mari,A., Ratti,A., Colosimo,A., Amati,F.,
            Penso,D., Sangiuolo,F., Calabrese,G., Palka,G., Silani,V.,
            Gennarelli,M., Mingarelli,R., Scarlato,G., Scambler,P. and
            Dallapiccola,B.
  TITLE     Human homologue sequences to the Drosophila dishevelled
            segment-polarity gene are deleted in the DiGeorge syndrome
  JOURNAL   Am J Hum Genet 58 (4), 722-729 (1996)
   PUBMED   8644734
REFERENCE   7  (bases 1 to 3374)
  AUTHORS   Millen,K.J., Hui,C.C. and Joyner,A.L.
  TITLE     A role for En-2 and other murine homologues of Drosophila segment
            polarity genes in regulating positional information in the
            developing cerebellum
  JOURNAL   Development 121 (12), 3935-3945 (1995)
   PUBMED   8575294
REFERENCE   8  (bases 1 to 3374)
  AUTHORS   Lijam,N. and Sussman,D.J.
  TITLE     Organization and promoter analysis of the mouse dishevelled-1 gene
  JOURNAL   Genome Res 5 (2), 116-124 (1995)
   PUBMED   9132266
REFERENCE   9  (bases 1 to 3374)
  AUTHORS   Sussman,D.J., Klingensmith,J., Salinas,P., Adams,P.S., Nusse,R. and
            Perrimon,N.
  TITLE     Isolation and characterization of a mouse homolog of the Drosophila
            segment polarity gene dishevelled
  JOURNAL   Dev Biol 166 (1), 73-86 (1994)
   PUBMED   7958461
REFERENCE   10 (bases 1 to 3374)
  AUTHORS   Neumann,P.E., Frankel,W.N., Letts,V.A., Coffin,J.M., Copp,A.J. and
            Bernfield,M.
  TITLE     Multifactorial inheritance of neural tube defects: localization of
            the major gene and recognition of modifiers in ct mutant mice
  JOURNAL   Nat Genet 6 (4), 357-362 (1994)
   PUBMED   8054974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL670236.9, U10115.1 and
            BC088987.1.
            
            On Oct 1, 2017 this sequence version replaced NM_010091.4.
            
            Summary: The protein encoded by this gene is a member of the
            Dishevelled family of proteins. These proteins have an N-terminal
            Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a
            central PDZ domain, and a C-terminal domain of approximately 200
            amino acids. They regulate both canonical and non-canonical Wnt
            signaling as well as planar cell polarity pathways. Mice deficient
            for this gene are viable and fertile but display reduced social
            interaction. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10115.1, AK155349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL670236.9         153992-154074
            84-164              U10115.1           13-93
            165-940             BC088987.1         1-776
            941-1528            U10115.1           870-1457
            1529-2045           BC088987.1         1436-1952
            2046-2048           U10115.1           1975-1977
            2049-3374           BC088987.1         1995-3320
FEATURES             Location/Qualifiers
     source          1..3374
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.61 cM"
     gene            1..3374
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /note="dishevelled segment polarity protein 1"
                     /db_xref="GeneID:13542"
                     /db_xref="MGI:MGI:94941"
     exon            1..503
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..2421
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /note="isoform 1 is encoded by transcript variant 1;
                     segment polarity protein dishevelled homolog DVL-1; DSH
                     homolog 1; dishevelled-1; dishevelled, dsh homolog 1"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-1 isoform 1"
                     /protein_id="NP_034221.3"
                     /db_xref="CCDS:CCDS19045.1"
                     /db_xref="GeneID:13542"
                     /db_xref="MGI:MGI:94941"
                     /translation="MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHA
                     YKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDL
                     PPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNRDEAARTN
                     GHPRGDRRRDLGLPPDSASTVLSSELESSSFIDSDEEDNTSRLSSSTEQSTSSRLVRK
                     HKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNMERHHFLGISIVGQSNDRGDG
                     GIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLT
                     VAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAITRTSSS
                     SLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADV
                     VDWLYTHVEGFKERREARKYASSMLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLN
                     LNSGSSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSCGSGSAG
                     SQQSEGSKSSGSTRSSHRTPGREERRATGAGGSGSESDHTVPSGSGSTGWWERPVSQL
                     SRGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQK
                     AMGNPCEFFVDIM"
     exon            504..573
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            574..695
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            696..799
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            800..938
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1032
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1102
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1242
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1319
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1387
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1540
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1672
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1840
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2047
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..3358
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /note="hexamer: ACTAAA"
     polyA_site      3358
                     /gene="Dvl1"
                     /gene_synonym="Dvl; mKIAA4029"
                     /note="major polyA site"
ORIGIN      
        1 tagtgacgtc accggccccg aagcgccctc cggcggcggc gcgctccacc ccagcaggcg
       61 gttcgtgaac agcccgaggg ggcggcgggc cgcgggagcc ctcagagccg ctttccctgg
      121 cgcccgctcc ggggccgcgg cggatgggcg gccgcgggcc gcggggcgac aggcggggaa
      181 cgggtgcgag ccgggaccgg gaggggcggc cgcgccaagg ggccgcgggg cggccgggcg
      241 gggcgcgggc cggcggtttg ggagggcgcc ccgcgtccga gaggcgagcc gggccctgac
      301 gccgcgcggg ttccgcgtcg cccctgccgc gccatggcgg agaccaaaat catctaccac
      361 atggacgagg aggagacgcc gtacctggtc aagctgcccg tagctcccga gcgcgtcacg
      421 ctggccgact tcaagaacgt gctcagcaac cggccggtgc acgcctacaa attcttcttc
      481 aagtccatgg accaggactt cggggtggtg aaggaggaga tcttcgatga caatgccaag
      541 ttgccctgct tcaatggccg ggtggtttcc tggctggtcc tggctgaggg cgctcactcg
      601 gatgcagggt cccagggcac tgacagccac acggacctgc ccccacccct tgagaggaca
      661 ggcggcattg gggactccag gcccccctcc ttccatccaa atgttgccag tagccgggac
      721 ggaatggaca atgagacagg cacagagtct atggtcagtc accggcggga gcgagcccga
      781 cgtcgaaacc gcgatgaggc tgcccggacc aatgggcacc cgagagggga tcggcggcgg
      841 gacctgggac tacctccaga cagtgcatcc actgtactga gcagtgagct tgaatctagc
      901 agctttattg actcagatga ggaggacaat acgagccggc tgagcagctc cacagagcag
      961 agcacctcct ctcggctagt tcggaagcac aaatgccgtc gtcggaagca gcgcttgagg
     1021 cagacagacc gggcatcctc cttcagcagc atcacagact ccaccatgtc cctgaacatc
     1081 atcaccgtca ctctcaacat ggagaggcac cacttcctgg gcatcagcat cgtgggccag
     1141 agcaacgacc ggggtgatgg cggcatctac attggatcca tcatgaaggg cggggccgtg
     1201 gctgctgatg gccgcattga gccgggcgac atgttgctgc aggtgaacga tgtcaacttt
     1261 gagaacatga gcaatgacga cgctgtacgg gtgcttcggg agatcgtgtc ccagacaggg
     1321 cccatcagtc tcacagtggc caagtgctgg gacccaaccc ctcggagcta cttcaccatc
     1381 ccaagggctg acccagtgcg acccatcgac ccggctgcct ggctgtccca cacagcagca
     1441 ctgacgggtg ccctgccccg ctatggtacg agtccctgct ccagcgccat cacacgcacc
     1501 agctcttcct cactaaccag ctcagtgcct ggcgccccac agcttgagga ggcaccgctg
     1561 actgtgaaga gtgacatgag tgccattgtc cgcgtcatgc agttgccaga ctcaggactg
     1621 gagatccggg accgcatgtg gcttaagatc accattgcca atgctgtcat tggggcggat
     1681 gtggtggact ggctgtacac acacgtggag ggcttcaagg agcgaaggga ggcaagaaag
     1741 tatgccagca gtatgctgaa gcacggtttc ctgaggcaca ccgtgaacaa gatcaccttt
     1801 tctgagcagt gctactatgt ctttggcgac ctgtgcagta acctcgcatc cctgaacctc
     1861 aacagtggct ccagtggagc ctcagatcag gacacactgg ccccactgcc ccacccatca
     1921 gtaccctggc ccttgggtca aggctacccc taccagtacc caggaccccc gccctgcttc
     1981 ccgcctgctt accaggaccc tggcttcagc tgcggcagcg gcagtgctgg gagccagcag
     2041 agtgaaggga gcaagagcag tgggtccaca cggagcagcc atcggacccc aggccgagag
     2101 gagcgccggg caactggagc tgggggtagt ggcagtgaat cagaccacac agtaccaagt
     2161 gggtctggta gcaccggctg gtgggagcgg cctgtcagcc agcttagccg tggcagtagc
     2221 cctcgaagtc aggcttcagc tgttgcccca gggctccccc cactgcaccc ccttacaaag
     2281 gcctatgcag tagtgggtgg gccacctgga gggccacccg tccgggagct ggctgctgtc
     2341 cctccagaac ttacaggtag ccgccagtcc ttccaaaagg ccatgggaaa cccctgtgag
     2401 ttctttgtgg acatcatgtg atgatcaacc aatgtcttca gcgctgcctg tggctgagtc
     2461 tgtgctcctg ctgtgccagg agctctgcgc tggccgtggt ggtggccagc caggatagat
     2521 cagctgtggg ctctgggcca gggcagaggg agcaggctac agaggagggc ctgagggcag
     2581 ccataccacc aggatattgg cttgacattt tgtctgctct tggggctgct gatggtggta
     2641 cagctcaagt atctatagag tcttgtaagg agacatctct gactttaagt cctcagcaca
     2701 agtctcaggg accacctcct ggttcccttc tttggaagtg acctccattt agaacaagaa
     2761 aggctctctt gggctcttgg taccccttgc cccaaagcct cacagaactg tgcacaggga
     2821 cacaggctga ctgtcgctaa gttcatgggc ctcacctgtc aggccaaggt gggatttttg
     2881 aggggttaga cagagccttc aaacctctct ggctgcccag gtggggtcta acttatttat
     2941 ttattgctag cctgcctgct ctaagggtgg cagctagtta cccaaagggg cagtttgcat
     3001 gcccctttcc ccacctgcta cttggcacat gacaacacag tttgtactga aggtatgtga
     3061 agggtagcta gtaggagaga caggagagag acctggcacc tagccactgt ctcagtctca
     3121 gtggtgggtg acagtgaaca caagagctgc agagctgggc cctgttctgt ttctgttctg
     3181 gtggctgccc atcatcatgt gccactgcca tcccggcaca gcggccccac acatctacac
     3241 tagacactgt gtcaaagtct gagtgactgg gtagttgaca tagagctgct tctgtgtaaa
     3301 tgctgcttct gtgtaaatgc tattttaaac actaaaaaaa gcgtttaatt ttatgggaaa
     3361 aaaaaaaaaa aaaa
//
