LOCUS       NM_183389               2146 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus double homeobox B-like 1 (Duxbl1), mRNA.
ACCESSION   NM_183389 XM_918041
VERSION     NM_183389.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Vega-Sendino,M., Luttmann,F.F., Olbrich,T., Chen,Y., Kuenne,C.,
            Stein,P., Tillo,D., Carey,G.I., Zhong,J., Savy,V., Radonova,L.,
            Lu,T., Saykali,B., Kim,K.P., Domingo,C.N., Schuler,L., Gunther,S.,
            Bentsen,M., Bosnakovski,D., Scholer,H., Kyba,M., Maity,T.K.,
            Jenkins,L.M., Looso,M., Williams,C.J., Kim,J. and Ruiz,S.
  TITLE     The homeobox transcription factor DUXBL controls exit from
            totipotency
  JOURNAL   Nat Genet (2024) In press
   PUBMED   38509386
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Bademci,G., Lachgar-Ruiz,M., Deokar,M., Zafeer,M.F., Abad,C.,
            Yildirim Baylan,M., Ingham,N.J., Chen,J., Sineni,C.J., Vadgama,N.,
            Karakikes,I., Guo,S., Duman,D., Singh,N., Harlalka,G., Jain,S.P.,
            Chioza,B.A., Walz,K., Steel,K.P., Nasir,J. and Tekin,M.
  TITLE     Mutations in MINAR2 encoding membrane integral NOTCH2-associated
            receptor 2 cause deafness in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 119 (26), e2204084119 (2022)
   PUBMED   35727972
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   De Iaco,A., Verp,S., Offner,S., Grun,D. and Trono,D.
  TITLE     DUX is a non-essential synchronizer of zygotic genome activation
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31806660
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Klein,F., Mitrovic,M., Roux,J., Engdahl,C., von Muenchow,L.,
            Alberti-Servera,L., Fehling,H.J., Pelczar,P., Rolink,A. and
            Tsapogas,P.
  TITLE     The transcription factor Duxbl mediates elimination of pre-T cells
            that fail beta-selection
  JOURNAL   J Exp Med 216 (3), 638-655 (2019)
   PUBMED   30765463
  REMARK    GeneRIF: Duxbl is a regulator of beta-selection by inducing
            apoptosis in T cells with a nonfunctional rearrangement.
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Rivera-Reyes,R., Kleppa,M.J. and Kispert,A.
  TITLE     Proteomic analysis identifies transcriptional cofactors and
            homeobox transcription factors as TBX18 binding proteins
  JOURNAL   PLoS One 13 (8), e0200964 (2018)
   PUBMED   30071041
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Wu,S.L., Tsai,M.S., Wong,S.H., Hsieh-Li,H.M., Tsai,T.S.,
            Chang,W.T., Huang,S.L., Chiu,C.C. and Wang,S.H.
  TITLE     Characterization of genomic structures and expression profiles of
            three tandem repeats of a mouse double homeobox gene: Duxbl
  JOURNAL   Dev Dyn 239 (3), 927-940 (2010)
   PUBMED   20063414
  REMARK    GeneRIF: Duxbl proteins play regulatory roles during myogenesis and
            reproductive developments
REFERENCE   8  (bases 1 to 2146)
  AUTHORS   Kawazu,M., Yamamoto,G., Yoshimi,M., Yamamoto,K., Asai,T.,
            Ichikawa,M., Seo,S., Nakagawa,M., Chiba,S., Kurokawa,M. and
            Ogawa,S.
  TITLE     Expression profiling of immature thymocytes revealed a novel
            homeobox gene that regulates double-negative thymocyte development
  JOURNAL   J Immunol 179 (8), 5335-5345 (2007)
   PUBMED   17911620
  REMARK    GeneRIF: Involved in thymocyte development. Knockdown by shRNA
            impaired CD4/8 double-negative thymocyte differentiation.
            Overexpression impaired TCR-beta expression and CD4/8
            double-positive thymocyte production. Expressed also in
            B-lymphocytes.
REFERENCE   9  (bases 1 to 2146)
  AUTHORS   Clapp,J., Mitchell,L.M., Bolland,D.J., Fantes,J., Corcoran,A.E.,
            Scotting,P.J., Armour,J.A. and Hewitt,J.E.
  TITLE     Evolutionary conservation of a coding function for D4Z4, the tandem
            DNA repeat mutated in facioscapulohumeral muscular dystrophy
  JOURNAL   Am J Hum Genet 81 (2), 264-279 (2007)
   PUBMED   17668377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC055782.1 and AK141686.1.
            
            On Mar 29, 2018 this sequence version replaced NM_183389.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141686.1, EF472598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1812              BC055782.1         199-2010
            1813-2146           AK141686.1         1687-2020
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 15.3 cM"
     gene            1..2146
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="double homeobox B-like 1"
                     /db_xref="GeneID:278672"
                     /db_xref="MGI:MGI:1916048"
     exon            1..343
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1374
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="Dux in lymphoid lineage; double homeobox B-like 2;
                     doubl homeobox B-like 2; double homeobox B-like 3; double
                     homeodomain protein"
                     /codon_start=1
                     /product="double homeobox B-like 1"
                     /protein_id="NP_899245.1"
                     /db_xref="CCDS:CCDS26878.1"
                     /db_xref="GeneID:278672"
                     /db_xref="MGI:MGI:1916048"
                     /translation="MELSCSTGLLEKEARRRRIILTQSQKDTLRVWFEKNPNPDLATR
                     GHLAKELGISESQIMTWFQKHRKIRKQAEFACCSEESQEQEQDKPRVKEARRSRTHFT
                     KFQTDILIEAFEKNRFPGIVTREKLAQQTGIPESRIHIWFQNRRARHPDPGQNTQKTP
                     HPPQSSQGPTQKTVGKLAPSKTLTSSASVILPLSPPHTPNGPLDLSKGRQKQLPGTTL
                     LQSSQVVQQRSDDQNPNKGHLSPTTTPGEQGFHSQPPLQLLTQNRGHNPRESGGLAVP
                     RLEDCTQVPAVNQHFRKLDQNDSSFLQHWDEWFGSMLAEWMPDKEYWSEKAELHPWQV
                     QLRQLASVSPQAHQTP"
     exon            344..498
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
     exon            499..592
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
     exon            593..738
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
     exon            739..2146
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcacagtcca tcatctgtca agagtctttt aaaacttcag tccatcaagg agttaaacca
       61 gtgattagct caactctctc atgatataat cttctctgga aaccacccca gacacaccca
      121 gaggcgggtt tcactaatct cccaggaacc tcttaatcca atcaagttga ctatcaagat
      181 ttgccacagt gctgcatatt taatgaaagg attaaacaac caacaggtat ttaagaaatg
      241 ggtgggccac tctgggctct actacatcct gtgtctctgt gacagctctc ttgggcctct
      301 tgggatccag atggctgcag catggagctg agctgcagta ctggcctact ggaaaaagaa
      361 gcccggagaa ggagaatcat tctaacccag agtcaaaagg acactcttcg tgtgtggttt
      421 gaaaagaatc ccaatcctga tctagctacc agaggacatc tggctaagga actcggcatc
      481 tctgagtctc aaattatgac ttggtttcaa aagcatagaa aaatacggaa gcaagcagag
      541 tttgcatgct gttctgaaga aagccaagag caggagcagg ataaacctag agttaaagaa
      601 gctagaagga gcagaacgca cttcacaaag ttccagactg atattctaat tgaagctttt
      661 gagaagaatc ggttccctgg gattgttacc agggaaaaac tggctcaaca aacaggcatc
      721 ccagaatcca ggattcatat atggtttcag aaccggagag cacggcaccc agacccagga
      781 cagaacactc agaaaactcc tcatccaccc cagagcagtc agggccctac ccagaaaact
      841 gtgggtaaac tcgctccttc caaaactctc accagcagcg cttcagttat actgcctctt
      901 tctccacccc acactccaaa tgggcctttg gatctctcta agggccgtca gaagcagtta
      961 ccagggacca cactacttca gtcctcccag gttgtacagc aaaggagtga tgatcaaaat
     1021 cccaataaag gtcacttatc accgacaaca actccaggag agcagggctt ccattctcag
     1081 cctcctttac agctcctaac ccaaaacaga gggcataatc ccagagagag cggtggtttg
     1141 gcggtaccgc gcttagaaga ttgtactcag gtcccagctg tcaatcaaca cttccggaaa
     1201 ctagaccaaa atgattcctc ctttctccaa cactgggacg agtggttcgg atccatgctt
     1261 gctgaatgga tgcctgacaa agaatactgg tctgagaaag ctgagctgca tccgtggcag
     1321 gtgcagctgc ggcagcttgc cagcgtgtct cctcaagcac accaaactcc gtagcagtag
     1381 gtttaagcct caagcctttt ccgttcattc ctcttgagca caggtttttc aggaaaagat
     1441 ctcttccttc ggcacccagg tccccacgtg gattcctgtg catggcttgg agagcttctc
     1501 aggagagtgt tgggttcttc acaggggaac gagtacatca gtgaggacct gccctcgggc
     1561 gtgaaatcag tggctatact gaagagtagg catgcagaat tagggaacaa gatcaagtta
     1621 gtatgtgcat aaaccacatg gacacaaaaa gggggcaatt atttttattc ttaatttatt
     1681 cttgagatct gatctcactg ttactctggc tggtcttgaa ctcctgtgct caagtcaatt
     1741 tcctgcctca gcctcctaaa taatcggtgc tacaaatata tccctccggg tccgtcttgg
     1801 ttttaatttt aattatttat ttatttttaa ttcacggttt catctaccat ctgttatgtt
     1861 tcaaagctga agtgtctctc acaaattcat gttctgaaat cttgcctctc agccaatggt
     1921 gctgtttgaa atctgtagag gttttaggtg ggtcctgacc ggcaggtgca ggccagggtg
     1981 gtaccttgaa agttataccc accatgtgaa cagcatgcac cacgcgttcc caatgtgtag
     2041 acggacttat gtccccacgc ctctctgtga caatgggcta aaacattctg acaagaatcc
     2101 aaataaacac tctcctgtca cgttgcttct ggtagttgtt tggatc
//
