LOCUS       NM_029352               2714 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus dual specificity phosphatase 9 (Dusp9), mRNA.
ACCESSION   NM_029352
VERSION     NM_029352.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2714)
  AUTHORS   Wang,J., Wei,T., Zhang,W., Chu,Y., Zhang,D., Zhang,M., Hu,J., Ji,Z.
            and Hao,Q.
  TITLE     Inhibition of miR-194-5p avoids DUSP9 downregulation thus limiting
            sepsis-induced cardiomyopathy
  JOURNAL   Sci Rep 14 (1), 20313 (2024)
   PUBMED   39218968
  REMARK    GeneRIF: Inhibition of miR-194-5p avoids DUSP9 downregulation thus
            limiting sepsis-induced cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2714)
  AUTHORS   Li,Z., Huang,Z., Luo,Y., Yang,H. and Yang,M.
  TITLE     DUSP9 alleviates hepatic ischemia/reperfusion injury by restraining
            both mitogen-activated protein kinase and IKK in an apoptosis
            signal-regulating kinase 1-dependent manner
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (12), 1811-1821 (2022)
   PUBMED   36789693
  REMARK    GeneRIF: DUSP9 alleviates hepatic ischemia/reperfusion injury by
            restraining both mitogen-activated protein kinase and IKK in an
            apoptosis signal-regulating kinase 1-dependent manner.
            Erratum:[Acta Biochim Biophys Sin (Shanghai). 2023 Nov
            22;55(12):2013. doi: 10.3724/abbs.2023265. PMID: 37990617]
REFERENCE   3  (bases 1 to 2714)
  AUTHORS   Zhong,Z., Liu,Z., Zheng,R., Chai,J. and Jiang,S.
  TITLE     miR-132-3p Modulates DUSP9-Dependent p38/JNK Signaling Pathways to
            Enhance Inflammation in the Amnion Leading to Labor
  JOURNAL   Int J Mol Sci 23 (3), 1864 (2022)
   PUBMED   35163786
  REMARK    GeneRIF: miR-132-3p Modulates DUSP9-Dependent p38/JNK Signaling
            Pathways to Enhance Inflammation in the Amnion Leading to Labor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2714)
  AUTHORS   Neamatallah,T., Jabbar,S., Tate,R., Schroeder,J., Shweash,M.,
            Alexander,J. and Plevin,R.
  TITLE     Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel
            Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene
            Expression and Function
  JOURNAL   Int J Mol Sci 20 (14), 3434 (2019)
   PUBMED   31336892
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2714)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2714)
  AUTHORS   Liu,Y., Lagowski,J., Sundholm,A., Sundberg,A. and Kulesz-Martin,M.
  TITLE     Microtubule disruption and tumor suppression by mitogen-activated
            protein kinase phosphatase 4
  JOURNAL   Cancer Res 67 (22), 10711-10719 (2007)
   PUBMED   18006813
  REMARK    GeneRIF: microtubule disruption by MKP4 provides a novel mechanism
            for tumor suppression by a cytosolic MKP
REFERENCE   7  (bases 1 to 2714)
  AUTHORS   Christie,G.R., Williams,D.J., Macisaac,F., Dickinson,R.J.,
            Rosewell,I. and Keyse,S.M.
  TITLE     The dual-specificity protein phosphatase DUSP9/MKP-4 is essential
            for placental function but is not required for normal embryonic
            development
  JOURNAL   Mol Cell Biol 25 (18), 8323-8333 (2005)
   PUBMED   16135819
  REMARK    GeneRIF: DUSP9/MKP-4 is essential for placental organogenesis but
            is otherwise dispensable for mammalian embryonic development.
REFERENCE   8  (bases 1 to 2714)
  AUTHORS   Lu,J., Qian,J., Izvolsky,K.I. and Cardoso,W.V.
  TITLE     Global analysis of genes differentially expressed in branching and
            non-branching regions of the mouse embryonic lung
  JOURNAL   Dev Biol 273 (2), 418-435 (2004)
   PUBMED   15328023
REFERENCE   9  (bases 1 to 2714)
  AUTHORS   Xu,H., Dembski,M., Yang,Q., Yang,D., Moriarty,A., Tayber,O.,
            Chen,H., Kapeller,R. and Tartaglia,L.A.
  TITLE     Dual specificity mitogen-activated protein (MAP) kinase
            phosphatase-4 plays a potential role in insulin resistance
  JOURNAL   J Biol Chem 278 (32), 30187-30192 (2003)
   PUBMED   12777378
  REMARK    GeneRIF: negatively regulates insulin signaling and, consequently,
            may contribute to the pathogenesis of insulin resistance
REFERENCE   10 (bases 1 to 2714)
  AUTHORS   Dickinson,R.J., Williams,D.J., Slack,D.N., Williamson,J.,
            Seternes,O.M. and Keyse,S.M.
  TITLE     Characterization of a murine gene encoding a developmentally
            regulated cytoplasmic dual-specificity mitogen-activated protein
            kinase phosphatase
  JOURNAL   Biochem J 364 (Pt 1), 145-155 (2002)
   PUBMED   11988087
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY316312.1.
            
            On Jul 13, 2003 this sequence version replaced NM_029352.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100309.1, AY316312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2714
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.37 cM"
     gene            1..2714
                     /gene="Dusp9"
                     /gene_synonym="Mpk4; Pyst3"
                     /note="dual specificity phosphatase 9"
                     /db_xref="GeneID:75590"
                     /db_xref="MGI:MGI:2387107"
     exon            1..201
                     /gene="Dusp9"
                     /gene_synonym="Mpk4; Pyst3"
                     /inference="alignment:Splign:2.1.0"
     exon            202..813
                     /gene="Dusp9"
                     /gene_synonym="Mpk4; Pyst3"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1595
                     /gene="Dusp9"
                     /gene_synonym="Mpk4; Pyst3"
                     /note="dual-specificity MAP kinase phosphatase 4"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 9"
                     /protein_id="NP_083628.3"
                     /db_xref="CCDS:CCDS30206.1"
                     /db_xref="GeneID:75590"
                     /db_xref="MGI:MGI:2387107"
                     /translation="MESLSRSCLWLRQELSSPRPQLLLLDCRSRELYESARICGALSV
                     ALPSLMLRRLRRGSMSVRSLLPGPPLQPPPPAPVLLYDQGSSGQCHREAAEAEAKAEP
                     KAEAEAEPKAEAEAEPKAEAENEAEAKAEAKAEAKAEAKAEAKAEAKAEAKAEAKAEA
                     KAEAKEEWDADSVLGVLLQKLREEGYPAYYLQGGFSKFQAECPHLCETSFSGRAGSGL
                     GSMSSPVPVVGLGGLCLSSDFSDAESEADRDTLSCGLDSENTTSPPAGLLPPFPVQIL
                     PNLYLGSARDSANLESLAKLGIRYILNVTPNLPNLFEKNGDFHYKQIPISDHWSQNLS
                     QFFPEAIAFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKK
                     SNISPNFNFMGQLLDFERSLRLGGKRSGGRGSGGPESTVSDPPSFFTTPTSDGVFELD
                     PT"
     exon            814..1269
                     /gene="Dusp9"
                     /gene_synonym="Mpk4; Pyst3"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..2700
                     /gene="Dusp9"
                     /gene_synonym="Mpk4; Pyst3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2674..2679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp9"
                     /gene_synonym="Mpk4; Pyst3"
                     /note="hexamer: AATAAA"
     polyA_site      2700
                     /gene="Dusp9"
                     /gene_synonym="Mpk4; Pyst3"
                     /note="major polyA site"
ORIGIN      
        1 ggattctgct gccaggaagc ggccggcgca cgagtggcgc gaggcttggc ttccacgtgc
       61 gagcctgctc caccaccccg ccctctccga gcgcccaagc ctgggggatc cgtctccatg
      121 aacgatacct acgccctgcc gtggcactag ctgtggccag gacgtccggg tgcagtcgcc
      181 tgcctctgga tctcgctcca gcacccactg cccgacgtgc aggacgctgc gcgaccatgg
      241 agagtctgag tcggtcatgc ctgtggctgc gtcaggagct gtcgtccccg cgcccacagc
      301 ttctgctgct ggactgccgc agccgggagc tgtatgagtc ggcgcgcatc tgcggggcgc
      361 tgagcgtggc cctgccctcg ctgatgctgc gccgcctgcg gagggggagc atgtcggtgc
      421 ggtcgctctt gcctgggcca ccactgcagc ctcccccacc ggcccctgtg ctcctgtacg
      481 accagggtag cagtggccag tgccatcgtg aagcagcgga ggctgaagcg aaggccgaac
      541 ctaaggctga agcggaggcc gaacctaagg ctgaagcgga ggccgaacct aaggctgaag
      601 cggagaacga agcggaggct aaagcggagg ccaaagcgga ggccaaagcg gaggctaaag
      661 cggaggccaa agcggaggcc aaagcggagg ccaaagcgga ggctaaagcg gaggccaaag
      721 cggaggccaa agaagagtgg gatgctgact cggtgctggg cgtcctgctc cagaagctgc
      781 gggaagaagg ctacccagca tactacctac agggtggctt cagcaagttc caggccgagt
      841 gtcctcacct gtgtgaaacc agcttcagtg gtcgtgccgg ctcaggcctg ggctcaatgt
      901 ctagcccagt gcctgtggtg gggctaggtg gcctgtgctt gagctctgat ttctctgatg
      961 cagagtctga ggctgaccgt gacaccttga gctgtggcct agattctgag aacaccacat
     1021 cccctccagc tgggctgcta ccacccttcc cagtccagat cctgcccaat ctctacctag
     1081 gcagtgctcg agattcagcc aatttggaga gcctggccaa gcttggcatc cgctatatcc
     1141 tcaatgtcac ccccaacctt cctaacctct ttgagaagaa tggtgacttc cactacaagc
     1201 agatccccat ctctgaccat tggagccaga atctgtccca gttctttccg gaggccattg
     1261 cattcattga tgaggccttg tcgcagaact gtggggtgct cgtccactgt ctggcagggg
     1321 tcagccgctc tgtcactgtc accgtggcct acctcatgca gaagcttcac ctctcactca
     1381 acgatgccta cgacttggtc aagcggaaga agtctaacat ctcacctaac ttcaacttta
     1441 tggggcagct gctagacttt gaacgcagcc tgcgcctggg ggggaagcgc tccggggggc
     1501 ggggcagtgg gggaccagag tccaccgtct cagacccacc ttccttcttt actaccccta
     1561 ccagtgatgg ggtctttgag ctggacccca cataaagccg catggagctg ataggctggt
     1621 ccctacttat gacccctagt ataagcaggg atgggatgca gccataagca gggagagggg
     1681 aaaggggaag gggggaggga aagcgcaata cctcatgtgg ggatggtgga gcaaggcagg
     1741 aacagagtag aaacctgccc cacccactca aggccagccc cagattctat ttcacgtgcc
     1801 tactggtggg cccgggcttc gggcctgacc ctcaccgctc tagagcgggg ccatgctcca
     1861 gaacctgcct cgtctgtgac tgttactttc ttttttcagg gtgggagtgg ggcttcctat
     1921 ccaagagacc attccagatt gctgcctggg ccctggccct tcttgctgtt tcattttcag
     1981 gaagagtgta tcattctttg ccacaggaac ctgctcttgg ctccatacct gtccccgaat
     2041 gcccacctgt gggagcagac ctggccactt tgactcgtgt agactccttc ctgcttctct
     2101 cactagggct tagacttctt ggaactgtag ggtgtgaacc cagagacaca atggctgctc
     2161 tccgcatcca cagggacagc ctctctgggt ggctttttgc tgggcagtgt cacatgggag
     2221 ggcatgggcc tgggagccaa tgggcgagat cccagccaca catctggtgc cctgactgtt
     2281 tctttcctcc tcccccagat gtcttgacag gatcactgag actctttgtg actgagggtg
     2341 gtcaaactgc caccggagga gatagggtct cagagctaga gctgaggggg agggagggaa
     2401 agatgaaggc ctcaattttg ctactgtgag tctcacacag ccactgttgg tttggggggc
     2461 agggaagggg ccaagctgca gacacacatg gtcattcatt gcagtccaca ccccgttgta
     2521 gactctgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtacac actagcccac tcacatactc
     2581 agcctggagc tggcaatacc tgtggcagca ggaccatctt gtctttgttt ttgtaatcca
     2641 catcataatc acattctttc attgttactc ctgaataaac agtttattta aggtactgaa
     2701 aaaaaaaaaa aaaa
//
