LOCUS       NM_008748               4839 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dual specificity phosphatase 8 (Dusp8), mRNA.
ACCESSION   NM_008748
VERSION     NM_008748.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4839)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4839)
  AUTHORS   Chuang,H.C., Hsueh,C.H., Hsu,P.M., Tsai,C.Y., Shih,Y.C., Chiu,H.Y.,
            Chen,Y.M., Yu,W.K., Chen,M.H. and Tan,T.H.
  TITLE     DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha
  JOURNAL   J Clin Invest 133 (21), e166269 (2023)
   PUBMED   37909329
  REMARK    GeneRIF: DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4839)
  AUTHORS   Ankawa,R., Goldberger,N., Yosefzon,Y., Koren,E., Yusupova,M.,
            Rosner,D., Feldman,A., Baror-Sebban,S., Buganim,Y., Simon,D.J.,
            Tessier-Lavigne,M. and Fuchs,Y.
  TITLE     Apoptotic cells represent a dynamic stem cell niche governing
            proliferation and tissue regeneration
  JOURNAL   Dev Cell 56 (13), 1900-1916 (2021)
   PUBMED   34197726
  REMARK    GeneRIF: Apoptotic cells represent a dynamic stem cell niche
            governing proliferation and tissue regeneration.
REFERENCE   4  (bases 1 to 4839)
  AUTHORS   Baumann,P., Schriever,S.C., Kullmann,S., Zimprich,A., Peter,A.,
            Gailus-Durner,V., Fuchs,H., Hrabe de Angelis,M., Wurst,W.,
            Tschop,M.H., Heni,M., Holter,S.M. and Pfluger,P.T.
  TITLE     Diabetes type 2 risk gene Dusp8 is associated with altered sucrose
            reward behavior in mice and humans
  JOURNAL   Brain Behav 11 (1), e01928 (2021)
   PUBMED   33131190
  REMARK    GeneRIF: Diabetes type 2 risk gene Dusp8 is associated with altered
            sucrose reward behavior in mice and humans.
REFERENCE   5  (bases 1 to 4839)
  AUTHORS   Liu,R., Peters,M., Urban,N., Knowlton,J., Napierala,T. and
            Gabrysiak,J.
  TITLE     Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance
            to diet-induced obesity
  JOURNAL   Biochem Biophys Res Commun 533 (1), 17-22 (2020)
   PUBMED   32917360
  REMARK    GeneRIF: Mice lacking DUSP6/8 have enhanced ERK1/2 activity and
            resistance to diet-induced obesity.
REFERENCE   6  (bases 1 to 4839)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
REFERENCE   7  (bases 1 to 4839)
  AUTHORS   Kato,R., Shirohzu,H., Yokomine,T., Mizuno,S., Mukai,T. and
            Sasaki,H.
  TITLE     Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal
            imprinted region of mouse chromosome 7
  JOURNAL   DNA Res 6 (6), 401-405 (1999)
   PUBMED   10691133
REFERENCE   8  (bases 1 to 4839)
  AUTHORS   Paulsen,M., Davies,K.R., Bowden,L.M., Villar,A.J., Franck,O.,
            Fuermann,M., Dean,W.L., Moore,T.F., Rodrigues,N., Davies,K.E.,
            Hu,R.J., Feinberg,A.P., Maher,E.R., Reik,W. and Walter,J.
  TITLE     Syntenic organization of the mouse distal chromosome 7 imprinting
            cluster and the Beckwith-Wiedemann syndrome region in chromosome
            11p15.5
  JOURNAL   Hum Mol Genet 7 (7), 1149-1159 (1998)
   PUBMED   9618174
REFERENCE   9  (bases 1 to 4839)
  AUTHORS   Theodosiou,A.M., Rodrigues,N.R., Nesbit,M.A., Ambrose,H.J.,
            Paterson,H., McLellan-Arnold,E., Boyd,Y., Leversha,M.A., Owen,N.,
            Blake,D.J., Ashworth,A. and Davies,K.E.
  TITLE     A member of the MAP kinase phosphatase gene family in mouse
            containing a complex trinucleotide repeat in the coding region
  JOURNAL   Hum Mol Genet 5 (5), 675-684 (1996)
   PUBMED   8733137
REFERENCE   10 (bases 1 to 4839)
  AUTHORS   Martell,K.J., Seasholtz,A.F., Kwak,S.P., Clemens,K.K. and
            Dixon,J.E.
  TITLE     hVH-5: a protein tyrosine phosphatase abundant in brain that
            inactivates mitogen-activated protein kinase
  JOURNAL   J Neurochem 65 (4), 1823-1833 (1995)
   PUBMED   7561881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603836.13, BC052705.1 and BQ043453.1.
            
            On Mar 26, 2011 this sequence version replaced NM_008748.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052705.1, SRR7974084.22419.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AL603836.13        82320-82561
            243-2238            BC052705.1         1-1996
            2239-4256           AL603836.13        95537-97554
            4257-4839           BQ043453.1         20-602
FEATURES             Location/Qualifiers
     source          1..4839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 87.59 cM"
     gene            1..4839
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /note="dual specificity phosphatase 8"
                     /db_xref="GeneID:18218"
                     /db_xref="MGI:MGI:106626"
     exon            1..362
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..685
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..2446
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="neuronal tyrosine threonine phosphatase 1"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 8"
                     /protein_id="NP_032774.1"
                     /db_xref="CCDS:CCDS22024.1"
                     /db_xref="GeneID:18218"
                     /db_xref="MGI:MGI:106626"
                     /translation="MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSCHVL
                     SSVNICCSKLVKRRLQQGKVTIAELIQPATRSQVDATEPQDVVVYDQSTRDASVLAAD
                     SFLSILLSKLDGCFDSVAILTGGFATFSSCFPGLCEGKPATLPSMSLSQPCLPVPSVG
                     LTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRIPINDNYC
                     EKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFV
                     KDRRPSISPNFNFLGQLLEYERSLKLLAALQTDGPHLGTPEPLMGPAAGIPLPRLPPS
                     TSESAATGSEAATAAREGSPSAGGDAPIPSTAPATSALQQGLRGLHLSSDRLQDTNRL
                     KRSFSLDIKSAYAPSRRPDFPGPPDPGEAPKLCKLDSPSGGTLGLPSPSPDSPDSVPE
                     CRPRPRRRRPPASSPARSPAHGLGLNFGDTARQTPRHGLSALSAPGLPGPGQPAGPGG
                     WVPPLDSPGTPSPDGPWCFSPEGAQGPGAVFSAFGRVSAGAPGPGNSSSSGGGGGGGG
                     GGGGGGGGGGSSSSNSSSSSSSSSSSSSSSSSSSDLRRRDVRTGWPEEPAADAQFKRR
                     SCQMEFEEGMVEGRARGEELAALGKQTSFSGSVEVIEVS"
     exon            686..824
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..991
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1151
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1275
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..4819
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4788..4793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /note="hexamer: AATAAA"
     polyA_site      4812
                     /gene="Dusp8"
                     /gene_synonym="5530400B01Rik; Nttp1"
                     /note="major polyA site"
ORIGIN      
        1 cgggcctgtc actcgcggct cccgcggtgg ccgagccggc tccgcggacc cccgccccac
       61 ccggacgccg gacgccggac gctgagccgg gccggagctg ccggccgcgc ccgccaagtc
      121 gcgggctggg atgcgcgccg tgagcgcgcg tgcccgaccg cagtacgcgc gctccgtccc
      181 gagcgagcgc tccccgcggt ggcggcgacg acggcggcgg cggcggcgac gcgccccgcg
      241 cgcctctccg gcccttgccc cggctacgcg ggcccccgac gggcccatgg gtggcggaac
      301 ggagcgggcg ccctgagcgc ggcaccggcg ttgggggcaa ccccagggca agcgagagcc
      361 aggtctggca ccatgcacta ggatacccag aacgctgcaa ggccacgccc tcctcacttc
      421 aggggtcact ctccccattg cccaccaccc caccatggct ggggatcggc tcccgaggaa
      481 ggtgatggac gcaaagaaac tggccagcct gctgcgtggc gggcctgggg gacccttggt
      541 catcgacagc cggtccttcg tggagtataa cagctgccac gtgctgagct ctgtgaatat
      601 ctgctgttca aagctggtga agcggcgcct tcagcaggga aaagtgacaa ttgctgagct
      661 tatccagcct gctacacgga gccaggtgga tgccacagaa ccacaggatg tagtggtgta
      721 tgaccagagc acacgagatg ccagcgtgct ggcagcagac agcttcctgt ccatcctgct
      781 cagcaagctg gacggctgct tcgacagtgt ggccatcctc acaggaggct tcgccacctt
      841 ctcctcctgc ttccctggcc tctgtgaggg caagcctgcc actctaccgt ccatgagcct
      901 ctctcagccc tgcctgcctg tgcccagtgt tggcctgacc cgaatcctgc ctcacctcta
      961 cctgggctct cagaaagatg tcttgaacaa ggatctgatg acccaaaacg gaataagcta
     1021 tgtcctcaat gccagcaact cctgccctaa accggacttc atctgtgaga gccgtttcat
     1081 gcgtatcccc atcaatgaca actactgtga aaagctgctg ccctggctgg acaagtccat
     1141 cgagtttatt gataaagcca agctgtccag ctgccaagtc attgttcact gtctggctgg
     1201 catctctcgc tctgccacca ttgccatcgc gtacatcatg aaaaccatgg gcatgtcttc
     1261 tgacgacgca tacaggtttg tgaaggatcg gcgcccctcc atctcgccca acttcaactt
     1321 cctgggccag ttgctggagt atgagaggag tctgaagctg ctggctgccc tgcagactga
     1381 tggacctcac ttggggaccc ctgagcccct catgggcccg gcagcaggca tcccactgcc
     1441 ccggctgcca ccatctacct cagagagcgc tgccactggg agcgaggcag ccaccgcagc
     1501 cagggagggc agcccaagtg ctggagggga tgctccgatc cccagcacag ctccagccac
     1561 cagcgcgctg cagcagggcc tgcgtggcct gcacctctcc tctgaccgcc tccaggacac
     1621 caaccgcctc aagcgttcct tttccctgga catcaagtcg gcctatgcac ccagcaggag
     1681 gcccgacttt cccggcccac ccgaccccgg tgaagccccg aagctctgca agctggacag
     1741 cccgtctggg ggcacactgg gcctgccctc gcccagccca gacagcccgg actccgttcc
     1801 agagtgccgc ccacgacccc gccggcgacg ccccccggct agttcgcctg cccgctcccc
     1861 cgcgcatggt ctgggcctga actttggaga cacggcccgg cagactccac ggcacggcct
     1921 ctcggccctg tcggcgcccg ggctgcctgg ccctggccag ccggctggcc ccgggggctg
     1981 ggtgccgcca ctggactccc caggcacacc gtcgcccgac ggcccctggt gcttcagccc
     2041 cgagggcgcg cagggtccag gcgctgtgtt ctccgccttt ggccgggtaa gtgcaggcgc
     2101 acctggaccc ggtaacagca gcagcagcgg tggtggtggt ggtggtggtg gcggcggcgg
     2161 cggcggcggc ggcggcggcg gcagcagcag cagcaacagc agcagcagca gcagcagcag
     2221 cagcagcagc agcagcagta gtagtagtag tagtgacctg cggaggcggg atgtgcggac
     2281 cggctggccc gaggagcctg ctgcagatgc acagttcaag aggcgcagct gccagatgga
     2341 gttcgaagag ggcatggtgg aggggcgggc acgtggcgag gagctggcag ccctgggcaa
     2401 gcaaaccagc ttctctggca gcgtggaggt catcgaagta tcgtgaccct tcagaagtcc
     2461 ctgtgccctt gctccagcca ggccaggtat aaatatatat tatatataaa acacacagaa
     2521 aaggtaaatg gttttactgc aatttttatc aagaagtaaa tatttcgatt ttttatttat
     2581 ttaagctagt gatctggcaa ctgtgcgggg cggccctaaa gctctgtttt tactgtctgg
     2641 tatttaaact gaaacaggtt tctaagcaat atgaggccac cttcaatccc aaactgggtt
     2701 gacaggcctg ggcccctcct tgcccctccc ctctggaaac attactgacc tttcaaagag
     2761 ctgcccagct ttcctgcact ttttacataa gaaaaaaggg ggggggggaa tgaaaaacaa
     2821 aaaaaaaaaa aaacaaaaaa cccaaaccct tacttgccac aaactgagcc gcagacccct
     2881 cccctctcct ttccctcttc tcctgtctct cctctcctgt ttctcctatc ttgggctctg
     2941 cagcaaagcc ataggtaagg ggaggagggg gaaaccctag tgtccctgca gaaggcccca
     3001 ctagcagtgt ccccacacct caaattgcca agtcttagtg gcatagagat agataccttc
     3061 tctgcccttc accccagggc tgttacctgg caggtgttgg tgggcactgg gcccagtgga
     3121 gcagagtttt cagggagact tggacaaggg ggttcctgaa agccagatga ggtagctctg
     3181 aaggcaagga cggaggacct cactcctgtg agagtgaggc ccagttccct agaagggccc
     3241 aggaggccat tcagaggaag catctctctt ttcctttgca gatgccctgc ccattgggaa
     3301 gccgagtaga cttccccagc atgtactggg gcagtgtcca atgccagcag gaggagctta
     3361 gctagctggg gctggcaggg gctatctctg ctggtcagag gggagctcta ggcccagtaa
     3421 gaatgggggt agagtcaagc tcttgttctg ggctcttcct gctacaggta ggacttggaa
     3481 ttctactgcg tctgcaggtt ggggagcccc tgaggcaggc ggggtaaagt acctaccaag
     3541 cccttaggct tacaggaagt gggaatcctc aactatagga gaactgtctc caagcagaga
     3601 aagaccccac ctaaggacag atgctgggca agtcccccat gactgcccca tcctccaaag
     3661 ggcttctcag gagagagtcc ctctgtatgc gcacttccca ggcagcatac ttccccagtg
     3721 tcttcaagat gttatgctag cctccaccca aggtggcttt tttaggctca gagccaatct
     3781 aggagaagga caaggagaaa agtgccagcc acccttgctg aatatcctct tggggaccca
     3841 aagttttgag gcagaatagg agttcttgct cttagatgtc tttaagtctt ggagtgggtc
     3901 tgtcctttga ggaagaagct aggggcttgt taacaagtag ctggggcagg atctagggtg
     3961 gcacctttct accccacctc tcttgctgtg tccttctgtc tgttcttctt ttgacctgct
     4021 ccccatgttc ctgtcaccct ccttcttaag caaaagtcct gtcctagttc tcttgatccc
     4081 acccatcctg atccctgaga aaataagcta ttgttgtatt tgcaatctat ggattagagg
     4141 tttaagtatt tattattatt ggttaattat tattataatt attattatta attatgtaaa
     4201 tttacctcct gtctgtcatt ggatttctga ggtgaccctg ggtgtggagg gtgcactggc
     4261 ttccccctcc atgcccccac tctactgctg tccaggagac agtggtgtgg ggccaccagt
     4321 tggaccctaa agctccccct tgggtctggt tcctcccctc tcttgatgga gatatggcat
     4381 ctatcctgga tacacggggc ccgttggcct cagtctgtct ctgttctcac ttacacatga
     4441 ccctggtctc cccaaagtga gcagacaaga tggaggaggt ctcagctccc cactcctttg
     4501 tgttggggga ggtggagcat aggctttccc tggtggcttt ccacccactg tccactgtgt
     4561 ggagggtata gggttctcta tcactctccc accactctta cctggtcact gccggcactg
     4621 gaatggccca gaatgcacct ggctccctct gttgtccagt acaggagagg tcccttgccc
     4681 aaggcttcca gtccccgagg gccagggtgc cagcttcccc cttgggacct tgccccatga
     4741 ggccgcactt tcctgtccct ccttttgtat ttgaaacaat gtgttgtaat aaatcatgag
     4801 acggatgttt tcctcaggca aaaaaaaaaa aaaaaaaaa
//
