LOCUS       NM_026268               2814 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus dual specificity phosphatase 6 (Dusp6), mRNA.
ACCESSION   NM_026268
VERSION     NM_026268.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2814)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2814)
  AUTHORS   Wu,X. and Zhang,W.
  TITLE     TRIM11 expression levels was downregulated and prevents ferroptosis
            of cardiomyocyte by Dusp6 in acute myocardial infarction
  JOURNAL   Anticancer Drugs 35 (8), 720-731 (2024)
   PUBMED   38718254
  REMARK    GeneRIF: TRIM11 expression levels was downregulated and prevents
            ferroptosis of cardiomyocyte by Dusp6 in acute myocardial
            infarction.
REFERENCE   3  (bases 1 to 2814)
  AUTHORS   Wang,Y., Lv,Y., Jiang,X., Yu,X., Wang,D., Liu,D., Liu,X. and Sun,Y.
  TITLE     Long non-coding RNA NORAD regulates megakaryocyte differentiation
            and proplatelet formation via the DUSP6/ERK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 715, 150004 (2024)
   PUBMED   38678784
  REMARK    GeneRIF: Long non-coding RNA NORAD regulates megakaryocyte
            differentiation and proplatelet formation via the DUSP6/ERK
            signaling pathway.
REFERENCE   4  (bases 1 to 2814)
  AUTHORS   Laragione,T., Harris,C., Rice,N. and Gulko,P.S.
  TITLE     DUSP6 deletion protects mice and reduces disease severity in
            autoimmune arthritis
  JOURNAL   iScience 27 (6), 110158 (2024)
   PUBMED   38974475
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2814)
  AUTHORS   Chen,P.C., Tsai,T.P., Liao,Y.C., Liao,Y.C., Cheng,H.W., Weng,Y.H.,
            Lin,C.M., Kao,C.Y., Tai,C.C. and Ruan,J.W.
  TITLE     Intestinal dual-specificity phosphatase 6 regulates the
            cold-induced gut microbiota remodeling to promote white adipose
            browning
  JOURNAL   NPJ Biofilms Microbiomes 10 (1), 22 (2024)
   PUBMED   38480743
  REMARK    GeneRIF: Intestinal dual-specificity phosphatase 6 regulates the
            cold-induced gut microbiota remodeling to promote white adipose
            browning.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2814)
  AUTHORS   Yashiro,K., Zhao,X., Uehara,M., Yamashita,K., Nishijima,M.,
            Nishino,J., Saijoh,Y., Sakai,Y. and Hamada,H.
  TITLE     Regulation of retinoic acid distribution is required for
            proximodistal patterning and outgrowth of the developing mouse limb
  JOURNAL   Dev Cell 6 (3), 411-422 (2004)
   PUBMED   15030763
REFERENCE   7  (bases 1 to 2814)
  AUTHORS   Dudley,A.T. and Tabin,C.J.
  TITLE     Deconstructing phosphatases in limb development
  JOURNAL   Nat Cell Biol 5 (6), 499-501 (2003)
   PUBMED   12776124
  REMARK    GeneRIF: During mouse limb bud development, Mkp3, a known MAPK/ERK
            regulator, is induced in the mesoderm by FGF8 signaling, through
            the PI3/Akt pathway.
REFERENCE   8  (bases 1 to 2814)
  AUTHORS   Kawakami,Y., Rodriguez-Leon,J., Koth,C.M., Buscher,D., Itoh,T.,
            Raya,A., Ng,J.K., Esteban,C.R., Takahashi,S., Henrique,D.,
            Schwarz,M.F., Asahara,H. and Izpisua Belmonte,J.C.
  TITLE     MKP3 mediates the cellular response to FGF8 signalling in the
            vertebrate limb
  JOURNAL   Nat Cell Biol 5 (6), 513-519 (2003)
   PUBMED   12766772
  REMARK    GeneRIF: MKP3 mediates the cellular response to FGF8 in the mouse
            limb.
REFERENCE   9  (bases 1 to 2814)
  AUTHORS   Klock,A. and Herrmann,B.G.
  TITLE     Cloning and expression of the mouse dual-specificity
            mitogen-activated protein (MAP) kinase phosphatase Mkp3 during
            mouse embryogenesis
  JOURNAL   Mech Dev 116 (1-2), 243-247 (2002)
   PUBMED   12128234
  REMARK    GeneRIF: cloning and expression analysis during embryogenesis
REFERENCE   10 (bases 1 to 2814)
  AUTHORS   Dickinson,R.J., Eblaghie,M.C., Keyse,S.M. and Morriss-Kay,G.M.
  TITLE     Expression of the ERK-specific MAP kinase phosphatase PYST1/MKP3 in
            mouse embryos during morphogenesis and early organogenesis
  JOURNAL   Mech Dev 113 (2), 193-196 (2002)
   PUBMED   11960712
  REMARK    GeneRIF: mPyst1 messenger RNA is found in important signaling
            centers associated with cell proliferation and patterning in
            developing mouse embryos
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159502.1, CJ278479.1 and BQ176279.1.
            
            On Jun 20, 2009 this sequence version replaced NM_026268.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003869.1, AK148192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2293              AK159502.1         2-2294
            2294-2792           CJ278479.1         191-689
            2793-2814           BQ176279.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2814
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 51.13 cM"
     gene            1..2814
                     /gene="Dusp6"
                     /gene_synonym="1300019I03Rik; MKP-3; MKP3; PYST1"
                     /note="dual specificity phosphatase 6"
                     /db_xref="GeneID:67603"
                     /db_xref="MGI:MGI:1914853"
     exon            1..861
                     /gene="Dusp6"
                     /gene_synonym="1300019I03Rik; MKP-3; MKP3; PYST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..1607
                     /gene="Dusp6"
                     /gene_synonym="1300019I03Rik; MKP-3; MKP3; PYST1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP kinase phosphatase 3; mitogen-activated protein
                     kinase phosphatase 3"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 6"
                     /protein_id="NP_080544.1"
                     /db_xref="CCDS:CCDS24147.1"
                     /db_xref="GeneID:67603"
                     /db_xref="MGI:MGI:1914853"
                     /translation="MIDTLRPVPFASEMAICKTVSWLNEQLELGNERLLLMDCRPQEL
                     YESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENS
                     SDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSP
                     PLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGC
                     AKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAI
                     SFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNF
                     NFMGQLLDFERTLGLSSPCDNRVPTPQLYFTTPSNQNVYQVDSLQST"
     exon            862..1299
                     /gene="Dusp6"
                     /gene_synonym="1300019I03Rik; MKP-3; MKP3; PYST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..2797
                     /gene="Dusp6"
                     /gene_synonym="1300019I03Rik; MKP-3; MKP3; PYST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2773..2778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp6"
                     /gene_synonym="1300019I03Rik; MKP-3; MKP3; PYST1"
                     /note="hexamer: AATAAA"
     polyA_site      2793
                     /gene="Dusp6"
                     /gene_synonym="1300019I03Rik; MKP-3; MKP3; PYST1"
                     /note="major polyA site"
ORIGIN      
        1 atccattgag gagctgcctc gcacaggggg tgtgctctcg cggagtccta gggactgtga
       61 gcaaacccag tcttgaataa tccggcgaga aacaccgggt tggatccgag gtgcagcctc
      121 agagggaagg attaagagcc gctagacttt ttttcttttc cctttttctc ctctcagtgg
      181 cacggagtcc gaattaattg gatttcattc actgggtagg aacaaaactg ggcaccttca
      241 ttcagagaga gagattcatt gactcggaga gtgatctggt gcagagggac caccgacttg
      301 acttctgtgt cgctttccct aaccgctagc ctcggcttgg gaaaggcgag gcggaatcaa
      361 accccgctcc gagagcggga gcttcgcgca gcgtgctcgg cctatgcctg cctcgagggg
      421 cgtctgctag gcaccccgcc ttctcctgca gctcgacccc catgatagat acgctcagac
      481 ccgtgccctt cgcgtcggaa atggcgatct gcaagacggt gtcgtggctc aacgagcagc
      541 tggagctggg caacgaacgg cttctgctga tggactgccg accacaggag ctgtacgagt
      601 cgtcacacat cgaatctgcc attaatgtgg ccatccccgg catcatgctg cggcgtctgc
      661 agaagggcaa cctgcccgtg cgtgcgctct tcacgcgctg cgaggaccgg gaccgcttta
      721 ccaggcgctg cggcaccgac accgtggtgc tgtacgacga gaatagcagc gactggaatg
      781 agaacactgg tggagagtcg gtcctcgggc tgctgctcaa gaaactcaaa gacgagggct
      841 gccgggcgtt ctacctggaa ggtggcttca gtaagttcca ggccgagttc gccctgcact
      901 gcgagaccaa tctagacggc tcgtgcagca gcagttcccc gcctttgcca gtgctggggc
      961 tcgggggcct gcggatcagc tcggactctt cctcggacat tgagtctgac cttgaccgag
     1021 accccaatag tgcaacggac tctgatggca gcccgctgtc caacagccag ccttccttcc
     1081 cggtggagat tttgcccttc ctttacctgg gctgtgccaa ggactcgacc aacttggacg
     1141 tgttggaaga gtttggcatc aagtacatct tgaatgtcac ccccaatttg cccaatctgt
     1201 ttgagaatgc gggcgagttc aaatacaagc aaattcctat ctcggatcac tggagccaaa
     1261 acctgtccca gtttttccct gaggccattt ctttcataga tgaagcccga ggcaaaaact
     1321 gtggtgtcct ggtgcattgc ttggcaggta tcagccgctc tgtcaccgtg acagtggcgt
     1381 acctcatgca gaagctcaac ctgtccatga acgatgctta cgacattgtt aagatgaaga
     1441 agtccaacat ctcccccaac ttcaacttca tgggccagct gcttgacttc gaaaggaccc
     1501 tgggactgag cagcccttgt gacaaccgtg tccccactcc gcagctgtac ttcaccacgc
     1561 cctccaacca gaacgtctac caggtggact ccctgcagtc tacgtgaaag gcacccacct
     1621 ctcctagccg ggagttgtcc ccattccttc agttcctctt gagcagcatc gaccaggctg
     1681 ctttctttct gtgtgtggcc ccgggtgtca aaagtgtcac cagctgtctg tgttagacaa
     1741 ggttgccaag tgcaaaattg gttattacgg agggagagat ttgctccatt cattgttttt
     1801 ttggaaggac aggacatgct gtctctagat ccagcaatag gtttgcttct gtaccccagc
     1861 ctacccaagc agggactgga catccatcca gatagagggt agcataggaa tagggacagg
     1921 agcatctgtt ctttaaggcc ttgtatggct gtttcctgtt gcatctggaa ctaactatat
     1981 atattgtctt cagtgaagac tgattcaact ttgggtatag tggagccaaa gagattttta
     2041 gctctgtatt tgcggtatcg gtttagaaga caaaaaaaat taaaacctga tacttttatc
     2101 tgattattgt aaatatttga tcttcaatca cttgacagtg tttgtttggc ttgtatttgt
     2161 tttttatctt tgggcttaaa agagatccaa agagagaaag agcagtatgc cacttcttag
     2221 aacaaaagta taaggaaaaa aatgttcttt ttaatccaaa gggtatattt gcagcatgct
     2281 tgaccttgat gtaccaattc tgacggcatt ttcgtggata ttattatcac taagactttg
     2341 ttatgatgag gtcttcagtc tctttcatat atcttccttg taactttttt tttcctctta
     2401 atgtagtttt gactctgcct tacctttgta aatatttggc ttacagtgtc tcaaggggta
     2461 ttttggaaag acaccaaaat tgtgggttca cttttttttt tttttttaaa taacttcagc
     2521 tgtgctaaac agcatattac ctctgtacaa aattcttcag ggagtgtcac ctcaaatgca
     2581 atactttggg ttggtttctt tccttttaaa aaaaaatacg aaactggaag tgtgtgtatg
     2641 tgtgcgagta tgagcgccca tttggtggat gcaacaggtt gagaggaagg gagaattaac
     2701 ttgctccatg atgttcgtgg tgtaaagttt tgagctggaa tttattataa gaatgtaaaa
     2761 ccttaaatta ttaataaata actattttgg ctattgaaaa aaaaaaaaaa aaaa
//
