LOCUS       NP_080544                381 aa            linear   ROD 08-APR-2025
DEFINITION  dual specificity protein phosphatase 6 [Mus musculus].
ACCESSION   NP_080544
VERSION     NP_080544.1
DBSOURCE    REFSEQ: accession NM_026268.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 381)
  AUTHORS   Avino-Esteban,L., Cardona-Blaya,H. and Sharpe,J.
  TITLE     Spatio-temporal reconstruction of gene expression patterns in
            developing mice
  JOURNAL   Development 152 (4) (2025)
   PUBMED   39982400
REFERENCE   2  (residues 1 to 381)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 381)
  AUTHORS   Png,C.W., Weerasooriya,M., Li,H., Hou,X., Teo,F.Y., Huang,S.,
            Ser,Z., Weng,F.Y.K., Rethnam,M., Chia,G., Sobota,R.M., Chong,C.S.,
            Tan,K.K. and Zhang,Y.
  TITLE     DUSP6 regulates Notch1 signalling in colorectal cancer
  JOURNAL   Nat Commun 15 (1), 10087 (2024)
   PUBMED   39572549
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 381)
  AUTHORS   Wu,X. and Zhang,W.
  TITLE     TRIM11 expression levels was downregulated and prevents ferroptosis
            of cardiomyocyte by Dusp6 in acute myocardial infarction
  JOURNAL   Anticancer Drugs 35 (8), 720-731 (2024)
   PUBMED   38718254
  REMARK    GeneRIF: TRIM11 expression levels was downregulated and prevents
            ferroptosis of cardiomyocyte by Dusp6 in acute myocardial
            infarction.
REFERENCE   5  (residues 1 to 381)
  AUTHORS   Laragione,T., Harris,C., Rice,N. and Gulko,P.S.
  TITLE     DUSP6 deletion protects mice and reduces disease severity in
            autoimmune arthritis
  JOURNAL   iScience 27 (6), 110158 (2024)
   PUBMED   38974475
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 381)
  AUTHORS   Yashiro,K., Zhao,X., Uehara,M., Yamashita,K., Nishijima,M.,
            Nishino,J., Saijoh,Y., Sakai,Y. and Hamada,H.
  TITLE     Regulation of retinoic acid distribution is required for
            proximodistal patterning and outgrowth of the developing mouse limb
  JOURNAL   Dev Cell 6 (3), 411-422 (2004)
   PUBMED   15030763
REFERENCE   7  (residues 1 to 381)
  AUTHORS   Dudley,A.T. and Tabin,C.J.
  TITLE     Deconstructing phosphatases in limb development
  JOURNAL   Nat Cell Biol 5 (6), 499-501 (2003)
   PUBMED   12776124
  REMARK    GeneRIF: During mouse limb bud development, Mkp3, a known MAPK/ERK
            regulator, is induced in the mesoderm by FGF8 signaling, through
            the PI3/Akt pathway.
REFERENCE   8  (residues 1 to 381)
  AUTHORS   Kawakami,Y., Rodriguez-Leon,J., Koth,C.M., Buscher,D., Itoh,T.,
            Raya,A., Ng,J.K., Esteban,C.R., Takahashi,S., Henrique,D.,
            Schwarz,M.F., Asahara,H. and Izpisua Belmonte,J.C.
  TITLE     MKP3 mediates the cellular response to FGF8 signalling in the
            vertebrate limb
  JOURNAL   Nat Cell Biol 5 (6), 513-519 (2003)
   PUBMED   12766772
  REMARK    GeneRIF: MKP3 mediates the cellular response to FGF8 in the mouse
            limb.
REFERENCE   9  (residues 1 to 381)
  AUTHORS   Klock,A. and Herrmann,B.G.
  TITLE     Cloning and expression of the mouse dual-specificity
            mitogen-activated protein (MAP) kinase phosphatase Mkp3 during
            mouse embryogenesis
  JOURNAL   Mech Dev 116 (1-2), 243-247 (2002)
   PUBMED   12128234
  REMARK    GeneRIF: cloning and expression analysis during embryogenesis
REFERENCE   10 (residues 1 to 381)
  AUTHORS   Dickinson,R.J., Eblaghie,M.C., Keyse,S.M. and Morriss-Kay,G.M.
  TITLE     Expression of the ERK-specific MAP kinase phosphatase PYST1/MKP3 in
            mouse embryos during morphogenesis and early organogenesis
  JOURNAL   Mech Dev 113 (2), 193-196 (2002)
   PUBMED   11960712
  REMARK    GeneRIF: mPyst1 messenger RNA is found in important signaling
            centers associated with cell proliferation and patterning in
            developing mouse embryos
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159502.1, CJ278479.1 and BQ176279.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003869.1, AK148192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 51.13 cM"
     Protein         1..381
                     /product="dual specificity protein phosphatase 6"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP kinase phosphatase 3; mitogen-activated protein
                     kinase phosphatase 3"
                     /calculated_mol_wt=42277
     Region          18..147
                     /region_name="DSP_MapKP"
                     /note="N-terminal regulatory rhodanese domain of dual
                     specificity phosphatases (DSP), such as Mapk Phosphatase.
                     This domain is believed to determine substrate specificity
                     by binding the substrate, such as ERK2, and activating the
                     C-terminal catalytic domain by...; cd01446"
                     /db_xref="CDD:238723"
     Site            63..65
                     /site_type="active"
                     /note="putative substrate binding residues [active]"
                     /db_xref="CDD:238723"
     Region          176..203
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DBB1.1)"
     Region          207..343
                     /region_name="DSP_MKP_classII"
                     /note="dual specificity phosphatase domain of class II
                     mitogen-activated protein kinase phosphatase; cd14566"
                     /db_xref="CDD:350414"
     CDS             1..381
                     /gene="Dusp6"
                     /gene_synonym="1300019I03Rik; MKP-3; MKP3; PYST1"
                     /coded_by="NM_026268.3:462..1607"
                     /db_xref="CCDS:CCDS24147.1"
                     /db_xref="GeneID:67603"
                     /db_xref="MGI:MGI:1914853"
ORIGIN      
        1 midtlrpvpf asemaicktv swlneqlelg nerlllmdcr pqelyesshi esainvaipg
       61 imlrrlqkgn lpvralftrc edrdrftrrc gtdtvvlyde nssdwnentg gesvlglllk
      121 klkdegcraf yleggfskfq aefalhcetn ldgscssssp plpvlglggl rissdsssdi
      181 esdldrdpns atdsdgspls nsqpsfpvei lpflylgcak dstnldvlee fgikyilnvt
      241 pnlpnlfena gefkykqipi sdhwsqnlsq ffpeaisfid eargkncgvl vhclagisrs
      301 vtvtvaylmq klnlsmnday divkmkksni spnfnfmgql ldfertlgls spcdnrvptp
      361 qlyfttpsnq nvyqvdslqs t
//
