LOCUS       NM_001085390            1815 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus dual specificity phosphatase 5 (Dusp5), mRNA.
ACCESSION   NM_001085390 XM_140740 XM_904896
VERSION     NM_001085390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Kidger,A.M., Saville,M.K., Rushworth,L.K., Davidson,J.,
            Stellzig,J., Ono,M., Kuebelsbeck,L.A., Janssen,K.P., Holzmann,B.,
            Morton,J.P., Sansom,O.J., Caunt,C.J. and Keyse,S.M.
  TITLE     Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic
            carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6
  JOURNAL   Oncogene 41 (20), 2811-2823 (2022)
   PUBMED   35418690
  REMARK    GeneRIF: Suppression of mutant Kirsten-RAS (KRAS(G12D))-driven
            pancreatic carcinogenesis by dual-specificity MAP kinase
            phosphatases 5 and 6.
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Liu,X., Liu,X., Du,Y., Hu,M., Tian,Y., Li,Z., Lv,L., Zhang,X.,
            Liu,Y., Zhou,Y. and Zhang,P.
  TITLE     DUSP5 promotes osteogenic differentiation through SCP1/2-dependent
            phosphorylation of SMAD1
  JOURNAL   Stem Cells 39 (10), 1395-1409 (2021)
   PUBMED   34169608
  REMARK    GeneRIF: DUSP5 promotes osteogenic differentiation through
            SCP1/2-dependent phosphorylation of SMAD1.
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Ferguson,B.S., Wennersten,S.A., Demos-Davies,K.M., Rubino,M.,
            Robinson,E.L., Cavasin,M.A., Stratton,M.S., Kidger,A.M., Hu,T.,
            Keyse,S.M., McKnight,R.A., Lane,R.H., Nozik,E.S.,
            Weiser-Evans,M.C.M. and McKinsey,T.A.
  TITLE     DUSP5-mediated inhibition of smooth muscle cell proliferation
            suppresses pulmonary hypertension and right ventricular hypertrophy
  JOURNAL   Am J Physiol Heart Circ Physiol 321 (2), H382-H389 (2021)
   PUBMED   34142888
  REMARK    GeneRIF: DUSP5-mediated inhibition of smooth muscle cell
            proliferation suppresses pulmonary hypertension and right
            ventricular hypertrophy.
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Bogush,N., Tan,L., Naib,H., Faizullabhoy,E., Calvert,J.W.,
            Iismaa,S.E., Gupta,A., Ramchandran,R., Martin,D.I.K., Graham,R.M.,
            Husain,A. and Naqvi,N.
  TITLE     DUSP5 expression in left ventricular cardiomyocytes of young hearts
            regulates thyroid hormone (T3)-induced proliferative ERK1/2
            signaling
  JOURNAL   Sci Rep 10 (1), 21918 (2020)
   PUBMED   33318551
  REMARK    GeneRIF: DUSP5 expression in left ventricular cardiomyocytes of
            young hearts regulates thyroid hormone (T3)-induced proliferative
            ERK1/2 signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Grasset,M.F., Gobert-Gosse,S., Mouchiroud,G. and Bourette,R.P.
  TITLE     Macrophage differentiation of myeloid progenitor cells in response
            to M-CSF is regulated by the dual-specificity phosphatase DUSP5
  JOURNAL   J Leukoc Biol 87 (1), 127-135 (2010)
   PUBMED   19801501
  REMARK    GeneRIF: After SSH between cDNA libraries from FD-Fms cells
            stimulated by M-CSF in the presence or the absence of U0126, we
            isolated DUSP5. DUSP5 expression is induced by M-CSF in various
            myeloid cells & acts as a specific negative-feedback regulator of
            ERK1/2.
REFERENCE   7  (bases 1 to 1815)
  AUTHORS   Kovanen,P.E., Bernard,J., Al-Shami,A., Liu,C.,
            Bollenbacher-Reilley,J., Young,L., Pise-Masison,C., Spolski,R. and
            Leonard,W.J.
  TITLE     T-cell development and function are modulated by dual specificity
            phosphatase DUSP5
  JOURNAL   J Biol Chem 283 (25), 17362-17369 (2008)
   PUBMED   18430737
  REMARK    GeneRIF: proper regulation of DUSP5 activity is critical for normal
            immune system development, IL-2 actions, and tolerance
REFERENCE   8  (bases 1 to 1815)
  AUTHORS   Breitwieser,W., Lyons,S., Flenniken,A.M., Ashton,G., Bruder,G.,
            Willington,M., Lacaud,G., Kouskoff,V. and Jones,N.
  TITLE     Feedback regulation of p38 activity via ATF2 is essential for
            survival of embryonic liver cells
  JOURNAL   Genes Dev 21 (16), 2069-2082 (2007)
   PUBMED   17699753
REFERENCE   9  (bases 1 to 1815)
  AUTHORS   Clee,S.M., Yandell,B.S., Schueler,K.M., Rabaglia,M.E.,
            Richards,O.C., Raines,S.M., Kabara,E.A., Klass,D.M., Mui,E.T.,
            Stapleton,D.S., Gray-Keller,M.P., Young,M.B., Stoehr,J.P., Lan,H.,
            Boronenkov,I., Raess,P.W., Flowers,M.T. and Attie,A.D.
  TITLE     Positional cloning of Sorcs1, a type 2 diabetes quantitative trait
            locus
  JOURNAL   Nat Genet 38 (6), 688-693 (2006)
   PUBMED   16682971
REFERENCE   10 (bases 1 to 1815)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137853.21.
            
            On Feb 8, 2019 this sequence version replaced NM_001085390.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.16145.1,
                                           SRR7345562.730958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               AC137853.21        9860-10411
            553-701             AC137853.21        14541-14689
            702-921             AC137853.21        18172-18391
            922-1815            AC137853.21        21631-22524
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 47.98 cM"
     gene            1..1815
                     /gene="Dusp5"
                     /gene_synonym="Gm337"
                     /note="dual specificity phosphatase 5"
                     /db_xref="GeneID:240672"
                     /db_xref="MGI:MGI:2685183"
     exon            1..552
                     /gene="Dusp5"
                     /gene_synonym="Gm337"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1328
                     /gene="Dusp5"
                     /gene_synonym="Gm337"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 5"
                     /protein_id="NP_001078859.1"
                     /db_xref="CCDS:CCDS38024.1"
                     /db_xref="GeneID:240672"
                     /db_xref="MGI:MGI:2685183"
                     /translation="MKVTSLDGRQLRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLN
                     VNLNSVVLRRARGGAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREE
                     SAARVVLTSLLACLPAGPRVYFLKGGYETFYSQYPECCVDVKPTSQEKIEGERSLLSQ
                     CGKPVLSVAYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEA
                     CTTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGGKVLVHCEAGVSRSPTICMA
                     YLMKTKQFRLKEAFDYVKQRRSVVSPNFGFMGQLLQYESEILPSTPTLQPPSCQGEAA
                     SSTFIGHLQTLSPDMQGTYCTFRTSVLAPVPTHSTVPELHRSPVATATSC"
     exon            553..701
                     /gene="Dusp5"
                     /gene_synonym="Gm337"
                     /inference="alignment:Splign:2.1.0"
     exon            702..921
                     /gene="Dusp5"
                     /gene_synonym="Gm337"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1815
                     /gene="Dusp5"
                     /gene_synonym="Gm337"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp5"
                     /gene_synonym="Gm337"
                     /note="hexamer: AATAAA"
     polyA_site      1678
                     /gene="Dusp5"
                     /gene_synonym="Gm337"
                     /note="major polyA site"
ORIGIN      
        1 agctttctgg ggcagcgagc ggcggggccg ggagcccagc gagcggggcg tggagagcgt
       61 cgcgcggccc ctcgcgccgg gctccgtttg caggccacag cccccgcgag gtggcccgcc
      121 cgtcctctgg cagctgtggg gcgcgcagcg tcgggccgct gggtggcagc ggcatgaagg
      181 tcacgtcgct cgacgggcgc cagctgcgca agatgctccg caaggaggcg gaggcgcgct
      241 gcgtggtgct cgactgccgg ccctacctgg ccttcgccgc gtcgagcgtg cgcggctcgc
      301 tcaacgtcaa cctcaactcg gtggtgctgc ggcgggcccg gggcggcgcg gtgtcggcgc
      361 gctacgtgct gcccgacgag gcggcccgcg ctcggctgct gcaggagggc ggcggcggtg
      421 tggcggcggt ggtcgtgctg gaccagggta gccgccactg gcagaagctg cgggaggaga
      481 gcgccgcgcg cgtcgtgctc acctcgctgc tggcctgcct gcccgccggc ccgcgggtct
      541 acttccttaa aggggggtat gagaccttct actcacagta tcctgagtgc tgtgtggatg
      601 tgaagcccac ctcacaagag aagatcgaag gcgagagaag cctcctcagc cagtgtggaa
      661 agcccgttct cagcgtcgcc tacagaccag cctatgacca gggtggcccg gttgaaatcc
      721 ttcccttcct ctaccttgga agtgcctacc acgcatccaa gtgcgagttc ctcgccaacc
      781 tgcacatcac agccctgctg aatgtttccc gccggacctc cgaggcctgc accacccacc
      841 tacactacaa gtggatcccc gtggaggaca gccacactgc tgacattagc tcccactttc
      901 aagaagcaat agattttatt gactgtgtca gggaagaagg aggcaaggtc ctggtccact
      961 gcgaagctgg ggtttcccgg tcgcccacca tctgcatggc ttacctcatg aagaccaagc
     1021 agttccggct gaaggaggcc ttcgattacg tcaagcagag gaggagcgtg gtctctccca
     1081 actttggctt catgggacag ctccttcagt atgaatctga gatcctgccc tccacaccca
     1141 ccctccagcc gccctcctgc caaggggagg cagccagctc cacgtttata ggccatttac
     1201 agacactgag ccctgatatg cagggcacct actgcacatt ccgtacctca gtgctggcac
     1261 cggtgcccac ccactccaca gtcccagagc tccacaggag ccccgtggcc acagccacat
     1321 cctgctgaga ccgtggtcgg tggctaccag cgagtcccca agagcaactg tgatttttgt
     1381 tttgttttgt tttgttttaa aacttgtgga catttcatac ccatgcaata ctgaagactg
     1441 ctgcccgctg ccccagtgag atgctgagtg gtcagcaagg cttgcagatg cacttcagac
     1501 catccccaag gatgggctct cgggactgta tggaaggcca agccatgccc caagcacagt
     1561 acgtgctgac tgctgtactt ccggaacccc tgcccactca ggaccaccta gtccttgcac
     1621 ctcaaaagtt cgccttttca tttcaagcat aaggcaataa ataaatcctt gcagcaaagt
     1681 gagagcgagc ttcgctggac caggacggga gaagccaatt cacctaggag gaagcacaat
     1741 tttcactgtt tttttgaact tcggtaaacc ttgtctgtct ctgtcgcttc agggaagaga
     1801 actggtcacc gccca
//
