LOCUS       NM_176933               4801 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus dual specificity phosphatase 4 (Dusp4), transcript
            variant 1, mRNA.
ACCESSION   NM_176933
VERSION     NM_176933.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4801)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   2  (bases 1 to 4801)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4801)
  AUTHORS   Jiao,H., James,S.J., Png,C.W., Cui,C., Li,H., Li,L., Chia,W.N.,
            Min,N., Li,W., Claser,C., Renia,L., Wang,H., Chen,M.I., Chu,J.J.H.,
            Tan,K.S.W., Deng,Y. and Zhang,Y.
  TITLE     DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response
  JOURNAL   Cell Death Differ 31 (3), 280-291 (2024)
   PUBMED   38383887
  REMARK    GeneRIF: DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN
            response.
REFERENCE   4  (bases 1 to 4801)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4801)
  AUTHORS   Wang,E., Pan,A.L., Bagchi,P., Rangaraju,S., Seyfried,N.T.,
            Ehrlich,M.E., Salton,S.R. and Zhang,B.
  TITLE     Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in
            Alzheimer's Disease
  JOURNAL   Biomolecules 14 (1), 66 (2024)
   PUBMED   38254666
  REMARK    GeneRIF: Proteomic Signaling of Dual-Specificity Phosphatase 4
            (DUSP4) in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4801)
  AUTHORS   Aulehla,A., Wiegraebe,W., Baubet,V., Wahl,M.B., Deng,C., Taketo,M.,
            Lewandoski,M. and Pourquie,O.
  TITLE     A beta-catenin gradient links the clock and wavefront systems in
            mouse embryo segmentation
  JOURNAL   Nat Cell Biol 10 (2), 186-193 (2008)
   PUBMED   18157121
REFERENCE   7  (bases 1 to 4801)
  AUTHORS   Breitwieser,W., Lyons,S., Flenniken,A.M., Ashton,G., Bruder,G.,
            Willington,M., Lacaud,G., Kouskoff,V. and Jones,N.
  TITLE     Feedback regulation of p38 activity via ATF2 is essential for
            survival of embryonic liver cells
  JOURNAL   Genes Dev 21 (16), 2069-2082 (2007)
   PUBMED   17699753
REFERENCE   8  (bases 1 to 4801)
  AUTHORS   Niwa,Y., Masamizu,Y., Liu,T., Nakayama,R., Deng,C.X. and
            Kageyama,R.
  TITLE     The initiation and propagation of Hes7 oscillation are
            cooperatively regulated by Fgf and notch signaling in the somite
            segmentation clock
  JOURNAL   Dev Cell 13 (2), 298-304 (2007)
   PUBMED   17681139
REFERENCE   9  (bases 1 to 4801)
  AUTHORS   Wang,J., Shen,W.H., Jin,Y.J., Brandt-Rauf,P.W. and Yin,Y.
  TITLE     A molecular link between E2F-1 and the MAPK cascade
  JOURNAL   J Biol Chem 282 (25), 18521-18531 (2007)
   PUBMED   17452331
  REMARK    GeneRIF: E2F-1 is a transcriptional activator of MKP-2 and MKP-2 is
            an essential cell death mediator in the E2F-1 pathway
REFERENCE   10 (bases 1 to 4801)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122458.3.
            
            On Aug 29, 2022 this sequence version replaced NM_176933.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.5281494.1, AK165991.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-880               AC122458.3         79664-80543
            881-1026            AC122458.3         88817-88962
            1027-1246           AC122458.3         89494-89713
            1247-4801           AC122458.3         90768-94322
FEATURES             Location/Qualifiers
     source          1..4801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 21.16 cM"
     gene            1..4801
                     /gene="Dusp4"
                     /gene_synonym="2700078F24Rik; E130306H24Rik; MKP2"
                     /note="dual specificity phosphatase 4"
                     /db_xref="GeneID:319520"
                     /db_xref="MGI:MGI:2442191"
     exon            1..880
                     /gene="Dusp4"
                     /gene_synonym="2700078F24Rik; E130306H24Rik; MKP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..1632
                     /gene="Dusp4"
                     /gene_synonym="2700078F24Rik; E130306H24Rik; MKP2"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity protein phosphatase 4"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 4 isoform
                     1"
                     /protein_id="NP_795907.1"
                     /db_xref="CCDS:CCDS22241.1"
                     /db_xref="GeneID:319520"
                     /db_xref="MGI:MGI:2442191"
                     /translation="MVTMEELREMDCSVLKRLMNRDENGGGGSAGGNGSGSHGALGLL
                     SGGKCLLLDCRPFLAHSAGYIRGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLR
                     SGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPE
                     FCSKTKALAAIPPPVPPSTNESLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARR
                     DMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDC
                     RGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQF
                     ESQVLTTSCAAEAASPSGPLRERGKATPTPTSQFVFSFPVSVGVHAAPSNLPYLHSPI
                     TTSPSC"
     exon            881..1026
                     /gene="Dusp4"
                     /gene_synonym="2700078F24Rik; E130306H24Rik; MKP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1246
                     /gene="Dusp4"
                     /gene_synonym="2700078F24Rik; E130306H24Rik; MKP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..4801
                     /gene="Dusp4"
                     /gene_synonym="2700078F24Rik; E130306H24Rik; MKP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4782..4787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp4"
                     /gene_synonym="2700078F24Rik; E130306H24Rik; MKP2"
                     /note="hexamer: AATAAA"
     polyA_site      4801
                     /gene="Dusp4"
                     /gene_synonym="2700078F24Rik; E130306H24Rik; MKP2"
                     /note="major polyA site"
ORIGIN      
        1 ggcgagcatt aataaatctc taagccagag gaggaaactc tggctggggc agtgcgtgca
       61 gctccggcgg tgcagcggtg ggggaaacgg cggagcccac ggcagaagca gccctagcta
      121 gcaaaacaca ccagaggcga caaaccgaga ggagccctct ctcgtaaaca cactcccctg
      181 ctcgatcgct tgccccgggt gccgcgcgcc cgccagcttt ggcgccagag aaggctggga
      241 ctgctatgta acgttgaggc tgcgggaggt ggaagcaggg gtgttagagg gagaagagcc
      301 tggggccaag tttgcgggtc acttctgcag gcgccctctt agccctcgcc tggttccttc
      361 ttgttagcct agctggctcc ggtgcccttg gccttctcca gctagctccc cagcttactg
      421 cgttttgccg gcgacatggt gacgatggag gaactgcggg agatggactg cagcgtgctc
      481 aaaaggctga tgaaccggga tgagaacggc ggcggcggca gcgcgggcgg caacggcagc
      541 ggcagccacg gcgccttggg gctgctgagc ggcggcaagt gcctgctgct ggactgcagg
      601 ccgtttctgg ctcacagcgc gggctacatc cgaggctcgg tgaacgtgcg ctgcaatacc
      661 atcgtgcggc ggagggccaa gggctccgtg agcctggagc agatcctgcc cgccgaggaa
      721 gaggtgcgtg cccgcctgcg ctctggcctc tactcggctg tcatcgtcta cgacgagcgc
      781 agcccgcgcg ccgagagtct ccgggaggac agcacggtgt cgctggtcgt gcaggcgttg
      841 cgccggaacg cggagcgcac ggacatctgc ctgcttaaag gtggctatga gaggttttct
      901 tctgaatacc cagaattctg ctctaaaacc aaggccctgg ccgccatccc accccctgta
      961 cctcccagca ccaatgagtc cttggacctg ggctgcagct cctgtggaac cccgctgcac
     1021 gaccaggggg gccccgtgga aatcctccct ttcctctacc tcggcagtgc ctaccatgct
     1081 gcccgcaggg acatgttgga tgccctgggg atcacggccc tcctgaatgt ctcttcagac
     1141 tgtcccaatc actttgaggg tcattaccag tacaagtgca tccccgtcga agacaaccac
     1201 aaggccgaca tcagctcctg gttcatggaa gccatcgagt acatcgacgc agtaaaggac
     1261 tgtcgagggc gagtgctggt tcactgccag gccggcatct cccgatcagc caccatctgc
     1321 ctggcctacc tgatgatgaa gaagcgggtg aggctggagg aggcttttga gttcgtcaag
     1381 cagcgccgaa gcatcatctc gcccaacttc agcttcatgg gccagttgct gcagtttgag
     1441 tctcaggtgc tcaccacgtc ctgcgccgcc gaggctgcca gcccttctgg gccccttcgg
     1501 gagaggggaa aggccacccc gacccccacc tcgcagttcg tcttcagctt ccctgtgtct
     1561 gtgggcgtgc acgcggcccc cagtaacctg ccgtacctgc acagccccat caccacctcc
     1621 cccagctgtt aggactcgtc tctggacccc aaatccagag tcggccccca gccagttgcc
     1681 agccacctgt gaacagcaaa tagggactga ccagtggggg atcaggtgac caggctccgt
     1741 ctccatttct ccttggccaa ccacagggcc agctaggatg gcaataacga ctttgaatac
     1801 acattaaaaa caaacacaac taaacactct aacataagca ataacggcgg tttccgctgc
     1861 cagagaagac ttggtttctg tgtcagtttt tactttgcag gtagaaattt acctcattat
     1921 tattattatt aaaaaagcaa tcaagcttga aagttatgaa accccacaga tcctggcaaa
     1981 tgtgcgcaac caatttttat tgagtggaga gggaaaggaa agaggagaaa aaatgagttt
     2041 gccaggaaag tgcctggttc tgtgtgtgtc tgttctcctg ttgttgaact cacaggaatt
     2101 ttgttctaga tccttctagg ccacagtatt atacttagtc gtcaactgga taatcactta
     2161 ctgtttaatg catattgaga acctcagcat gtgtgtgcag gagtctagtg actctgggag
     2221 atatttctgt tgaggtcaca cagtcgagca gagaaacaca caggtgtgtg agcagtgaga
     2281 ggagcgtcgg gtaggtggtc accatggtta ccatcagacg cagggtgaca tgcaaggaaa
     2341 aaggtttatg gttggtcact tttgcagctg gcccctgggc ccactgaccc agccacgtga
     2401 gatttttctc tccagcggtc tgtttggctg gggatagagt ggtttcttcc cacttggcct
     2461 aggatctggc tattggtctg tggtaaacgc catctttacc aaggtgctcc tggaaaactg
     2521 ggtgccgttc agattttcct gccgtgaatc atttggtaag gccagatcag aaccagatca
     2581 ctgaagatga actaaaaatg aatctccctc tcgcggatac attgggtgtt tcagatttag
     2641 cagtttactt gaagtataca taccaagaaa ttcttgttac aaaatctggt gaatactctg
     2701 aaacgccctc cctcttttga ataaaaagat acgcatatgc ctgacttggg cctcctaaaa
     2761 gtctggaaag gtgagagaaa agagggtgtg gggccggatg ccagctcctg ttttactgat
     2821 atagggtgac ttaggagcca tgctgggttc caactgggcc aacaccattt taaaggagcc
     2881 tttccaagtg gaggaatggc tttggaggaa taagtgtgtt ttctaggggg aatgtgaggg
     2941 gtaggggagg gaacctgttt tatctgtagt attgggggac aagttttgtg atggtgtgtc
     3001 agattagagg tcactgcaga cttggcagaa attagcatgg tccccgtgcc ctcctccccc
     3061 acaccttgag cagacatgta accaagcctc catgtcacgt ggtgacatcc agaaccccca
     3121 gacaagcctg ggttcatggc ttttccttcc atgaaatgtg aacctgtgtt ggtagaactt
     3181 ggattgagtg gcctgtgcca aattctgcct ttaggtgaga agtgaggggt gccctgctcg
     3241 cttcccctac tgtccgaagg cttggctgaa ggcatagcgg gtccgagctt ccccgatggc
     3301 ggactgcctt tgcttagttg gatggtccca tatttttacc cccactgcct tcctggcagc
     3361 tgtttcatgt ttggtgaaga attagattaa atgagctctg tagctagtcg agtcctgggc
     3421 tctgagaatg ttgagggcat ctggagagca gatagcttgt agactacatt cactttctag
     3481 atgagtgttt gccaaatgtg tcctagttcc cagactggat cccaacgaca caggcattgg
     3541 gagctccaaa tgtccctccc ctgcttccta attcaaacct cctatgacag tgtcaagggg
     3601 ctatttataa agtcattttc tttgtacttg ataacagcat gagatccaaa acgcttagaa
     3661 agtaggacat tggtttgatt ggaaaaaaag gggggggggc ggggggtaca ccttaaagct
     3721 ctccagaagt ttctgcaata gcgttagttg aagatcctgc cattcctcat ggttagttag
     3781 tttcaaaaga cagtatccca tccgtgagct gatttctggt gatgggaagt tttggaatgt
     3841 cagaaggctg ttgagtatct gcccgagagt gagggacact cagttctccc tggggatctt
     3901 ggctccatca tccatatagt gtttgtgaga ctgagggctg aagcacaggc gagcaggtag
     3961 ctagcagcag ctctccgctc cattcgcccc tgagaccttg tgccctggtt cttggcttct
     4021 gggaaagcca tgggaaggga ttaaaagtcc ttgggaagat ttgatagtta ctcccaaggg
     4081 gaaggggact gggcaatggc caagaaagcc tgtggcaata ataacaatag ttcatatggg
     4141 ttcatcctat cacctaaggt agcctttaat ctcctcatag ctaggtgacc cttgaccaaa
     4201 taaaccagga cttgtgtggg taggacctgg atgccaatat gttacagtgt tcctatgggc
     4261 tgtcactggt acggccaagt cctggagatg ccattgcgtc actatggtga aaggcgggtc
     4321 ttcttagcac acagctagct tgtgacacag acgtttccag tagggctttg taatggtgtc
     4381 agtgtggtct tgctctccac aagccagctg agggatgagg tggtttctgt gaggcctctg
     4441 agaaccagtt ttgtggagca ttgtgagtga gctcaatata gtgtctgggt gttgatgtta
     4501 tttccttaaa ttttgtctgc aagaaagata gagaaagtat gtgtctgttt tgaagtcctc
     4561 cttctagtgc cccacccctt ccttagagtt cacaaatcat tcaagggact tcagtaagat
     4621 aacaatgcaa tacttgtaac ttgtgtaaat agccccatct ttctgagtgg tgtcatttct
     4681 acatttgata tgcttgtatt tctgtaggat gtacattttt tttagaagag tcaaccatgt
     4741 ctgtttttat ttattgcttg aaaaaagatc atttgaagaa aaataaatac attttcaacc
     4801 a
//
