LOCUS       NM_028207               4204 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus dual specificity phosphatase 3 (vaccinia virus
            phosphatase VH1-related) (Dusp3), mRNA.
ACCESSION   NM_028207 XR_106412 XR_106602
VERSION     NM_028207.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4204)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4204)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   3  (bases 1 to 4204)
  AUTHORS   Jiang,A., Zhao,C., Zhang,D. and Yu,K.
  TITLE     Dual Specificity Phosphatase 3 (DUSP3) Knockdown Alleviates Acute
            Myocardial Infarction Damage via Inhibiting Apoptosis and
            Inflammation
  JOURNAL   Curr Neurovasc Res 20 (1), 14-22 (2023)
   PUBMED   37272465
  REMARK    GeneRIF: Dual Specificity Phosphatase 3 (DUSP3) Knockdown
            Alleviates Acute Myocardial Infarction Damage via Inhibiting
            Apoptosis and Inflammation.
REFERENCE   4  (bases 1 to 4204)
  AUTHORS   Khbouz,B., Rowart,P., Poma,L., Dahlke,E., Bottner,M., Stokes,M.,
            Bolen,G., Rahmouni,S., Theilig,F. and Jouret,F.
  TITLE     The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3)
            attenuates kidney damage and inflammation following
            ischaemia/reperfusion injury in mouse
  JOURNAL   Acta Physiol (Oxf) 234 (2), e13735 (2022)
   PUBMED   34704357
  REMARK    GeneRIF: The genetic deletion of the Dual Specificity Phosphatase 3
            (DUSP3) attenuates kidney damage and inflammation following
            ischaemia/reperfusion injury in mouse.
REFERENCE   5  (bases 1 to 4204)
  AUTHORS   Celaya,A.M., Rodriguez-de la Rosa,L., Bermudez-Munoz,J.M.,
            Zubeldia,J.M., Roma-Mateo,C., Avendano,C., Pallardo,F.V. and
            Varela-Nieto,I.
  TITLE     IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear
            Inflammation and Increases Noise-Induced Hearing Loss
  JOURNAL   Cells 10 (7), 1686 (2021)
   PUBMED   34359856
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4204)
  AUTHORS   Quiel,A., Jurgen,B., Greinacher,A., Lassen,S., Worl,R., Witt,S. and
            Schweder,T.
  TITLE     Sensitive detection of idiotypic platelet-reactive alloantibodies
            by an electrical protein chip
  JOURNAL   Biosens Bioelectron 36 (1), 207-211 (2012)
   PUBMED   22572157
REFERENCE   7  (bases 1 to 4204)
  AUTHORS   Wentworth,C.C., Alam,A., Jones,R.M., Nusrat,A. and Neish,A.S.
  TITLE     Enteric commensal bacteria induce extracellular signal-regulated
            kinase pathway signaling via formyl peptide receptor-dependent
            redox modulation of dual specific phosphatase 3
  JOURNAL   J Biol Chem 286 (44), 38448-38455 (2011)
   PUBMED   21921027
  REMARK    GeneRIF: Enteric commensal bacteria induce extracellular
            signal-regulated kinase pathway signaling via formyl peptide
            receptor-dependent redox modulation of dual specific phosphatase 3
REFERENCE   8  (bases 1 to 4204)
  AUTHORS   Kang,T.H. and Kim,K.T.
  TITLE     VRK3-mediated inactivation of ERK signaling in adult and embryonic
            rodent tissues
  JOURNAL   Biochim Biophys Acta 1783 (1), 49-58 (2008)
   PUBMED   18035061
REFERENCE   9  (bases 1 to 4204)
  AUTHORS   Roma-Mateo,C., Rios,P., Tabernero,L., Attwood,T.K. and Pulido,R.
  TITLE     A novel phosphatase family, structurally related to
            dual-specificity phosphatases, that displays unique amino acid
            sequence and substrate specificity
  JOURNAL   J Mol Biol 374 (4), 899-909 (2007)
   PUBMED   17976645
REFERENCE   10 (bases 1 to 4204)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591145.25 and AK008734.1.
            
            On or before Dec 17, 2010 this sequence version replaced
            XR_106602.1, XR_106412.1, NM_028207.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170772.1, ERR3363658.983971.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL591145.25        31267-31287         c
            22-1188             AK008734.1         3-1169
            1189-4204           AL591145.25        17639-20654         c
FEATURES             Location/Qualifiers
     source          1..4204
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..4204
                     /gene="Dusp3"
                     /gene_synonym="2210015O03Rik; 5031436O03Rik; T-DSP11; VHR"
                     /note="dual specificity phosphatase 3 (vaccinia virus
                     phosphatase VH1-related)"
                     /db_xref="GeneID:72349"
                     /db_xref="MGI:MGI:1919599"
     exon            1..180
                     /gene="Dusp3"
                     /gene_synonym="2210015O03Rik; 5031436O03Rik; T-DSP11; VHR"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..613
                     /gene="Dusp3"
                     /gene_synonym="2210015O03Rik; 5031436O03Rik; T-DSP11; VHR"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="vaccinia H1-related phosphatase"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 3"
                     /protein_id="NP_082483.1"
                     /db_xref="CCDS:CCDS25482.1"
                     /db_xref="GeneID:72349"
                     /db_xref="MGI:MGI:1919599"
                     /translation="MSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASV
                     AQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYF
                     ERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREI
                     GPNDGFLAQLCQLNDRLAKEGKVKL"
     exon            181..407
                     /gene="Dusp3"
                     /gene_synonym="2210015O03Rik; 5031436O03Rik; T-DSP11; VHR"
                     /inference="alignment:Splign:2.1.0"
     exon            408..4204
                     /gene="Dusp3"
                     /gene_synonym="2210015O03Rik; 5031436O03Rik; T-DSP11; VHR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1880
                     /gene="Dusp3"
                     /gene_synonym="2210015O03Rik; 5031436O03Rik; T-DSP11; VHR"
                     /note="major polyA site"
     regulatory      4183..4188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp3"
                     /gene_synonym="2210015O03Rik; 5031436O03Rik; T-DSP11; VHR"
                     /note="hexamer: AATAAA"
     polyA_site      4204
                     /gene="Dusp3"
                     /gene_synonym="2210015O03Rik; 5031436O03Rik; T-DSP11; VHR"
                     /note="major polyA site"
ORIGIN      
        1 ccggcttctc cccctcgttc gctcctgccc tggcgtgcag cgccccgccg ccgccatgtc
       61 cagctcgttc gaactctcgg tgcaagatct caacgacctg ctctcggatg gcagcggctg
      121 ctacagcctg ccgagccagc cctgcaacga ggtcgtcccg agggtctacg tgggcaacgc
      181 gtctgtggct caggacatca cccagctgca gaaactgggc atcacccacg tcctgaatgc
      241 tgccgagggc aggtccttca tgcacgtcaa caccagtgct agcttctacg aggattctgg
      301 catcacctac ttgggcatca aggccaatga tacgcaggag ttcaacctca gtgcttactt
      361 tgaaagggcc acagatttca ttgaccaggc gctggcccat aaaaatggcc gggtgcttgt
      421 ccattgccgc gagggctaca gccgctcccc aacgctagtt atcgcctacc tcatgatgcg
      481 gcagaagatg gacgtcaagt ctgctctgag tactgtgagg cagaatcgtg agatcggccc
      541 caacgatggc ttcctggccc aactctgcca gctcaatgac agactagcca aggagggcaa
      601 ggtgaaactc tagggtgccc acagcctctt ttgcagaggt ctgactggga gggccctggc
      661 agccatgttt aggaaacaca gtatacccac tccctgcacc accagacacg tgcccacatc
      721 tgtcccactc tggtcctcgg gggccactcc acccttaggg agcacatgaa gaagctccct
      781 aagaagttct gctccttagc catcctttcc tgtaatttat gtctctccct gaggtgaggt
      841 tcaggtttat gtccctgtct gtggcataga tacatctcag tgacccaggg tgggagggct
      901 atcagggtgc atggcccggg acacgggcac tcttcatgac ccctccccca cctgggttct
      961 tcctgtgtgg tccagaacca cgagcctggt aaaggaacta tgcaaacaca ggccctgacc
     1021 tccccatgtc tgttcctggt cctcacagcc cgacacgccc tgctgaggca gacgaatgac
     1081 attaagttct gaagcagagt ggagatagat tagtgactag atttccaaaa agaaggaaaa
     1141 aaaaggctgc attttaaaat tatttcctta gaattaaaga tactacatag gggcccttgg
     1201 gtaagcaaat ccatttttcc cagaggctat cttgattctt tggaatgttt aaagtgtgcc
     1261 ttgccagaga gcttacgatc tatatctgct gcttcagagc cttccctgag gatggctctg
     1321 ttcctttgct tgttagaaga gcgatgcctt gggcagggtt tccccctttt cagaatacag
     1381 ggtgtaaagt ccagcctatt acaaacaaac aaacaaacaa acaaacaaag gacctccatt
     1441 tggagaattg caaggatttt atcctgaatt atagtgttgg tgagttcaag tcatcacgcc
     1501 aagtgcttgc catcctggtt gctattctaa gaataattag gaggaggaac ctagccaatt
     1561 gcagctcatg tccgtgggtg tgtgcacggg tgcatatgtt ggaaggggtg cctgtcccct
     1621 tggggacaga aggaaaatga aaggcccctc tgctcaccct ggccatttac gggaggctct
     1681 gctggttcca cggtgtctgt gcaggatcct gaaactgact cgctggacag aaacgagact
     1741 tggcggcacc atgagaatgg agagagagag agcaaagaaa gaaacagcct ttaaaagaac
     1801 tttctaaggg tggtttttga acctcgctgg accttgtatg tgtgcacatt tgccagagat
     1861 tgaacataat cctcttggga cttcacgttc tcattatttg tatgtctccg gggtcacgca
     1921 gagccgtcag ccaccacccc agcacccggc acataggcgt ctcataaaag cccattttat
     1981 gagaaccaga gctgtttgag taccccgtgt atagagagag ttgttgtcgt ggggcacccg
     2041 gatcccagca gcctggttgc ctgcctgtag gatgtcttac aggagtttgc agagaaacct
     2101 tccttggagg gaaagaaata tcagggattt ttgttgaata tttcaaattc agctttaagt
     2161 gtaagactca gcagtgttca tggttaaggt aaggaacatg ccttttccag agctgctgca
     2221 agaggcagga gaagcagacc tgtcttagga tgtcactccc agggtaaaga cctctgatca
     2281 cagcaggagc agagctgtgc agcctggatg gtcattgtcc cctattctgt gtgaccacag
     2341 caaccctggt cacatagggc tggtcatcct tttttttttt tttttttttt ttttttggcc
     2401 cagaatgaag tgaccatagc caagttgtgt acctcagtct ttagtttcca agcggctctc
     2461 ttgctcaata caatgtgcat ttcaaaataa cactgtagag ttgacagaac tggttcatgt
     2521 gttatgagag aggaaaagag aggaaagaac aaaacaaaac aaaacaccac aaaccaaaaa
     2581 catctgggct agccaggcat gattgcaatg tctacaggcc cagttcatga gaggcagaga
     2641 caggaagacc gccgaaaggt caaggatagc atggtctacg tatcgagact ccagccaggg
     2701 ctacggtccc aagatcctag gttttggatt ttgggctttg gtttttgaga cagggtttct
     2761 ctgtgtagcc ctggctgtcc tggaactcgc tctgtagacc aggctggcct caaacttaga
     2821 gatctgcctg actctgcctt tgagggctgg gacgaatgcc accactgccc aactaagatt
     2881 ccattaaaaa aaaaaaaagt tcaagataat taagagttgc cagctcgtta aagctaagta
     2941 gaagcagtct caggcctgct gcttgaggct gttcttggct tggacctgaa atctgccccc
     3001 aacagtgtcc aagtgcacat gactttgagc catctccaga gaaggaagtg aaaattgtgg
     3061 ctccccagtc gattgggaca cagtctctct ttgtctaggt aacacatggt gacacatagc
     3121 attgaactct ccactctgag ggtgggtttc cctccccctg cctcttctgg gttggtcacc
     3181 ccataggaca gccacaggac agtcactagc acctactgga aacctctttg tgggaacatg
     3241 aagaaagagc ctttgggaga ttcctggctt tccattaggg ctgaaagtac aacggttctt
     3301 ggttggcttt gcctcgtgtt tataaaacta gctactattc ttcaggtaaa ataccgatgt
     3361 tgtggaaaag ccaaccccgt ggctgcccgt gagtaggggg tggggttggg aatcctggat
     3421 agtgttctat ccatggaaag tggtggaata ggaattaagg gtgttccccc cccccccaac
     3481 ctcttcctca gacccagcca ctttctatga cttataaaca tccaggtaaa aattacaaac
     3541 ataaaaatgg tttctcttct caatcttcta aagtctgcct gccttttcca ggggtaggtc
     3601 tgtttctttg ctgttctatt gtcttgagag cacagactaa cacttaccaa atgagggaac
     3661 tcttggccca tactaaggct cttctgggct ccagcactct taagttattt taagaattct
     3721 cacttggcct ttagcacacc cgccaccccc aagtgggtgt ggataatgcc atggccagca
     3781 gggggcactg ttgaggcggg tgcctttcca ccttaagttg cttatagtat ttaagatgct
     3841 aaatgtttta atcaagagaa gcactgatct tataatacga ggataagaga ttttctcaca
     3901 ggaaattgtc tttttcataa ttcttttaca ggctttgtcc tgatcgtagc atagagagaa
     3961 tagctggata tttaacttgt attccatttt cctctgccag cgttaggtta actccgtaaa
     4021 aagtgattca gtggaccgaa gaggctcaga gggcagggga tggtggggtg aggcagagca
     4081 ctgtcacctg ccaggcatgg gaggtcctgc catccgggag gaaaaggaaa gtttagcctc
     4141 tagtctacca ccagtgttaa cgcactctaa agttgtaacc aaaataaatg tcttacatta
     4201 caaa
//
