LOCUS       NM_025869               1888 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus dual specificity phosphatase 26 (Dusp26), transcript
            variant 1, mRNA.
ACCESSION   NM_025869
VERSION     NM_025869.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1888)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1888)
  AUTHORS   Eroglu,B., Jin,X., Deane,S., Ozturk,B., Ross,O.A., Moskophidis,D.
            and Mivechi,N.F.
  TITLE     Dusp26 phosphatase regulates mitochondrial respiration and
            oxidative stress and protects neuronal cell death
  JOURNAL   Cell Mol Life Sci 79 (4), 198 (2022)
   PUBMED   35313355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1888)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   4  (bases 1 to 1888)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1888)
  AUTHORS   Gomez-Banoy,N., Guseh,J.S., Li,G., Rubio-Navarro,A., Chen,T.,
            Poirier,B., Putzel,G., Rosselot,C., Pabon,M.A., Camporez,J.P.,
            Bhambhani,V., Hwang,S.J., Yao,C., Perry,R.J., Mukherjee,S.,
            Larson,M.G., Levy,D., Dow,L.E., Shulman,G.I., Dephoure,N.,
            Garcia-Ocana,A., Hao,M., Spiegelman,B.M., Ho,J.E. and Lo,J.C.
  TITLE     Adipsin preserves beta cells in diabetic mice and associates with
            protection from type 2 diabetes in humans
  JOURNAL   Nat Med 25 (11), 1739-1747 (2019)
   PUBMED   31700183
  REMARK    GeneRIF: these data suggest that adipsin/C3a and DUSP26-directed
            therapies may represent a novel approach to achieve beta cell
            health to treat and prevent type 2 diabetes.
REFERENCE   6  (bases 1 to 1888)
  AUTHORS   Ye,P., Liu,J., Xu,W., Liu,D., Ding,X., Le,S., Zhang,H., Chen,S.,
            Chen,M. and Xia,J.
  TITLE     Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty
            Liver Disease in Mice Through Transforming Growth Factor
            Beta-Activated Kinase 1 Suppression
  JOURNAL   Hepatology 69 (5), 1946-1964 (2019)
   PUBMED   30582764
  REMARK    GeneRIF: expression decreased in the liver tissue of mice with
            hepatic steatosis and genetically obese mice
REFERENCE   7  (bases 1 to 1888)
  AUTHORS   Shi,Y., Ma,I.T., Patel,R.H., Shang,X., Chen,Z., Zhao,Y., Cheng,J.,
            Fan,Y., Rojas,Y., Barbieri,E., Chen,Z., Yu,Y., Jin,J., Kim,E.S.,
            Shohet,J.M., Vasudevan,S.A. and Yang,J.
  TITLE     NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in
            p53-mediated apoptosis
  JOURNAL   Cell Death Dis 6 (8), e1841 (2015)
   PUBMED   26247726
  REMARK    GeneRIF: DUSP26 down-regulation is an effective antineoplastic
            neuroblastoma strategy through activation of the p53 and p38 MAPK
            tumor-suppressor pathways.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1888)
  AUTHORS   Kim,H., Lee,H.J., Oh,Y., Choi,S.G., Hong,S.H., Kim,H.J., Lee,S.Y.,
            Choi,J.W., Su Hwang,D., Kim,K.S., Kim,H.J., Zhang,J., Youn,H.J.,
            Noh,D.Y. and Jung,Y.K.
  TITLE     The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD
            phosphorylation and cell growth
  JOURNAL   Nat Commun 5, 3351 (2014)
   PUBMED   24548998
  REMARK    GeneRIF: results suggest that AK2 is an associated activator of
            DUSP26 and suppresses cell proliferation by FADD dephosphorylation,
            postulating AK2 as a negative regulator of tumour growth.
REFERENCE   9  (bases 1 to 1888)
  AUTHORS   Rardin,M.J., Wiley,S.E., Murphy,A.N., Pagliarini,D.J. and
            Dixon,J.E.
  TITLE     Dual specificity phosphatases 18 and 21 target to opposing sides of
            the mitochondrial inner membrane
  JOURNAL   J Biol Chem 283 (22), 15440-15450 (2008)
   PUBMED   18385140
REFERENCE   10 (bases 1 to 1888)
  AUTHORS   Roma-Mateo,C., Rios,P., Tabernero,L., Attwood,T.K. and Pulido,R.
  TITLE     A novel phosphatase family, structurally related to
            dual-specificity phosphatases, that displays unique amino acid
            sequence and substrate specificity
  JOURNAL   J Mol Biol 374 (4), 899-909 (2007)
   PUBMED   17976645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109163.16, BY150541.1, AK009781.1 and BY648474.1.
            
            On Oct 24, 2017 this sequence version replaced NM_025869.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009781.1, SRR7345562.2902349.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC109163.16        74002-74044
            44-135              BY150541.1         101-192
            136-1877            AK009781.1         2-1743
            1878-1888           BY648474.1         385-395
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 17.93 cM"
     gene            1..1888
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /note="dual specificity phosphatase 26"
                     /db_xref="GeneID:66959"
                     /db_xref="MGI:MGI:1914209"
     exon            1..369
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..512
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            513..808
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             588..1223
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="dual-specificity phosphatase SKRP3; dual
                     specificity phosphatase 26 (putative)"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 26"
                     /protein_id="NP_080145.1"
                     /db_xref="CCDS:CCDS22219.1"
                     /db_xref="GeneID:66959"
                     /db_xref="MGI:MGI:1914209"
                     /translation="MCPGNWLWASMTFMARFSRGSSRSPVRTRGSLEEMPSVHHPFLN
                     VFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHNRWRGT
                     PEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSA
                     TLVLAYLMLYHHFTLVEAIKKVKDHRGITPNRGFLRQLLALDRRLRQGLEA"
     exon            809..1023
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1881
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1858..1863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /note="hexamer: AATAAA"
     polyA_site      1863
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
                     /note="major polyA site"
     polyA_site      1877
                     /gene="Dusp26"
                     /gene_synonym="2310043K02Rik; Skrp3"
ORIGIN      
        1 gagcgagcag tgtatataga ccctgtctgg aaaggcttgc aacaaggctt tgccattggt
       61 ctacagggca gcagccctgg cgtgcacgcg aggcggggct gcgggcctgc gcggggctgt
      121 aaacaggggc gggctgtgtc gctgcggtgt ggcggctccc accgctgcgt gacacggtgt
      181 ccctgggtgt caccagcgcg cacaccgaga ggaacctgct tcgatgtgcg tgtcatggcg
      241 taaaaatagc tgccatccac ctgcgcgccg gggcggcggc gcagcggcgg gggccgcgaa
      301 agagccatgg gcaccggact gcgggagccc gcaggccacc tcgggatctg agacccttgc
      361 gaccaggagg aggaatagtc cagaggacag cggctacctg cttcttctct cctgccagtc
      421 tccgtgcctt tcaccagcac ttaggcagca gaatctattc tgagagaggt tattggaggg
      481 aaaggatggg tctttgagcc ccaggagtag agcgacacct acctggtgac ggagcccatc
      541 atcactgaaa ccactccaca ttggccacag ttcctgccac cttgaaaatg tgccccggta
      601 actggctctg ggcctccatg acttttatgg cccgcttctc tcgaggcagc tcaaggtccc
      661 ctgtccgtac tcgagggagc ctggaggaga tgccctctgt tcaccatccc ttcctcaacg
      721 tctttgagtt ggaaaggctc ctctacacag gcaagacagc ctgtaaccat gctgacgaag
      781 tctggccggg cctctacctc ggagaccagg acatggccaa caaccgccgt gagcttcggc
      841 gcctgggcat cacccacgtg ctcaacgcct cacacaacag gtggcgaggc acccccgagg
      901 cctatgaggg actgggcatc cgctacctgg gtgtggaggc gcacgactct ccagcctttg
      961 atatgagcat ccactttcag acggctgcgg acttcatcca tcgggcgctg agccagccag
     1021 gagggaagat cctggtgcac tgtgcggtgg gagtgagcag atccgctacc ctggtgctgg
     1081 cctacctcat gctgtatcac cacttcaccc ttgtggaggc catcaagaaa gtcaaggacc
     1141 accgaggcat cacccccaac cggggcttct tgaggcagct cctagccctg gaccgtaggc
     1201 tgcggcaggg tctagaggca tgaactgaaa ggaaccaggc caggtctctg ggtggtttcc
     1261 tggctcccag ctgggaagag aaaacccaag tgacaggtag tagaaagacc agacaaccca
     1321 tcctccctca gcagcaggag agtgaagagc cccaagacca ctgtggctct ttggggatgg
     1381 ggatggagag ccaggttggg cagtgtgatg ggtaggggct gctgacctgg gaaggaagca
     1441 gctgagctgt aagaggatgg ttgtgtggtt aggccagtcc tgggttagag cagggtgtgc
     1501 ccaaatgact cagaatctct tcccctcatt gtgttcaagt gccccccccc aaacaaagga
     1561 ccactgccct gaagtacgtg agcagtgggg atgtcagggt tgcagacaca tagatgtgaa
     1621 ggaaggtggt acaggttgca gaaagcaaca ttagagtcgg tcggtcagtg atggagtggt
     1681 gtgaaagcca ccaatgcaga gggagcaggt tgtaggttat agctgtgcaa ctccaggaag
     1741 agggaggtgt gtgaggactg acatgacacc ctacgggagc tgctcagggt caaataactt
     1801 ggagtctttt aggtggtcat agtctcactg aaaaccatgc gtctggagtt aaaaaaaaat
     1861 aaagaggtga aaaagaagaa aaaaaaaa
//
