LOCUS       NM_026725               1380 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dual specificity phosphatase 23 (Dusp23), mRNA.
ACCESSION   NM_026725 XM_129566
VERSION     NM_026725.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Gallegos,L.L., Ng,M.R., Sowa,M.E., Selfors,L.M., White,A.,
            Zervantonakis,I.K., Singh,P., Dhakal,S., Harper,J.W. and
            Brugge,J.S.
  TITLE     A protein interaction map for cell-cell adhesion regulators
            identifies DUSP23 as a novel phosphatase for beta-catenin
  JOURNAL   Sci Rep 6, 27114 (2016)
   PUBMED   27255161
  REMARK    GeneRIF: Results show that DUSP23 controls the association between
            alpha- and beta-catenin by promoting dephosphorylation of Tyr142
            and identify a previously unrecognized role for DUSP23 in
            regulating E-cadherin adherens junctions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Takagaki,K., Satoh,T., Tanuma,N., Masuda,K., Takekawa,M., Shima,H.
            and Kikuchi,K.
  TITLE     Characterization of a novel low-molecular-mass dual-specificity
            phosphatase-3 (LDP-3) that enhances activation of JNK and p38
  JOURNAL   Biochem J 383 (Pt. 3), 447-455 (2004)
   PUBMED   15281913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131177.9.
            
            On Oct 19, 2022 this sequence version replaced NM_026725.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004912.1, SRR7345562.1051521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               AC131177.9         100544-100865       c
            323-1380            AC131177.9         98697-99754         c
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.05 cM"
     gene            1..1380
                     /gene="Dusp23"
                     /gene_synonym="1300005N15Rik; LDP-3"
                     /note="dual specificity phosphatase 23"
                     /db_xref="GeneID:68440"
                     /db_xref="MGI:MGI:1915690"
     exon            1..322
                     /gene="Dusp23"
                     /gene_synonym="1300005N15Rik; LDP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..508
                     /gene="Dusp23"
                     /gene_synonym="1300005N15Rik; LDP-3"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="low-molecular-mass dual-specificity phosphatase;
                     low molecular mass dual specificity phosphatase 3"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 23"
                     /protein_id="NP_081001.1"
                     /db_xref="CCDS:CCDS15518.1"
                     /db_xref="GeneID:68440"
                     /db_xref="MGI:MGI:1915690"
                     /translation="MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDQGVRHLVSLTE
                     RGPPHSDSCPGLTLHRMRIPDFCPPSPEQIDQFVKIVDEANARGEAVGVHCALGFGRT
                     GTMLACYLVKERALAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK"
     exon            323..1380
                     /gene="Dusp23"
                     /gene_synonym="1300005N15Rik; LDP-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp23"
                     /gene_synonym="1300005N15Rik; LDP-3"
                     /note="hexamer: AATAAA"
     polyA_site      1380
                     /gene="Dusp23"
                     /gene_synonym="1300005N15Rik; LDP-3"
                     /note="major polyA site"
ORIGIN      
        1 aatctcccgg cagagtagga aaggccagcc tcgccctgag taaactcccc ccacgatggg
       61 cgtgcaaccc cccaacttct cctgggtgct tccgggacgg ctggccggac tggcgttgcc
      121 ccggctgccc gcgcactacc agttcctgct ggaccagggt gtgcggcacc tggtgtccct
      181 gacggagcgc ggaccccctc acagtgacag ctgtcccggc ctcacgctgc accgaatgcg
      241 catccctgac ttttgcccgc cgtccccgga acagatcgac caatttgtga agatcgtgga
      301 cgaggccaat gcccggggag aggctgttgg agtgcactgt gccctaggct ttggccgcac
      361 tggcaccatg ctagcctgct acttggtgaa ggagcgggct ttggccgcag gagatgccat
      421 tgctgagatc cggcgcctgc gaccaggatc cattgagacg tatgaacagg agaaggccgt
      481 cttccagttc taccagcgaa caaaatgagg acttcaacag cccgcctttc cccctcccca
      541 actcctgcgg ccagggagga aggggagtga actaaagtac tgcatccttc aggtccctct
      601 gactcctatt ggacaaaagt agtccttccc caaagccata acgtggccgg caggatggcc
      661 gagaccccac aaaaatgagg taataactga taagaactca tcaccgctgc atagcatgta
      721 cacagcactc ccaatacatc tgggtggttg aaaagacaaa aaaaaaaaaa acaaaaaaaa
      781 aaaaaaaaaa accacttctg ttctttggat gaggtgtcta gagttcagaa aggcctccgg
      841 tcacagttct gggaaacaga aggataggcc aggactccag cacacacctt tgtcatcctg
      901 aggatgatgg gattctaagt gctgttccct gacatgtgat agaggagaac tggtcagtga
      961 aggagaccca tgtccctggc cacatggcct ccaagcagcc tcaggccgct gcactcctac
     1021 accagcagtg cccccttgac atcacccctt atgtagggtc atccgtccta cctgagccac
     1081 ctttgttctc tcagggtaca gaagacctgc atatcgtgct acagatgagg tctctctctg
     1141 tcttatctgt ttctctcttg gtctccccct cccactctcc ctcttaatct ccctctctcc
     1201 ctcccccttc ctccccccac cagggctggc cacctcttac cagcctcagg tgactcagct
     1261 catctgtcac ctccaacccc tatgtcgtcc ccagcctcag accaacgaat gctgaaactg
     1321 tgtcttggtg gttttagagt ggatattaag tgatcaaata aataactctg ggactatgaa
//
