LOCUS       NM_134068               1070 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus dual specificity phosphatase 22 (Dusp22), transcript
            variant 2, mRNA.
ACCESSION   NM_134068
VERSION     NM_134068.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1070)
  AUTHORS   Chen,X., Fang,M., Hong,J. and Guo,Y.
  TITLE     JNK Pathway-Associated Phosphatase Deficiency Facilitates
            Atherosclerotic Progression by Inducing T-Helper 1 and 17
            Polarization and Inflammation in an ERK- and NF-kappaB
            Pathway-Dependent Manner
  JOURNAL   J Atheroscler Thromb 31 (10), 1460-1478 (2024)
   PUBMED   38797677
  REMARK    GeneRIF: JNK Pathway-Associated Phosphatase Deficiency Facilitates
            Atherosclerotic Progression by Inducing T-Helper 1 and 17
            Polarization and Inflammation in an ERK- and NF-kappaB
            Pathway-Dependent Manner.
REFERENCE   2  (bases 1 to 1070)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1070)
  AUTHORS   Shih,Y.C., Chen,H.F., Wu,C.Y., Ciou,Y.R., Wang,C.W., Chuang,H.C.
            and Tan,T.H.
  TITLE     The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination
            and activation of Lck downstream of TCR signalling
  JOURNAL   Nat Commun 15 (1), 532 (2024)
   PUBMED   38225265
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1070)
  AUTHORS   Chen,M.H., Chuang,H.C., Yeh,Y.C., Chou,C.T. and Tan,T.H.
  TITLE     Dual-specificity phosphatases 22-deficient T cells contribute to
            the pathogenesis of ankylosing spondylitis
  JOURNAL   BMC Med 21 (1), 46 (2023)
   PUBMED   36765305
  REMARK    GeneRIF: Dual-specificity phosphatases 22-deficient T cells
            contribute to the pathogenesis of ankylosing spondylitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1070)
  AUTHORS   Ge,C., Tan,J., Dai,X., Kuang,Q., Zhong,S., Lai,L., Yi,C., Sun,Y.,
            Luo,J., Zhang,C., Zhu,L., Wang,B. and Xu,M.
  TITLE     Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by
            targeting FAK
  JOURNAL   Nat Commun 13 (1), 5945 (2022)
   PUBMED   36209205
  REMARK    GeneRIF: Hepatocyte phosphatase DUSP22 mitigates NASH-HCC
            progression by targeting FAK.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1070)
  AUTHORS   Lin,H.P., Ho,H.M., Chang,C.W., Yeh,S.D., Su,Y.W., Tan,T.H. and
            Lin,W.J.
  TITLE     DUSP22 suppresses prostate cancer proliferation by targeting the
            EGFR-AR axis
  JOURNAL   FASEB J 33 (12), 14653-14667 (2019)
   PUBMED   31693867
REFERENCE   7  (bases 1 to 1070)
  AUTHORS   Hamada,N., Mizuno,M., Tomita,H., Iwamoto,I., Hara,A. and
            Nagata,K.I.
  TITLE     Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in
            mouse tissues
  JOURNAL   Med Mol Morphol 51 (2), 111-117 (2018)
   PUBMED   29282540
  REMARK    GeneRIF: Dusp22 expression in the adult mouse tissues and organs
REFERENCE   8  (bases 1 to 1070)
  AUTHORS   Li,J.P., Yang,C.Y., Chuang,H.C., Lan,J.L., Chen,D.Y., Chen,Y.M.,
            Wang,X., Chen,A.J., Belmont,J.W. and Tan,T.H.
  TITLE     The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and
            autoimmunity by inactivating Lck
  JOURNAL   Nat Commun 5, 3618 (2014)
   PUBMED   24714587
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1070)
  AUTHORS   Sekine,Y., Tsuji,S., Ikeda,O., Sato,N., Aoki,N., Aoyama,K.,
            Sugiyama,K. and Matsuda,T.
  TITLE     Regulation of STAT3-mediated signaling by LMW-DSP2
  JOURNAL   Oncogene 25 (42), 5801-5806 (2006)
   PUBMED   16636663
  REMARK    GeneRIF: DSP2 acts as a negative regulator of the
            IL-6/LIF/STAT3-mediated signaling pathway.
REFERENCE   10 (bases 1 to 1070)
  AUTHORS   Chen,A.J., Zhou,G., Juan,T., Colicos,S.M., Cannon,J.P.,
            Cabriera-Hansen,M., Meyer,C.F., Jurecic,R., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Fletcher,F., Tan,T.H. and Belmont,J.W.
  TITLE     The dual specificity JKAP specifically activates the c-Jun
            N-terminal kinase pathway
  JOURNAL   J Biol Chem 277 (39), 36592-36601 (2002)
   PUBMED   12138158
  REMARK    GeneRIF: cloning and characterization of JKAP, a positive regulator
            of the JNK pathway
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX236611.1, AK148708.1, AA137950.1, AK003947.1 and BY477408.1.
            
            On Feb 17, 2021 this sequence version replaced NM_134068.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.118907.1,
                                           SRR17784644.237413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CX236611.1         26-32
            8-550               AK148708.1         1-543
            551-817             AA137950.1         285-551
            818-1068            AK003947.1         432-682
            1069-1070           BY477408.1         502-503
FEATURES             Location/Qualifiers
     source          1..1070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.26 cM"
     gene            1..1070
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /note="dual specificity phosphatase 22"
                     /db_xref="GeneID:105352"
                     /db_xref="MGI:MGI:1915926"
     exon            1..63
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..597
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform b is encoded by transcript variant 2; dual
                     specificity protein phosphatase 22; low molecular weight
                     dual specificity phosphatase 2; JNK pathway associated
                     phosphatase"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 22 isoform
                     b"
                     /protein_id="NP_598829.1"
                     /db_xref="CCDS:CCDS26417.1"
                     /db_xref="GeneID:105352"
                     /db_xref="MGI:MGI:1915926"
                     /translation="MGSGMSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPM
                     LEGVKYLCIPAADTPSQNLTRHFKESIKFIHECRLQGESCLVHCLAGVSRSVTLVIAY
                     IMTVTDFGWEDALHTVRAGRSCANPNLGFQRQLQEFEKHEVHQYRQWLREEYGENPLR
                     DAEEAKNILAAPGILKYWAFLRRL"
     exon            64..97
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            98..180
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            181..230
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            231..305
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            306..477
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            478..550
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            551..1070
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1050..1055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /note="hexamer: AATAAA"
     polyA_site      1070
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /note="major polyA site"
ORIGIN      
        1 ggtctcctcc cgcgagcgcg gagcggcgag cccggcgcgg ccatggggag tgggatgagc
       61 cagatcctgc cgggcctgta cattggcaac ttcaaagacg caagagatgc agaacagttg
      121 agcaggaaca aggtgacaca cattctttct gtgcacgata ctgccaggcc catgttggag
      181 ggagttaaat acctgtgtat tccagcggca gacacaccat ctcaaaacct gacaagacat
      241 ttcaaagaaa gcattaaatt cattcatgag tgccgactcc agggtgagag ctgtcttgta
      301 cattgcctgg ctggggtctc caggagtgtg acattggtga tcgcatacat catgactgtc
      361 accgactttg gctgggaaga tgccttgcac actgttcgtg cggggaggtc ctgtgccaac
      421 cccaacctgg gctttcaaag gcagctgcag gagtttgaga aacatgaagt gcaccagtat
      481 cggcaatggc tgagagaaga gtatggagag aaccctttgc gggatgcaga agaagccaaa
      541 aatattctgg ctgccccggg aattctgaag tactgggcct ttctcagaag actgtaatgt
      601 acctgaagtt tctgaaatat tgcaaagttc aggctggtgc tgccaaaaag aaaagtgatg
      661 taaagtttat ttttaagaat ccaatagtga tttgtatact tgtttttttt tcattttaaa
      721 ccaaatgcat gtataatcat gttggaatat gttaagatct atggatattc tgtagcaaga
      781 gaaaatatct ttgccttaac tccactgctg tggttgttcc ttggacctga ccgatgctca
      841 tacaataatc tcaagagccc tgtctgtttc gtaatagtaa ctacttctca tgaacactac
      901 ccaaggagga agcctgcacc tgggaagtgt gcagtgtgag ctctgccctc ctgttaagtt
      961 ctccagctct agacatgtct cttggtgtgt gttttatcta ctggtgttat tctatatggt
     1021 agaattacca aaagctattc agatttctta ataaagggca aatcaaccaa
//
