LOCUS       NM_001037955            3058 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus dual specificity phosphatase 22 (Dusp22), transcript
            variant 1, mRNA.
ACCESSION   NM_001037955
VERSION     NM_001037955.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3058)
  AUTHORS   Chen,X., Fang,M., Hong,J. and Guo,Y.
  TITLE     JNK Pathway-Associated Phosphatase Deficiency Facilitates
            Atherosclerotic Progression by Inducing T-Helper 1 and 17
            Polarization and Inflammation in an ERK- and NF-kappaB
            Pathway-Dependent Manner
  JOURNAL   J Atheroscler Thromb 31 (10), 1460-1478 (2024)
   PUBMED   38797677
  REMARK    GeneRIF: JNK Pathway-Associated Phosphatase Deficiency Facilitates
            Atherosclerotic Progression by Inducing T-Helper 1 and 17
            Polarization and Inflammation in an ERK- and NF-kappaB
            Pathway-Dependent Manner.
REFERENCE   2  (bases 1 to 3058)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3058)
  AUTHORS   Shih,Y.C., Chen,H.F., Wu,C.Y., Ciou,Y.R., Wang,C.W., Chuang,H.C.
            and Tan,T.H.
  TITLE     The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination
            and activation of Lck downstream of TCR signalling
  JOURNAL   Nat Commun 15 (1), 532 (2024)
   PUBMED   38225265
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3058)
  AUTHORS   Chen,M.H., Chuang,H.C., Yeh,Y.C., Chou,C.T. and Tan,T.H.
  TITLE     Dual-specificity phosphatases 22-deficient T cells contribute to
            the pathogenesis of ankylosing spondylitis
  JOURNAL   BMC Med 21 (1), 46 (2023)
   PUBMED   36765305
  REMARK    GeneRIF: Dual-specificity phosphatases 22-deficient T cells
            contribute to the pathogenesis of ankylosing spondylitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3058)
  AUTHORS   Ge,C., Tan,J., Dai,X., Kuang,Q., Zhong,S., Lai,L., Yi,C., Sun,Y.,
            Luo,J., Zhang,C., Zhu,L., Wang,B. and Xu,M.
  TITLE     Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by
            targeting FAK
  JOURNAL   Nat Commun 13 (1), 5945 (2022)
   PUBMED   36209205
  REMARK    GeneRIF: Hepatocyte phosphatase DUSP22 mitigates NASH-HCC
            progression by targeting FAK.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3058)
  AUTHORS   Lin,H.P., Ho,H.M., Chang,C.W., Yeh,S.D., Su,Y.W., Tan,T.H. and
            Lin,W.J.
  TITLE     DUSP22 suppresses prostate cancer proliferation by targeting the
            EGFR-AR axis
  JOURNAL   FASEB J 33 (12), 14653-14667 (2019)
   PUBMED   31693867
REFERENCE   7  (bases 1 to 3058)
  AUTHORS   Hamada,N., Mizuno,M., Tomita,H., Iwamoto,I., Hara,A. and
            Nagata,K.I.
  TITLE     Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in
            mouse tissues
  JOURNAL   Med Mol Morphol 51 (2), 111-117 (2018)
   PUBMED   29282540
  REMARK    GeneRIF: Dusp22 expression in the adult mouse tissues and organs
REFERENCE   8  (bases 1 to 3058)
  AUTHORS   Li,J.P., Yang,C.Y., Chuang,H.C., Lan,J.L., Chen,D.Y., Chen,Y.M.,
            Wang,X., Chen,A.J., Belmont,J.W. and Tan,T.H.
  TITLE     The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and
            autoimmunity by inactivating Lck
  JOURNAL   Nat Commun 5, 3618 (2014)
   PUBMED   24714587
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3058)
  AUTHORS   Sekine,Y., Tsuji,S., Ikeda,O., Sato,N., Aoki,N., Aoyama,K.,
            Sugiyama,K. and Matsuda,T.
  TITLE     Regulation of STAT3-mediated signaling by LMW-DSP2
  JOURNAL   Oncogene 25 (42), 5801-5806 (2006)
   PUBMED   16636663
  REMARK    GeneRIF: DSP2 acts as a negative regulator of the
            IL-6/LIF/STAT3-mediated signaling pathway.
REFERENCE   10 (bases 1 to 3058)
  AUTHORS   Chen,A.J., Zhou,G., Juan,T., Colicos,S.M., Cannon,J.P.,
            Cabriera-Hansen,M., Meyer,C.F., Jurecic,R., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Fletcher,F., Tan,T.H. and Belmont,J.W.
  TITLE     The dual specificity JKAP specifically activates the c-Jun
            N-terminal kinase pathway
  JOURNAL   J Biol Chem 277 (39), 36592-36601 (2002)
   PUBMED   12138158
  REMARK    GeneRIF: cloning and characterization of JKAP, a positive regulator
            of the JNK pathway
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX236611.1, AK148708.1, AK149363.1, AA137950.1, AK003947.1 and
            BY477408.1.
            
            On Oct 30, 2013 this sequence version replaced NM_001037955.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080718.1, AK149363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CX236611.1         1-32
            33-1846             AK148708.1         1-1814
            1847-2285           AK149363.1         1814-2252
            2286-2798           AA137950.1         39-551
            2799-3049           AK003947.1         432-682
            3050-3058           BY477408.1         502-510
FEATURES             Location/Qualifiers
     source          1..3058
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.26 cM"
     gene            1..3058
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /note="dual specificity phosphatase 22"
                     /db_xref="GeneID:105352"
                     /db_xref="MGI:MGI:1915926"
     exon            1..88
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..685
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1; dual
                     specificity protein phosphatase 22; low molecular weight
                     dual specificity phosphatase 2; JNK pathway associated
                     phosphatase"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 22 isoform
                     a"
                     /protein_id="NP_001033044.1"
                     /db_xref="CCDS:CCDS26418.1"
                     /db_xref="GeneID:105352"
                     /db_xref="MGI:MGI:1915926"
                     /translation="MGSGMSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPM
                     LEGVKYLCIPAADTPSQNLTRHFKESIKFIHECRLQGESCLVHCLAGVSRSVTLVIAY
                     IMTVTDFGWEDALHTVRAGRSCANPNLGFQRQLQEFEKHEVHQYRQWLREEYGENPLR
                     DAEEAKNILGKYKEQGRMEPRPSSRRWSSFSTLPPLTYNNYTTET"
     exon            89..122
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            123..205
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            206..255
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            256..330
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            331..502
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     exon            503..3058
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3031..3036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /note="hexamer: AATAAA"
     polyA_site      3051
                     /gene="Dusp22"
                     /gene_synonym="JKAP; JSP1; LMW-DSP2; MKPX"
                     /note="major polyA site"
ORIGIN      
        1 cgcctgcccg cccggctgcg cgcccggtct cctcccgcga gcgcggagcg gcgagcccgg
       61 cgcggccatg gggagtggga tgagccagat cctgccgggc ctgtacattg gcaacttcaa
      121 agacgcaaga gatgcagaac agttgagcag gaacaaggtg acacacattc tttctgtgca
      181 cgatactgcc aggcccatgt tggagggagt taaatacctg tgtattccag cggcagacac
      241 accatctcaa aacctgacaa gacatttcaa agaaagcatt aaattcattc atgagtgccg
      301 actccagggt gagagctgtc ttgtacattg cctggctggg gtctccagga gtgtgacatt
      361 ggtgatcgca tacatcatga ctgtcaccga ctttggctgg gaagatgcct tgcacactgt
      421 tcgtgcgggg aggtcctgtg ccaaccccaa cctgggcttt caaaggcagc tgcaggagtt
      481 tgagaaacat gaagtgcacc agtatcggca atggctgaga gaagagtatg gagagaaccc
      541 tttgcgggat gcagaagaag ccaaaaatat tctgggtaaa tataaagagc aagggcgcat
      601 ggagccccgg cctagcagca ggcggtggag cagcttctca accctgcctc ctctcaccta
      661 caataactac acaacagaga cctaacagag agagctggtg tctgccttcc tgctgcgggt
      721 cttctgggtt gcctaccatg tgctggtgtg cctggtgtgc tggctcctgc ctctgaggac
      781 tacgagagga ggtcgcagca aggtggagca ctcagggctc cttctcagaa taccgcccta
      841 ctcaggcttt ttcactctcc catcttcgcc ccatcttttc ctcacctgaa cttgcccagc
      901 ctgggatgct gcccggccac cgtgtacttc tcgtatgtgt gcaggcgtgt ggatgtgcat
      961 gtatgtgtct aagagtgtgc atatatacct acaaatgtat gcattgtgaa caagtacaca
     1021 tgtaaatgtg tctctgcatg tgggcactga gtgtttatgg tgctgaaagt tataaacacc
     1081 cgctgccaga actgcaatgg tcacattgtt cagtccacat ggaagtcatt tgaacttggc
     1141 ctctggaaag ctactcacca agtaacagct tatgcctgtg ctgagtgaga gctcagggtg
     1201 tgggcagctg gaaacagtgg tgttccagat tctgagatgg cacagaggaa gggacaggac
     1261 cctcctgagg aagagtggca taatcctaga gagttttatg tctgtgggaa caagggaggg
     1321 gctttctgag cactgtcttg gacttgataa gtatacttgc cagcccgtca tggccctgag
     1381 ttccactggt gcctgctctg cgtgggacca gcgtcatttg actttcatgg tgatatggta
     1441 tggtgacagg gtggacctga gactcagtag ccctatacca gaggtctggc ccacctcctg
     1501 tctgctttta aacactttag cctctggctt agcctcttgt tgcaggggtc tcatctcagg
     1561 tttgcatgta cctgcaggaa ctggaaagaa aggcagttat taaactccat agccatttgt
     1621 gatttaaaat gcctacgcat tcactgagct cattgttgta tgctgtggat ttgaccgcta
     1681 cctcatgaag ttccttcctt ccttccttcc ttccttcctt ccttccttcc ttccttcctt
     1741 ccttccttcc tttctttctt ctttaaggtt gaggtttctt tggtacccca gtcaactctg
     1801 cttcatagtt gagaatgttt gtcatgtgac tattgttttt gaaaccaaag agaagagcat
     1861 acttatgtca ttgagtgatt taaaatttgc agcttggctt ctgtaaggtt ttctagtgag
     1921 tcaaacccta cattctgacc atgagagctc cttagttcaa agtatgtggc agcaggcacc
     1981 cctagaagct ctgcacagtc cagtgtccag tcctttatgc caattcacgt tgcttaagca
     2041 tgcaggacca tgcaaatgaa aaatacactc aacctctccc taaacgtact gtgaccaggc
     2101 atctctgaag cttaagaaac ccccaagaag cccccgagga gctggacagt ggtggcacac
     2161 acctttaatc ccagcttttg ggaggcagag gcaggcggat ttctgagttc aaggccagcc
     2221 tggtctacag agtgagttcc aggacagcca gggctacaca gagaaaccct gtctcgaaaa
     2281 accaaaaaaa aaaaaaaaaa aaggagaagc ccctgaggaa gaagcagcag gcctctctct
     2341 gtgtgtgtgg agccctcagg gacccaggga aggtgtggtt gccagctctc tgtgtgcagg
     2401 ccgtgccaag caatagcatg agtgacgcct gagtacctga gtatgtgtgc acgtgtatga
     2461 acagctgcat acctttccat aggttctcaa ctgtcttaat ttttgttgcc agtaatgttc
     2521 tttctccaca gctgccccgg gaattctgaa gtactgggcc tttctcagaa gactgtaatg
     2581 tacctgaagt ttctgaaata ttgcaaagtt caggctggtg ctgccaaaaa gaaaagtgat
     2641 gtaaagttta tttttaagaa tccaatagtg atttgtatac ttgttttttt ttcattttaa
     2701 accaaatgca tgtataatca tgttggaata tgttaagatc tatggatatt ctgtagcaag
     2761 agaaaatatc tttgccttaa ctccactgct gtggttgttc cttggacctg accgatgctc
     2821 atacaataat ctcaagagcc ctgtctgttt cgtaatagta actacttctc atgaacacta
     2881 cccaaggagg aagcctgcac ctgggaagtg tgcagtgtga gctctgccct cctgttaagt
     2941 tctccagctc tagacatgtc tcttggtgtg tgttttatct actggtgtta ttctatatgg
     3001 tagaattacc aaaagctatt cagatttctt aataaagggc aaatcaacca agcctgac
//
