LOCUS       NM_010090               1630 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus dual specificity phosphatase 2 (Dusp2), mRNA.
ACCESSION   NM_010090
VERSION     NM_010090.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Blumm,C., Bonaterra,G.A., Schwarzbach,H., Eiden,L.E., Weihe,E. and
            Kinscherf,R.
  TITLE     PAC1 deficiency reduces chondrogenesis in atherosclerotic lesions
            of hypercholesterolemic ApoE-deficient mice
  JOURNAL   BMC Cardiovasc Disord 23 (1), 566 (2023)
   PUBMED   37980508
  REMARK    GeneRIF: PAC1 deficiency reduces chondrogenesis in atherosclerotic
            lesions of hypercholesterolemic ApoE-deficient mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Jiang,X., Yan,Q., He,J., Zheng,Z., Peng,X., Cao,X., Zhou,F., Nie,J.
            and Kang,T.
  TITLE     Interfering with Dusp2 alleviates high glucose-induced vascular
            endothelial cell dysfunction by promoting p38 MAPK pathway
            activation
  JOURNAL   Exp Cell Res 430 (2), 113720 (2023)
   PUBMED   37479052
  REMARK    GeneRIF: Interfering with Dusp2 alleviates high glucose-induced
            vascular endothelial cell dysfunction by promoting p38 MAPK pathway
            activation.
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Dan,Lu., Liu,L., Sun,Y., Song,J., Yin,Q., Zhang,G., Qi,F., Hu,Z.,
            Yang,Z., Zhou,Z., Hu,Y., Zhang,L., Ji,J., Zhao,X., Jin,Y.,
            McNutt,M.A. and Yin,Y.
  TITLE     The phosphatase PAC1 acts as a T cell suppressor and attenuates
            host antitumor immunity
  JOURNAL   Nat Immunol 21 (3), 287-297 (2020)
   PUBMED   31932812
  REMARK    GeneRIF: Deletion of PAC1 enhances immune responses and reduces
            cancer susceptibility in mice. Through activation of EGR1,
            excessive reactive oxygen species in the tumor microenvironment
            induce expression of PAC1, which recruits the Mi-2beta
            nucleosome-remodeling and histone-deacetylase complex, eventually
            leading to chromatin remodeling of effector T cells.
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   Celaya,A.M., Sanchez-Perez,I., Bermudez-Munoz,J.M., Rodriguez-de la
            Rosa,L., Pintado-Berninches,L., Perona,R., Murillo-Cuesta,S. and
            Varela-Nieto,I.
  TITLE     Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1)
            accelerates progressive hearing loss
  JOURNAL   Elife 8, e39159 (2019)
   PUBMED   30938680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Kanemaru,H., Yamane,F., Tanaka,H., Maeda,K., Satoh,T. and Akira,S.
  TITLE     BATF2 activates DUSP2 gene expression and up-regulates NF-kappaB
            activity via phospho-STAT3 dephosphorylation
  JOURNAL   Int Immunol 30 (6), 255-265 (2018)
   PUBMED   29534174
  REMARK    GeneRIF: BATF2 activates DUSP2 gene expression and up-regulates
            NF-kappaB activity via phospho-STAT3 dephosphorylation
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Li,C., Xu,X., Nelson,D.K., Williams,T., Kuehn,M.R. and Deng,C.X.
  TITLE     FGFR1 function at the earliest stages of mouse limb development
            plays an indispensable role in subsequent autopod morphogenesis
  JOURNAL   Development 132 (21), 4755-4764 (2005)
   PUBMED   16207751
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Theodosiou,A. and Ashworth,A.
  TITLE     MAP kinase phosphatases
  JOURNAL   Genome Biol 3 (7), REVIEWS3009 (2002)
   PUBMED   12184814
  REMARK    Review article
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Gerondakis,S., Economou,C. and Grumont,R.J.
  TITLE     Structure of the gene encoding the murine dual specificity
            tyrosine-threonine phosphatase PAC1
  JOURNAL   Genomics 24 (1), 182-184 (1994)
   PUBMED   7896276
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Grumont,R.J. and Gerondakis,S.
  TITLE     Alternative splicing of RNA transcripts encoded by the murine p105
            NF-kappa B gene generates I kappa B gamma isoforms with different
            inhibitory activities
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4367-4371 (1994)
   PUBMED   8183915
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Rohan,P.J., Davis,P., Moskaluk,C.A., Kearns,M., Krutzsch,H.,
            Siebenlist,U. and Kelly,K.
  TITLE     PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase
  JOURNAL   Science 259 (5102), 1763-1766 (1993)
   PUBMED   7681221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK088059.1, L11330.1 and BC048696.1.
            
            On Apr 26, 2004 this sequence version replaced NM_010090.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048696.1, AK134067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AK088059.1         2-51
            51-269              L11330.1           6-224
            270-1162            BC048696.1         256-1148
            1163-1191           L11330.1           1118-1146
            1192-1617           AK088059.1         1188-1613
            1618-1630           BC048696.1         1604-1616
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.93 cM"
     gene            1..1630
                     /gene="Dusp2"
                     /gene_synonym="PAC1"
                     /note="dual specificity phosphatase 2"
                     /db_xref="GeneID:13537"
                     /db_xref="MGI:MGI:101911"
     exon            1..479
                     /gene="Dusp2"
                     /gene_synonym="PAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1036
                     /gene="Dusp2"
                     /gene_synonym="PAC1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="dual specificity protein phosphatase PAC-1"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 2"
                     /protein_id="NP_034220.2"
                     /db_xref="CCDS:CCDS16699.1"
                     /db_xref="GeneID:13537"
                     /db_xref="MGI:MGI:101911"
                     /translation="MPIAMGLETACELECAALGALLREPREAERTLLLDCRPFLAFCR
                     SHVRAARPVPWNALLRRRARGTPAAALACLLPDRALRARLGRGELARAVVLDESSASV
                     AELPPDGPAHLLLAALQHEMRGGPTTVCFLRGGFKSFQTYCPDLCSEAPAQALPPAGA
                     ENSNSDPRVPIYDQGGPVEILPYLYLGSCNHSSDLQGLQACGITAVLNVSASCPNHFE
                     GLFHYKSIPVEDNQMVEISAWFQEAISFIDSVKNSGGRVLVHCQAGISRSATICLAYL
                     IQSHRVRLDEAFDFVKQRRGVISPNFSFMGQLLQLETQVLCH"
     exon            480..601
                     /gene="Dusp2"
                     /gene_synonym="PAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..821
                     /gene="Dusp2"
                     /gene_synonym="PAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1618
                     /gene="Dusp2"
                     /gene_synonym="PAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1584..1589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp2"
                     /gene_synonym="PAC1"
                     /note="hexamer: AATAAA"
     polyA_site      1612
                     /gene="Dusp2"
                     /gene_synonym="PAC1"
                     /note="major polyA site"
ORIGIN      
        1 agaaccgtca gctcccgcca cacagacacc gcgccgccgg agccgaggga gaggacatcc
       61 ggaagcagga ggctttgcga tgccgatcgc catggggctg gagacggcgt gcgagctaga
      121 gtgcgcggcg ctgggcgcgc tgctgcggga gccgcgggag gccgagcgca cgctgctgct
      181 cgactgccgc ccgttcctgg ccttctgccg gagccacgtg cgcgccgcgc gaccggtgcc
      241 ctggaacgcg ctgctgcggc ggcgtgcgcg cggcaccccc gccgctgccc tcgcctgtct
      301 gttgcccgac cgcgcactcc gggcgcgcct gggccgcggg gagctggccc gtgccgtggt
      361 gctggatgaa agcagcgcgt ctgtggccga gctcccgccg gacggccccg ctcacctgct
      421 gctagccgca ctgcagcacg agatgcgcgg gggacccacg accgtgtgct tcttgcgagg
      481 cggtttcaaa agcttccaga cgtactgtcc ggatctgtgc tctgaagctc ctgcccaggc
      541 cctgcctcct gctggggccg aaaatagcaa ctctgacccg agggttccga tctatgacca
      601 gggtggtcct gtggaaatct tgccctacct gtacttgggc agctgcaacc actcctcaga
      661 tcttcagggc ctgcaggcct gcggcatcac agcagttctc aatgtctctg ccagctgccc
      721 caaccacttt gagggtcttt tccattacaa gagcattcca gtagaagata accagatggt
      781 ggagataagt gcctggttcc aggaggctat cagcttcata gactcggtga agaatagtgg
      841 gggccgggtg ctggtgcact gccaagctgg catctctcgc tcagccacca tctgcctggc
      901 atacctgatt cagagccacc gggtacggct ggacgaggcc tttgactttg ttaagcaacg
      961 tcggggagtc atctccccca acttcagttt catggggcag ctgctacagc tggagaccca
     1021 ggtgctgtgt cactgaggca aagcccagcc tggccccacc cacagctctg gctttgactg
     1081 actcctgggg gaagctgctg tggcccagct cctccctcct catcttgccg tcccactggg
     1141 gtgctaggaa atccaggatg acggctgctc tgatatggtg ctcttctgag gtggcataag
     1201 ggctggccct tatttgctct ccctccttcg acttgcagaa attaatttaa ttaattaatt
     1261 tactatatta aagcccttgg tcacccaagg gctcagaaaa caagctgtga caagcagaaa
     1321 ccatgtctag gggtgtgcag cccttgaccc aaagcttaag ccttgtgctc ccaggggagc
     1381 caggaagtga cgtgtgtgtc atgttacgga catctgactt ttgtgtgtgt gtgtgtgggc
     1441 atctcgctgt aattggtgct gaaaagttat ttgtgttcaa ctgacattta acgctctctc
     1501 cccaacttcc tcccggccct gtgggccagg gaggggcgtt ggaaacagca ctttatattt
     1561 atatagaaca ttgaggttgt gtcaataaaa acagtgtttt gtttaaaaaa gagcagtaaa
     1621 aaaaaaaaaa
//
