LOCUS       NM_024438               1463 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus dual specificity phosphatase 19 (Dusp19), mRNA.
ACCESSION   NM_024438
VERSION     NM_024438.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1463)
  AUTHORS   Zama,T., Aoki,R., Kamimoto,T., Inoue,K., Ikeda,Y. and Hagiwara,M.
  TITLE     Scaffold role of a mitogen-activated protein kinase phosphatase,
            SKRP1, for the JNK signaling pathway
  JOURNAL   J Biol Chem 277 (26), 23919-23926 (2002)
   PUBMED   11959862
REFERENCE   2  (bases 1 to 1463)
  AUTHORS   Zama,T., Aoki,R., Kamimoto,T., Inoue,K., Ikeda,Y. and Hagiwara,M.
  TITLE     A novel dual specificity phosphatase SKRP1 interacts with the MAPK
            kinase MKK7 and inactivates the JNK MAPK pathway. Implication for
            the precise regulation of the particular MAPK pathway
  JOURNAL   J Biol Chem 277 (26), 23909-23918 (2002)
   PUBMED   11959861
REFERENCE   3  (bases 1 to 1463)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL928869.11.
            
            On Apr 29, 2007 this sequence version replaced NM_024438.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077871.1, AF237618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               AL928869.11        26244-26636
            394-440             AL928869.11        30224-30270
            441-593             AL928869.11        33238-33390
            594-1463            AL928869.11        39822-40691
FEATURES             Location/Qualifiers
     source          1..1463
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 48.31 cM"
     gene            1..1463
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /note="dual specificity phosphatase 19"
                     /db_xref="GeneID:68082"
                     /db_xref="MGI:MGI:1915332"
     exon            1..393
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..833
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="protein phosphatase SKRP1; stress-activated protein
                     kinase pathway-regulating phosphatase 1"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 19"
                     /protein_id="NP_077758.1"
                     /db_xref="CCDS:CCDS16178.1"
                     /db_xref="GeneID:68082"
                     /db_xref="MGI:MGI:1915332"
                     /translation="MHSLNQEIKAFSRDNLRKQCTRVTTLTGKKLIETWEDATVHVVE
                     TEPSGGGGCGYVQDLTLDLQVGVIKPWLLLGSQDAAHDLELLRKHKVTHILNVAYGVE
                     NAFLSEFTYKTISILDVPETNILSYFPECFEFIEQAKLKDGVVLVHCNAGVSRAAAIV
                     IGFLMSSEEATFTTALSLVKEARPSICPNPGFMEQLRTYQVGKESNGGDKVPAEDTTG
                     GL"
     exon            394..440
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..593
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..1463
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      973..978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /note="hexamer: AATACA"
     polyA_site      991
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /note="major polyA site"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
                     /note="hexamer: TATAAA"
     polyA_site      1406
                     /gene="Dusp19"
                     /gene_synonym="5930436K22Rik; SKRP1; TS-DSP1"
ORIGIN      
        1 gctcgggaag caggcctggg ctgtgctctt ctctggaagg ggtgaggttg tcactgcagg
       61 ggccagctcc agtaagtggc tagtgactga ctagcagtgc agtgcctttt ttgttttgtt
      121 ttttatttct tttttcttga gcttgctgct tttccttctc cgctcatgta atgcactccc
      181 tgaaccaaga aatcaaagca ttctcccggg ataatctcag gaagcagtgc accagggtga
      241 ccacgctaac tggaaagaaa cttatagaaa cctgggaaga tgccacagtt catgttgtgg
      301 agacagagcc cagcggtggg ggtggttgtg gctatgtgca ggaccttacc ttggacctgc
      361 aagttggcgt tattaagccc tggttgcttc tggggtcaca ggatgctgct catgacctgg
      421 agctactgag aaagcataag gtgactcata ttctcaatgt tgcatatgga gttgaaaatg
      481 ctttcctcag tgagtttaca tataagacca tttctatact ggatgtgcct gaaaccaata
      541 tcctgtctta ttttccagaa tgttttgagt ttattgagca agcaaaactg aaggatggcg
      601 tggttctcgt gcactgtaat gcaggtgttt ccagggctgc tgcaattgtc attggcttcc
      661 tcatgagttc tgaagaagcc actttcacca ctgccctgtc gttggtgaaa gaggcgagac
      721 catccatatg tccgaatcct ggcttcatgg aacaactccg cacctaccaa gtaggcaagg
      781 agagcaatgg aggtgacaaa gtgcccgcgg aggacacgac cggtggtctg tgatctgtac
      841 tccagcagag gcaaacgact tctgcatcag actctgtcct cttgcctgtg ttttggaagg
      901 aaacttggaa aacttccctt ttctgttgtc ttttaccagt ggaaatgaac gttacctttg
      961 tcgccctgaa ttaatacatt ttaaagtttt accttttcct tgttatttca gtatctagtt
     1021 aagtgtttct ttgagttcta agagaaaata gtgtattatc aagtcagtaa atcagtggtt
     1081 tgtgtaggaa aaagtttaaa cctaaaaacc tttcttagag ttagaaaaac aagccatgaa
     1141 gccttttaac cccttctttt ctcatatgct ttctgacctg agaacctttg aagtgatgaa
     1201 cttactaagt gaagacttag catttcaaag ggaagtcaaa tttttgagaa tatttttaag
     1261 gttaaaaata atacctgtac ctcctcccct ctccccccgc caagagtacc agaatcaaaa
     1321 ggaatttata ttcattatat aaacatttat ataatgatta taaattcatg tgatcgttat
     1381 atcctcttat aaaaacctaa tttccatttt cacttttttt ttattttgac ttttacattt
     1441 ggtcctatta caaacatttc tct
//
