LOCUS       NM_173745               4632 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus dual specificity phosphatase 18 (Dusp18), mRNA.
ACCESSION   NM_173745
VERSION     NM_173745.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4632)
  AUTHORS   Zhou,X., Wang,G., Tian,C., Du,L., Prochownik,E.V. and Li,Y.
  TITLE     Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes
            anti-tumor immunity in colorectal cancer
  JOURNAL   Nat Commun 15 (1), 5851 (2024)
   PUBMED   38992029
  REMARK    GeneRIF: Inhibition of DUSP18 impairs cholesterol biosynthesis and
            promotes anti-tumor immunity in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4632)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4632)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4632)
  AUTHORS   Rardin,M.J., Wiley,S.E., Murphy,A.N., Pagliarini,D.J. and
            Dixon,J.E.
  TITLE     Dual specificity phosphatases 18 and 21 target to opposing sides of
            the mitochondrial inner membrane
  JOURNAL   J Biol Chem 283 (22), 15440-15450 (2008)
   PUBMED   18385140
  REMARK    GeneRIF: Dual specificity phosphatases 18 and 21 target to opposing
            sides of the mitochondrial inner membrane
REFERENCE   5  (bases 1 to 4632)
  AUTHORS   Roma-Mateo,C., Rios,P., Tabernero,L., Attwood,T.K. and Pulido,R.
  TITLE     A novel phosphatase family, structurally related to
            dual-specificity phosphatases, that displays unique amino acid
            sequence and substrate specificity
  JOURNAL   J Mol Biol 374 (4), 899-909 (2007)
   PUBMED   17976645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN536942.1, AK081916.1, AK052827.1 and BB512576.2.
            
            On Jul 18, 2009 this sequence version replaced NM_173745.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.162633.1,
                                           SRR1660813.28379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               CN536942.1         285-671
            388-2112            AK081916.1         347-2071
            2113-2689           AK052827.1         1615-2191
            2690-4302           AK052827.1         2194-3806
            4303-4304           BB512576.2         398-399
            4305-4632           AK052827.1         3807-4134
FEATURES             Location/Qualifiers
     source          1..4632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.74 cM"
     gene            1..4632
                     /gene="Dusp18"
                     /gene_synonym="4930527G07Rik; DSP18; DUSP20; LMWDSP20"
                     /note="dual specificity phosphatase 18"
                     /db_xref="GeneID:75219"
                     /db_xref="MGI:MGI:1922469"
     exon            1..278
                     /gene="Dusp18"
                     /gene_synonym="4930527G07Rik; DSP18; DUSP20; LMWDSP20"
                     /inference="alignment:Splign:2.1.0"
     exon            279..4632
                     /gene="Dusp18"
                     /gene_synonym="4930527G07Rik; DSP18; DUSP20; LMWDSP20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4176..4181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp18"
                     /gene_synonym="4930527G07Rik; DSP18; DUSP20; LMWDSP20"
                     /note="hexamer: AATAAA"
     polyA_site      4195
                     /gene="Dusp18"
                     /gene_synonym="4930527G07Rik; DSP18; DUSP20; LMWDSP20"
ORIGIN      
        1 gcgtgcaggc ggtgggtgta gcaatggtcc ttctggctac ttggcgcatt tctgtgaaga
       61 caggcagccc acccagcttt tcccaaacgc ctgggaactg cgtagtcctt cgaggtacag
      121 aatcagtcgc ggggtccccc taagccccga actgcccatt gttccgcgag gagaagccgt
      181 tgctaccaag gtccggaatc atgaagggcc ctctctttct tggagagggt cgtccgcggc
      241 tctgccctga aagatttcgg gggcactgag ggaaggaggt ttcagtgggc acagcctagc
      301 agaaagatgc aagcttaata cggcacggac tgtcgacttc cactttgatg acttcaccgt
      361 ggagtgcctt cccagttcag atcccccagc cttcgatcag aggcctctcg cagatcacca
      421 agagcctgtt tatcagcaat ggtgtggctg ccaacaacaa gctcctactg tccagcaatc
      481 agatcaccac agtcatcaac gtctcagtag aggtagcaaa caccttctac gaggatatcc
      541 agtatgtgca ggtgcctgtg gtcgatgcgc ccgtcgcacg cctctccaat ttcttcgatt
      601 ccgttgccga ccgtatccat tcggtggaga tgcagaaggg ccgcacactg ttgcattgtg
      661 ctgctggggt gagccgctca gctgcgctgt gcctcgccta cctcatgaag taccatgcca
      721 tgtcccttgt agatgcccac acttggacca agtcatgcag gcccatcatc cggcccaaca
      781 gtggcttttg ggagcagctc atccattacg agttgcagct ctttggcaag aatacaatgc
      841 agatgatgga ctcgccaatg ggacggatcc cagacatcta cgagaaggag acccgtttga
      901 tgatcccact gtaagccagc ccaccagtaa ctccagtaca ccaaggtctg aacttgaact
      961 tcgacttttg ttgctgcagg agcacagcag atggtgcttt tcatgacgcc agaaaaagtg
     1021 ttgctatagc atttaacctc gcagtccagc caggtttggt ggtgcatgcc tgtaacctca
     1081 gattgctgaa gcagaaagat tacaaggtga gtttgaggcc agcctaggct acatatgaga
     1141 ccctatctca aaaacaaaat caagaacaga aattcccaac aattactatc ttgtcatctg
     1201 tgctttcaga gagtacattc atttcttata atatagtgaa ggtaactttt ctgtgagtgg
     1261 tagggtggag ctggcagatg gtgctgggtc ataggaacca gtgcccagtg catatggcaa
     1321 gctggggttc ctgcagccct cccggagatg accaacccag aaacaaatct gccaaaatcc
     1381 cacctggttc tttcagaggc aaatcctgaa gcttcctggt gctcttggat gtctctcaat
     1441 gtaagtgcca gcctgctaga ttaggggtct tcaaccaggg ttacagagac tgccccttct
     1501 acctttacca cagtggccca attctggttt tctagatcag attcacacag tgcttggatc
     1561 ccagtggtgc ccagatcagc aatcctacct gtacacaggc cttagtttat acatgttctc
     1621 agagcctcta tgtgagagag atgaagaaat ggcttgatct ctgctaggcc tcatccgaga
     1681 agccgcctcc agagttctca ctttgcaacc tgagagtcct gacacaagac cgcgtgcaga
     1741 attgcagacc atgagactca gggtcccagg ctggctgact gttgaggagc tgtgaggact
     1801 gtgaggaaca agtgagttgt ctctagcaag cctgagattc agggctgctc agaagccctt
     1861 ggtgttaggg tctgattcaa gaaggcttgg tttgggttgg tttggtttaa gccctgctcc
     1921 caggtagccc aggctgtgta gccttgagca ccggtctgtc tctttgcctg tactttagga
     1981 atgctgggtt cacaggtatg tgccaccttg tccagcctag acttagtgct acagtgtgtt
     2041 tttttgtggt ataaactcac ccaaagcatc ttgggggagg aaagggttta tttgacttac
     2101 atgttacact ctgtcatgaa ggaatgtggc ttgctccccg tgacttgctc agtgccacct
     2161 gcccaggtag ccacaaccat ggtggactag accctctcac atcaagaagc ccatctccgt
     2221 ggagggtccc ttgtcccagg tgactccagt tacactgaca aacactgtaa cagtctaatg
     2281 gagagcctgg tatgaggtag gcaggagagg atgaagctaa ctgctgttct agactaatgt
     2341 catccttcat caagagcagc cccatccctt cccaccccag ccttcacctg gtagaaacac
     2401 agattttttt tttaacaaag aactttattt gagccttttt gtcattaaaa gaaaacattt
     2461 ggaggtggag gctcggtgac tatgagaact tactgttctt cccgaggacc tggggtttga
     2521 ttcccagcac cgcatagtgg cccacaactg tctatggttc tagtaccaaa gaatctgttg
     2581 cccttttctc gtctcctaga gtaccaggca cacatgcagt acaaatacat atgtttaggg
     2641 aaaacactca tacacagaaa agaaaaataa atctttaaaa aaaaaaaaac cttctaaatt
     2701 agcacgttaa attaacttga actcagttct ctgggtcatc ctaccctaag gcctcaatgc
     2761 atgctaggca gatgctctac caccaagcca atccccagtc cagttctttg agattggttt
     2821 tggtcagggt ctccctacgt aactctggcc gccctgtaac ttgatatata atctaggcta
     2881 gcctccaact caggtcagcc tgcctctgtc tgtacacaga ttcacatatt tatcacaaat
     2941 caggactcca gcagttctac tgcccaaacg atcctgtttt gggtcccatt tgtggtcaga
     3001 ccccaaccca gcccaaccct accacagcct ctggtgagca tgtgcctgcc tgtgtgcatc
     3061 ctatgggttt gctgatgctc ggtatgtgcg gcctgcagtg tgcctttccc acagccacgc
     3121 gtctttgctt tatggtggtg tgtgtggctg tgctacactg cactcaatga agcacacctg
     3181 agttgtctgt tttaggggat tgtagataaa attactataa acatgtgtac acaggttagt
     3241 gtatgtgtga acataagttt tcatttctct agggtgtgta ctacagaatg agatattagt
     3301 catgatgatg gtgtgtggaa tcatttttat ttttaaaatg ctaaccttac agagtggcca
     3361 tccttccttc tcgccgaact tgatggacac tggtcatact cacccctgtg ctctcttatc
     3421 ccctcccaca ttctcagaac accttttccc agtaagttac accacccctc ccccatgctc
     3481 ataacatttc tgtgttcaca tctttaaaaa ctgggctagt aaggcgttgt gttacagcag
     3541 cttcatacat ggcatcacac tgttctcggg gtccccctcc tggtccatat cgttatttat
     3601 tttgtaaact gtatttttgg aaaatacaca tttataggat ctgtgtgcca gttcctccta
     3661 gcgccctcat cctgcctccc tcccaacaag tccaccttgt tttgttctta acatcaatac
     3721 cctggatcca gttggtgctg cctgttgctc atggtgtggg atcatctgct agggtgtggg
     3781 caccttacca gtggccgagt cgccaaagga ggatggcctc cctccctctg tagccatcag
     3841 cgccaatagc tcctcccgca agagcaggtg gataagtatg tttacccagt atgagttgag
     3901 ttgatgagtt gatgtgacaa cagccttaag atagccagca gcctcaccct ccagcgccta
     3961 cattcttcct actctggggc catgaaaagg aacaggaagc tggttgacac ctcctgcaga
     4021 attccagcac aattactgtt tgtcgtaaag attgccagct agaagtcaca ctttttattt
     4081 atagaaattt tgtgttaaaa taatagtgaa tgtggcctta ctcctaaaca gtttctggga
     4141 attaaaaaaa taagactttt ttttaaaaaa aaataaataa aaatgtcccc tgtaagcctg
     4201 tgacctatga ctttccttac cttagctgtg aacctatcca gtgcagaaac tagaaactag
     4261 ccatgatcac attagactaa gttccaaagc cactggaaac tctgtgtgtg tgtgtgtgtg
     4321 tgtgtgtgta tgtgtgtgtg tgtgtgtgtg tctttgtgtg tgtctttgtg tgtgtctatg
     4381 tgtgtgtgag agagagacag agatagacag acacacagag agacagactg acagacacag
     4441 acagacagat tcagacagag gggaggactg gtggagtggg gagagactta accatgactc
     4501 tgagatgccc agccacatgt gttggaaaga gtttgcttcc tttccctggt cctctttttc
     4561 taaatccttg tgcttaatat atctgggttt tttgcttttt gtttgtttta aataaactct
     4621 taactctgct tc
//
