LOCUS       NM_130447               5112 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dual specificity phosphatase 16 (Dusp16), transcript
            variant A1, mRNA.
ACCESSION   NM_130447
VERSION     NM_130447.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5112)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5112)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5112)
  AUTHORS   Wu,Y.K., Hu,L.F., Lou,D.S., Wang,B.C. and Tan,J.
  TITLE     Targeting DUSP16/TAK1 signaling alleviates hepatic dyslipidemia and
            inflammation in high fat diet (HFD)-challenged mice through
            suppressing JNK MAPK
  JOURNAL   Biochem Biophys Res Commun 524 (1), 142-149 (2020)
   PUBMED   31982140
  REMARK    GeneRIF: Targeting DUSP16/TAK1 signaling alleviates hepatic
            dyslipidemia and inflammation in high fat diet (HFD)-challenged
            mice through suppressing JNK MAPK.
REFERENCE   4  (bases 1 to 5112)
  AUTHORS   Kusuyama,J., Amir,M.S., Albertson,B.G., Bandow,K., Ohnishi,T.,
            Nakamura,T., Noguchi,K., Shima,K., Semba,I. and Matsuguchi,T.
  TITLE     JNK inactivation suppresses osteogenic differentiation, but
            robustly induces osteopontin expression in osteoblasts through the
            induction of inhibitor of DNA binding 4 (Id4)
  JOURNAL   FASEB J 33 (6), 7331-7347 (2019)
   PUBMED   30884976
  REMARK    GeneRIF: Studies in knockout mice show that DUSP16 is an endogenous
            regulator of OPN-type osteoblast differentiation, via JNK
            dephosphorylation by DUSP16.
REFERENCE   5  (bases 1 to 5112)
  AUTHORS   Celaya,A.M., Sanchez-Perez,I., Bermudez-Munoz,J.M., Rodriguez-de la
            Rosa,L., Pintado-Berninches,L., Perona,R., Murillo-Cuesta,S. and
            Varela-Nieto,I.
  TITLE     Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1)
            accelerates progressive hearing loss
  JOURNAL   Elife 8, e39159 (2019)
   PUBMED   30938680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5112)
  AUTHORS   Willoughby,E.A., Perkins,G.R., Collins,M.K. and Whitmarsh,A.J.
  TITLE     The JNK-interacting protein-1 scaffold protein targets MAPK
            phosphatase-7 to dephosphorylate JNK
  JOURNAL   J Biol Chem 278 (12), 10731-10736 (2003)
   PUBMED   12524447
  REMARK    GeneRIF: JIP-1 targets MKP-7 to dephosphorylate JNK.
REFERENCE   7  (bases 1 to 5112)
  AUTHORS   Musikacharoen,T., Yoshikai,Y. and Matsuguchi,T.
  TITLE     Histone acetylation and activation of cAMP-response element-binding
            protein regulate transcriptional activation of MKP-M in
            lipopolysaccharide-stimulated macrophages
  JOURNAL   J Biol Chem 278 (11), 9167-9175 (2003)
   PUBMED   12511574
REFERENCE   8  (bases 1 to 5112)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5112)
  AUTHORS   Masuda,K., Shima,H., Watanabe,M. and Kikuchi,K.
  TITLE     MKP-7, a novel mitogen-activated protein kinase phosphatase,
            functions as a shuttle protein
  JOURNAL   J Biol Chem 276 (42), 39002-39011 (2001)
   PUBMED   11489891
REFERENCE   10 (bases 1 to 5112)
  AUTHORS   Matsuguchi,T., Musikacharoen,T., Johnson,T.R., Kraft,A.S. and
            Yoshikai,Y.
  TITLE     A novel mitogen-activated protein kinase phosphatase is an
            important negative regulator of lipopolysaccharide-mediated c-Jun
            N-terminal kinase activation in mouse macrophage cell lines
  JOURNAL   Mol Cell Biol 21 (20), 6999-7009 (2001)
   PUBMED   11564882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122193.5, BC057321.1 and AC126692.4.
            
            On Nov 8, 2013 this sequence version replaced NM_130447.2.
            
            Transcript Variant: This variant (A1) represents the longer
            transcript and encodes the longer isoform (A1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF345951.1, BC057321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC122193.5         1491-1656           c
            167-5107            BC057321.1         18-4958
            5108-5112           AC126692.4         75507-75511
FEATURES             Location/Qualifiers
     source          1..5112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 65.77 cM"
     gene            1..5112
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /note="dual specificity phosphatase 16"
                     /db_xref="GeneID:70686"
                     /db_xref="MGI:MGI:1917936"
     exon            1..352
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /inference="alignment:Splign:2.1.0"
     exon            353..941
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /inference="alignment:Splign:2.1.0"
     CDS             714..2696
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /note="isoform A1 is encoded by transcript variant A1; map
                     kinase phosphatase-M; MAP kinase phosphatase-7"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 16 isoform
                     A1"
                     /protein_id="NP_569714.2"
                     /db_xref="CCDS:CCDS39679.1"
                     /db_xref="GeneID:70686"
                     /db_xref="MGI:MGI:1917936"
                     /translation="MAHEMIGTQIVTESLVALLESGTEKVLLIDSRPFVEYNTSHILE
                     AININCSKLMKRRLQQDKVLITELIQHSAKHKVDIDCNQKVVVYDQSSQDVGSLSSDC
                     FLTVLLGKLERSFNSVHLLAGGFAEFSRCFPGLCEGKSTLVPTCISQPCLPVANIGPT
                     RILPNLYLGCQRDVLNKDLMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEK
                     ILPWLDKSVDFIEKAKASNGCVLIHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKE
                     KRPTISPNFNFMGQLMDYEKTINNQTGMSGPKSKLKLLHLDKPSEPVPAASEGGWKSA
                     LSLSPPCANSTSEASGQRLVHPASVPSLQPSLLEDSPLVQALSGLQLSSEKLEDSTKL
                     KRSFSLDIKSVSYSASMAASLHGFSSEEALDYYKPSATLDGTNKLCQFSPVQEVSEQS
                     PETSPDKEEAHIPKQPQPPRPSESQVTRLHSVRTGSSGSTQRPFFSPLHRSGSVEDNY
                     HTNFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQSSAPSLTSSWYFATEPSHLYSASA
                     IYGGNSSYSAYSCGQLPTCSDQIYSVRRRQKPTDRADSRRSWHEESPFEKQFKRRSCQ
                     MEFGESIMSENRSREELGKVGSQSSFSGSMEIIEVS"
     exon            942..1080
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1244
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1404
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1528
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..5112
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5079..5084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /note="hexamer: AATAAA"
     polyA_site      5107
                     /gene="Dusp16"
                     /gene_synonym="3830417M17Rik; D6Ertd213e; MKP-7; MKP7;
                     Mkpm"
                     /note="major polyA site"
ORIGIN      
        1 ctctctcccc aacccccaca ctaccccccc tggtcccctc ctgcgggcat caccgtttgg
       61 gggggctctc atcccgtttc caaccattta ccctccccct ctcgcttttc ccgcgcggac
      121 ccccaacttt acctcaactt cttcatccct gtcgacattt ttttttccct ctttcggggg
      181 gcggtggaag agaaagtgaa gaaaagttgc aaacgcccgg gctctcgcta agctctccgc
      241 ccacccttca gaggagaagc cccggcggcg aggaggacgc gcgagcgacg gctgggcgac
      301 gcggtgacaa cgctcgctcc cctccgcgag cctggagccg gcggcccctc aagttgtcag
      361 cccagtgtaa agctgttgga gtgagggcag aaaggtaaag gatgatgtaa tgcctggctg
      421 ccctagagca tcttttgttg tgggatgggt attcccatca tctctatgaa tctagtgtga
      481 ggggctgctt tgtggaagga atcctttgca agagcatatc aacaggaaag agaaagagac
      541 attcagttgg agggctcttg ctgaaatgga tttaactctc ctcttgccag tcaccactag
      601 cctgacctca tacattttta gtacaatgga gtggctgagc ctttgagcac agcaccatta
      661 catcatcgtg gcaaattaaa gaacgaggtg gggaaagagg acttattgtt gtcatggccc
      721 atgagatgat tggaactcaa attgttactg agagcttggt ggctctgctg gaaagtggaa
      781 cggaaaaagt gctgctaatt gatagccgac catttgtgga atacaatacg tctcacattt
      841 tggaagccat taatatcaac tgctccaaac tgatgaagcg aaggttgcaa caggacaaag
      901 tattaattac agaacttatc caacattctg caaagcataa ggttgacatt gactgcaatc
      961 agaaggtggt agtttatgat caaagttccc aagatgttgg ttctctgtcg tcagactgct
     1021 ttctcactgt acttctgggt aaactggaga ggagcttcaa ctctgtccac ctgcttgcag
     1081 gtggctttgc tgagttctct cgttgtttcc ctggcctctg tgaaggaaag tccactctag
     1141 tccctacctg catatctcag ccttgcttac ctgttgcgaa cattgggcca actcgaattc
     1201 ttcccaatct ctatcttggc tgccagcgag atgtcctcaa caaggacctg atgcaacaga
     1261 atgggattgg ctatgtgtta aatgccagca atacctgtcc aaagcctgac ttcatacctg
     1321 aatctcactt cctgcgagtg cctgtgaatg acagcttttg tgagaaaatc ctaccatggt
     1381 tggacaagtc tgtggatttc attgagaaag caaaagcctc caatggctgt gtgcttatcc
     1441 actgcttagc tgggatctct cgctccgcca ctattgctat tgcctacatc atgaagagga
     1501 tggacatgtc tctagatgag gcttacagat ttgtgaaaga aaaaagacct actatatctc
     1561 cgaattttaa ttttatgggc caactcatgg actatgagaa gacgattaat aaccagactg
     1621 gaatgtcagg gccaaagagc aaactgaagc tgctgcacct agacaaaccc agtgagcccg
     1681 tgcctgcagc ctcagagggc ggatggaaga gtgcactgtc tctcagtcca ccctgtgcca
     1741 actcgacctc ggaggcatca gggcaaaggc ttgtgcatcc tgcaagtgtg cccagcttac
     1801 agccgtcact cttagaggac agtccgctgg tacaggcgct cagtgggctc cagctgtcct
     1861 cagagaagct ggaagacagc actaagctca agcgttcctt ctctctcgat atcaaatctg
     1921 tttcatattc agccagtatg gccgcgtccc tacacggctt ctcgtcagag gaggctttag
     1981 actactacaa accttctgcc acactggatg ggaccaacaa gctctgccag ttctcccccg
     2041 ttcaggaggt atcagaacag agtccagaga ccagcccgga taaggaggag gcccacatcc
     2101 ccaagcagcc ccaacctccc aggccttctg agagccaggt cacacgcttg cactcagtga
     2161 gaaccggcag tagtgggtcc acccagaggc ccttcttctc gccactgcat cggagcggga
     2221 gtgtagagga caattaccat accaacttcc tttttggcct ttccaccagc cagcaacacc
     2281 tcaccaagtc tgcagggctt ggcctcaagg gctggcactc agatattctg gctccccagt
     2341 cctctgcccc ctccctgacc agcagttggt attttgctac ggagccttca cacttgtact
     2401 ctgcttcagc catctatgga ggcaacagca gttactctgc ctacagctgt ggccagctgc
     2461 ccacttgcag tgaccaaatc tattctgttc gtaggcggca gaagcctact gacagagctg
     2521 actcgaggcg gagctggcat gaagagagcc cctttgaaaa gcagtttaaa cgcagaagct
     2581 gccaaatgga atttggagag agcattatgt cggagaacag gtccagggag gagctgggca
     2641 aggtgggcag ccagtccagc ttctccggca gcatggagat catcgaggtc tcttgagaag
     2701 acctcgtcgc ttctgttgac agttttgttt cctgttcaca aaaaatagtc cctgtaaatc
     2761 tgaaatatgt atatgtacat acatatatat ttttggaata tagagctacg gtataaaagc
     2821 aacagatgga tcaacacagt tgttctctca gcacctgcac tgagaatagc taactctcag
     2881 aaaagattgg aagggtagat gttagaattc tcccagccag gagaagagat ttggttcagt
     2941 gaattgcaca tcttcttgtt cctacaaaag caagggtttt gtttgtttgt atgttgtttg
     3001 tttttaatgt tagagggcaa aatccctccc attttcacgt gcaacagagg tctcagaact
     3061 catctctgtc caggcccttc cctagtgcac cttagcgcta agactgagcc agctgtgggt
     3121 caggtgggaa gaccctccct ctaatggtaa ctccaaggga aatgatcctg tcttaagctg
     3181 cgtaataaac ccaaacttga ttgacagctg aaggatacgg acatcattct gctggatgaa
     3241 ctatttagga gccttgccta gatctactta taaccaatcc agtacctcag acaagacatt
     3301 tggggccatc accactacca tgtctagtag accattttct aggcattgtg aataagtagg
     3361 taacttgtca ctttccagac tatgcacaaa atcccagtgg gcctgttgcc catgtaaccc
     3421 tcctgtcagc ttgaatgaag aggggaaacc aactagagtt tagcttcgcc agagattggg
     3481 cagtcagata gcttagagac ttaagccagg gatggaacac tgaacagtct ccctccctcc
     3541 ctccctccct gtaacataag aattctcttt agtgggattg ttacttcttc acttggccac
     3601 agacctggtt tagagataag catgaatcac tgggcttggt agcagaccga cagaacctca
     3661 ggttctcact tctgtttcgt gtcctggaat aaaactatgg caagacttgg gaaggtaaaa
     3721 cctgaagcag gaaatggatt tccttggctt tttttctcta tggtatgcaa cgagggtaat
     3781 atttctagaa tcttcttaaa cttccaaact taaccatggg ctttggtaag caagaactag
     3841 tcagaataaa acatactaga aaggttaaga gggcgttgtt gaattttgtt tagttttgaa
     3901 tacaggaaag ctcttttcca aagctatccc agcatgcttt ccagggaagg ggcatatcag
     3961 agggaaggac cacagtggtg tcttggtccc tgacatacaa tcactgtgta gactcaatcc
     4021 tggcagctga ggataggaga taagaacaag aagtgtgtac acgatagtcc atatctgccc
     4081 ttaaacttcc tggcttgagt tgtatcctct agagtacggt cctccttacg gccttaattc
     4141 actcacgtca gcagggtgtg ggtgtggggt agatgttgtc attgttcttt actgtaagtg
     4201 tagctagggg ctgactcata tctcaggttt ttctgttagt gaaatggatg gtcctttggc
     4261 taggatgtga cttactgttt cctatactga ttgctgaaac cagcatagag tgacggtggt
     4321 tggaagctga caggcttgat tgtgaggagg attaggggcc tcgtgaacag actgggtctg
     4381 tacagataag ctgtgtgtgg gcataaggtg aaggtagagc agatactgca cagggagcac
     4441 gttgccactc ttggagattc tgttcagcaa tcttcttaga tatatatcaa aatgtctaaa
     4501 gttctcaaag cttcacagta aattttgata cattgtgtac acacacttaa gtatgtaaca
     4561 atccaccttc ttaaaatctg gtcacaccgg taagatgtaa tttatttaag aatgaaaaca
     4621 acggctccaa catgaagtat gttccagaag actggggact tggcttcagt agcttcgggc
     4681 agtgcgttac ctaatgccag atgtcctgta gagaagtgct ctctggactg tgtggctgac
     4741 agtcatacac tacagctgtc agtccttcgt cactaatgtc gtatcagttc ttggaatcac
     4801 gactaccatg ctgaaagggc tgcctctgag gcacattgtg ggtggtggtg gttaggtctc
     4861 ctcacgtaag cacagggaag tctgtgaagt ctactgggat ggtacaaaat ggactctgtg
     4921 agaaatgctg gaaaccgttc aggccgttta taaagttaga gtggaaagac tatataaatg
     4981 tttaatatga atatcgtgtc cttgagtaaa aggcaagctg ttgaatggtt cacttgtgca
     5041 tctctcattc tcaagtgtca cgtatgttaa tatgatgaaa taaaatcaga actggtacct
     5101 atttgtacgt aa
//
