LOCUS       NM_001159376            3121 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus dual specificity phosphatase-like 15 (Dusp15),
            transcript variant 1, mRNA.
ACCESSION   NM_001159376
VERSION     NM_001159376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3121)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3121)
  AUTHORS   Kikkawa,K., Matsuda,T., Fujimuro,M. and Sekine,Y.
  TITLE     The Atypical Dual Specificity Phosphatase DUSP15 Regulates
            Jak1-Mediated STAT3 Activation
  JOURNAL   Biol Pharm Bull 47 (9), 1487-1493 (2024)
   PUBMED   39261048
  REMARK    GeneRIF: The Atypical Dual Specificity Phosphatase DUSP15 Regulates
            Jak1-Mediated STAT3 Activation.
REFERENCE   3  (bases 1 to 3121)
  AUTHORS   Rawlings-Mortimer,F., Gullino,L.S., Ruhling,S., Ashton,A.,
            Barkus,C. and Johansen-Berg,H.
  TITLE     DUSP15 expression is reduced in the hippocampus of Myrf knock-out
            mice but attention and object recognition memory remain intact
  JOURNAL   PLoS One 18 (2), e0281264 (2023)
   PUBMED   36730342
  REMARK    GeneRIF: DUSP15 expression is reduced in the hippocampus of Myrf
            knock-out mice but attention and object recognition memory remain
            intact.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3121)
  AUTHORS   Gacem,N., Kavo,A., Zerad,L., Richard,L., Mathis,S., Kapur,R.P.,
            Parisot,M., Amiel,J., Dufour,S., de la Grange,P., Pingault,V.,
            Vallat,J.M. and Bondurand,N.
  TITLE     ADAR1 mediated regulation of neural crest derived melanocytes and
            Schwann cell development
  JOURNAL   Nat Commun 11 (1), 198 (2020)
   PUBMED   31924792
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3121)
  AUTHORS   Rodriguez-Molina,J.F., Lopez-Anido,C., Ma,K.H., Zhang,C., Olson,T.,
            Muth,K.N., Weider,M. and Svaren,J.
  TITLE     Dual specificity phosphatase 15 regulates Erk activation in Schwann
            cells
  JOURNAL   J Neurochem 140 (3), 368-382 (2017)
   PUBMED   27891578
  REMARK    GeneRIF: Dusp15 is necessary for full activation of Erk 1/2
            phosphorylation in Schwann cells.
REFERENCE   6  (bases 1 to 3121)
  AUTHORS   Sun,M., Mondal,K., Patel,V., Horner,V.L., Long,A.B., Cutler,D.J.,
            Caspary,T. and Zwick,M.E.
  TITLE     Multiplex Chromosomal Exome Sequencing Accelerates Identification
            of ENU-Induced Mutations in the Mouse
  JOURNAL   G3 (Bethesda) 2 (1), 143-150 (2012)
   PUBMED   22384391
REFERENCE   7  (bases 1 to 3121)
  AUTHORS   Jerez-Timaure,N.C., Eisen,E.J. and Pomp,D.
  TITLE     Fine mapping of a QTL region with large effects on growth and
            fatness on mouse chromosome 2
  JOURNAL   Physiol Genomics 21 (3), 411-422 (2005)
   PUBMED   15769905
REFERENCE   8  (bases 1 to 3121)
  AUTHORS   Alonso,A., Narisawa,S., Bogetz,J., Tautz,L., Hadzic,R., Huynh,H.,
            Williams,S., Gjorloff-Wingren,A., Bremer,M.C., Holsinger,L.J.,
            Millan,J.L. and Mustelin,T.
  TITLE     VHY, a novel myristoylated testis-restricted dual specificity
            protein phosphatase related to VHX
  JOURNAL   J Biol Chem 279 (31), 32586-32591 (2004)
   PUBMED   15138252
  REMARK    GeneRIF: VHY is a new member of a subgroup of myristoylated
            VH1-like small dual specificity phosphatases
REFERENCE   9  (bases 1 to 3121)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   10 (bases 1 to 3121)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833801.9.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.101.1,
                                           SRR7345562.704183.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AL833801.9         89007-89254         c
            249-282             AL833801.9         88293-88326         c
            283-365             AL833801.9         86710-86792         c
            366-415             AL833801.9         83960-84009         c
            416-490             AL833801.9         83099-83173         c
            491-662             AL833801.9         81823-81994         c
            663-3121            AL833801.9         78667-81125         c
FEATURES             Location/Qualifiers
     source          1..3121
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..3121
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /note="dual specificity phosphatase-like 15"
                     /db_xref="GeneID:252864"
                     /db_xref="MGI:MGI:1934928"
     exon            1..248
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..935
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity protein phosphatase 15; dual specificity
                     protein phosphatase T-DSP10"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 15 isoform
                     1"
                     /protein_id="NP_001152848.1"
                     /db_xref="CCDS:CCDS50754.1"
                     /db_xref="GeneID:252864"
                     /db_xref="MGI:MGI:1934928"
                     /translation="MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIISIHESPQPL
                     LQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTIVIAY
                     VMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFGEIPFR
                     DEEDLRALLPLCRRCRQGSATSAASATTASSAAEGTLQRLVPRSPRDSHQPLPLLARV
                     KQTFFCLPRCLSRKGGK"
     exon            249..282
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /inference="alignment:Splign:2.1.0"
     exon            283..365
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /inference="alignment:Splign:2.1.0"
     exon            366..415
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /inference="alignment:Splign:2.1.0"
     exon            416..490
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..662
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /inference="alignment:Splign:2.1.0"
     exon            663..3121
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1758..1763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /note="hexamer: AATAAA"
     polyA_site      1779
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /note="major polyA site"
     regulatory      3097..3102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
                     /note="hexamer: AATAAA"
     polyA_site      3119
                     /gene="Dusp15"
                     /gene_synonym="LMW-DSP10; T-DSP10"
ORIGIN      
        1 agcggcggcg gcggcagcag cagcggcagc ggcagcggct ccctccatca cttccctccg
       61 gggctggggg tcggcgggca gcggcggcgg cggctggaca gagctgacac cggacccctg
      121 gtttcccatc aggctacagg ctgggcctgg gccagtcggg cagcagtgaa cctagcgctt
      181 tgaaggcgct aagatagggg tgcgccccgc caccctgcct caggatcatg gggaatggca
      241 tgaccaaggt acttcctgga ctctaccttg gaaacttcat tgatgccaaa gacccggatc
      301 agctgggccg gaataagatc acacatatca tctctatcca cgaatcaccc cagcctctgt
      361 tgcaggatat cacctacctt cgaatctcag tgtctgatac tcctgaggta cccatcaaaa
      421 agcacttcaa agaatgcgtc cactttatcc actcctgccg cctcaacggg ggtaactgcc
      481 ttgtgcactg ctttgcaggt atatctcgaa gtaccaccat agtgatcgcc tatgtgatga
      541 cggtgactgg acttggctgg caggaagtgc tggaagccat caaagcctcc cggcccatcg
      601 ccaacccaaa cccgggcttt aggcagcagc tcgaggagtt tggctgggca aactcccaga
      661 agcttcgccg gcagctggag gagcgcttcg gggagatccc gttccgcgac gaggaagact
      721 tgcgcgcgct gctgcctctc tgcaggcgct gtcgccaggg ctcggcgaca tcggcagcgt
      781 cggccaccac agcttcctcg gccgctgagg ggaccctgca gcgcctggtg ccgcgatcgc
      841 cgcgggactc acaccagccg ctgccgctgc tggcgcgcgt caagcagact ttcttctgcc
      901 tcccgcggtg cctgtcgcgc aagggcggca agtgagcgcc ctgtccgccg ctcctcccgt
      961 cctgacgcag cagccttcgc gggcggccgg ggcttcccgc ggctgggacg cacccagagc
     1021 ccatgggagc ctcgcccctg ccccgtagcc accacgcttg tctgcgtctg tcctcggtgt
     1081 ccgctctgtg agtctgtgtt cggccggcct gctgcaagcc acctggtgcc ttagtccgtg
     1141 gactcgggag aagggtcctg gtcctccacc cccacaggcg aggagcagga gggagggtcg
     1201 ggtggggcgg attggcctgg aggagattaa agagacacag aagttgcctg gccgggtgcc
     1261 tctggtcatt ccgcagagct tgggctccag gggcctgcgg gaagcagagc agggacaact
     1321 tccaggggcc cccgggaagc gccattctcc accagtcttc agagctgaac tccaagacca
     1381 cgcccttctt tgacaccagc ccacccacct ccatctctcc agaggcctgg actcctgaca
     1441 ccacccttgt gccccttttc tctccaaatc ccctttcctc ttcttcagtt ctccttccct
     1501 ctctgcacag ataactggtc aatgtggtcc aattggtggt gttaccttca cgtcatcttt
     1561 tactgtctga gatggcttta tcctcaggga gaacacccag gctcagagag gtcaggcagc
     1621 tggcccaagc acacacagca agggcaagtt gtttccagtg gtggcagtag ggaggaagca
     1681 cctcctagtg tgaaggttcc tggagagaaa gacctcacag gatgcgattt tttttttatt
     1741 ttaaaggtta ccaagccaat aaaacagtaa gtaaccctat gggtgaacag aggagtgtgt
     1801 catcagagct gccgacctga aagagcccaa gtagactctt ggggcttcat ggccgatggg
     1861 gaggcagaga tctcagcact gggctgagcc aatggtgaaa tgaccacacc aacctctaat
     1921 tcctcactca cacaagtgtt cacaccgtgt gccaggtact gtgctgggct ctggggctac
     1981 cacagtgagc aaagctctgc ctgtgcgatg ctgacattct agtggaaggc actagataaa
     2041 agaaggtaag agagtgggac catcttgcca tctggctggg agggactccc actgagggca
     2101 ggaagtcccc ctgcatcctc ctgattggtt ggttttctag ccctgcggtg aggaaaccct
     2161 ttggtttcca gatccagatc cctccagacg ctgccctccc tgaatatcac ctctacgcct
     2221 tagccttatg gcgcagtgag ggctctctac tgaggacgct gtcactgtgc taaacactgc
     2281 agctcagctg atcctcattc caccctcccc aaagctatcc catttatcag agaagaaaac
     2341 tgaggctggt gccccaggtt acaagcaaga gtcaggactc ggatgtgagc tcaggcagcc
     2401 tggctgcaga ctccactctt cattacttac cctttgtgat cgagaaatat gaaaggctcc
     2461 tctaagacat gggagccggg tgcttggagg gacagcacgc ctcggattgg tgtctaaaac
     2521 gccatcccgg ttggagtata gatgggaaga ttatctactg acttttttcc tagccactgt
     2581 tccctaaaca gtacatcagg cacctggcat ttgttttgga tttggtggat ttttagagat
     2641 ggttcaaagt atgtagtgtt cttgcaggtt ctgtgtacat tgtccacccc ttggcttaaa
     2701 ggatttgcca tgcatctcaa cattcagtgg ggccctggaa ccaacccaac acaaagggac
     2761 aactaattat tactcttgtt aatcacacaa aatgttttgt gcccatctcc ccctcccccg
     2821 ctcccacccc ggtgttcatg ggtctgagtg gactctgtct gcatgaattt catgggacag
     2881 ctgctggcgt atgggaccaa gaggaagagg aataagaatg ccctcccacc ggtgcttgtg
     2941 aaggggagac cggactcccc acctctgtcc atgctggctg gaacagccgc tgcactaggg
     3001 gatttttttt tcttttggag cttcagttct atctacagca agggctgggg cagcctgaac
     3061 tactcaacac atttcatagt gcaaatattt cttcataata aaaaaacaga ctctaaaaac
     3121 a
//
