LOCUS       NM_001408746            1578 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus dual specificity phosphatase 14 (Dusp14), transcript
            variant 7, mRNA.
ACCESSION   NM_001408746 XM_006533796
VERSION     NM_001408746.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1578)
  AUTHORS   Sandovici,I., Georgopoulou,A., Perez-Garcia,V., Hufnagel,A.,
            Lopez-Tello,J., Lam,B.Y.H., Schiefer,S.N., Gaudreau,C., Santos,F.,
            Hoelle,K., Yeo,G.S.H., Burling,K., Reiterer,M., Fowden,A.L.,
            Burton,G.J., Branco,C.M., Sferruzzi-Perri,A.N. and Constancia,M.
  TITLE     The imprinted Igf2-Igf2r axis is critical for matching placental
            microvasculature expansion to fetal growth
  JOURNAL   Dev Cell 57 (1), 63-79 (2022)
   PUBMED   34963058
REFERENCE   2  (bases 1 to 1578)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1578)
  AUTHORS   Hong,L., Ai,J. and Ma,D.
  TITLE     Activation of Dusp14 protects against osteoclast generation and
            bone loss by regulating AMPKalpha-dependent manner
  JOURNAL   Biochem Biophys Res Commun 519 (3), 445-452 (2019)
   PUBMED   31526569
  REMARK    GeneRIF: Results indicate that dual specificity phosphatase 14
            (Dusp14) as an important molecular switch resulting in osteoporosis
            through an protein kinase AMP-activated alpha 1 catalytic subunit
            (AMPKalpha)-dependent manner.
REFERENCE   4  (bases 1 to 1578)
  AUTHORS   Celaya,A.M., Sanchez-Perez,I., Bermudez-Munoz,J.M., Rodriguez-de la
            Rosa,L., Pintado-Berninches,L., Perona,R., Murillo-Cuesta,S. and
            Varela-Nieto,I.
  TITLE     Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1)
            accelerates progressive hearing loss
  JOURNAL   Elife 8, e39159 (2019)
   PUBMED   30938680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1578)
  AUTHORS   Jianrong,S., Yanjun,Z., Chen,Y. and Jianwen,X.
  TITLE     DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by
            reducing inflammation and apoptosis via the activation of Nrf-2
  JOURNAL   Biochem Biophys Res Commun 509 (3), 713-721 (2019)
   PUBMED   30638656
  REMARK    GeneRIF: DUSP14 up-regulation inhibits inflammation and oxidative
            stress in brain of cerebral ischemia/reperfusion mice. DUSP14
            evokes Nrf-2-meditated anti-oxidative stress and inflammatory
            response.
REFERENCE   6  (bases 1 to 1578)
  AUTHORS   Roma-Mateo,C., Rios,P., Tabernero,L., Attwood,T.K. and Pulido,R.
  TITLE     A novel phosphatase family, structurally related to
            dual-specificity phosphatases, that displays unique amino acid
            sequence and substrate specificity
  JOURNAL   J Mol Biol 374 (4), 899-909 (2007)
   PUBMED   17976645
REFERENCE   7  (bases 1 to 1578)
  AUTHORS   Sanchez-Tillo,E., Comalada,M., Xaus,J., Farrera,C., Valledor,A.F.,
            Caelles,C., Lloberas,J. and Celada,A.
  TITLE     JNK1 Is required for the induction of Mkp1 expression in
            macrophages during proliferation and lipopolysaccharide-dependent
            activation
  JOURNAL   J Biol Chem 282 (17), 12566-12573 (2007)
   PUBMED   17337450
  REMARK    GeneRIF: critical role for JNK1 in the regulation of Mkp1 induction
            and in LPS-dependent macrophage activation.
REFERENCE   8  (bases 1 to 1578)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (bases 1 to 1578)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1578)
  AUTHORS   Marti,F., Krause,A., Post,N.H., Lyddane,C., Dupont,B., Sadelain,M.
            and King,P.D.
  TITLE     Negative-feedback regulation of CD28 costimulation by a novel
            mitogen-activated protein kinase phosphatase, MKP6
  JOURNAL   J Immunol 166 (1), 197-206 (2001)
   PUBMED   11123293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645615.14.
            
            On Jun 23, 2022 this sequence version replaced XM_006533796.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.8058815.1,
                                           SRR17253014.936675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AL645615.14        142293-142411       c
            120-219             AL645615.14        141702-141801       c
            220-308             AL645615.14        124053-124141       c
            309-1578            AL645615.14        121262-122531       c
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.29 cM"
     gene            1..1578
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="dual specificity phosphatase 14"
                     /db_xref="GeneID:56405"
                     /db_xref="MGI:MGI:1927168"
     exon            1..119
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     exon            120..219
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     exon            220..308
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1578
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1002
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP kinase phosphatase 6; mitogen-activated protein
                     kinase phosphatase 6; Mkp-1 like protein tyrosine
                     phosphatase; MAP kinase phsophatase 6"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 14"
                     /protein_id="NP_001395675.1"
                     /db_xref="GeneID:56405"
                     /db_xref="MGI:MGI:1927168"
                     /translation="MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRASVASN
                     WHLLQARGITCVINATIEIPNFNWPQFEYVKVPLADIPHAPIRLYFDTVADKIHSVSK
                     KHGATLVHCAAGVSRSATLCIAYLMKFHNLCLLEAYNWVKARRPVIRPNLGFWRQLID
                     YESQLFGKSSVKMVQTPYGIIPDVYEKESRHLMPYWGI"
     regulatory      1559..1564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="hexamer: AATAAA"
     polyA_site      1578
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="major polyA site"
ORIGIN      
        1 gagtctgact cactgcagag gctggaggaa gtcgttccta ccgcccctgt atcgcccctc
       61 agttttgcga agagaagagt agggtggcgc taaagtcagt ttgcatccat tcatttcagt
      121 tgcctctctg catttggaca gattcttcga acgccagctc agaagctggg ccggaggaca
      181 acgcggcttc aaggagcagg ggtctgcgag taagtccaga tctgatttgt actcactgta
      241 acaagcaccg ctcccaagac cttctggatc cagacccagg gctccagctc cctggaaatc
      301 cttagcacga aggaggctgc agtcttggat tccctggtgg aggacggact ccactgctct
      361 ctggtcttgc cccctgatga tgatagtgtg accactggca tcttcatgag ctccagaggt
      421 cacagcacgc tcccacggac tctcatggcc cctcggatga tttccgaggg agacatagga
      481 ggcattgctc agatcacctc ctctctcttc ttgggcagag ccagcgtggc ctccaactgg
      541 cacctcctcc aggcccgcgg catcacctgc gtcatcaatg ccaccatcga gatccccaac
      601 ttcaactggc cccagtttga atatgttaaa gtgcctctgg ctgacattcc tcatgccccc
      661 attagactgt actttgacac tgtggccgac aagatccaca gtgtgagcaa gaagcacggg
      721 gctaccttgg tgcactgtgc ggcaggcgtg agccgctcgg ccaccctctg tattgcgtac
      781 ctgatgaaat tccacaatct gtgcctgttg gaggcataca actgggtgaa agcccggagg
      841 cctgtcatca ggcccaacct gggcttctgg aggcagctga tagactacga gagccagctc
      901 tttgggaagt cttcagttaa gatggtacag acaccctatg gcatcatccc agacgtttat
      961 gagaaggagt cccgacactt gatgccttat tgggggattt agtgttgcca cagctggcat
     1021 ccacagcccc tcagcagtac cagcatctgc cacacaccat ctgttcccct cttcctctct
     1081 ctctggttct cccgagaggg tttctacgct gggtgttcgg gtttaagaga tggggagggg
     1141 aaatacgtgc gttgcctgtg acgtttttta aaactagcat tttgaaatag tgaacatgga
     1201 aatctttaac tggcctttaa tcatttgtaa cagctggacc agtgtaggac acctttcctg
     1261 ctttctttct ggctcctgac ttttaagagc cttagcaggt gcagtaggag ctcattgctc
     1321 agttctggtc ctgattaacc ctctagagac cagctttgcc aagggctgca ggctggtcgg
     1381 tttaaggaag atcaagggca gctcagtccc tacaggatta gcctggtcct tttcctctgt
     1441 tatttgattc tataagttaa gttcattgtt gtttagttga taagtggtta tgataaaaat
     1501 ctgttgcaaa gaccctcttg aaattagtgt gccctgggat cacattagcg ttatttttaa
     1561 taaacttgct taacataa
//
