LOCUS       NM_001408745            1477 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus dual specificity phosphatase 14 (Dusp14), transcript
            variant 6, mRNA.
ACCESSION   NM_001408745 XM_006533798
VERSION     NM_001408745.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1477)
  AUTHORS   Sandovici,I., Georgopoulou,A., Perez-Garcia,V., Hufnagel,A.,
            Lopez-Tello,J., Lam,B.Y.H., Schiefer,S.N., Gaudreau,C., Santos,F.,
            Hoelle,K., Yeo,G.S.H., Burling,K., Reiterer,M., Fowden,A.L.,
            Burton,G.J., Branco,C.M., Sferruzzi-Perri,A.N. and Constancia,M.
  TITLE     The imprinted Igf2-Igf2r axis is critical for matching placental
            microvasculature expansion to fetal growth
  JOURNAL   Dev Cell 57 (1), 63-79 (2022)
   PUBMED   34963058
REFERENCE   2  (bases 1 to 1477)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1477)
  AUTHORS   Hong,L., Ai,J. and Ma,D.
  TITLE     Activation of Dusp14 protects against osteoclast generation and
            bone loss by regulating AMPKalpha-dependent manner
  JOURNAL   Biochem Biophys Res Commun 519 (3), 445-452 (2019)
   PUBMED   31526569
  REMARK    GeneRIF: Results indicate that dual specificity phosphatase 14
            (Dusp14) as an important molecular switch resulting in osteoporosis
            through an protein kinase AMP-activated alpha 1 catalytic subunit
            (AMPKalpha)-dependent manner.
REFERENCE   4  (bases 1 to 1477)
  AUTHORS   Celaya,A.M., Sanchez-Perez,I., Bermudez-Munoz,J.M., Rodriguez-de la
            Rosa,L., Pintado-Berninches,L., Perona,R., Murillo-Cuesta,S. and
            Varela-Nieto,I.
  TITLE     Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1)
            accelerates progressive hearing loss
  JOURNAL   Elife 8, e39159 (2019)
   PUBMED   30938680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1477)
  AUTHORS   Jianrong,S., Yanjun,Z., Chen,Y. and Jianwen,X.
  TITLE     DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by
            reducing inflammation and apoptosis via the activation of Nrf-2
  JOURNAL   Biochem Biophys Res Commun 509 (3), 713-721 (2019)
   PUBMED   30638656
  REMARK    GeneRIF: DUSP14 up-regulation inhibits inflammation and oxidative
            stress in brain of cerebral ischemia/reperfusion mice. DUSP14
            evokes Nrf-2-meditated anti-oxidative stress and inflammatory
            response.
REFERENCE   6  (bases 1 to 1477)
  AUTHORS   Roma-Mateo,C., Rios,P., Tabernero,L., Attwood,T.K. and Pulido,R.
  TITLE     A novel phosphatase family, structurally related to
            dual-specificity phosphatases, that displays unique amino acid
            sequence and substrate specificity
  JOURNAL   J Mol Biol 374 (4), 899-909 (2007)
   PUBMED   17976645
REFERENCE   7  (bases 1 to 1477)
  AUTHORS   Sanchez-Tillo,E., Comalada,M., Xaus,J., Farrera,C., Valledor,A.F.,
            Caelles,C., Lloberas,J. and Celada,A.
  TITLE     JNK1 Is required for the induction of Mkp1 expression in
            macrophages during proliferation and lipopolysaccharide-dependent
            activation
  JOURNAL   J Biol Chem 282 (17), 12566-12573 (2007)
   PUBMED   17337450
  REMARK    GeneRIF: critical role for JNK1 in the regulation of Mkp1 induction
            and in LPS-dependent macrophage activation.
REFERENCE   8  (bases 1 to 1477)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (bases 1 to 1477)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1477)
  AUTHORS   Marti,F., Krause,A., Post,N.H., Lyddane,C., Dupont,B., Sadelain,M.
            and King,P.D.
  TITLE     Negative-feedback regulation of CD28 costimulation by a novel
            mitogen-activated protein kinase phosphatase, MKP6
  JOURNAL   J Immunol 166 (1), 197-206 (2001)
   PUBMED   11123293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645615.14.
            
            On Jun 23, 2022 this sequence version replaced XM_006533798.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784651.911115.1,
                                           SRR17253013.1919658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL645615.14        141996-142013       c
            19-118              AL645615.14        141702-141801       c
            119-207             AL645615.14        124053-124141       c
            208-1477            AL645615.14        121262-122531       c
FEATURES             Location/Qualifiers
     source          1..1477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.29 cM"
     gene            1..1477
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="dual specificity phosphatase 14"
                     /db_xref="GeneID:56405"
                     /db_xref="MGI:MGI:1927168"
     exon            1..18
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     exon            19..118
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     exon            119..207
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     exon            208..1477
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..901
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP kinase phosphatase 6; mitogen-activated protein
                     kinase phosphatase 6; Mkp-1 like protein tyrosine
                     phosphatase; MAP kinase phsophatase 6"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 14"
                     /protein_id="NP_001395674.1"
                     /db_xref="GeneID:56405"
                     /db_xref="MGI:MGI:1927168"
                     /translation="MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRASVASN
                     WHLLQARGITCVINATIEIPNFNWPQFEYVKVPLADIPHAPIRLYFDTVADKIHSVSK
                     KHGATLVHCAAGVSRSATLCIAYLMKFHNLCLLEAYNWVKARRPVIRPNLGFWRQLID
                     YESQLFGKSSVKMVQTPYGIIPDVYEKESRHLMPYWGI"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="hexamer: AATAAA"
     polyA_site      1477
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="major polyA site"
ORIGIN      
        1 agaggcaggc gagtctcttt gcctctctgc atttggacag attcttcgaa cgccagctca
       61 gaagctgggc cggaggacaa cgcggcttca aggagcaggg gtctgcgagt aagtccagat
      121 ctgatttgta ctcactgtaa caagcaccgc tcccaagacc ttctggatcc agacccaggg
      181 ctccagctcc ctggaaatcc ttagcacgaa ggaggctgca gtcttggatt ccctggtgga
      241 ggacggactc cactgctctc tggtcttgcc ccctgatgat gatagtgtga ccactggcat
      301 cttcatgagc tccagaggtc acagcacgct cccacggact ctcatggccc ctcggatgat
      361 ttccgaggga gacataggag gcattgctca gatcacctcc tctctcttct tgggcagagc
      421 cagcgtggcc tccaactggc acctcctcca ggcccgcggc atcacctgcg tcatcaatgc
      481 caccatcgag atccccaact tcaactggcc ccagtttgaa tatgttaaag tgcctctggc
      541 tgacattcct catgccccca ttagactgta ctttgacact gtggccgaca agatccacag
      601 tgtgagcaag aagcacgggg ctaccttggt gcactgtgcg gcaggcgtga gccgctcggc
      661 caccctctgt attgcgtacc tgatgaaatt ccacaatctg tgcctgttgg aggcatacaa
      721 ctgggtgaaa gcccggaggc ctgtcatcag gcccaacctg ggcttctgga ggcagctgat
      781 agactacgag agccagctct ttgggaagtc ttcagttaag atggtacaga caccctatgg
      841 catcatccca gacgtttatg agaaggagtc ccgacacttg atgccttatt gggggattta
      901 gtgttgccac agctggcatc cacagcccct cagcagtacc agcatctgcc acacaccatc
      961 tgttcccctc ttcctctctc tctggttctc ccgagagggt ttctacgctg ggtgttcggg
     1021 tttaagagat ggggagggga aatacgtgcg ttgcctgtga cgttttttaa aactagcatt
     1081 ttgaaatagt gaacatggaa atctttaact ggcctttaat catttgtaac agctggacca
     1141 gtgtaggaca cctttcctgc tttctttctg gctcctgact tttaagagcc ttagcaggtg
     1201 cagtaggagc tcattgctca gttctggtcc tgattaaccc tctagagacc agctttgcca
     1261 agggctgcag gctggtcggt ttaaggaaga tcaagggcag ctcagtccct acaggattag
     1321 cctggtcctt ttcctctgtt atttgattct ataagttaag ttcattgttg tttagttgat
     1381 aagtggttat gataaaaatc tgttgcaaag accctcttga aattagtgtg ccctgggatc
     1441 acattagcgt tatttttaat aaacttgctt aacataa
//
