LOCUS       NM_001408743            1453 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus dual specificity phosphatase 14 (Dusp14), transcript
            variant 4, mRNA.
ACCESSION   NM_001408743
VERSION     NM_001408743.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Sandovici,I., Georgopoulou,A., Perez-Garcia,V., Hufnagel,A.,
            Lopez-Tello,J., Lam,B.Y.H., Schiefer,S.N., Gaudreau,C., Santos,F.,
            Hoelle,K., Yeo,G.S.H., Burling,K., Reiterer,M., Fowden,A.L.,
            Burton,G.J., Branco,C.M., Sferruzzi-Perri,A.N. and Constancia,M.
  TITLE     The imprinted Igf2-Igf2r axis is critical for matching placental
            microvasculature expansion to fetal growth
  JOURNAL   Dev Cell 57 (1), 63-79 (2022)
   PUBMED   34963058
REFERENCE   2  (bases 1 to 1453)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1453)
  AUTHORS   Hong,L., Ai,J. and Ma,D.
  TITLE     Activation of Dusp14 protects against osteoclast generation and
            bone loss by regulating AMPKalpha-dependent manner
  JOURNAL   Biochem Biophys Res Commun 519 (3), 445-452 (2019)
   PUBMED   31526569
  REMARK    GeneRIF: Results indicate that dual specificity phosphatase 14
            (Dusp14) as an important molecular switch resulting in osteoporosis
            through an protein kinase AMP-activated alpha 1 catalytic subunit
            (AMPKalpha)-dependent manner.
REFERENCE   4  (bases 1 to 1453)
  AUTHORS   Celaya,A.M., Sanchez-Perez,I., Bermudez-Munoz,J.M., Rodriguez-de la
            Rosa,L., Pintado-Berninches,L., Perona,R., Murillo-Cuesta,S. and
            Varela-Nieto,I.
  TITLE     Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1)
            accelerates progressive hearing loss
  JOURNAL   Elife 8, e39159 (2019)
   PUBMED   30938680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1453)
  AUTHORS   Jianrong,S., Yanjun,Z., Chen,Y. and Jianwen,X.
  TITLE     DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by
            reducing inflammation and apoptosis via the activation of Nrf-2
  JOURNAL   Biochem Biophys Res Commun 509 (3), 713-721 (2019)
   PUBMED   30638656
  REMARK    GeneRIF: DUSP14 up-regulation inhibits inflammation and oxidative
            stress in brain of cerebral ischemia/reperfusion mice. DUSP14
            evokes Nrf-2-meditated anti-oxidative stress and inflammatory
            response.
REFERENCE   6  (bases 1 to 1453)
  AUTHORS   Roma-Mateo,C., Rios,P., Tabernero,L., Attwood,T.K. and Pulido,R.
  TITLE     A novel phosphatase family, structurally related to
            dual-specificity phosphatases, that displays unique amino acid
            sequence and substrate specificity
  JOURNAL   J Mol Biol 374 (4), 899-909 (2007)
   PUBMED   17976645
REFERENCE   7  (bases 1 to 1453)
  AUTHORS   Sanchez-Tillo,E., Comalada,M., Xaus,J., Farrera,C., Valledor,A.F.,
            Caelles,C., Lloberas,J. and Celada,A.
  TITLE     JNK1 Is required for the induction of Mkp1 expression in
            macrophages during proliferation and lipopolysaccharide-dependent
            activation
  JOURNAL   J Biol Chem 282 (17), 12566-12573 (2007)
   PUBMED   17337450
  REMARK    GeneRIF: critical role for JNK1 in the regulation of Mkp1 induction
            and in LPS-dependent macrophage activation.
REFERENCE   8  (bases 1 to 1453)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (bases 1 to 1453)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1453)
  AUTHORS   Marti,F., Krause,A., Post,N.H., Lyddane,C., Dupont,B., Sadelain,M.
            and King,P.D.
  TITLE     Negative-feedback regulation of CD28 costimulation by a novel
            mitogen-activated protein kinase phosphatase, MKP6
  JOURNAL   J Immunol 166 (1), 197-206 (2001)
   PUBMED   11123293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645615.14.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052836.1, AK166840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL645615.14        141702-141795       c
            95-183              AL645615.14        124053-124141       c
            184-1453            AL645615.14        121262-122531       c
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.29 cM"
     gene            1..1453
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="dual specificity phosphatase 14"
                     /db_xref="GeneID:56405"
                     /db_xref="MGI:MGI:1927168"
     exon            1..94
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     exon            95..183
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     exon            184..1453
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..877
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP kinase phosphatase 6; mitogen-activated protein
                     kinase phosphatase 6; Mkp-1 like protein tyrosine
                     phosphatase; MAP kinase phsophatase 6"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 14"
                     /protein_id="NP_001395672.1"
                     /db_xref="GeneID:56405"
                     /db_xref="MGI:MGI:1927168"
                     /translation="MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRASVASN
                     WHLLQARGITCVINATIEIPNFNWPQFEYVKVPLADIPHAPIRLYFDTVADKIHSVSK
                     KHGATLVHCAAGVSRSATLCIAYLMKFHNLCLLEAYNWVKARRPVIRPNLGFWRQLID
                     YESQLFGKSSVKMVQTPYGIIPDVYEKESRHLMPYWGI"
     regulatory      1434..1439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="hexamer: AATAAA"
     polyA_site      1453
                     /gene="Dusp14"
                     /gene_synonym="1110014C10Rik; 2310042C07Rik; D11Ertd395e;
                     MKP-L; Mkp6"
                     /note="major polyA site"
ORIGIN      
        1 ctctgcattt ggacagattc ttcgaacgcc agctcagaag ctgggccgga ggacaacgcg
       61 gcttcaagga gcaggggtct gcgagtaagt ccagatctga tttgtactca ctgtaacaag
      121 caccgctccc aagaccttct ggatccagac ccagggctcc agctccctgg aaatccttag
      181 cacgaaggag gctgcagtct tggattccct ggtggaggac ggactccact gctctctggt
      241 cttgccccct gatgatgata gtgtgaccac tggcatcttc atgagctcca gaggtcacag
      301 cacgctccca cggactctca tggcccctcg gatgatttcc gagggagaca taggaggcat
      361 tgctcagatc acctcctctc tcttcttggg cagagccagc gtggcctcca actggcacct
      421 cctccaggcc cgcggcatca cctgcgtcat caatgccacc atcgagatcc ccaacttcaa
      481 ctggccccag tttgaatatg ttaaagtgcc tctggctgac attcctcatg cccccattag
      541 actgtacttt gacactgtgg ccgacaagat ccacagtgtg agcaagaagc acggggctac
      601 cttggtgcac tgtgcggcag gcgtgagccg ctcggccacc ctctgtattg cgtacctgat
      661 gaaattccac aatctgtgcc tgttggaggc atacaactgg gtgaaagccc ggaggcctgt
      721 catcaggccc aacctgggct tctggaggca gctgatagac tacgagagcc agctctttgg
      781 gaagtcttca gttaagatgg tacagacacc ctatggcatc atcccagacg tttatgagaa
      841 ggagtcccga cacttgatgc cttattgggg gatttagtgt tgccacagct ggcatccaca
      901 gcccctcagc agtaccagca tctgccacac accatctgtt cccctcttcc tctctctctg
      961 gttctcccga gagggtttct acgctgggtg ttcgggttta agagatgggg aggggaaata
     1021 cgtgcgttgc ctgtgacgtt ttttaaaact agcattttga aatagtgaac atggaaatct
     1081 ttaactggcc tttaatcatt tgtaacagct ggaccagtgt aggacacctt tcctgctttc
     1141 tttctggctc ctgactttta agagccttag caggtgcagt aggagctcat tgctcagttc
     1201 tggtcctgat taaccctcta gagaccagct ttgccaaggg ctgcaggctg gtcggtttaa
     1261 ggaagatcaa gggcagctca gtccctacag gattagcctg gtccttttcc tctgttattt
     1321 gattctataa gttaagttca ttgttgttta gttgataagt ggttatgata aaaatctgtt
     1381 gcaaagaccc tcttgaaatt agtgtgccct gggatcacat tagcgttatt tttaataaac
     1441 ttgcttaaca taa
//
