LOCUS       NM_023173               1413 bp    mRNA    linear   ROD 20-MAY-2024
DEFINITION  Mus musculus dual specificity phosphatase 12 (Dusp12), transcript
            variant 1, mRNA.
ACCESSION   NM_023173
VERSION     NM_023173.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   He,J., Li,S., Teng,Y., Xiong,H., Wang,Z., Han,X., Gong,W. and
            Gao,Y.
  TITLE     Increasing expression of dual-specificity phosphatase 12 mitigates
            oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis
            and inflammation through inactivation of the ASK1-JNK/p38 MAPK
            pathway
  JOURNAL   Autoimmunity 57 (1), 2345919 (2024)
   PUBMED   38721693
  REMARK    GeneRIF: Increasing expression of dual-specificity phosphatase 12
            mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal
            apoptosis and inflammation through inactivation of the ASK1-JNK/p38
            MAPK pathway.
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Li,H., Yang,Q., Huang,Z., Liang,C., Zhang,D.H., Shi,H.T., Du,J.Q.,
            Du,B.B. and Zhang,Y.Z.
  TITLE     Dual-specificity phosphatase 12 attenuates oxidative stress injury
            and apoptosis in diabetic cardiomyopathy via the ASK1-JNK/p38
            signaling pathway
  JOURNAL   Free Radic Biol Med 192, 13-24 (2022)
   PUBMED   36108935
  REMARK    GeneRIF: Dual-specificity phosphatase 12 attenuates oxidative
            stress injury and apoptosis in diabetic cardiomyopathy via the
            ASK1-JNK/p38 signaling pathway.
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Boldorini,R., Clemente,N., Alchera,E. and Carini,R.
  TITLE     DUSP12 acts as a novel endogenous protective signal against hepatic
            ischemia-reperfusion damage by inhibiting ASK1 pathway
  JOURNAL   Clin Sci (Lond) 135 (1), 161-166 (2021)
   PUBMED   33416082
  REMARK    GeneRIF: DUSP12 acts as a novel endogenous protective signal
            against hepatic ischemia-reperfusion damage by inhibiting ASK1
            pathway.
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Qiu,T., Wang,T., Zhou,J., Chen,Z., Zou,J., Zhang,L. and Ma,X.
  TITLE     DUSP12 protects against hepatic ischemia-reperfusion injury
            dependent on ASK1-JNK/p38 pathway in vitro and in vivo
  JOURNAL   Clin Sci (Lond) 134 (17), 2279-2294 (2020)
   PUBMED   32803262
  REMARK    GeneRIF: DUSP12 protects against hepatic ischemia-reperfusion
            injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo.
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Li,W.M., Zhao,Y.F., Zhu,G.F., Peng,W.H., Zhu,M.Y., Yu,X.J.,
            Chen,W., Xu,D.C. and Xu,Y.W.
  TITLE     Dual specific phosphatase 12 ameliorates cardiac hypertrophy in
            response to pressure overload
  JOURNAL   Clin Sci (Lond) 131 (2), 141-154 (2017)
   PUBMED   27702885
  REMARK    GeneRIF: The regulatory role of DUSP12 is primarily through c-Jun
            N-terminal kinase (JNK) inhibition.
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Zhang,X.M., Dormady,S.P., Chaung,W. and Basch,R.S.
  TITLE     mVH1, a dual-specificity phosphatase whose expression is cell cycle
            regulated
  JOURNAL   Mamm Genome 11 (12), 1154-1156 (2000)
   PUBMED   11130991
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099453.1.
            
            On Jul 13, 2005 this sequence version replaced NM_023173.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099453.1, AF280810.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 77.27 cM"
     gene            1..1413
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /note="dual specificity phosphatase 12"
                     /db_xref="GeneID:80915"
                     /db_xref="MGI:MGI:1890614"
     exon            1..474
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1153
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity protein phosphatase 12; dual specificity
                     phosphatase VH1; dual specificity phosphatase T-DSP4"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 12 isoform
                     1"
                     /protein_id="NP_075662.2"
                     /db_xref="CCDS:CCDS15474.1"
                     /db_xref="GeneID:80915"
                     /db_xref="MGI:MGI:1890614"
                     /translation="MLEAQGSNHGCERQAPTASPASSAGHAVEVRPGLYLGGAAAVAE
                     PGHLREAGITAVLTVDSEPAFPAGAGFEGLRSLFVPALDKPETDLLSHLDRCVAFIGQ
                     ARSEGRAVLVHCHAGVSRSVAVVMAFIMKTDQLTFEKAYDILRTVKPEAKVNEGFEWQ
                     LKLYEAMGYEVDTSSAFYKQYRLQKVTEKCPKLWNLPQELFAVDPTTISQGLKDDILY
                     KCRKCRRSLFRHSSILGHSEGSGPIAFAHKRTAPSSVLTTGSQAQCTSYFIEPVQWME
                     STLLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWITPAFQIHKNRVDEMKMLPVLGS
                     QTKKL"
     exon            475..588
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..707
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..804
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..991
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1374
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /note="hexamer: ATTAAA"
     polyA_site      1374
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcattt tccctattgc catggtcctc ccacggcgct gctgagcggc tggagctatt
       61 ccgacacagg agtcagtcac tctagccggt gacttggtgg cgggcagcgg ctgcctggct
      121 tcctggctct gccatgttgg aagcgcaggg ttctaaccat ggctgcgagc gccaggctcc
      181 gactgccagt cccgccagct cggcagggca cgccgtggaa gtgcggcccg ggctgtatct
      241 gggtggggca gcggcagtgg cggaaccggg ccatctgagg gaggcgggca tcaccgccgt
      301 gctgacggtg gactctgaac cggctttccc ggctggggct gggttcgaag gtctccggag
      361 cctcttcgtg ccggcgctgg acaaacccga gaccgacctg ctcagccacc tggatcgctg
      421 cgtggccttc atcggccagg ctcgctccga aggccgcgcg gtgttggtgc actgtcatgc
      481 aggagtcagt cgcagtgttg ctgtagtgat ggcttttata atgaagaccg accagcttac
      541 ctttgaaaaa gcctacgaca tcctccggac ggtcaagcca gaggctaaag tgaatgaggg
      601 gtttgaatgg caactgaaac tgtatgaggc aatgggatac gaagtcgata cgtccagtgc
      661 cttttacaag cagtaccgtt tacaaaaggt gactgagaag tgtccaaaac tttggaattt
      721 acctcaggaa ctcttcgctg ttgacccaac taccatttca cagggattaa aagatgacat
      781 tctctacaaa tgcagaaaat gcaggcggtc tttatttaga cattctagta ttttgggtca
      841 tagtgaagga agtgggccaa tagcctttgc tcacaagaga acggcgccat cttctgtact
      901 taccacaggg agtcaggctc agtgcacgtc ttacttcatt gagcctgtgc agtggatgga
      961 atctactctg ttgggcgtta tggatggaca gcttctttgc ccaaaatgca gtgccaagtt
     1021 gggttccttt aactggtatg gtgaacagtg ctcctgtggt cgatggataa cccctgcttt
     1081 tcaaatacac aagaacagag tggatgaaat gaaaatgttg ccggtgctgg gatcacagac
     1141 aaagaagctg tgaacttagg acccagcttg ggctagatcc tgtgaaaggc acttccccgt
     1201 tgtcatcatt catggtggat gtcaaacttc ttttggaatg tccaaagaca gttactgact
     1261 gtaacagctg tgggttggta gcttattatg tggcatatat acagttacgt tgcttggcaa
     1321 ttcagatatt tagttatgta agttggattt gttattaaaa tcttttataa cccaaaaaaa
     1381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
