LOCUS       NM_001356486            1388 bp    mRNA    linear   ROD 20-MAY-2024
DEFINITION  Mus musculus dual specificity phosphatase 12 (Dusp12), transcript
            variant 3, mRNA.
ACCESSION   NM_001356486 XM_006497042
VERSION     NM_001356486.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1388)
  AUTHORS   He,J., Li,S., Teng,Y., Xiong,H., Wang,Z., Han,X., Gong,W. and
            Gao,Y.
  TITLE     Increasing expression of dual-specificity phosphatase 12 mitigates
            oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis
            and inflammation through inactivation of the ASK1-JNK/p38 MAPK
            pathway
  JOURNAL   Autoimmunity 57 (1), 2345919 (2024)
   PUBMED   38721693
  REMARK    GeneRIF: Increasing expression of dual-specificity phosphatase 12
            mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal
            apoptosis and inflammation through inactivation of the ASK1-JNK/p38
            MAPK pathway.
REFERENCE   2  (bases 1 to 1388)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1388)
  AUTHORS   Li,H., Yang,Q., Huang,Z., Liang,C., Zhang,D.H., Shi,H.T., Du,J.Q.,
            Du,B.B. and Zhang,Y.Z.
  TITLE     Dual-specificity phosphatase 12 attenuates oxidative stress injury
            and apoptosis in diabetic cardiomyopathy via the ASK1-JNK/p38
            signaling pathway
  JOURNAL   Free Radic Biol Med 192, 13-24 (2022)
   PUBMED   36108935
  REMARK    GeneRIF: Dual-specificity phosphatase 12 attenuates oxidative
            stress injury and apoptosis in diabetic cardiomyopathy via the
            ASK1-JNK/p38 signaling pathway.
REFERENCE   4  (bases 1 to 1388)
  AUTHORS   Boldorini,R., Clemente,N., Alchera,E. and Carini,R.
  TITLE     DUSP12 acts as a novel endogenous protective signal against hepatic
            ischemia-reperfusion damage by inhibiting ASK1 pathway
  JOURNAL   Clin Sci (Lond) 135 (1), 161-166 (2021)
   PUBMED   33416082
  REMARK    GeneRIF: DUSP12 acts as a novel endogenous protective signal
            against hepatic ischemia-reperfusion damage by inhibiting ASK1
            pathway.
REFERENCE   5  (bases 1 to 1388)
  AUTHORS   Qiu,T., Wang,T., Zhou,J., Chen,Z., Zou,J., Zhang,L. and Ma,X.
  TITLE     DUSP12 protects against hepatic ischemia-reperfusion injury
            dependent on ASK1-JNK/p38 pathway in vitro and in vivo
  JOURNAL   Clin Sci (Lond) 134 (17), 2279-2294 (2020)
   PUBMED   32803262
  REMARK    GeneRIF: DUSP12 protects against hepatic ischemia-reperfusion
            injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo.
REFERENCE   6  (bases 1 to 1388)
  AUTHORS   Li,W.M., Zhao,Y.F., Zhu,G.F., Peng,W.H., Zhu,M.Y., Yu,X.J.,
            Chen,W., Xu,D.C. and Xu,Y.W.
  TITLE     Dual specific phosphatase 12 ameliorates cardiac hypertrophy in
            response to pressure overload
  JOURNAL   Clin Sci (Lond) 131 (2), 141-154 (2017)
   PUBMED   27702885
  REMARK    GeneRIF: The regulatory role of DUSP12 is primarily through c-Jun
            N-terminal kinase (JNK) inhibition.
REFERENCE   7  (bases 1 to 1388)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1388)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
REFERENCE   9  (bases 1 to 1388)
  AUTHORS   Zhang,X.M., Dormady,S.P., Chaung,W. and Basch,R.S.
  TITLE     mVH1, a dual-specificity phosphatase whose expression is cell cycle
            regulated
  JOURNAL   Mamm Genome 11 (12), 1154-1156 (2000)
   PUBMED   11130991
REFERENCE   10 (bases 1 to 1388)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113490.10.
            
            On Oct 5, 2017 this sequence version replaced XM_006497042.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU512353.1, ERR2680377.68460.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               AC113490.10        36099-36572
            475-601             AC113490.10        40598-40724
            602-720             AC113490.10        40948-41066
            721-817             AC113490.10        41413-41509
            818-1004            AC113490.10        41793-41979
            1005-1388           AC113490.10        47069-47452
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 77.27 cM"
     gene            1..1388
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /note="dual specificity phosphatase 12"
                     /db_xref="GeneID:80915"
                     /db_xref="MGI:MGI:1890614"
     exon            1..474
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..601
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..1166
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 3 is encoded by transcript variant 3; dual
                     specificity protein phosphatase 12; dual specificity
                     phosphatase VH1; dual specificity phosphatase T-DSP4"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 12 isoform
                     3"
                     /protein_id="NP_001343415.1"
                     /db_xref="GeneID:80915"
                     /db_xref="MGI:MGI:1890614"
                     /translation="MAFIMKTDQLTFEKAYDILRTVKPEAKVNEGFEWQLKLYEAMGY
                     EVDTSSAFYKQYRLQKVTEKCPKLWNLPQELFAVDPTTISQGLKDDILYKCRKCRRSL
                     FRHSSILGHSEGSGPIAFAHKRTAPSSVLTTGSQAQCTSYFIEPVQWMESTLLGVMDG
                     QLLCPKCSAKLGSFNWYGEQCSCGRWITPAFQIHKNRVDEMKMLPVLGSQTKKL"
     exon            602..720
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..817
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1004
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1388
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /note="hexamer: ATTAAA"
     polyA_site      1387
                     /gene="Dusp12"
                     /gene_synonym="1190004O14Rik; ESTM36; LMW-DSP4; mVH1;
                     T-DSP4; VH1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcattt tccctattgc catggtcctc ccacggcgct gctgagcggc tggagctatt
       61 ccgacacagg agtcagtcac tctagccggt gacttggtgg cgggcagcgg ctgcctggct
      121 tcctggctct gccatgttgg aagcgcaggg ttctaaccat ggctgcgagc gccaggctcc
      181 gactgccagt cccgccagct cggcagggca cgccgtggaa gtgcggcccg ggctgtatct
      241 gggtggggca gcggcagtgg cggaaccggg ccatctgagg gaggcgggca tcaccgccgt
      301 gctgacggtg gactctgaac cggctttccc ggctggggct gggttcgaag gtctccggag
      361 cctcttcgtg ccggcgctgg acaaacccga gaccgacctg ctcagccacc tggatcgctg
      421 cgtggccttc atcggccagg ctcgctccga aggccgcgcg gtgttggtgc actggtctct
      481 ttttcagtca tgcaggagtc agtcgcagtg ttgctgtagt gatggctttt ataatgaaga
      541 ccgaccagct tacctttgaa aaagcctacg acatcctccg gacggtcaag ccagaggcta
      601 aagtgaatga ggggtttgaa tggcaactga aactgtatga ggcaatggga tacgaagtcg
      661 atacgtccag tgccttttac aagcagtacc gtttacaaaa ggtgactgag aagtgtccaa
      721 aactttggaa tttacctcag gaactcttcg ctgttgaccc aactaccatt tcacagggat
      781 taaaagatga cattctctac aaatgcagaa aatgcaggcg gtctttattt agacattcta
      841 gtattttggg tcatagtgaa ggaagtgggc caatagcctt tgctcacaag agaacggcgc
      901 catcttctgt acttaccaca gggagtcagg ctcagtgcac gtcttacttc attgagcctg
      961 tgcagtggat ggaatctact ctgttgggcg ttatggatgg acagcttctt tgcccaaaat
     1021 gcagtgccaa gttgggttcc tttaactggt atggtgaaca gtgctcctgt ggtcgatgga
     1081 taacccctgc ttttcaaata cacaagaaca gagtggatga aatgaaaatg ttgccggtgc
     1141 tgggatcaca gacaaagaag ctgtgaactt aggacccagc ttgggctaga tcctgtgaaa
     1201 ggcacttccc cgttgtcatc attcatggtg gatgtcaaac ttcttttgga atgtccaaag
     1261 acagttactg actgtaacag ctgtgggttg gtagcttatt atgtggcata tatacagtta
     1321 cgttgcttgg caattcagat atttagttat gtaagttgga tttgttatta aaatctttta
     1381 taacccag
//
