LOCUS       NM_028099               6445 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dual specificity phosphatase 11 (RNA/RNP complex
            1-interacting) (Dusp11), mRNA.
ACCESSION   NM_028099
VERSION     NM_028099.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6445)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6445)
  AUTHORS   Choi,J.H., Burke,J.M., Szymanik,K.H., Nepal,U., Battenhouse,A.,
            Lau,J.T., Stark,A., Lam,V. and Sullivan,C.S.
  TITLE     DUSP11-mediated control of 5'-triphosphate RNA regulates RIG-I
            sensitivity
  JOURNAL   Genes Dev 34 (23-24), 1697-1712 (2020)
   PUBMED   33184222
REFERENCE   3  (bases 1 to 6445)
  AUTHORS   Yang,C.Y., Chuang,H.C., Tsai,C.Y., Xiao,Y.Z., Yang,J.Y.,
            Huang,R.H., Shih,Y.C. and Tan,T.H.
  TITLE     DUSP11 Attenuates Lipopolysaccharide-Induced Macrophage Activation
            by Targeting TAK1
  JOURNAL   J Immunol 205 (6), 1644-1652 (2020)
   PUBMED   32796023
REFERENCE   4  (bases 1 to 6445)
  AUTHORS   Celaya,A.M., Sanchez-Perez,I., Bermudez-Munoz,J.M., Rodriguez-de la
            Rosa,L., Pintado-Berninches,L., Perona,R., Murillo-Cuesta,S. and
            Varela-Nieto,I.
  TITLE     Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1)
            accelerates progressive hearing loss
  JOURNAL   Elife 8, e39159 (2019)
   PUBMED   30938680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6445)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 6445)
  AUTHORS   Aoki,N., Aoyama,K., Nagata,M. and Matsuda,T.
  TITLE     A growing family of dual specificity phosphatases with low
            molecular masses
  JOURNAL   J Biochem 130 (1), 133-140 (2001)
   PUBMED   11432789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB613140.1, BC067028.1, AK089506.1 and BC055282.1.
            
            On Apr 9, 2010 this sequence version replaced NM_028099.3.
            
            CCDS Note: The coding region has been updated to shorten the
            N-terminus to one that is more supported by available transcript
            data. Although this CDS may be partial, as suggested by comparison
            to the related human protein, there is no unambiguous mouse
            transcript support for an extension of the N-terminus.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067028.1, AK081629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BB613140.1         2-47
            47-2542             BC067028.1         1-2496
            2543-4217           BC067028.1         2498-4172
            4218-5281           AK089506.1         172-1235
            5282-6445           BC055282.1         109-1272
FEATURES             Location/Qualifiers
     source          1..6445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.54 cM"
     gene            1..6445
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /note="dual specificity phosphatase 11 (RNA/RNP complex
                     1-interacting)"
                     /db_xref="GeneID:72102"
                     /db_xref="MGI:MGI:1919352"
     exon            1..230
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1098
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /EC_number="3.1.3.48"
                     /note="phosphatase that interacts with RNA/RNP complex 1"
                     /codon_start=1
                     /product="RNA/RNP complex-1-interacting phosphatase"
                     /protein_id="NP_082375.4"
                     /db_xref="CCDS:CCDS20306.1"
                     /db_xref="GeneID:72102"
                     /db_xref="MGI:MGI:1919352"
                     /translation="MNQHYGRHGRGRGRDFAACAPPKKKGRNHIPERWKDYLPVGQRM
                     PGTRFIAFKVPLQKKFEAKLMPEECFSPLDLFNKIQEQNEELGLIIDLTYTQRYYKVE
                     DLPETISYIKIFTVGHQIPDNDTIFQFKCAVKEFLKKNKNNDKLIGVHCTHGLNRTGY
                     LICRYLIDVEGMRPDDAIELFNSCRGHCIERQNYIENLQKRHVRKNRNVSAPRTDGLE
                     DSADPTEQVYTNNKPVKKKPRKNRRGGHLAPSQHFQHQTQSSPYSLRKWSQNQSVYQR
                     GLVPPPGPAGEDYSQRRFFWSARPNKWTAESYQRPFYPYYWEWNL"
     exon            231..306
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            307..438
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            439..562
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..623
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..670
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            671..746
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            747..926
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            927..6435
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /note="hexamer: AACAAA"
     polyA_site      1359
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
     regulatory      6412..6417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6435
                     /gene="Dusp11"
                     /gene_synonym="2010300F21Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcgagacgt cgacgcgtcg cgttcctttg cgggcgcctc tggatcccgc ggcctcttct
       61 ggcctccctg aagtcgccac tttggccgct ctggcacgcc tggcgttggg tgggcggcat
      121 ctctgcgccc acatgaacca gcattatggc cgacatggtc gtggacgggg ccgggacttt
      181 gctgcctgtg ccccacccaa gaagaagggc agaaaccaca tccccgaaag gtggaaagac
      241 tatctcccag ttgggcagcg gatgcctggg actcgtttca ttgctttcaa agttcctttg
      301 caaaaaaaat ttgaagcaaa gcttatgcca gaagaatgct tttccccttt ggatctgttt
      361 aataaaatac aagaacaaaa tgaagaactt ggattgataa tcgatttaac atatactcag
      421 cgctattata aagtagagga tttgccagaa actatttctt acataaaaat atttacagtt
      481 ggtcatcaaa tacctgataa tgacactatc tttcaattca aatgtgcagt taaagaattt
      541 ttaaagaaaa ataaaaacaa tgacaaactt atcggtgtcc actgcaccca tggcttaaat
      601 aggactggct acctcatttg cagatatttg attgatgtag aaggcatgag gccagatgat
      661 gcaattgaat tgttcaacag ctgccggggg cactgcatag aaaggcagaa ctacattgaa
      721 aacctgcaga aacgtcatgt cagaaagaac cggaatgtta gtgcacctag gacagatggc
      781 cttgaagact cagcagatcc tacggagcaa gtctacacca acaacaaacc tgtgaaaaaa
      841 aagcctagga aaaaccggcg tggtggtcat ctggcacctt cccagcattt ccagcaccag
      901 acgcagagct caccgtactc actcagaaaa tggtcacaaa atcagagtgt ttaccagaga
      961 ggccttgtcc ctcctcctgg tccagccgga gaggactatt cacaaagaag attcttctgg
     1021 agtgcgaggc caaataagtg gactgctgag agttaccaga gacctttcta cccatactac
     1081 tgggaatgga acctgtgagg cacgctgtgg ctggactgtc gtcagggcca cctgagacca
     1141 gagctggaca gaagacagct gaatgaattt aataaaatca ggtcaaaaga atttagaaaa
     1201 ctttctgaac atttttaact gttcaaactg ttgtactgtc ctgatatatg ttacactgct
     1261 ctgtgctggc ggacgcggtg gctccggcag tctagagcac ctccattcca ggcctcaact
     1321 tttctcagag ttctgaatag ataacaaatt ctaaattgcc ttctgttttc cctgtatatt
     1381 tcctttgctc atgcttgtaa tgtgttgtgt aggtgcagag attcgtagtg tttttaccac
     1441 atgttcttta ctgacaatct ttatgggtgt gttttccatg actgttcaaa ttttctacta
     1501 aaactctagc caggggacag ttcttttctt tgcacctgtt ctttgtcctc gtgggactct
     1561 gatcagcgtt ttttccttgg tggtcagtgt tgggatttga ccagcttctt gctgacctgc
     1621 cagctaaggc atctaacaca gagaaggttc aaactttagg tactggttga ttgccaagtt
     1681 gggtaactgc caccaacagg gtagaactat ccaggaggct agaaaccctc tgtagatttt
     1741 aaaggttgaa cagacatcct tggatatctg ggaaagctga gggttatact gactccgagg
     1801 acctcaattc aggatctctg tccactggcc tcccacacta gaatggtgct ctttctctag
     1861 gacacacttc aggctacatg gaggtgctaa ttacttgtcc ttagaactca ctcaggaagt
     1921 tgctcctcat aacacatcaa gtccacagca agtttttgct atgcacagta gttttctctc
     1981 tcatgtatga acatgtggag ggaacttttc cctaatgaag tcccggcaga tcatgtattc
     2041 cagcttgcag ctaattttgc ccaaacttta gtcaagttgc tctgcactcc agtgatggct
     2101 ttttctctac ccatcacatt aacagattca aagtgcttct tgttgtgaga cccccccact
     2161 ccacccccga ggaattcttc cccagaatat actgggtcag tgtattgtcc agtgtaagaa
     2221 actggaacag acagttagga accaaaagag gacaaagctg ggacaggtac agaatgcacc
     2281 cagtctggac ggtgcaaaga acacattgac aagcagcctc tggaggacac tgccaggtag
     2341 ggtcactgcg tgagttctgc cacggttagg agttgttcct gccacctgcc ctgttcctct
     2401 accaggaatt ggattgccaa cacctagtga aaaccacctt tatcattgga taactcataa
     2461 ctaactttca ttcttacaca ctcgtctggc ttctgtccat gtcacacaat acaaaggcct
     2521 agtggaagga cacttctttt ttaaagtttc tagtggtcta tttagtattc ttaagttata
     2581 ttttacttta gaaacataca tgaatatttt ctcaggtagc tttcctgaaa ttcccatgga
     2641 aaggcaccct gcatgtttct tgattgtcag tctcagaggt agcccgccta aggatttctt
     2701 atgctatgta ttttcctcct tttttttttt ttaaatactc ttacagatca ccattgcttc
     2761 attttccaat ttatgataac atgcgttgat gaattcttcc tttggcaaat gaggatttag
     2821 ctctcagcct acccactcac tccacagccc tttgcagcct ttgatgaagt tactagataa
     2881 gtgtggtcat cacgcgcgtc gtgttcatgg ctgtgggttc tttctggcct tcctctttcc
     2941 ttaacgtttt tgcctcattc atttggccat tttctgttga ttatgtcaca aattcatctt
     3001 ctccatctga tagcattata aaccgtctca gtgaatgatg cgccctttga tttgactcct
     3061 tttctggagc ttctttaaat gccccagtca ggtgccaggt ctcgttggta gggctgccat
     3121 gctagagtac cacagactga gggagaacat ctataggaac tttttgtgtc tcatagtttt
     3181 agaagctggg aaggatagag tcagcaagaa tttcttcttg tagatgactg gtacttcact
     3241 gtcttcttgc ggtcttctgt gtcttaacat ctcctccact cgtccctccc cccctttcct
     3301 tttttccctt atgatacgct gagatgcatc gccagctctg tcttctcaaa gatgccaggt
     3361 cattagactc agactcactg tggagacctc atttgcctct tgaaagactc cccaaatgcg
     3421 gtgatatttc agatactggg gcttagaact ttaccagcaa tttgaggaaa cacaactgtc
     3481 cataggaggc aaactggctg ttccttacac gtggggcaaa gctcccatct gagctctctt
     3541 ccctcttgtc atttatttct tagaacctgg gtcccagggt tctacttcca tgactataat
     3601 ttcccatttg ctcattatgt ccttcagcag cctctcaggg ctgggagggt gtaacagccg
     3661 agccacagaa gtggatctgt ttgcttctct gctcctgtcc tttgatgagc agtaggtagg
     3721 cacttttcag agtcctagtt catggtgttc agacggttgc tgttggctgt tgaaaccctg
     3781 tctcctaatc tcagatcttt gggacctgta attcttctct tgaagtctta gggtctttat
     3841 ctcacatgtc atagtgtatt ttctatccac catgacatat accagctgag tcctttcaat
     3901 atggcaaatt gtaagaagtt tttatttaat gctattatat tagcattaat ccctaaccct
     3961 agtgcagctt ctagtaggat gttggacttc tttcctgaaa ttacatctga tttaattatc
     4021 tgtttttatt tttatttaac cttttcgtgt tactatctag cacttttctt ctgatacatt
     4081 ggggttgtag atgctgggat tgaccagggc cttgagcatg ccaggcatgt actctgtaat
     4141 tgagctgtgc ctccagcctt cttcagacct atatatgtca tttgtataaa cataataaaa
     4201 atacaaaaga taaagcattt tctgatattt aagtatgtta catgattttt taaaaacaga
     4261 cacagggctt cagtatattc cgcaggctag ctttgaactc cagggctcca gcagtcatct
     4321 gccccaggct ccagagcaag taggacgtca ggtacctgct ctcttgcctg gctctagatt
     4381 ttaatttcta agagttaact catttttttc tttaaaaaca ataataacta cagtatatat
     4441 cttgactatt acatgtttgc tacactcaca ttatggaggg aggtcccatg tggaatccta
     4501 attaaatagc ctttccagca aaacttacag cttcccagaa aacaaattcc tgtgttcctt
     4561 tcctcttgga agagacaaat ggcttacggc cttggggcag ggactgccaa ggctttctgt
     4621 atctggccgt aaactgactt ttcaagtcct ttgtttaccc tctgtctgaa tactagccat
     4681 tttgtggcca tacagtctgt cttgaaagtt gttctttggc tgtaatctgt gctgtgatct
     4741 gagccaggca tccatgtatg aaccactttt tagaaagcct gccccagcga gtgatctctt
     4801 tttctacagt gtactttgtg tacactgtgc taaaatacta cttcaggttc tgtgccacca
     4861 tgtcaagtag cacagtatga cagtaccttt ttgcagggaa ggatacaccc tgtcttatct
     4921 ttgcaaatgt gtctttaaaa tcccaaacta aatctttaat ctcagcactt gggaggccga
     4981 ggcagacaga tctccagacc tgcttggtct acagagggag atccaggacg gccagagcta
     5041 cctagagaaa acttagcatg aaaatgcaaa aaaaacattc ccagccaagt gggacgcatt
     5101 gactggtcac acgtggtacc tctggccttt cttttattta tttatttatt tatatatgaa
     5161 accccacttt caactaaagg gggatgggac acactaggcc atggcatcag gctccttgag
     5221 ctgcttgcca gagagtgagg tggataatct actccccctg cagaggacag gaggcgccta
     5281 gcaagcagac gacgttcttc ctgttctgct gtagatcact tgtacagttt cattaatgag
     5341 cttccagaga aagtccagac tgagactgtc atgccaggga gcctggcgtg ttcttggctt
     5401 actgaagcag ggcagcatat tgtatcacgt ggctttgctg tttcctgctt aagacctttc
     5461 ctcaccattc tgtatgtatg tgtacgtcaa agaaaacacc agtgacttag ttcttaatcc
     5521 tcgcctcaag acctgcttcc tggaggacct caagtgtctt atggatctgg cagccatgca
     5581 ctcttaatgg tttgacctta cacatgaatg atatacctgg tctcttcctg acttgacata
     5641 ccacaaaaac ttggagcatt tgaaaatacc attatcagtt atttcgacat aacaatttat
     5701 caataattaa ggtttcattt gaggttatat ttgcatgaca tgggggtaaa ttttagaatc
     5761 tggattaaga ttatattcac tttaacagtg aggacagcta tgactgttta tgcaagtccc
     5821 atgtctcagc ataacaccct gtcatgcatt ctgaactaac ttccatatgc tatatagtgg
     5881 tctcccttaa ttctggagga aggagggtca ttagctctga aataactttt ttttaaaaga
     5941 aaagaaacta caacaaattc ctctctagga taggcttttg tgcaccctga ccaaggaatt
     6001 taccgcagcc ccagactcca cccttccagc tttctctggg tcacagcccc tcccatcagc
     6061 ccagcccctg gcagctactg atacagtttt cctcttacca tctctaaaat gctgtgcagg
     6121 tgaaattagg atgtgggctt ctgagtgggg tttcttgttt ggctactggc tttaaggtct
     6181 gtgttacaaa atggatcgac aggtctcgct tccctctgtt gctgagttgc tcttgtatat
     6241 ggttgtctca cactttgctt aatcatcaac cagttaaaag atatttaggt tttctgtagg
     6301 ggttttttaa tttaaatttt aaatataaat tttttatata gcattttatg taaacatctt
     6361 tccttccccc tccccttgga gtggaatgct gccgtgtatg tttaacttta taataaatta
     6421 tcaaactttg ccaaaaaaaa aaaaa
//
