LOCUS       NM_022019               2792 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus dual specificity phosphatase 10 (Dusp10), mRNA.
ACCESSION   NM_022019
VERSION     NM_022019.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2792)
  AUTHORS   Song,N.N., Zhao,Y., Sun,C., Zhang,J., Lin,G.J., Yin,X.W. and
            Ma,C.Y.
  TITLE     DUSP10 alleviates ischemic stroke-induced neuronal damage by
            restricting p38/JNK pathway
  JOURNAL   Behav Brain Res 450, 114478 (2023)
   PUBMED   37164190
  REMARK    GeneRIF: DUSP10 alleviates ischemic stroke-induced neuronal damage
            by restricting p38/JNK pathway.
REFERENCE   2  (bases 1 to 2792)
  AUTHORS   Yu,Q., Chen,S., Li,J., Tang,H., Shi,J., Guo,W. and Zhang,S.
  TITLE     Mitogen activated protein kinase phosphatase 5 alleviates liver
            ischemia-reperfusion injury by inhibiting TAK1/JNK/p38 pathway
  JOURNAL   Sci Rep 13 (1), 11110 (2023)
   PUBMED   37429895
  REMARK    GeneRIF: Mitogen activated protein kinase phosphatase 5 alleviates
            liver ischemia-reperfusion injury by inhibiting TAK1/JNK/p38
            pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2792)
  AUTHORS   Zhong,C., Min,K., Zhao,Z., Zhang,C., Gao,E., Huang,Y., Zhang,X.,
            Baldini,M., Roy,R., Yang,X., Koch,W.J., Bennett,A.M. and Yu,J.
  TITLE     MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure
            Overload-Induced Cardiac Fibrosis
  JOURNAL   Front Immunol 12, 790511 (2021)
   PUBMED   34992607
  REMARK    GeneRIF: MAP Kinase Phosphatase-5 Deficiency Protects Against
            Pressure Overload-Induced Cardiac Fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2792)
  AUTHORS   Li,L., Zuo,H., Huang,X., Shen,T., Tang,W., Zhang,X., An,T., Dou,L.
            and Li,J.
  TITLE     Bone marrow macrophage-derived exosomal miR-143-5p contributes to
            insulin resistance in hepatocytes by repressing MKP5
  JOURNAL   Cell Prolif 54 (12), e13140 (2021)
   PUBMED   34647385
  REMARK    GeneRIF: Bone marrow macrophage-derived exosomal miR-143-5p
            contributes to insulin resistance in hepatocytes by repressing
            MKP5.
REFERENCE   5  (bases 1 to 2792)
  AUTHORS   Foray,A.P., Candon,S., Hildebrand,S., Marquet,C., Valette,F.,
            Pecquet,C., Lemoine,S., Langa-Vives,F., Dumas,M., Hu,P.,
            Santamaria,P., You,S., Lyon,S., Scott,L., Bu,C.H., Wang,T., Xu,D.,
            Moresco,E.M.Y., Scazzocchio,C., Bach,J.F., Beutler,B. and
            Chatenoud,L.
  TITLE     De novo germline mutation in the dual specificity phosphatase 10
            gene accelerates autoimmune diabetes
  JOURNAL   Proc Natl Acad Sci U S A 118 (47) (2021)
   PUBMED   34782469
  REMARK    GeneRIF: De novo germline mutation in the dual specificity
            phosphatase 10 gene accelerates autoimmune diabetes.
REFERENCE   6  (bases 1 to 2792)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 2792)
  AUTHORS   Breitwieser,W., Lyons,S., Flenniken,A.M., Ashton,G., Bruder,G.,
            Willington,M., Lacaud,G., Kouskoff,V. and Jones,N.
  TITLE     Feedback regulation of p38 activity via ATF2 is essential for
            survival of embryonic liver cells
  JOURNAL   Genes Dev 21 (16), 2069-2082 (2007)
   PUBMED   17699753
REFERENCE   8  (bases 1 to 2792)
  AUTHORS   Zhang,Y., Blattman,J.N., Kennedy,N.J., Duong,J., Nguyen,T.,
            Wang,Y., Davis,R.J., Greenberg,P.D., Flavell,R.A. and Dong,C.
  TITLE     Regulation of innate and adaptive immune responses by MAP kinase
            phosphatase 5
  JOURNAL   Nature 430 (7001), 793-797 (2004)
   PUBMED   15306813
  REMARK    GeneRIF: MKP5 has a principal function in both innate and adaptive
            immune responses, and represents a novel target for therapeutic
            intervention of immune diseases
REFERENCE   9  (bases 1 to 2792)
  AUTHORS   Zama,T., Aoki,R., Kamimoto,T., Inoue,K., Ikeda,Y. and Hagiwara,M.
  TITLE     A novel dual specificity phosphatase SKRP1 interacts with the MAPK
            kinase MKK7 and inactivates the JNK MAPK pathway. Implication for
            the precise regulation of the particular MAPK pathway
  JOURNAL   J Biol Chem 277 (26), 23909-23918 (2002)
   PUBMED   11959861
REFERENCE   10 (bases 1 to 2792)
  AUTHORS   Masuda,K., Shima,H., Kikuchi,K., Watanabe,Y. and Matsuda,Y.
  TITLE     Expression and comparative chromosomal mapping of MKP-5 genes
            DUSP10/Dusp10
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 71-74 (2000)
   PUBMED   11060451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY283666.1, CK626309.1 and AK142568.1.
            
            On Feb 17, 2018 this sequence version replaced NM_022019.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142568.1, BC025066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BY283666.1         2-74
            74-79               CK626309.1         3-8
            80-2792             AK142568.1         2-2714
FEATURES             Location/Qualifiers
     source          1..2792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 88.2 cM"
     gene            1..2792
                     /gene="Dusp10"
                     /gene_synonym="2610306G15Rik; MKP-5; MKP5"
                     /note="dual specificity phosphatase 10"
                     /db_xref="GeneID:63953"
                     /db_xref="MGI:MGI:1927070"
     exon            1..189
                     /gene="Dusp10"
                     /gene_synonym="2610306G15Rik; MKP-5; MKP5"
                     /inference="alignment:Splign:2.1.0"
     exon            190..1041
                     /gene="Dusp10"
                     /gene_synonym="2610306G15Rik; MKP-5; MKP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1679
                     /gene="Dusp10"
                     /gene_synonym="2610306G15Rik; MKP-5; MKP5"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="MAP kinase phosphatase 5; mitogen-activated protein
                     kinase phosphatase 5"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 10"
                     /protein_id="NP_071302.2"
                     /db_xref="CCDS:CCDS15591.1"
                     /db_xref="GeneID:63953"
                     /db_xref="MGI:MGI:1927070"
                     /translation="MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSASPGSGSHAP
                     VLATAVVTLKAANLTYMPSSSGSARSLNCGCSSTSCCTVATYDKDHQAQTQAIAAGTA
                     TTAIGTSTTCPANQMVNNNENTGSVLSPSGGVGSPVSGTPKQLASIKIIYPNDLAKKM
                     TKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLIS
                     CREGKDSFKRIFSKEIIVYDENTNEPSRVTPSQPLHIVLESLKREGKEPLVLKGGLSS
                     FKQNHGNLCDNSLQLQECREVGGGASAASSMLPQSVPTTPDIENAELTPILPFLFLGN
                     EQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAF
                     EFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNL
                     NFMGQLLEFEEDLNNGVTPRILTPKLMGMETVV"
     exon            1042..1413
                     /gene="Dusp10"
                     /gene_synonym="2610306G15Rik; MKP-5; MKP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..2792
                     /gene="Dusp10"
                     /gene_synonym="2610306G15Rik; MKP-5; MKP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2013..2018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dusp10"
                     /gene_synonym="2610306G15Rik; MKP-5; MKP5"
                     /note="hexamer: AATAAA"
     polyA_site      2034
                     /gene="Dusp10"
                     /gene_synonym="2610306G15Rik; MKP-5; MKP5"
                     /note="major polyA site"
ORIGIN      
        1 attggcgtat cgcgccgtcg ctcggaggca accccgcccc ctccaaagct tacatttacg
       61 ctgtagcaaa agagaaagta actctgtgtt gctgctgggg atcaatgaag ctgagtgaat
      121 gggggcgcac tgcgcgagcg catagctgga gcgggcgcca gatggtagag ggctacgctt
      181 attgatgaaa ctcttgactt cttgaattgc cagttttcag cctcctcatg cctccatctc
      241 ctttagacga cagggtagta gtggcactat ctaggcctgt ccgacctcag gatctcaacc
      301 tttgtttaga ctcaagctac cttggctctg ccagcccagg tagtggtagc cacgctcctg
      361 tccttgccac cgccgttgtg accctcaagg ctgcgaatct gacgtatatg ccctcatcca
      421 gcggctctgc ccgctccctg aattgcggat gcagcagcac tagctgctgc actgtggcaa
      481 cctacgacaa ggatcatcag gcccagactc aagccattgc tgcaggcact gccaccaccg
      541 ccataggaac ctcgaccacc tgccctgcta accagatggt caacaacaat gaaaacacag
      601 gctctgtgtt aagtccatcg ggtggggtgg gcagccctgt gtcagggact cccaagcagc
      661 tagccagcat caagatcatc taccccaatg acctggcaaa gaagatgacc aaatgcagca
      721 agagtcacct gcccagccag ggtcccgtca tcatcgattg caggcctttc atggagtaca
      781 acaagagtca catccaagga gctgtccaca ttaactgtgc cgataagatc agccggcgaa
      841 ggctgcagca gggcaagatc actgtcttag acttgatttc ctgtagggaa ggcaaagact
      901 ctttcaagag gatcttttcc aaagaaatta tagtttatga tgagaatacc aatgagccga
      961 gccgtgtgac accatcccag ccacttcaca tagtcctcga gtccctgaag agagaaggca
     1021 aagaacccct ggtattgaaa gggggactca gtagttttaa acagaaccat ggaaacctct
     1081 gtgacaactc cctccagctc caagagtgcc gggaggtggg gggtggtgca tctgcggcct
     1141 cgagcatgct acctcagtct gtccccacca cccctgacat cgagaacgca gagctaacgc
     1201 ccatcctgcc cttcctgttc ctcggcaatg agcaggatgc tcaggaccta gacaccatgc
     1261 agaggctcaa catcggctat gtcatcaacg tcaccacgca ccttcctctg taccattatg
     1321 agaaaggcct cttcaactac aagaggctgc cagccacaga cagcaacaaa cagaacctgc
     1381 ggcagtactt tgaagaggcc ttcgagttca tcgaggaagc tcaccagtgt gggaagggcc
     1441 ttctcatcca ctgccaggcc ggcgtgtccc gatccgccac catcgtcatc gcctacttga
     1501 tgaagcacac acggatgacc atgactgacg cttacaaatt cgtcaaaggc aaacgaccaa
     1561 ttatttcccc gaacctcaac ttcatggggc agttgctgga atttgaggaa gacctaaaca
     1621 acggcgtgac gccaagaatc cttacaccaa agctcatggg catggagaca gttgtgtgac
     1681 aacgggcagg acggaaaggg ctgtgctctc tcaggagacg aaaaggaggg aaggtggatt
     1741 ctagcttgtc gctcttcttt cctttccttt tcttttctct tctcttcttt tcttttcttt
     1801 tctttttctt cttttctttc tctttctttc tctctttttt tttaaggttg ggagtgtttg
     1861 tgaaagtaaa caaacttgtc taaagactct atttttaata agtgtaagaa gactgtaact
     1921 tttgatgcga atgagaccca cttctcttaa actggtattg cagttaggtt aaagaggtct
     1981 tttttgtttt gttttgtttt tttaagccaa caaataaaaa tattataaaa cttgtttctt
     2041 cccagtttcc cttgtaagct tattgtagag ttttgagtaa atagtctgtg cgggctcata
     2101 gaccgaagat accacccttc aattacaaag aaccaaaagg aaatggaaaa gactccagac
     2161 ctggaactga ctgcacaacc atgtcaaaag caaaccctgc caaaccgtgc ccagttgtgc
     2221 tcactggtgt gaagaaaggg ccggcaagct cagtggactc ggctcgcctc acaccttctc
     2281 tggggagaca ggctagtgtc ggttttgtgt gttctatgct ccggatatct tttccccttc
     2341 tgtgggtctg agagaacttt ttgtttgttt gtttgtttgt ttgtttggca gaaggaaact
     2401 gaccattcta ccatgtgcct ttgctggcac tcgtgcaata aaaatggtgt ttggagtgtg
     2461 cagctgaggg agagctggca gctgagtgag gagtggcgtt ggagacaggc attcaacagt
     2521 accagtggct tcccctccct cctttctcct tctccccccc ccctttcttc ctcatcccct
     2581 tttatttgtc tttcttttga tttgattctg gttacagtgc catacacctt gttacatatg
     2641 tatatcagaa tgtaaaaaaa caaaacaaaa aaaaaaacaa aaatttattt aaaaaatatt
     2701 tttcgcaaaa aaaaaatatc cttggtgtgt ttttgttgat ggtgtaagaa tttattttca
     2761 ttatataaat gaacctcgtt tggggatgtg tc
//
