LOCUS       NM_025518               1910 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dihydrouridine synthase 2 (Dus2), transcript variant
            1, mRNA.
ACCESSION   NM_025518 XM_001000087 XM_134309 XM_915859
VERSION     NM_025518.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Rinaldi,T., Gambadoro,A., Francisci,S. and Frontali,L.
  TITLE     Nucleo-mitochondrial interactions in Saccharomyces cerevisiae:
            characterization of a nuclear gene suppressing a defect in
            mitochondrial tRNA(Asp) processing
  JOURNAL   Gene 303, 63-68 (2003)
   PUBMED   12559567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB596733.1, AK009391.1 and AK077451.1.
            
            On Jul 24, 2014 this sequence version replaced NM_025518.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009391.1, BC116934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BB596733.1         2-30
            30-1889             AK009391.1         2-1861
            1890-1910           AK077451.1         1818-1838
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.07 cM"
     gene            1..1910
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /note="dihydrouridine synthase 2"
                     /db_xref="GeneID:66369"
                     /db_xref="MGI:MGI:1913619"
     exon            1..101
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            102..243
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            244..289
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            290..381
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            382..425
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            426..486
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            487..534
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            535..600
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            601..671
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            672..758
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            759..927
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1049
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1199
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1287
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1361
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1910
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /note="hexamer: AATAAA"
     polyA_site      1891
                     /gene="Dus2"
                     /gene_synonym="2310016K04Rik; Dus2l"
                     /note="major polyA site"
ORIGIN      
        1 agtctggagt acggtggctg gcgcggatca gggtggcgtg tggcgctgca gcaccggctg
       61 gaaggaggga ggaggatcct taagagttca gtggctgcga ggcatcacag agcaggaatg
      121 attgtgaaca gcctctccct gtgctaccac aataagctca tcttagcccc gatggttcgg
      181 gtggggactc tgccaatgcg cctcctagcc ctggattatg gagcggacat tgtttactgt
      241 gaggagctga ttgacctcaa gatgctccag tgcaagcgag ttgtaaacga ggtgctcagc
      301 acagtggact ttgttgctcc tgatgaccgg gtagtcttcc gtacgtgtga aagagaacag
      361 agcagggtgg tcttccagat ggggacttca gacgcagagc gagcccttgc tgtggccagg
      421 cttgtagaaa atgatgtagc tggtattgat gtcaacatgg gctgtccaaa agagtattcc
      481 actaagggag gaatgggagc cgctctgctg tcagaccctg acaagatcga gaagatcctc
      541 agcactcttg ttaaagggac acacagacct gtgacctgta aaatccgaat cctgccctcg
      601 ctggaagata ccctgaactt ggtgaagcgg atagagagga ctggcatttc agccattgca
      661 gttcatggga ggaatcgtga cgagcgacct cagcacccgg tcagctgtga agttataaga
      721 gccattgctg aaaccctctc cattcctgtc atagccaacg gaggatctca tgaccatatc
      781 cagcaacatg tggacataga agactttcga caagccacgg ctgcctcctc tgtgatggtg
      841 gctcgagcag ccatgtggaa cccctccatc ttcctcaagg atggccttcg tcccctggag
      901 gaagtcatgc agaagtacat cagatatgcg gtgcagtatg ataaccacta caccaacacc
      961 aagtactgct tgtgccaaat gctgcgggaa cagttggagt cgccccaggg aagactgctt
     1021 catgctgccc agtcttccca ggaaatttgt gaggcctttg gccttggtgc cttctatgag
     1081 gagaccattc gggagctcga tgctcggcga gctgacctcc tggccaagac tccagaggct
     1141 gttgaggagc cagctgaaga tacttctggc atcattaaaa tggctatcag gtttgaccgg
     1201 agagcatatc caccccagat cactcccaag atgtgcctgc tggaatggtg tcggagggag
     1261 aagctgccac aacctgtgta tgaaacagtt cagcgaacta tagatcgcat gttttgctct
     1321 gttgtcactg ttgcggaaca aaagtaccag tccaccttgt gggacaagtc caagaaactg
     1381 gcggagcaga ctgcagcaat tgtgtgtctt aggagccagg gcctccctga gggtcggctg
     1441 ggtgaggaga gtccctcctt gaacaagcgc aagcgagagg cccctgacca agaccctggg
     1501 ggcccaagag ttcaggagcc agcactacct ggggagatat gcaagaagcc atttgtaacc
     1561 ttggacagta gtgaggagaa tcttctggaa ggctgctgac tcctgctctg gctgacagtg
     1621 tgtgggactg atgtgaaggg gtgatgggtg ccaggaccta aaccaggtgc ccttggacag
     1681 tttgctggcc gttgacatgc aaacctagag gtcttggccc aggtcatcag tctgaaacaa
     1741 gtgccaagaa atgcccaagg gtaatactgt ctctcatatg tctgatggcc aatccaagtt
     1801 cctaatgacc tgagtgtgtc tttgaaaatg aggtttttag gcctcacttc caacttgaca
     1861 ttggtatcgt gcaataaaga ctctcaccca aggccacctg cttcaacctt
//
