LOCUS       NM_025777               1314 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dual oxidase maturation factor 2 (Duoxa2), mRNA.
ACCESSION   NM_025777 XM_917617
VERSION     NM_025777.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1314)
  AUTHORS   Burgueno,J.F., Fritsch,J., Gonzalez,E.E., Landau,K.S.,
            Santander,A.M., Fernandez,I., Hazime,H., Davies,J.M.,
            Santaolalla,R., Phillips,M.C., Diaz,S., Dheer,R., Brito,N.,
            Pignac-Kobinger,J., Fernandez,E., Conner,G.E. and Abreu,M.T.
  TITLE     Epithelial TLR4 Signaling Activates DUOX2 to Induce
            Microbiota-Driven Tumorigenesis
  JOURNAL   Gastroenterology 160 (3), 797-808 (2021)
   PUBMED   33127391
REFERENCE   3  (bases 1 to 1314)
  AUTHORS   van der Weyden,L., Swiatkowska,A., Iyer,V., Speak,A.O. and
            Adams,D.J.
  TITLE     A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators
            of Pulmonary Metastatic Colonisation
  JOURNAL   G3 (Bethesda) 10 (6), 1869-1877 (2020)
   PUBMED   32245826
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1314)
  AUTHORS   Burgueno,J.F., Fritsch,J., Santander,A.M., Brito,N., Fernandez,I.,
            Pignac-Kobinger,J., Conner,G.E. and Abreu,M.T.
  TITLE     Intestinal Epithelial Cells Respond to Chronic Inflammation and
            Dysbiosis by Synthesizing H2O2
  JOURNAL   Front Physiol 10, 1484 (2019)
   PUBMED   31871440
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1314)
  AUTHORS   Shindo,R., Ohmuraya,M., Komazawa-Sakon,S., Miyake,S., Deguchi,Y.,
            Yamazaki,S., Nishina,T., Yoshimoto,T., Kakuta,S., Koike,M.,
            Uchiyama,Y., Konishi,H., Kiyama,H., Mikami,T., Moriwaki,K.,
            Araki,K. and Nakano,H.
  TITLE     Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate
            Lymphoid Cell-Dependent Lethal Ileitis
  JOURNAL   iScience 15, 536-551 (2019)
   PUBMED   31132747
REFERENCE   6  (bases 1 to 1314)
  AUTHORS   Chang,S., Linderholm,A., Franzi,L., Kenyon,N., Grasberger,H. and
            Harper,R.
  TITLE     Dual oxidase regulates neutrophil recruitment in allergic airways
  JOURNAL   Free Radic Biol Med 65, 38-46 (2013)
   PUBMED   23770197
REFERENCE   7  (bases 1 to 1314)
  AUTHORS   Grasberger,H., El-Zaatari,M., Dang,D.T. and Merchant,J.L.
  TITLE     Dual oxidases control release of hydrogen peroxide by the gastric
            epithelium to prevent Helicobacter felis infection and inflammation
            in mice
  JOURNAL   Gastroenterology 145 (5), 1045-1054 (2013)
   PUBMED   23860501
REFERENCE   8  (bases 1 to 1314)
  AUTHORS   Grasberger,H., De Deken,X., Mayo,O.B., Raad,H., Weiss,M., Liao,X.H.
            and Refetoff,S.
  TITLE     Mice deficient in dual oxidase maturation factors are severely
            hypothyroid
  JOURNAL   Mol Endocrinol 26 (3), 481-492 (2012)
   PUBMED   22301785
REFERENCE   9  (bases 1 to 1314)
  AUTHORS   Kennedy,K.A., Ostrakhovitch,E.A., Sandiford,S.D., Dayarathna,T.,
            Xie,X., Waese,E.Y., Chang,W.Y., Feng,Q., Skerjanc,I.S.,
            Stanford,W.L. and Li,S.S.
  TITLE     Mammalian numb-interacting protein 1/dual oxidase maturation factor
            1 directs neuronal fate in stem cells
  JOURNAL   J Biol Chem 285 (23), 17974-17985 (2010)
   PUBMED   20233719
REFERENCE   10 (bases 1 to 1314)
  AUTHORS   Qin,H., Percival-Smith,A., Li,C., Jia,C.Y., Gloor,G. and Li,S.S.
  TITLE     A novel transmembrane protein recruits numb to the plasma membrane
            during asymmetric cell division
  JOURNAL   J Biol Chem 279 (12), 11304-11312 (2004)
   PUBMED   14670962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844566.8.
            
            On Nov 8, 2022 this sequence version replaced NM_025777.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018569.1, BC031111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AL844566.8         184817-185104       c
            289-346             AL844566.8         183799-183856       c
            347-481             AL844566.8         183305-183439       c
            482-695             AL844566.8         182619-182832       c
            696-910             AL844566.8         182129-182343       c
            911-1314            AL844566.8         181397-181800       c
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.62 cM"
     gene            1..1314
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /note="dual oxidase maturation factor 2"
                     /db_xref="GeneID:66811"
                     /db_xref="MGI:MGI:1914061"
     exon            1..288
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1104
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /note="Numb-interacting protein 2"
                     /codon_start=1
                     /product="dual oxidase maturation factor 2"
                     /protein_id="NP_080053.1"
                     /db_xref="CCDS:CCDS16660.1"
                     /db_xref="GeneID:66811"
                     /db_xref="MGI:MGI:1914061"
                     /translation="MTAWDGVLPFYPQPRHAASFSVPLLIVILVFLSLAASFLFILPG
                     IRGHSRWFWLVRVLLSLFIGAEIVAVHFSGDWFVGRVWTNTSYKAFSPSRVQVHVGLH
                     VGLAGVNITLRGTPRQQLNETIDYNERFTWRLNEDYTKEYVHALEKGLPDPVLYLAEK
                     FTPSSPCGLYHQYHLAGHYAAATLWVAFCFWIIANALLSMPAPLYGGLALLTTGAFTL
                     FGVFAFASISSVPLCHFRLGSAVLTPYYGASFWLTLATGILSLLLGGAVVILHYTRPS
                     ALRSFLDLSVKDCSNQAKGNSPLTLNNPQHEQLKSPDLNITTLL"
     exon            289..346
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..481
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..695
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..910
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1314
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1280..1285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /note="hexamer: AATAAA"
     polyA_site      1314
                     /gene="Duoxa2"
                     /gene_synonym="9030623N16Rik; Nip2"
                     /note="major polyA site"
ORIGIN      
        1 gaacactgcg tgaagtcgca gggccaggaa agagtttcgg gagatcacgc ctctgcgctt
       61 cttaggagag ccgcagggct cggacttttt atcactcatc ccagctcgct gcctgcgaac
      121 agttctcgaa cttcttgcag gatgactgcg tgggacgggg tgctaccctt ttacccccag
      181 cccaggcatg ccgccagctt cagcgtaccg ctgctcattg ttatcctggt gttcttgtct
      241 ttggctgcta gcttcctgtt catcttgcct ggaatccgtg ggcactcgcg ctggttctgg
      301 ttggtgagag tccttcttag cctgttcata ggtgccgaaa ttgtggctgt gcacttcagt
      361 ggagactggt tcgtggggag agtgtggacc aacacatcct acaaagcctt cagtccatcc
      421 cgtgttcaag tccatgtcgg tctgcacgtg gggctggcgg gcgttaacat tacactccga
      481 ggaacaccga ggcagcagct gaacgagacc attgactaca atgagcgttt cacttggcgt
      541 ctgaacgaag actacaccaa ggagtatgtc catgccttgg agaagggact gccggaccca
      601 gtgctatacc tggcagagaa gttcacaccg agcagtcctt gcgggctgta ccaccaatat
      661 cacctggccg gtcactatgc cgcagcaaca ctgtgggtgg cattctgctt ctggatcatc
      721 gccaatgcgc tgctctccat gcccgcccca ctctacggag gcctggcttt gctcaccacc
      781 ggtgccttca cgctcttcgg tgtcttcgcc ttcgcctcga tttccagcgt gccgctctgc
      841 cacttccgcc tgggctccgc cgtcctcacg ccttactacg gcgcctcctt ttggctcacg
      901 ctggccaccg gcatcctgag cctcctcctc ggaggggcgg tggtgattct ccactatact
      961 cggcccagcg cccttcgctc ctttctggat ctaagtgtca aagactgtag caaccaggct
     1021 aaaggaaact cacctctcac cctcaacaac ccgcaacacg aacagttgaa gagtccagac
     1081 ttaaatatta ccactctcct gtgaaaataa ctgactccgg atttctaccc ctctttggga
     1141 ccccatagac ctgaagactg tgttaagagc gcgtgccagg agcatagctt agtctggaga
     1201 actgcttgtc cctgcgggac gacaaggggg caccccatgt gcctttgctc tagagaatgg
     1261 atttctcagg agaactgtaa ataaactttt ttgtttcttt ttttttcttc aaaa
//
