LOCUS       NM_001305262            1559 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus dual oxidase maturation factor 1 (Duoxa1), mRNA.
ACCESSION   NM_001305262 XM_006499092
VERSION     NM_001305262.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Burgueno,J.F., Fritsch,J., Gonzalez,E.E., Landau,K.S.,
            Santander,A.M., Fernandez,I., Hazime,H., Davies,J.M.,
            Santaolalla,R., Phillips,M.C., Diaz,S., Dheer,R., Brito,N.,
            Pignac-Kobinger,J., Fernandez,E., Conner,G.E. and Abreu,M.T.
  TITLE     Epithelial TLR4 Signaling Activates DUOX2 to Induce
            Microbiota-Driven Tumorigenesis
  JOURNAL   Gastroenterology 160 (3), 797-808 (2021)
   PUBMED   33127391
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Sun,J.
  TITLE     Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into
            enzyme activation and regulation
  JOURNAL   Nat Struct Mol Biol 27 (11), 1086-1093 (2020)
   PUBMED   32929281
  REMARK    GeneRIF: Structures of mouse DUOX1-DUOXA1 provide mechanistic
            insights into enzyme activation and regulation.
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Burgueno,J.F., Fritsch,J., Santander,A.M., Brito,N., Fernandez,I.,
            Pignac-Kobinger,J., Conner,G.E. and Abreu,M.T.
  TITLE     Intestinal Epithelial Cells Respond to Chronic Inflammation and
            Dysbiosis by Synthesizing H2O2
  JOURNAL   Front Physiol 10, 1484 (2019)
   PUBMED   31871440
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1559)
  AUTHORS   Amano,I., Takatsuru,Y., Toya,S., Haijima,A., Iwasaki,T.,
            Grasberger,H., Refetoff,S. and Koibuchi,N.
  TITLE     Aberrant Cerebellar Development in Mice Lacking Dual Oxidase
            Maturation Factors
  JOURNAL   Thyroid 26 (5), 741-752 (2016)
   PUBMED   26914863
  REMARK    GeneRIF: The proliferation and migration of granule cells was
            delayed after P15 in Duoxa-/- mice. However, these changes
            disappeared by P25. Although the cerebellar structure of Duoxa-/-
            mice was not significantly different from that of Wt mice at P25,
            motor coordination was impaired. It was also found that the
            amplitude of paired-pulse facilitation at parallel fiber-Purkinje
            cell synapses decreased in Duoxa-/- mice.
REFERENCE   6  (bases 1 to 1559)
  AUTHORS   Chang,S., Linderholm,A., Franzi,L., Kenyon,N., Grasberger,H. and
            Harper,R.
  TITLE     Dual oxidase regulates neutrophil recruitment in allergic airways
  JOURNAL   Free Radic Biol Med 65, 38-46 (2013)
   PUBMED   23770197
REFERENCE   7  (bases 1 to 1559)
  AUTHORS   Grasberger,H., De Deken,X., Mayo,O.B., Raad,H., Weiss,M., Liao,X.H.
            and Refetoff,S.
  TITLE     Mice deficient in dual oxidase maturation factors are severely
            hypothyroid
  JOURNAL   Mol Endocrinol 26 (3), 481-492 (2012)
   PUBMED   22301785
REFERENCE   8  (bases 1 to 1559)
  AUTHORS   Ostrakhovitch,E.A. and Semenikhin,O.A.
  TITLE     p53-mediated regulation of neuronal differentiation via regulation
            of dual oxidase maturation factor 1
  JOURNAL   Neurosci Lett 494 (1), 80-85 (2011)
   PUBMED   21362455
  REMARK    GeneRIF: DUOXA1 is a novel p53-regulated neurogenic factor involved
            in p53 dependent neuronal differentiation.
REFERENCE   9  (bases 1 to 1559)
  AUTHORS   Kennedy,K.A., Ostrakhovitch,E.A., Sandiford,S.D., Dayarathna,T.,
            Xie,X., Waese,E.Y., Chang,W.Y., Feng,Q., Skerjanc,I.S.,
            Stanford,W.L. and Li,S.S.
  TITLE     Mammalian numb-interacting protein 1/dual oxidase maturation factor
            1 directs neuronal fate in stem cells
  JOURNAL   J Biol Chem 285 (23), 17974-17985 (2010)
   PUBMED   20233719
  REMARK    GeneRIF: Nip1 has an important role in the guidance of neuronal
            differentiation through ROS generation and modulation of
            intermediate filaments
REFERENCE   10 (bases 1 to 1559)
  AUTHORS   Qin,H., Percival-Smith,A., Li,C., Jia,C.Y., Gloor,G. and Li,S.S.
  TITLE     A novel transmembrane protein recruits numb to the plasma membrane
            during asymmetric cell division
  JOURNAL   J Biol Chem 279 (12), 11304-11312 (2004)
   PUBMED   14670962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844566.8 and CO039809.1.
            
            On Mar 6, 2015 this sequence version replaced XM_006499092.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the reference strain was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019755.1, SRR5189676.122905.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL844566.8         170274-170334
            62-107              AL844566.8         170560-170605
            108-224             AL844566.8         170956-171072
            225-284             AL844566.8         176054-176113
            285-468             AL844566.8         177141-177324
            469-526             AL844566.8         177636-177693
            527-661             AL844566.8         178316-178450
            662-875             AL844566.8         178728-178941
            876-1093            AL844566.8         179161-179378
            1094-1539           AL844566.8         180006-180451
            1540-1559           CO039809.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.62 cM"
     gene            1..1559
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /note="dual oxidase maturation factor 1"
                     /db_xref="GeneID:213696"
                     /db_xref="MGI:MGI:2384861"
     exon            1..61
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..107
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..224
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..284
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..468
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1347
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /note="Numb-interacting protein 1; dual oxidase activator
                     1"
                     /codon_start=1
                     /product="dual oxidase maturation factor 1"
                     /protein_id="NP_001292191.1"
                     /db_xref="CCDS:CCDS16661.1"
                     /db_xref="GeneID:213696"
                     /db_xref="MGI:MGI:2384861"
                     /translation="MAALGHTLPFYTGTKPTFPMDTTLAVIITIFLTALVTFIIILPG
                     IRGKTRLFWLLRVVTSLFIGAVILAVNFSSEWSVGHVNANTTYKAFSPKWVSVDVGLQ
                     IGLGGVNITLTGTPVQQLNETINYNEAFAWRLGRSYAEEYAKALEKGLPDPVLYLAEK
                     FTPRSPCGLYNQYRLAGHYASAMLWVAFLCWLLANVMLSMPVLVYGGHMLLATGLFQL
                     LALFFFSMTTSLISPCPLRLGTAVLHTHHGPAFWITLATGLLCILLGLVMAVAHRMQP
                     HRLKAFFNQSSEDPVLEWGSEEGGLLSPHYRSIAESPETQDIPMSVASSETCFKEEHP
                     KESDCSL"
     exon            469..526
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..661
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..875
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1093
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1543
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /note="hexamer: AATAAA"
     regulatory      1526..1531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /note="hexamer: AATGAA"
     polyA_site      1540
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /note="major polyA site"
     polyA_site      1543
                     /gene="Duoxa1"
                     /gene_synonym="Nip; Nip1"
                     /note="major polyA site"
ORIGIN      
        1 cagtagggcg gaatagaagc tagcgcgggg acccgcgtga aaggggaccg gagcatgaaa
       61 gatcagacct gtcgccaaag caaggtatcc atctgtcccc aaaacctgac gtccacgtct
      121 ggacccggtt cctgccctat ccccacgacc aggagcgttg tgagtgagtg cccaaagacg
      181 agcagcgcca ggtgccatgc gcacagtatc tgaaagagag gaagtaaaac tcaaaagaag
      241 tgaaattcca aaagacagaa gcagaattca agctctggag ctgccatcaa cacccccttc
      301 ccccagcgta ccccaaccaa aatggctgct cttggacaca cactgccctt ctacactggc
      361 accaagccaa cctttccaat ggacactact ctggctgtca ttatcaccat cttcctgact
      421 gcactggtca ccttcatcat tatcctgcct ggcatccgtg ggaagacgag gctgttctgg
      481 ctgcttcggg tggtgaccag cttattcatc ggggctgtga tcctggctgt gaacttcagt
      541 tctgagtggt ctgtgggcca tgtcaacgcc aacacaacgt acaaagcctt cagtcccaag
      601 tgggtcagtg tggacgtggg actgcagatc gggctcggcg gcgtcaacat caccctcaca
      661 ggcaccccag tgcagcagct gaatgaaacc atcaactaca atgaggcatt cgcatggcgc
      721 ctgggcagga gctatgcaga ggagtatgca aaggccctgg agaagggcct tccagaccca
      781 gtgctatacc tggctgagaa gttcacccct cgaagcccat gtggcctgta caaccagtac
      841 cgcctggcag gacactatgc ctctgccatg ctgtgggtgg cattcctctg ctggctactg
      901 gccaatgtga tgttgtcgat gccagtgctg gtttatggtg gccacatgct gctggccact
      961 ggtctcttcc agctgttggc cctgttcttc ttctccatga ccacgtcact catatcgccc
     1021 tgtcccctgc gcttgggcac tgctgtgctg cacactcacc atgggcccgc tttctggatc
     1081 acgttagcca caggactgct gtgtattctg cttggcctgg tcatggcagt ggcccacagg
     1141 atgcagcctc acagactgaa ggctttcttc aaccagagtt cagaggaccc agtgctggag
     1201 tggggctctg aagaaggagg actcttgagc ccccactacc ggtccatagc tgagagtcct
     1261 gagacccagg acattcccat gtcagtggct tcctctgaga catgttttaa ggaggaacac
     1321 cccaaagagt ccgactgttc cctgtaaagc tcttctcctg gtagccactg agtttccaga
     1381 ctgcctccag acattattgg agccccacaa aaccagcaga actgtccagg aagtgggttt
     1441 cagttgtatc atgttcagtt gtaatatgta tccaacttgt tgatgtaaca gaataatata
     1501 cacagcctac taatgcaaaa aaataaatga acaaaagtgc taaaaaaaaa aaaaaaaaa
//
