LOCUS       NM_001362755            5890 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus dual oxidase 2 (Duox2), mRNA.
ACCESSION   NM_001362755
VERSION     NM_001362755.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5890)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5890)
  AUTHORS   Castrillon-Betancur,J.C., Lopez-Agudelo,V.A., Sommer,N.,
            Cleeves,S., Bernardes,J.P., Weber-Stiehl,S., Rosenstiel,P. and
            Sommer,F.
  TITLE     Epithelial Dual Oxidase 2 Shapes the Mucosal Microbiome and
            Contributes to Inflammatory Susceptibility
  JOURNAL   Antioxidants (Basel) 12 (10), 1889 (2023)
   PUBMED   37891968
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5890)
  AUTHORS   Duan,J., Matute,J.D., Unger,L.W., Hanley,T., Schnell,A., Lin,X.,
            Krupka,N., Griebel,P., Lambden,C., Sit,B., Grootjans,J., Pyzik,M.,
            Sommer,F., Kaiser,S., Falk-Paulsen,M., Grasberger,H., Kao,J.Y.,
            Fuhrer,T., Li,H., Paik,D., Lee,Y., Refetoff,S., Glickman,J.N.,
            Paton,A.W., Bry,L., Paton,J.C., Sauer,U., Macpherson,A.J.,
            Rosenstiel,P., Kuchroo,V.K., Waldor,M.K., Huh,J.R., Kaser,A. and
            Blumberg,R.S.
  TITLE     Endoplasmic reticulum stress in the intestinal epithelium initiates
            purine metabolite synthesis and promotes Th17 cell differentiation
            in the gut
  JOURNAL   Immunity 56 (5), 1115-1131 (2023)
   PUBMED   36917985
REFERENCE   4  (bases 1 to 5890)
  AUTHORS   Hazime,H., Ducasa,G.M., Santander,A.M., Brito,N., Gonzalez,E.E.,
            Ban,Y., Kaunitz,J., Akiba,Y., Fernandez,I., Burgueno,J.F. and
            Abreu,M.T.
  TITLE     Intestinal Epithelial Inactivity of Dual Oxidase 2 Results in
            Microbiome-Mediated Metabolic Syndrome
  JOURNAL   Cell Mol Gastroenterol Hepatol 16 (4), 557-572 (2023)
   PUBMED   37369278
  REMARK    GeneRIF: Intestinal Epithelial Inactivity of Dual Oxidase 2 Results
            in Microbiome-Mediated Metabolic Syndrome.
REFERENCE   5  (bases 1 to 5890)
  AUTHORS   Tang,H., Liang,T., Zhou,Y., Ju,H., Song,D. and Fang,H.
  TITLE     Telocytes reduce oxidative stress by downregulating DUOX2
            expression in inflamed lungs of mice
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (4), 574-582 (2022)
   PUBMED   35607956
  REMARK    GeneRIF: Telocytes reduce oxidative stress by downregulating DUOX2
            expression in inflamed lungs of mice.
REFERENCE   6  (bases 1 to 5890)
  AUTHORS   Lipinski,S., Till,A., Sina,C., Arlt,A., Grasberger,H., Schreiber,S.
            and Rosenstiel,P.
  TITLE     DUOX2-derived reactive oxygen species are effectors of
            NOD2-mediated antibacterial responses
  JOURNAL   J Cell Sci 122 (Pt 19), 3522-3530 (2009)
   PUBMED   19759286
  REMARK    GeneRIF: DUOX2 and NOD2 cooperatively facilitate antibacterial
            action.
REFERENCE   7  (bases 1 to 5890)
  AUTHORS   Cheret,C., Gervais,A., Lelli,A., Colin,C., Amar,L., Ravassard,P.,
            Mallet,J., Cumano,A., Krause,K.H. and Mallat,M.
  TITLE     Neurotoxic activation of microglia is promoted by a nox1-dependent
            NADPH oxidase
  JOURNAL   J Neurosci 28 (46), 12039-12051 (2008)
   PUBMED   19005069
REFERENCE   8  (bases 1 to 5890)
  AUTHORS   Johnson,K.R., Marden,C.C., Ward-Bailey,P., Gagnon,L.H.,
            Bronson,R.T. and Donahue,L.R.
  TITLE     Congenital hypothyroidism, dwarfism, and hearing impairment caused
            by a missense mutation in the mouse dual oxidase 2 gene, Duox2
  JOURNAL   Mol Endocrinol 21 (7), 1593-1602 (2007)
   PUBMED   17440044
  REMARK    GeneRIF: The cochleae of mutant mice exhibit abnormalities
            characteristic of hypothyroidism, including a delayed formation of
            the inner sulcus and tunnel of Corti and an abnormally thickened
            tectorial membrane.
REFERENCE   9  (bases 1 to 5890)
  AUTHORS   Milenkovic,M., De Deken,X., Jin,L., De Felice,M., Di Lauro,R.,
            Dumont,J.E., Corvilain,B. and Miot,F.
  TITLE     Duox expression and related H2O2 measurement in mouse thyroid:
            onset in embryonic development and regulation by TSH in adult
  JOURNAL   J Endocrinol 192 (3), 615-626 (2007)
   PUBMED   17332529
REFERENCE   10 (bases 1 to 5890)
  AUTHORS   Sandell,L.L., Guan,X.J., Ingram,R. and Tilghman,S.M.
  TITLE     Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4622-4627 (2003)
   PUBMED   12671064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844566.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC172138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL844566.8         185777-185908
            133-222             AL844566.8         186192-186281
            223-387             AL844566.8         186464-186628
            388-575             AL844566.8         187135-187322
            576-777             AL844566.8         187485-187686
            778-944             AL844566.8         187843-188009
            945-1005            AL844566.8         188650-188710
            1006-1102           AL844566.8         188823-188919
            1103-1193           AL844566.8         189325-189415
            1194-1296           AL844566.8         189911-190013
            1297-1460           AL844566.8         190537-190700
            1461-1636           AL844566.8         191237-191412
            1637-1755           AL844566.8         191627-191745
            1756-1893           AL844566.8         192055-192192
            1894-2007           AL844566.8         192450-192563
            2008-2210           AL844566.8         192738-192940
            2211-2396           AL844566.8         193223-193408
            2397-2622           AL844566.8         194311-194536
            2623-2716           AL844566.8         194619-194712
            2717-2904           AL844566.8         196807-196994
            2905-2974           AL844566.8         197452-197521
            2975-3058           AL844566.8         197896-197979
            3059-3237           AL844566.8         198665-198843
            3238-3468           AL844566.8         199026-199256
            3469-3568           AL844566.8         199332-199431
            3569-3618           AL844566.8         200106-200155
            3619-3746           AL844566.8         200427-200554
            3747-3900           AL844566.8         200790-200943
            3901-4133           AL844566.8         202055-202287
            4134-4292           AL844566.8         202474-202632
            4293-4448           AL844566.8         202935-203090
            4449-4577           AL844566.8         203185-203313
            4578-5890           AL844566.8         203445-204757
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.61 cM"
     gene            1..5890
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /note="dual oxidase 2"
                     /db_xref="GeneID:214593"
                     /db_xref="MGI:MGI:3036280"
     exon            1..132
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            133..222
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            223..387
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..575
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..777
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..944
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1005
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1102
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1193
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1296
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1460
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1636
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1755
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1893
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2007
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2210
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2396
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2622
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2716
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2904
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..2974
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3058
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3237
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3468
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3568
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3618
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3746
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3900
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4133
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4134..4292
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4448
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4449..4577
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4578..5890
                     /gene="Duox2"
                     /gene_synonym="A430065P05Rik; LNOX2; NOXEF2; P138-TOX;
                     THOX2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taccagccgt gggagtgtgc gctcttgaca cactaccccc caccgccggg atcaaggaca
       61 gcatgcttcc aacaagtccc aagactctag ttctcctggg cgctctgctg actggacccc
      121 tgggcccagc aggtggccag gacgcaccct cactgccctg ggaagtgcag cgctacgacg
      181 gctggtttaa taatctgaag taccaccagc gcggtgcggc tggctcgcgg ctgcgtcgcc
      241 taataccggc taattatgct gacggtgttt atcaggctct ggaagagccg ctactgccca
      301 accctcgccg gctaagcgat gctgtcgcta agggcaaagc agggctgccc tcggtccaca
      361 accgcacagt gctgggggtc ttctttggct accacgtgct ctcagacctg gtgagtgtgg
      421 aaacaccagg ctgccccgca gagttcctca acatttacat cccacgtggg gacccggtgt
      481 tcgaccctga caagcgcggg aacgtggtgc tgccctttca aaggagccgc tgggaccaca
      541 acactggaca gagccccagc aacccccggg accagagcaa ccaggtgacc ggctggctag
      601 atggcagcgc catctatggc tcctctcatt cctggagtga cactctgagg agcttctctg
      661 gaggacagct ggcttctggg cctgaccctg ctttcccgcg gaactcccag agctctctgc
      721 tcatgtggat ggcgccggac ccctccacgg ggcggggcgg gccacaaggg gtgtatgcct
      781 ttggggccca gcgcgggaac agggagccct ttctgcaggc tctgggcttg ttgtggtttc
      841 gctaccacaa cctgtgtgcc aggaagctgg cgcaggagca cccgcactgg ggggatgagg
      901 aactgttcca gcatgctcgc aagagggtca ttgccaccta ccagaacatt gctctatacc
      961 aatggctgcc cagcttcctg cagaaaactc ctccagagta ttcagggtac cgccctttca
     1021 tggaccccag catctccccg gagttcgtgg tggcctctga gcagttcctc tctactatgg
     1081 tgccccctgg ggtctacatg agaaactcca gctgtcattt ccggaaattc ccgaaggaag
     1141 gttcagacag ctctccagct ctcagagtct gcaacagcta ctggattcgg gagaacccca
     1201 atctgaagac tgctcaagat gtggatcagt tgctgctggg aatggcttcc cagatctcag
     1261 agctggagga caggatagtg attgaagacc tgagagatta ctggcctggc ccagagagat
     1321 tctctcgcac agactacgtg gctagcagta tccagcgtgg ccgagatatg gggctcccca
     1381 gttatagcca ggctctgctg gccttgggac tggagcctcc taagaactgg agtgctctca
     1441 acccccaagt agaaccccag gtgctggagg ccacagctgc tctgtacaac caggacctgt
     1501 cccagttgga actactcctg ggtggactcc tggagagcca tggggaccct ggacctctat
     1561 tcagcaacat cattcttgac cagtttgtga ggctccggga tggtgatcgc tactggtttg
     1621 agaacactag gaatgggctg ttctccaaag aggagattgc agaaatcaga aacaccacct
     1681 tgcgggatgt actggtagct gtctccaatg tggaccccag tgccttgcaa cccaacgttt
     1741 tcttctggca ggaaggtgca ccctgcccac agcctcggca actcacaacg gacggcttgc
     1801 cccagtgtgc gcctgttact gtgattgact actttgaggg cagtggtgct ggctatggtg
     1861 tcacgcttgt agctgtctgc tgctttccat tagtgagtct gattgtcgct ggggtggtgg
     1921 ctcatttccg gaaccgagaa cacaagatgc tactaaagaa aggcaaagag agtctgaaga
     1981 aacaaccagc cagtgatggg gtaccagcaa tggagtggcc gggccccaag gagaagagct
     2041 atccagtcac tctccagttg cttccagaca gaagtctgca ggtccttgac aaacggttca
     2101 ctgtgctccg gaccatccaa ctgcagtccc cacagcaggt taacctcatc ctgtccagca
     2161 acagtggacg tcgcaccctg ctgctcaaga tccccaagga gtatgacctg gtgctgatgt
     2221 ttaactctga agaggaccgg ggtgccttcg tgcggctgtt gcaagacctc tgtatctgct
     2281 gcactcccgg cctccacata gctgaggtgg atgagaagga gctattgaga aaggctgtga
     2341 ccaagcagca acgggcaggc atcttggaga tcttcttcag acagcttttt gctcaggtgc
     2401 tggacatcaa ccaggctgat gcagggactc tgcccctgga ctcatcccag caagtgcgtg
     2461 aggctctgac ctgtgagctg agcagagctg agtttgctga ctccctaggc ctcaagcccc
     2521 aggacatgtt tgtggagtcc atgttttctc tggctgacaa ggatggcaat ggctacatat
     2581 ccttccggga gttcctggac atcctggtgg tcttcatgaa aggctcctca gaggataagt
     2641 cccgcctgat gtttaccatg tatgacctgg atgggaatgg cttcctctcc aaggacgagt
     2701 tcttcaccat gatgcggtcc ttcattgaga tctccaacaa ctgcctgtcc aaggcccagc
     2761 tggctgaggt ggttgagtct atgttccggg agtctgggtt ccaggacaag gaggagctga
     2821 cctgggagga cttccacttc atgctgcggg accacgacag tgatctccga ttcacacagc
     2881 tctgtgtcaa aggtggagct ggaggcacca aggacatctt taaacaaagc agtgcctgtc
     2941 gagtctcgtt catcaaccgg actcctggga acagttcctg ccccccagaa acggcactct
     3001 ctgacatgga aaccccagaa ctgggaagta ctggcctaaa gaagaggttt ggcaaaaagg
     3061 taatggggcc ctctccccgg ctgtacacgg aggcactgca ggagaaaaaa cagagtggct
     3121 tcctggccca gaagttcaag cagtacaagc gatttgtgga aaactaccgg cgccacattg
     3181 tgtgtgttac aatcttctca gccatctgca taggcctgtt tgcagaccgt gcctactact
     3241 atggctttgc ctcaccaccc acggacatcg aagaaaccac ctatgtgggc atcatcctgt
     3301 cccggggcac ggcggccagc atctccttca tgttctccta catcctgctc accatgtgcc
     3361 gcaacctcat caccttcttg cgggagacct tcctcaaccg ctacatcccc tttgatgccg
     3421 ctgtggactt ccatcgctgg attgctatgg ctgcagttgt cctagctgtt ctgcacagtg
     3481 ctggacatgc agtcaatgtg tacattttct cagtcagtcc cctcagcctg atggcctgcg
     3541 tcttccctaa cgtctttgtg aatgacgggt ccaagtttcc cccaaagtac tactggtggt
     3601 tctttgagac agttccaggt atgacaggag tcctcctgct cctggtcctg gccatcatgt
     3661 acgtcttcgc ctcccaccac ttccgccgcc acagtttccg gggcttctgg ctgacccacc
     3721 acctctatgt tgtgctttat gtcctgatca tcatccatgg cagctatgcc ctcatccaat
     3781 tacccagctt ccacatctac ttcctggtcc cagcaattat ctatggaggg gacaagctag
     3841 tgagcctgag ccggaagaag gtggagatca gtgtggtgaa ggcggagctg ctgccttcag
     3901 gggtgaccta cttgcagttc cagagaccca agacatttga gtacaaatca gggcagtggg
     3961 tgcgaatcgc gtgcctggat ctgggtacca atgagtatca ccccttcacg ctgacctctg
     4021 caccccatga ggacacactc agcctgcaca tcagggctgt gggaccttgg actactcgcc
     4081 tcagagagat ctactcaccc ccagtgggtg gcacctgtgc cagataccca aagctgtacc
     4141 tcgatggacc atttggagag ggccatcagg agtggcataa gtttgaggtg tcagtgctgg
     4201 taggaggggg cattggagtc accccctttg cctccatcct caaagacctg gtcttcaaat
     4261 cgtccatggg cagccagatg ctctgtaaga agatctactt catctgggtg acaaggactc
     4321 agaggcagtt tgagtggctg gctgacatca tccgggaggt ggaggagaat gactgccagg
     4381 acctggtgtc tgtgcacatc tacattactc agctggctga gaagttcgac ctcaggacca
     4441 ccatgctgta catctgtgag aggcacttcc agaaggcgct gaacaggagt ttgttcacgg
     4501 gcctgcgttc catcacccac tttggtcgcc ctccctttga gctcttcttc aactctctac
     4561 aggaagtcca tccacaggta cgtaagattg gagtcttcag ctgtggtcct ccagggatga
     4621 ccaagaatgt ggagaaggcc tgccagctca tcaacaggca ggaccgggcc cactttgtgc
     4681 atcattatga gaacttctga acctgctctc cttggtccct gtcctgtctg ctgttctcct
     4741 tatttattgt tactgtcact tgagaccgta gccagggaac tggagcccca ctcctaacag
     4801 cgcctatgtt ctgggcaggt agacaaggcc actccaatac ttagctcatg tcacagtaag
     4861 ctttgcgatg tatagcaagg agaggaaagc ccctatttct gacaactgtg gatgggaaca
     4921 gaacactggg gatcacgtct gatgggtctc tgtttctgtt ttgccttcac aaaattacta
     4981 tattgctatg gacttttgtt gggggaatta agaaaagcat gacaatcttc tctgagtttg
     5041 tctcagaaac cacacactgc acatagcccg cacagccctc ctgcctcaac tcaggctctg
     5101 ggtctttccc caccccacta ccccccagct tctgccccac accttcctgc tctgagagga
     5161 ccacaaacca taaggctgcc agagaacaaa tgtccagagt tcctaatgtc atccagtagt
     5221 gtctgctgtc ttgacccttc agtgaatcct cctgtgagca tgaagccatt ccctgggctc
     5281 cagggtcaag gcagtaatgg tatctctacc acacacccca aacccctcag ctccctttcc
     5341 ccagaggaag caaaacagct ttcctggttt gtgcagttcg ggcgctggaa gcctcttacc
     5401 ctaggggaat cagctgccac ccaaccgcag tacacagatg ttacctctac ccgcaaaaac
     5461 ccttttcctt ctttccctgg gattttccta aaaagctgag ctgtaacata tgtacagttg
     5521 aggtgtattt gcataaagtg tataaatctt atagtagctg ccgtcctggt caagatagaa
     5581 aacattccaa cattccagtc accccggaag cttcgccggt gaatctccct catgtaaaag
     5641 caaccactag catggcttct gtcactgtac tttgggtcat atggaatgca cttttgatct
     5701 tggccccttt ctcatcccct gatgcttttg tgattcatcc gtgtcattgt gcatgttgga
     5761 catttgttcc tttttattgc tgagtagcat ttcattaaag agatgtatct atttgtttag
     5821 tcactctgct ggtagacagt tggcttgttt ctgggtttgg ctgattgtaa ataaagttgc
     5881 tataaacatc
//
