LOCUS       NM_001099297            5267 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus dual oxidase 1 (Duox1), mRNA.
ACCESSION   NM_001099297 XM_001480692 XM_130483
VERSION     NM_001099297.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5267)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5267)
  AUTHORS   Pato,A., Bolcskei,K., Donko,A., Kaszas,D., Boros,M., Bodrogi,L.,
            Varady,G., Pape,V.F.S., Roux,B.T., Enyedi,B., Helyes,Z., Watt,F.M.,
            Sirokmany,G. and Geiszt,M.
  TITLE     Hydrogen peroxide production by epidermal dual oxidase 1 regulates
            nociceptive sensory signals
  JOURNAL   Redox Biol 62, 102670 (2023)
   PUBMED   36958249
REFERENCE   3  (bases 1 to 5267)
  AUTHORS   Gupta,T., Sarr,D., Fantone,K., Ashtiwi,N.M., Sakamoto,K.,
            Quinn,F.D. and Rada,B.
  TITLE     Dual oxidase 1 is dispensable during Mycobacterium tuberculosis
            infection in mice
  JOURNAL   Front Immunol 14, 1044703 (2023)
   PUBMED   36936954
  REMARK    GeneRIF: Dual oxidase 1 is dispensable during Mycobacterium
            tuberculosis infection in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5267)
  AUTHORS   Habibovic,A., Hristova,M., Morris,C.R., Lin,M.J., Cruz,L.C.,
            Ather,J.L., Geiszt,M., Anathy,V., Janssen-Heininger,Y.M.W.,
            Poynter,M.E., Dixon,A.E. and van der Vliet,A.
  TITLE     Diet-induced obesity worsens allergen-induced type 2/type 17
            inflammation in airways by enhancing DUOX1 activation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 324 (2), L228-L242 (2023)
   PUBMED   36625485
  REMARK    GeneRIF: Diet-induced obesity worsens allergen-induced type 2/type
            17 inflammation in airways by enhancing DUOX1 activation.
REFERENCE   5  (bases 1 to 5267)
  AUTHORS   Morris,C.R., Habibovic,A., Dustin,C.M., Schiffers,C., Lin,M.C.,
            Ather,J.L., Janssen-Heininger,Y.M.W., Poynter,M.E., Utermohlen,O.,
            Kronke,M. and van der Vliet,A.
  TITLE     Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and
            mucus metaplasia during allergic airway disease
  JOURNAL   Mucosal Immunol 15 (5), 977-989 (2022)
   PUBMED   35654836
REFERENCE   6  (bases 1 to 5267)
  AUTHORS   Kennedy,K.A., Ostrakhovitch,E.A., Sandiford,S.D., Dayarathna,T.,
            Xie,X., Waese,E.Y., Chang,W.Y., Feng,Q., Skerjanc,I.S.,
            Stanford,W.L. and Li,S.S.
  TITLE     Mammalian numb-interacting protein 1/dual oxidase maturation factor
            1 directs neuronal fate in stem cells
  JOURNAL   J Biol Chem 285 (23), 17974-17985 (2010)
   PUBMED   20233719
REFERENCE   7  (bases 1 to 5267)
  AUTHORS   Cheret,C., Gervais,A., Lelli,A., Colin,C., Amar,L., Ravassard,P.,
            Mallet,J., Cumano,A., Krause,K.H. and Mallat,M.
  TITLE     Neurotoxic activation of microglia is promoted by a nox1-dependent
            NADPH oxidase
  JOURNAL   J Neurosci 28 (46), 12039-12051 (2008)
   PUBMED   19005069
REFERENCE   8  (bases 1 to 5267)
  AUTHORS   Rigutto,S., Hoste,C., Dumont,J.E., Corvilain,B., Miot,F. and De
            Deken,X.
  TITLE     Duox1 is the main source of hydrogen peroxide in the rat thyroid
            cell line PCCl3
  JOURNAL   Exp Cell Res 313 (18), 3892-3901 (2007)
   PUBMED   17643428
  REMARK    GeneRIF: Duox1 is the main source of H(2)O(2) in the rat thyroid
            cell line PCCl3.
REFERENCE   9  (bases 1 to 5267)
  AUTHORS   Milenkovic,M., De Deken,X., Jin,L., De Felice,M., Di Lauro,R.,
            Dumont,J.E., Corvilain,B. and Miot,F.
  TITLE     Duox expression and related H2O2 measurement in mouse thyroid:
            onset in embryonic development and regulation by TSH in adult
  JOURNAL   J Endocrinol 192 (3), 615-626 (2007)
   PUBMED   17332529
REFERENCE   10 (bases 1 to 5267)
  AUTHORS   Sandell,L.L., Guan,X.J., Ingram,R. and Tilghman,S.M.
  TITLE     Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4622-4627 (2003)
   PUBMED   12671064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844566.8.
            
            On or before Jul 25, 2007 this sequence version replaced
            XM_001480692.1, XM_130483.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.3152.1,
                                           SRR10223969.3002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AL844566.8         168244-168332       c
            90-173              AL844566.8         166002-166085       c
            174-338             AL844566.8         165452-165616       c
            339-526             AL844566.8         164380-164567       c
            527-728             AL844566.8         164016-164217       c
            729-895             AL844566.8         163695-163861       c
            896-956             AL844566.8         163234-163294       c
            957-1053            AL844566.8         163046-163142       c
            1054-1144           AL844566.8         160694-160784       c
            1145-1247           AL844566.8         159873-159975       c
            1248-1420           AL844566.8         159480-159652       c
            1421-1596           AL844566.8         157846-158021       c
            1597-1715           AL844566.8         157467-157585       c
            1716-1853           AL844566.8         156788-156925       c
            1854-1967           AL844566.8         156031-156144       c
            1968-2167           AL844566.8         155115-155314       c
            2168-2353           AL844566.8         154277-154462       c
            2354-2579           AL844566.8         150768-150993       c
            2580-2673           AL844566.8         150509-150602       c
            2674-2849           AL844566.8         150126-150301       c
            2850-2919           AL844566.8         148099-148168       c
            2920-3045           AL844566.8         147589-147714       c
            3046-3224           AL844566.8         146574-146752       c
            3225-3455           AL844566.8         146185-146415       c
            3456-3555           AL844566.8         145588-145687       c
            3556-3605           AL844566.8         145330-145379       c
            3606-3733           AL844566.8         143802-143929       c
            3734-3887           AL844566.8         139786-139939       c
            3888-4120           AL844566.8         139193-139425       c
            4121-4279           AL844566.8         138804-138962       c
            4280-4435           AL844566.8         137601-137756       c
            4436-4564           AL844566.8         137378-137506       c
            4565-5267           AL844566.8         136032-136734       c
FEATURES             Location/Qualifiers
     source          1..5267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.63 cM"
     gene            1..5267
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /note="dual oxidase 1"
                     /db_xref="GeneID:99439"
                     /db_xref="MGI:MGI:2139422"
     exon            1..89
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..4687
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /EC_number="1.6.3.1"
                     /note="dual oxidase 2"
                     /codon_start=1
                     /product="dual oxidase 1 precursor"
                     /protein_id="NP_001092767.1"
                     /db_xref="CCDS:CCDS38222.1"
                     /db_xref="GeneID:99439"
                     /db_xref="MGI:MGI:2139422"
                     /translation="MGFHLALAWILLVGTLASLGAQNSISWEVQRFDGWYNNLMEHRW
                     GSKGSRLQRLVPASYADGVYQPLKEPYLPNPRHLSNRVMRGSAGQPSLRNRTVLGVFF
                     GYHVLSDLVSVETPGCPAEFLNIYIPHGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPS
                     NPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSLLMWMA
                     PDPSTGQGGPRGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELF
                     QHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYRPFLDPSISPEFVVASEQFLSTMV
                     PSGVYMRNASCHFQGIPSHNSSVSGALRVCNSYWSREHPKLQRAEDVDALLLGMASQI
                     AEREDHVVVEDMQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLSPISHW
                     QDINPALSRSNGTVLEATAALYNQDLSRLELLPGGLLESHGDPGPLFSTIVLDQFVRL
                     RDGDRYWFENTRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPNVFFWLAGDPCP
                     QPSQLSAKGLPACAPLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRKRNF
                     KRLQRQDRQSIMSEKLVGGVEALEWQGRNEPCRPVLVHLQPGQIRVVDGRLTVLRTIQ
                     LRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENVRGALKENGLSF
                     QEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREAL
                     TCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKS
                     RLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEE
                     LTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHC
                     ARNNMKTASSPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQT
                     VQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRG
                     TAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLIASTAIILTVLHSA
                     GHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAI
                     MYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVG
                     DKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP
                     FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWH
                     KFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADII
                     REVEENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFG
                     RPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF"
     exon            90..173
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            174..338
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..526
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..728
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..895
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..956
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1053
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1144
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1247
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1420
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1596
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1715
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1853
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1967
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2167
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2353
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2579
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2673
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2849
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2919
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3045
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3224
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3455
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3555
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3605
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3733
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3887
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4120
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4279
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4280..4435
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4564
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            4565..5267
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5247..5252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /note="hexamer: AATAAA"
     polyA_site      5265
                     /gene="Duox1"
                     /gene_synonym="9930101G15Rik; Duox2; LNOX1; LNOX2; NOXEF1;
                     NOXEF2; P138-TOX; THOX1; THOX2"
                     /note="major polyA site"
ORIGIN      
        1 caatatttaa tcccacgtta ccatttccat catggggttc cacttagctc tggcctggat
       61 tctcctggtt gggacactgg cttctttggg agctcagaac tccatttctt gggaggtaca
      121 gcgatttgat ggatggtata acaacctcat ggagcacaga tggggcagca aaggctctcg
      181 gctgcagcgc cttgttccag ccagctatgc agatggtgtc taccagcccc tgaaagaacc
      241 ctacctgcct aacccccgac accttagtaa cagggtcatg agaggttctg cagggcagcc
      301 atctcttcgg aaccgtacag tcctgggtgt cttctttggc taccacgtgc tctcagacct
      361 ggtgagtgtg gaaacaccag gctgccccgc agagttcctc aacatttaca tcccgcatgg
      421 ggacccggtg ttcgaccctg acaagcgcgg gaacgtggtg ctgccctttc aaaggagccg
      481 ctgggaccgc aacactggac agagccccag caacccccgg gaccagagca accaggtgac
      541 cggctggcta gatggcagcg ccatctatgg ctcctctcat tcctggagtg acactctgag
      601 gagcttctct ggaggacagc tggcttctgg gcctgaccct gctttcccat cggactccca
      661 gagctctctg ctcatgtgga tggcgccgga cccctccaca gggcagggag ggccacgggg
      721 ggtgtatgcc ttcggggccc agcgcgggaa cagggagccc tttctgcagg ctctgggctt
      781 gttgtggttt cgctaccaca acctgtgtgc caggaagctg gcgcaggagc acccgcactg
      841 gggggatgag gaactgttcc agcatgctcg caagagggtc attgccacct accagaacat
      901 tgcgatgtat gagtggctgc ccagcttcct gaagcaaact cctccggagt atccaggata
      961 ccgtccattt ctggacccca gtatctcccc agagttcgtt gtggcctctg agcagttcct
     1021 ctctaccatg gtgccctctg gggtctacat gaggaatgcc agttgtcatt tccaggggat
     1081 tcccagtcat aactcaagtg tctctggagc tctccgggtc tgcaacagct actggagtcg
     1141 agagcacccc aagctacaaa gggctgaaga tgtggatgca ctgctgctgg gcatggcctc
     1201 ccagattgct gagagagagg accacgtggt ggttgaggac atgcaagatt tctggcctgg
     1261 gccactgaag ttttcccgta cagactacct ggccagctgc ctgcagaggg gccgggatct
     1321 aggcctgcct tcttacacca aagccaggga ggcactgggc ctgtctccca tttcccactg
     1381 gcaggacatc aaccctgcac tctccaggag caatggcact gtgctggagg ccacagctgc
     1441 cctgtacaat caggacctgt ctcggctgga gctactccca ggggggcttc tggagagcca
     1501 tggagaccct ggaccccttt tcagcactat tgtccttgac cagtttgtca ggctacgaga
     1561 tggtgaccgt tactggtttg aaaacaccag gaacggattg ttctctaagg aagagatcgc
     1621 agagatccga aacacttccc tacgggacat tctagtggct gtcaccaatg tggaccccag
     1681 tgccctacag cccaatgtct tcttttggct tgcaggagac ccctgtccac agccaagtca
     1741 gctcagcgcc aagggcctgc cagcctgtgc ccccctcttc attcgggact atttcgaggg
     1801 gagtggattt ggcttcggac tcaccattgg gaccctttgc tgtttcccct tagtcagcct
     1861 ccttagtgcc tggattgttg cccggcttcg aaagaggaat ttcaagaggc tccagagaca
     1921 agaccgccag agcatcatgt cggagaagct tgtaggggga gtggaagctt tggagtggca
     1981 gggccgcaat gaaccctgca ggccagtgct tgtgcactta cagccgggac agattcgagt
     2041 agtggatggc aggctcaccg tgctccggac catccagctg cgacccccac agcaggtcaa
     2101 cctcatcctg tccagcaacc gtggacgccg caccctgctg ctcaagatcc ccaaggagta
     2161 tgacctggtt ctgttgttta acatggagga ggaacggcag gcactggtgg aaaacgtcag
     2221 gggagctctg aaggaaaatg ggctgagctt ccaggagtgg gaactgaggg agcaggagct
     2281 gatgagggca gcagtgacca ggcaacaacg gggccacctc ctggagacct tcttcaggca
     2341 ccttttctcc caggtgttag acatcaatca ggctgatgca gggactctgc ctctggattc
     2401 ctcgaccaaa gtgcgtgagg ccctgacctg tgagctgagc agagctgagt ttgcagactc
     2461 cctaggcctc aagccccagg acatgtttgt ggagtccatg ttttctctag ccgacaagga
     2521 tggcaatggc tacctgtcct tccgggagtt cctggacatc ctggtggtct tcatgaaagg
     2581 ctccccagag gagaagtctc gtcttatgtt ccgaatgtat gactttgatg ggaacggtct
     2641 catttccaag gatgagttca ttaggatgct aaggtccttc atcgagatct ccaacaactg
     2701 cctgtccaag gcccagctgg ctgaggtggt tgagtctatg ttccgggagt ctggcttcca
     2761 ggacaaggag gagctgacct gggaggactt ccacttcatg ctgcgggacc acgacagtga
     2821 tctccgattc acacagctct gtgtcaaagg tgtggaagtg ccggaagtga tcaagaacct
     2881 ctgccggcga gcctcctaca tcagccagga gaagatctgc ccttcgccca gaatgagcgc
     2941 ccactgtgcc cgaaacaaca tgaagactgc gtcatcacca cagagactgc agtgccccat
     3001 ggacacagac cctcctcaag agattcgacg gaggtttggc aaaaaggtaa cttcattcca
     3061 gcccttactg ttcactgagg cacaccgaga gaagtttcaa cgcagccgcc gccaccaaac
     3121 ggtgcagcag ttcaagcgct ttattgagaa ttacaggcgc cacattggct gtgtggcggt
     3181 gttttacacc atcactgggg cgctcttcct ggagagagcc tactactatg catttgcagc
     3241 acaccacagc ggcatcaccg ataccacccg tgtaggcatc atcctgtccc ggggcacggc
     3301 ggccagcatc tcctttatgt tttcctacat cctgctcacc atgtgtcgca acctcatcac
     3361 cttcttgcgg gagaccttcc tcaaccgcta cattcccttc gatgctgccg tggacttcca
     3421 tcgcctcatc gcctccacgg ccatcatcct cacagtctta cacagtgctg gccacgtagt
     3481 gaatgtgtac ctgttctcca tcagtccact cagtgtcctc tcttgcctct tccctggcct
     3541 cttccacgat gatgggtcgg agttccctca gaagtattac tggtggttct tccagactgt
     3601 gccaggtctc actggggtcc tcctgctcct ggccctggcc atcatgtacg tcttcgcctc
     3661 ccaccacttc cgccgccgca gtttccgggg cttctggctg acccatcacc tctacatttt
     3721 tctctacatt ctgctcatca tacatggcag ctttgctctg atccagatgc cccggttcca
     3781 catcttcttc ctggtccctg caattattta tgtgggggac aagctggtga gcctgagccg
     3841 gaagaaggtg gagatcagcg tggtgaaggc tgagctgctg ccatcaggag tgacccacct
     3901 gcggttccag aggcctcagg gctttgagta taagtcaggg cagtgggttc ggattgcgtg
     3961 cctggctctg ggaaccaccg agtatcaccc tttcacactg acttctgcac cccacgagga
     4021 cacactcagc ctgcacatcc gggcggctgg accctggacc actcgcctca gggaaatcta
     4081 ctcaccccca acgggtgaca cctgtgccag atacccaaag ctgtacctcg atggaccgtt
     4141 tggagagggc caccaggagt ggcacaagtt tgaggtgtca gtgctggtag gagggggcat
     4201 tggagtcact ccctttgcct ccatcctcaa agacctggtt ttcaagtcat cagtcagctg
     4261 ccaagtgttc tgtaagaaga tctacttcat ctgggtgaca aggactcaga ggcagtttga
     4321 gtggctggct gacatcatcc gggaggtgga ggagaatgac cgccaggacc tggtgtctgt
     4381 gcacatctat attactcagc tggctgagaa gttcgacctc aggaccacca tgctgtacat
     4441 ctgtgagcgg cacttccaga aggtgctgaa caggagtctg ttcacgggcc tgcgctccat
     4501 cacccacttt ggtcgccctc cctttgagcc ctttttcaac tctctgcagg aagtccaccc
     4561 ccaagtccga aagattggag tatttagctg tggtccccct ggcatgacca agaatgtgga
     4621 gaaggcttgt cagctcatca acaggcagga caggactcat ttttctcacc attatgagaa
     4681 cttctaggcc tcctgcccag caactatgcc cactactgcc ctgctgggac agcaggggct
     4741 ttggcctgtg ccttaaccca gtactcattt ctggccacct cagccttggc ccttcccacc
     4801 tgccaacttg gttggtccaa gtagcctcgc tcaggcatca tgtgtaggct cagagatctc
     4861 tagggccaga atgtgtcttg agtttgtcga aggagcactg tttaagaact ataggttcag
     4921 aagtagggga gcttttgggt tgagacaaag tgagaattaa gcaaaaactt gacagtagac
     4981 aacctgtcaa gtttttgaaa gtgagtctga gtgatagtat ggatgctggc gtcttcaagt
     5041 cctcttcact gtgttcttcc tctcttcaaa atggttggga gatgtcttag agtagccagg
     5101 ggcaacttac agaaaccctc aggaccagcc taactgaaca actgatctct caaaatgtaa
     5161 aatgtagtca gacctttctg tgcccactaa ccgcctggag cagtgcccct cagccccatc
     5221 tccctcttct agtggtctgt tttgcaaata aacggtgttt ccccctt
//
