LOCUS       NM_001105667            1006 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus deoxythymidylate kinase (Dtymk), transcript variant 1,
            mRNA.
ACCESSION   NM_001105667
VERSION     NM_001105667.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Tiani,K.A. and Stover,P.J.
  TITLE     DTYMK is an essential gene in mice and heterozygosity does not
            cause neural tube defects
  JOURNAL   Arch Biochem Biophys 755, 109991 (2024)
   PUBMED   38621447
REFERENCE   2  (bases 1 to 1006)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1006)
  AUTHORS   Moon,S., Im,S.K., Kim,N., Youn,H., Park,U.H., Kim,J.Y., Kim,A.R.,
            An,S.J., Kim,J.H., Sun,W., Hwang,J.T., Kim,E.J. and Um,S.J.
  TITLE     Asxl1 exerts an antiproliferative effect on mouse lung maturation
            via epigenetic repression of the E2f1-Nmyc axis
  JOURNAL   Cell Death Dis 9 (11), 1118 (2018)
   PUBMED   30389914
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1006)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   5  (bases 1 to 1006)
  AUTHORS   Liang,P., Averboukh,L., Zhu,W., Haley,T. and Pardee,A.B.
  TITLE     Molecular characterization of the murine thymidylate kinase gene
  JOURNAL   Cell Growth Differ 6 (10), 1333-1338 (1995)
   PUBMED   8845311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY098372.1, CB182101.1, C78743.1 and AI462533.1.
            
            Transcript Variant: This variant represents the longer transcript
            and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009220.1, AK088416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               BY098372.1         2-309
            309-635             CB182101.1         265-591
            636-1000            C78743.1           1-365               c
            1001-1006           AI462533.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.34 cM"
     gene            1..1006
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
                     /note="deoxythymidylate kinase"
                     /db_xref="GeneID:21915"
                     /db_xref="MGI:MGI:108396"
     exon            1..237
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
                     /inference="alignment:Splign:2.1.0"
     exon            238..346
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
                     /inference="alignment:Splign:2.1.0"
     exon            347..437
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
                     /inference="alignment:Splign:2.1.0"
     exon            438..635
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
                     /inference="alignment:Splign:2.1.0"
     exon            636..1003
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      975..980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
                     /note="hexamer: AATAAA"
     polyA_site      988
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
     polyA_site      996
                     /gene="Dtymk"
                     /gene_synonym="CDC8; D10Ertd203e; mtmk; Tmk; TMPK; TYPK"
                     /note="major polyA site"
ORIGIN      
        1 agaattcgtt ttccaaccgg aagagggcag ggcttccgtg cacgccgggc ttctgctgca
       61 tctaacattg gcgggaacct ggcaagttga ccggtgctgt gcgggcgatg gcgtcgcgtc
      121 ggggagcgct catcgtgctg gagggtgtgg accgtgctgg caagaccacg cagggcctca
      181 agctggtgac cgcgctgtgc gcctcgggcc acagagcgga gctgctgcgt ttccccgaaa
      241 gatcaacgga aatcggcaag cttctgaatt cctacttgga aaagaaaacg gaactagagg
      301 atcactccgt gcacctgctc ttctctgcaa accgctggga acaagtacca ttaattaagg
      361 cgaagttgaa ccagggtgtg acccttgttt tggacagata cgccttttct ggggttgcct
      421 tcactggtgc caaagagaat ttttccctgg attggtgtaa acaaccggac gtgggccttc
      481 ccaaacctga cctgatcctg ttccttcagt tacaattgct ggacgctgct gcacggggag
      541 agtttggcct tgagcgatat gagaccggga ctttccaaaa gcaggttctg ttgtgtttcc
      601 agcagctcat ggaagagaaa aacctcaact ggaaggtggt tgatgcttcc aaaagcattg
      661 aggaagtcca taaagaaatc cgtgcacact ctgaggacgc catccgaaac gctgcacaga
      721 ggccactggg ggagctatgg aaataaatca gcttccattg ccaatacaat tttctggttc
      781 tgcaagagac tggtagaagg ctcacatctc tacactattc agcaggagct agttctcagc
      841 agaagagatc tacaagaccc ctctcataac ctgagattta agttgtgcag tatctctctt
      901 tacctactgc ttggctgtaa aggtgtagca gtttccttga gatcaattgg tgagaaatca
      961 catttttttt acagaataaa aatttaccca aaaatatatc tcaaaa
//
