LOCUS       NM_172442               5786 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus deltex 4, E3 ubiquitin ligase (Dtx4), transcript
            variant 1, mRNA.
ACCESSION   NM_172442 XM_001000437 XM_001000448 XM_001000458 XM_001000473
            XM_001000490
VERSION     NM_172442.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5786)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5786)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5786)
  AUTHORS   Wang,Z., Dai,Z., Pan,Y., Wu,S., Li,Z. and Zuo,C.
  TITLE     E3 ubiquitin ligase DTX4 is required for adipogenic differentiation
            in 3T3-L1 preadipocytes cell line
  JOURNAL   Biochem Biophys Res Commun 492 (3), 419-424 (2017)
   PUBMED   28842252
  REMARK    GeneRIF: The results indicate that DTX4 stable knockdown inhibits
            adipogenesis of 3T3-L1 cells through inhibiting C/EBPalpha and
            PPARgamma, arresting mitotic clonal expansion and regulating Wnt
            signaling pathway.
REFERENCE   4  (bases 1 to 5786)
  AUTHORS   Heng,X., Guo,Q., Leung,A.W. and Li,J.Y.
  TITLE     Analogous mechanism regulating formation of neocortical basal
            radial glia and cerebellar Bergmann glia
  JOURNAL   Elife 6, e23253 (2017)
   PUBMED   28489004
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5786)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 5786)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   7  (bases 1 to 5786)
  AUTHORS   Tachikawa,K., Sasaki,S., Maeda,T. and Nakajima,K.
  TITLE     Identification of molecules preferentially expressed beneath the
            marginal zone in the developing cerebral cortex
  JOURNAL   Neurosci Res 60 (2), 135-146 (2008)
   PUBMED   18055048
REFERENCE   8  (bases 1 to 5786)
  AUTHORS   Lehar,S.M. and Bevan,M.J.
  TITLE     T cells develop normally in the absence of both Deltex1 and Deltex2
  JOURNAL   Mol Cell Biol 26 (20), 7358-7371 (2006)
   PUBMED   16923970
REFERENCE   9  (bases 1 to 5786)
  AUTHORS   Storck,S., Delbos,F., Stadler,N., Thirion-Delalande,C., Bernex,F.,
            Verthuy,C., Ferrier,P., Weill,J.C. and Reynaud,C.A.
  TITLE     Normal immune system development in mice lacking the Deltex-1 RING
            finger domain
  JOURNAL   Mol Cell Biol 25 (4), 1437-1445 (2005)
   PUBMED   15684394
REFERENCE   10 (bases 1 to 5786)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU705490.1, CF537541.1, BC058647.1, CA328050.1 and CN525673.1.
            
            On May 15, 2008 this sequence version replaced NM_172442.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058647.1, SRR1660815.219521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BU705490.1         9-100
            93-542              CF537541.1         1-450
            543-1592            BC058647.1         1-1050
            1593-2189           CA328050.1         30-626
            2190-3040           BC058647.1         1648-2498
            3041-3081           CN525673.1         729-769
            3082-5786           BC058647.1         2539-5243
FEATURES             Location/Qualifiers
     source          1..5786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.72 cM"
     gene            1..5786
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /note="deltex 4, E3 ubiquitin ligase"
                     /db_xref="GeneID:207521"
                     /db_xref="MGI:MGI:2672905"
     exon            1..990
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     CDS             780..2630
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein deltex-4; deltex4; E3 ubiquitin-protein ligase
                     DTX4; deltex 4 homolog; RING-type E3 ubiquitin transferase
                     DTX4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DTX4 isoform 1"
                     /protein_id="NP_766030.3"
                     /db_xref="CCDS:CCDS29631.1"
                     /db_xref="GeneID:207521"
                     /db_xref="MGI:MGI:2672905"
                     /translation="MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSV
                     VLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSW
                     TPYDMEVGITIQYAYEKQHPWIDLTSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLI
                     YPMVTGTMPKTQSWPVSPGPATSSPAPPCSCPQCVLVMSVKAAVVHGGTGPPAVRKNM
                     ALSGVGKLPQPPGPGAKPLDTTGTIRGPGKTAPSQVIRRQVSNAPAGATVGSPASPQG
                     SNRKTGRVALATLNRSNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGI
                     LMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLK
                     KYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHIYHIYCLVAMY
                     NNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGI
                     QGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESD
                     TVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSHEKD"
     exon            991..1705
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1767
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1929
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..1991
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2144
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2306
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2396
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..5770
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3636..3641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
                     /note="hexamer: AATAAA"
     polyA_site      3664
                     /gene="Dtx4"
                     /gene_synonym="D930042H13; RNF155"
ORIGIN      
        1 agagagagag agagagagag agagagagag agagagagag agagagagaa tgcgtatgca
       61 tgcacgagct gtagggagat gcgagcctct gagctcacgc cgcggacacg gccggtgctg
      121 agctgaaaac agacagacag acagttccat atttgaacag gctgcaaagt tgggtcctgg
      181 cagtggcagc tgggaccggg atggcgcgcg tgctctcgag actgggggac cagggaagcc
      241 tccgcgggcg cgagctcgcc ttggcgctct gcccgggagg ggcgactcct cctggaggcc
      301 actgagccga gccgcaggga gggggagctg tgccaccgcg gtcggcttac tcgaagcgga
      361 gagagggcgg agggcgtgac cgtgcggcgc gatccacgcg ggcgcccgcg gagcccgagg
      421 cgcaactggt gcgaggcggg tgcagcgtcg cgctcgggcc gcgcgccccc gggtggcttt
      481 gcaaggcggg gcggcgagtg cgcagggccg ggcctttgca tgaagccgct ggacccctcg
      541 gagcagcggc agaggcggcg gagcccggcg gagcgcagtc ggagacgggc agctccgggg
      601 tccgtgtccc agtgcctacg cggctgcgga ctcccccatg ggccgcagct gaggcttccc
      661 gcagcggtgg ggcgcagacc ggggggcgcg gttgagaccc ggaggcggcg gcgccggagg
      721 aagcgcagaa ggccgggccc gggaggtggg cagcaccgcg ccgcaacccc gggctcgcca
      781 tgctcctggc ctcggcagtg gtggtgtggg aatggctgaa cgaacacggc cgctggcgtc
      841 cctacagccc agccgtgagt caccacatcg aggcggtggt gcgcgctggt ccccgcgccg
      901 ggggcagcgt ggtgttgggc caggtggaca gccggctcgc gccctacatc atcgacctgc
      961 agtccatgaa ccagttccgc caagacacgg ggaccctccg cccagttcga cgaaactact
     1021 atgacccatc ctcagcccct ggtaagggag tcgtgtggga atgggagaat gacaatggtt
     1081 cctggactcc ctatgacatg gaagtcggca tcaccatcca gtatgcctat gagaagcagc
     1141 acccatggat cgacctcacc tccattggct tcagctacat aatagacttc agcaccatgg
     1201 gccagatcaa caggcagacc caacgccagc gccgtgtcag acgacgacta gacctcatct
     1261 accccatggt cacgggcact atgccaaaga ctcagtcctg gccagtcagt cctggaccgg
     1321 cgacgtcctc ccctgcacca ccttgctcct gtccacagtg tgttttggtg atgagcgtca
     1381 aggctgctgt ggtccatggg ggcactgggc ctccagcagt acgaaagaac atggccctct
     1441 ctggagtggg caagctgccc cagccacctg gccctggagc aaagccacta gacaccactg
     1501 gcaccattcg aggcccaggg aagacagccc catcgcaggt tatcagaaga caagtctcta
     1561 atgcaccagc tggggcgact gtaggctccc ctgccagccc acaaggaagc aacaggaaga
     1621 ctggaagggt ggcactggcc actttgaatc ggtccaatct gcagcgactg gccattgccc
     1681 agtcccgggt gctgattgcc tccggggttc ccactgtgcc tgtgaaaaac ttgaatgggt
     1741 ccagccctgt taatcctgcc ttggcaggaa tcaccgggat actcatgagt gcagcgggat
     1801 tgcctgtgtg cctcactcgc ccaccaaagc tggtcctcca cccgccccct gtcagcaaga
     1861 gtgagataaa gtccatccca ggggtctcga acacgagccg caagaccacc aaaaagcaag
     1921 ccaagaaagg taaaacccca gaggaagtgc taaagaagta cctgcagaag gtccggcacc
     1981 caccagaaga ggattgtacc atctgtatgg agcgtctcac agccccctct ggctacaaag
     2041 gcccacagcc tacagtcaag cctgacctgg tgggaaagct gtccaggtgt ggccacatct
     2101 accacatcta ctgcctggtg gctatgtaca acaatgggaa caaggatggg agtttacagt
     2161 gcccaacatg taagaccatt tatggcgtca agacaggcac ccagcctcca gggaagatgg
     2221 aataccacct catcccccac tccttgcctg gccatccgga ctgcaagacc atccggatca
     2281 tctacagtat cccccctggc attcagggac cagagcatcc gaatcctggg aagagcttca
     2341 gtgcccgtgg cttcccacga cattgttacc ttccagacag cgagaagggg agaaaagttc
     2401 tgaagctgct tctagtggcc tgggaccgcc gtctcatctt tgccattgga acctccagca
     2461 ccacgggcga gtccgatact gtcatctgga atgaggttca ccacaaaaca gaatttggct
     2521 ctaatctcac tggccatggc tacccagatg ccaattacct ggataacgtg ctggctgaac
     2581 tggctgccca gggtatctct gaagacagca cttcccatga aaaggactga ggagggaggg
     2641 tactggggac cacagggcag aaaatggaga gagtcaaggt tgatgccatg cctcctgact
     2701 ccctcatgtc ccttcttgta ttattcccat ctcccatccc tctcagtcac agagggcgct
     2761 ggattaagat gatgtcgttc ttacacttca tccaaaacga accagacacg ggatgagggc
     2821 caacctcctt ctgtccccat ggagtcttca gttctgggta gtcaaggacc tgcacctctc
     2881 cccaccccta agcagggagt atgttcagca tatttaatgt atgggcacta ttgaggtatt
     2941 ccatatcctg gccttgtgaa gctgagatcc ctatcctcag ctggcttctt gctgcttcca
     3001 ctctgccttg agagtggagt ttctgctttt tttttttttt tctcctccac tggagtcagg
     3061 gagctctcac tgtgcacaat tggggagaga ggtgtagact gctgtgacat cagaaattgg
     3121 atgccttggt gcagtgtaag gaagcagttc atgttaagag ggtcagagtc aaatgcctct
     3181 gggaggagcc tgggcccttc cttcctcctc atctattgac ctgtccatag gcatctgatt
     3241 ctctcaagtg ggtgggaggg ctcaggaatt cctctctggg gtggcatccc atgatgctgt
     3301 ttccaagcaa ccgctctctg atccaatcag agcctgcatc ccagtgagca tctgcactat
     3361 cctcagggag aggagcccat agccttcttc ccaactcatt gcaaaccagc tcagtttcat
     3421 caagtcactg tgagttggag cccacaccag gctctttgtc atctgtgttt gtgcatatgt
     3481 ttgtgtgggt gtgtgtgcat tattgggcca ggttattggg aaagtcccat cacgtctcta
     3541 aattctgttt cacgtgccaa atcccaattc tgttggggat tctatagtaa aggcatggcc
     3601 ctttgacttt tctcaccttt gccagcccat ctcgtaataa acttggaccc taatggacat
     3661 agaattgtac ttgggaagat gtcttgattc aagagctaga ttgacccttc tccttcttat
     3721 taatattaga tcagagccag cttccatcca gtcttcttta tataagagct caattcatct
     3781 ccccacagat ttgctaattc aagaccagag acattattgt tccctgtccc agccccttgc
     3841 tctagccccc atctagcaca gattggccaa aaccatggtg gcagaagtcg ctttagctca
     3901 ttcctaacac agttaggaac acattctggt cttccctaac cggcatctgg gtggtgtccc
     3961 aagatccaat ctatccccaa catctcaact ttggctccat taaagaatgg attaggtgtc
     4021 aggtaaaaga gaatggagaa tcaagaaggg aaaataattt cccctttgta agtgggttct
     4081 ttgaactttg tgtttgggga aagttcctct ggatactaat ttgaacttat atacctcatg
     4141 tctcgagggt ttgactatat atatgtgtat atatacacat acatatatat cataagattt
     4201 gaaacgtttg atgcttggta aaaataagtg agaaattcaa caaccttcca catttgtact
     4261 tacgttagaa ctggagtcca cattttcata ccaccctgca ccagagatgc ctcctgttgg
     4321 gcttccacca ttgttgatat tgctgtggcc agtagaatca cccaagtgtc cctaacccac
     4381 ttccctggtg ctgagttttc tttcactcta caaatggcta atggaatttt aatcgccttc
     4441 cactaggggg agctgtggtt ggagggaatg ttctgccatc ttagtccagc ctgtcctatc
     4501 aatgggaggc cattttgtct cacaagcaga gcagaagatt gctgcattca ctgcacctcg
     4561 gggaaaactc ctgctaaagt agagaaagat acagcagaac taaatggaag gcaagtagcc
     4621 acgggcgtta atgtcacacc cttttatcag gttaccgaat ttcagagata atcggaccct
     4681 cattgaaggc ttacaatcat gtttgtcttc agttactcgt tgttatctac agtccctgct
     4741 tcttggcaac aaggatgaga aattagactg ggagttcatg gataggaaag tgaagcagta
     4801 ggaagtgaag aaatgaaaac aggctctgag atgtgggaat ggccagtggg ggatgttttc
     4861 acgtagcaaa ggaggtagac gcaggaaaag catagcatga ggcagaagga agagcccaga
     4921 aggacatctc agggagtgac tgttctacaa gaaagaccat tttgagggtt agtcttcaag
     4981 aatttcccca gaggacttta aaatgtctat gtctcatttc cttattcccc gaggatgctc
     5041 tgagaggcta cctcaccctc aagtttcact ctttcagctt tctggtctga tggaagcttg
     5101 gcaatctcaa caatgtgtgg gtcaagcagt agctggtacc ttactccttc tcttgtgcca
     5161 acccccaaat atacagaatt catttcaatg agattaggcc ctggacacaa gcgactttga
     5221 cccagagtgc ttccccagag aagccctggt gtgctctact gggccaagca gggagccccc
     5281 atgccctttc ttttacagtc tcagcaccag cagccatgtt cttccttcat gagactcccg
     5341 gggtgaacaa atgggattgg agacacagct atgagatgct tatcccttga aaagctatgt
     5401 ggtatatctg tggttgtctg tgcctttgtg cttccattcc cctgtccttt ttgtaagatt
     5461 tagacttctg tgtgatttta tacttcagtc aaaagtactt gtcctggcat cgcattgctg
     5521 tgtgcatgag aggattggga gaaggctgct gtggcccaag aaataaccac tgccccaccc
     5581 ccccttgctt gttcgttggt cacttatatc tcagtggggg tttctgggag agggctggtg
     5641 aatgtccaga tgtcaggtgt tctgttagta actgctgtga tttgaagttg ttggtgttgt
     5701 tctgtgggag gacatcgccc cctggtgctc atgaggtgta cgtgcagaac aataaactgc
     5761 aaatgaacaa aaaaaaaaaa aaaaaa
//
