LOCUS       NM_001013371            5181 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus deltex 3-like, E3 ubiquitin ligase (Dtx3l), mRNA.
ACCESSION   NM_001013371 XM_489547
VERSION     NM_001013371.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5181)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5181)
  AUTHORS   Choi,D., Park,E., Jung,E., Seong,Y.J., Yoo,J., Lee,E., Hong,M.,
            Lee,S., Ishida,H., Burford,J., Peti-Peterdi,J., Adams,R.H.,
            Srikanth,S., Gwack,Y., Chen,C.S., Vogel,H.J., Koh,C.J., Wong,A.K.
            and Hong,Y.K.
  TITLE     Laminar flow downregulates Notch activity to promote lymphatic
            sprouting
  JOURNAL   J Clin Invest 127 (4), 1225-1240 (2017)
   PUBMED   28263185
REFERENCE   3  (bases 1 to 5181)
  AUTHORS   Zhang,Y., Mao,D., Roswit,W.T., Jin,X., Patel,A.C., Patel,D.A.,
            Agapov,E., Wang,Z., Tidwell,R.M., Atkinson,J.J., Huang,G.,
            McCarthy,R., Yu,J., Yun,N.E., Paessler,S., Lawson,T.G.,
            Omattage,N.S., Brett,T.J. and Holtzman,M.J.
  TITLE     PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C
            protease to enhance interferon signaling and control viral
            infection
  JOURNAL   Nat Immunol 16 (12), 1215-1227 (2015)
   PUBMED   26479788
  REMARK    GeneRIF: Data indicate that PARP polymerase PARP9-E3 ligase DTX3L
            interacts with STAT1 transcription factor and enhances
            translocation of STAT1 to the nucleus.
REFERENCE   4  (bases 1 to 5181)
  AUTHORS   Hakme,A., Huber,A., Dolle,P. and Schreiber,V.
  TITLE     The macroPARP genes Parp-9 and Parp-14 are developmentally and
            differentially regulated in mouse tissues
  JOURNAL   Dev Dyn 237 (1), 209-215 (2008)
   PUBMED   18069692
REFERENCE   5  (bases 1 to 5181)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN668148.1, AK146802.1 and AC129574.8.
            
            On Mar 22, 2007 this sequence version replaced NM_001013371.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by mRNA and EST alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085093.1, AK146802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                CN668148.1         1-93
            94-3165             AK146802.1         2-3073
            3166-5181           AC129574.8         1700-3715
FEATURES             Location/Qualifiers
     source          1..5181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.43 cM"
     gene            1..5181
                     /gene="Dtx3l"
                     /note="deltex 3-like, E3 ubiquitin ligase"
                     /db_xref="GeneID:209200"
                     /db_xref="MGI:MGI:2656973"
     exon            1..334
                     /gene="Dtx3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2397
                     /gene="Dtx3l"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase DTX3L"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DTX3L"
                     /protein_id="NP_001013389.2"
                     /db_xref="CCDS:CCDS37325.1"
                     /db_xref="GeneID:209200"
                     /db_xref="MGI:MGI:2656973"
                     /translation="MASSPDPPSPLLVRLRESIPKAHRKLEIYFQSRASGGGECSVQP
                     VGPSAPDTYEVKFLKKADKEKVLKKSEHEMLVHNKPVTIVLETTKKPVEDLRPRLPSL
                     TQPVETPSSRPPSLTGSLDEALCDDIHPQDGLVSNSVDSVVQKIFLAVTAELNCDLLS
                     KEQRASITTVCPHIIKSMEGSDGIKKVCGNFKDIEKIHHFLSEQLLEREQKRKGSEQK
                     RKCAPQKHTPPDVEREPPDQSSIQVPVLLLEYFKHVNPGRLEFIEYKFGVNIEIQASS
                     PNMVTVGFTSSPFGNVEEASQSFVRDFQKCSQSLKQDCISLEEHQRAKEVRQELSRCF
                     PKLLIKGQGRTLTLLGSPADISAATEKVSQGLGLRPVKITASGYTTGIEVDSTRFKLL
                     EPELLQEISEIEQKFNTRGKVQEKGQKTCILFVPKDKDLDLSVQSYTGFTDAFQRATW
                     QLRTEVLSLKGLGKERARLHNTKFADNFKKEHPNVHFVTSQESVTLTGLPHHLAQAMQ
                     YVSKRMGLAPSSGEKLAMDQETPMEISSSDPHGDQQENAALPAPRGTSSSPAASKGTE
                     DYCVICMDTISNKHVLPKCKHEFCTSCISKAMLIKPVCPVCLTSYGIQKGNQPEGTMS
                     YSTQKGSLPGYEGCGTIVINYEIKDGIQTKEHPNPGKAYHGTRRTAYLPDNTEGRKVL
                     DLLHEAFKHRLTFTIGYSRATGVSDVITWNDIHHKTSKFGGPANFGYPDPDYLKRVKE
                     ELKAKGIE"
     exon            335..585
                     /gene="Dtx3l"
                     /inference="alignment:Splign:2.1.0"
     exon            586..2109
                     /gene="Dtx3l"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2327
                     /gene="Dtx3l"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..5181
                     /gene="Dtx3l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5157..5162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtx3l"
                     /note="hexamer: AATAAA"
     polyA_site      5181
                     /gene="Dtx3l"
                     /note="major polyA site"
ORIGIN      
        1 caggcggcgg ctctgcggag aacaaggagg gaccttctgg ggaatcgaaa ctgaaacttt
       61 gcctctcggg tctttagggc agggctcgcc tttgctcttc cctgtctgtg cagcgcccct
      121 gagccccaaa cgagccagac gcggatagcc atggcttcca gtcccgaccc gccgtccccg
      181 ctactcgtac ggctgcggga gtccatcccc aaggcgcaca ggaagctcga gatatacttc
      241 cagagccggg cctcgggagg tggggagtgc tctgtccagc ccgtgggccc cagcgccccg
      301 gacacctacg aggtgaagtt cctaaaaaaa gcagataagg agaaagtgtt gaaaaagagc
      361 gaacacgaga tgttggtcca taacaaacct gtgaccattg tcctggaaac tactaaaaag
      421 ccagtagagg acctgagacc cagactccca tccttgacac agccagtgga gacaccaagc
      481 tccagacctc cgtccttgac ggggtctctg gatgaagcac tttgtgatga catacatccc
      541 caggacgggc tcgtttctaa ctctgttgac tcagttgtcc aaaagatctt tcttgctgtg
      601 accgctgagc tgaactgtga cctgctctct aaagagcaga gagcatctat aaccactgtc
      661 tgccctcaca tcatcaaaag catggagggt agtgatggaa ttaagaaggt gtgtggcaac
      721 ttcaaagata ttgaaaagat acatcacttc ttgagtgagc agcttttgga acgggagcag
      781 aaacggaagg gaagcgagca gaaacggaag tgcgccccac agaaacacac acctcccgat
      841 gtggagcggg agccccctga tcagagcagt attcaagttc ctgtgcttct ccttgaatat
      901 ttcaagcatg ttaatccggg tagactagag ttcatagagt acaaatttgg tgtaaacatt
      961 gaaatccaag ctagttctcc caatatggtc actgtaggct tcacctccag cccatttggc
     1021 aacgtagaag aagcaagtca gtcctttgtc agagactttc agaaatgctc gcagtctctg
     1081 aagcaagatt gtatctcttt agaggagcac cagagagcaa aggaggtcag acaggagctg
     1141 agtcgctgct tcccaaagct cttgataaag ggacagggaa gaacgctgac tctcctcggc
     1201 tctcctgctg acatttcagc cgccacagaa aaagtctccc aaggtcttgg cctgagacct
     1261 gtgaaaataa ccgcatctgg gtacacgacg ggcatcgagg tcgattcaac acgctttaag
     1321 cttctagagc ctgaactgct ccaggaaatc tcagagatcg agcagaagtt taacacccgt
     1381 ggcaaagtcc aggaaaaagg ccagaaaacc tgcattcttt ttgtccccaa ggataaagac
     1441 ttagacctgt cagtgcagtc ctacacaggt tttactgatg ccttccagcg tgccacgtgg
     1501 cagctgagga cagaagttct gtcgctgaaa gggttgggca aggagagagc tcgcttacac
     1561 aataccaagt ttgccgacaa ctttaaaaaa gagcacccga atgtgcactt tgtgacatct
     1621 caggagtcag tgaccttgac tggcttgcca catcaccttg cgcaggcaat gcagtatgtc
     1681 tccaaaagaa tgggactggc accgtcatct ggagagaaac tcgctatgga tcaggaaacc
     1741 cccatggaga tcagcagtag tgacccccat ggagatcagc aggagaatgc agccttacct
     1801 gctccccgag gcacctctag cagccctgca gcttcgaagg ggactgagga ctactgtgtc
     1861 atctgcatgg ataccatcag caacaagcac gtgctcccca agtgcaagca tgaattctgc
     1921 acctcgtgta tcagcaaagc catgcttatc aagcctgtct gtcctgtgtg tctgacttcc
     1981 tacggcatcc agaaagggaa ccagccagag ggaaccatgt cttactccac tcaaaaaggg
     2041 tcacttccag gttatgaagg ctgtggcacc attgtgatta attatgaaat aaaagatggc
     2101 atccaaacaa aagagcaccc aaacccagga aaggcttatc atggaacacg gcgaactgca
     2161 tacttgcctg ataatactga gggaagaaag gttttggatc tgctccacga agcctttaag
     2221 cacagactga ctttcacaat aggatactct cgagcaacag gagtctcgga tgtcattaca
     2281 tggaatgata ttcatcacaa aacatccaag tttggaggac cagcaaattt tggctaccct
     2341 gatcctgatt acctgaaacg tgtcaaggag gagctgaaag caaaaggcat tgagtaagga
     2401 aactgcaggg aagatgtctg tccactctca aaagacatgt gtcaggaggc tggatagtac
     2461 agaccaaaat ctgtttctag aacgactttg taacattttt catgttaagt agtctgtttg
     2521 ccagtctttt ctagagtggc tggcactctt tcatggaagg caaactctac aggcacaggt
     2581 tggggggaat ggccctgtct acaaagcatg aagaaatgag ctcagatctg aaattatcca
     2641 tggaaaagcc tggtgtgttg gcatgcactt gtaatcttag cactggtgag tagagacagg
     2701 aggattcctg gagcttactg gccaactagc ctagttaaaa ccatgagctc tggattcact
     2761 gagagacctt atctcaagaa ataaggtgga tcgggacatg ggggtgcatg cctttaatgt
     2821 cagaacttgg aaggcagaag cgggcaatct ctgagttcca gacctcacct ggtctacagt
     2881 gtccaagtcc caggacagcc agctatacat agtgagacct tgtctcaaaa caaatattag
     2941 gaagacagaa acaaatatat ctaacatcat cctctgttct gcatacacac ctacacacac
     3001 acacacactg gggagcgggg agatagaaaa gaaaacttta tagttttata ggatttcaat
     3061 ttttgctgaa gaaatctgac gtcattcttg tgttacggtt ggggtgttgg gtgagtctgt
     3121 aatcatcttc tatgtcctta cataatggaa ccttccctga tttttgtttg ctttgtttat
     3181 ttgagacagg gtctcactgc atagctctgg aactcaattt gtggaccagc ttggtcttga
     3241 acttagatct gcctatatca gcctcctgag tgctggcatt gcctggtttt ttgtttgttt
     3301 gtttgtttgt ttgtttgttt gggggttttg gttttagctt ttttggtttg ggttgatttg
     3361 gtttggttta gttcggcttg atttgatttt gatgttggaa tttaaaccct aggccagtga
     3421 gttccatccc ataattcttt ttcatgtcca tctctgtagc aatacattag ttgtttattt
     3481 tttaatctct tcctgaaccc ttgtgtaagt gggaaagtga aacccttgta taaatgggaa
     3541 ctttaaaaac aggtttggca gccggacgtg gtggcgcacc cctttaatcc cagcacttgg
     3601 gaggcagagg caggtggatt tctgagttcg aggccagcct ggtctacaga gtgagttcca
     3661 ggacagccag ggctatacag agaaaccctg tctaggaaaa aaaaaaaaaa aagacaacaa
     3721 caacaacaac aaacaggttt ggctggaaaa gactcatatt tccttcccta cccatagcaa
     3781 gagaagtttc caggagatga ggcaactttt ggtaataaat agaacaaaaa gacttatatt
     3841 tttcaggaca cagagcctag gagatactgt gtgactactg cctgactcaa gatgctagta
     3901 gctcagcaga ggagtgaata gataaaaaga tatgttcccc aaatcttcgg gagagagatg
     3961 acttgagacc gtgacattca tttggaaaat agttttctta ccccaacttg tactgattag
     4021 acactgacta agccttgaat ttgggctcta ctctcccctg atccatggaa cctgtcctag
     4081 aggatgcact tgccctgcca cagaagtgca acatagtttt tatattcttc cctacacatt
     4141 atgttgtact tttagaatat atattgtttc aagttttaac gggtaaatag ccttccctta
     4201 gtttaatatt tcacagtatt tgctacctgc aatgtagtgg ctttttgttt tttaatcctt
     4261 tgagcgaatc ccagcagtct gttatctcat atatagtctt tctaatcctt tccctggaca
     4321 ggagtaaagg agaaagttca acctactgta gagtctggat ggcacatcac agttcactgt
     4381 aagtggttct ccaagttaga agaaaaccac agcaggcaat gacctggtga tctgtattcc
     4441 agccactctc caaaatggta gatgacaccc taaccttctc cttaagacac atatgcacat
     4501 acataaaacc attttggcca gatattaata ggaagtatta atcaagtact tatcctgtaa
     4561 gtacttaaca ttgatgggat caatctgatt aatagctcta ttctttgaac agaaaactca
     4621 tatacagagc acagtagtca atcactgagg gtgacataac caataagtag aagtgctaac
     4681 ttttactttc atccccattt tggttttttt gtttgtttag attttttttt tttttttttt
     4741 tgagccaggg tctcatgtaa cctagactgg cctctcccta tgtagccaag gctattcttg
     4801 aactctgacc ctcctgcctc acctcctgcc caggttcttg catgtatcct aggcagagct
     4861 ctcaggatct gcttccacag ccttccaagt gcaaggcctg caccatcata gctgccttct
     4921 gcatccggtt cggacctttc cctttggatg attcaccaag tgtttatcat taagaccaac
     4981 tgatcatttt ctgtcttcta atcttgtaat caaatttact ctaaagaaga aaaaaatggt
     5041 ttctgttaag ttctggatct tttatttcat ccagtgtgca catgcaaatt ccacgtggtg
     5101 gagggctcaa tgacatttgg atttttttct tttgcaaggt gttattatct gcattaaata
     5161 aagtcaggtc cttacataca a
//
