LOCUS       NM_001256096            2658 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus deltex 2, E3 ubiquitin ligase (Dtx2), transcript
            variant 1, mRNA.
ACCESSION   NM_001256096
VERSION     NM_001256096.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2658)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   2  (bases 1 to 2658)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2658)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2658)
  AUTHORS   Luo,D., de Morree,A., Boutet,S., Quach,N., Natu,V., Rustagi,A. and
            Rando,T.A.
  TITLE     Deltex2 represses MyoD expression and inhibits myogenic
            differentiation by acting as a negative regulator of Jmjd1c
  JOURNAL   Proc Natl Acad Sci U S A 114 (15), E3071-E3080 (2017)
   PUBMED   28351977
REFERENCE   5  (bases 1 to 2658)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 2658)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 2658)
  AUTHORS   Suzuki,T., Shen,H., Akagi,K., Morse,H.C., Malley,J.D., Naiman,D.Q.,
            Jenkins,N.A. and Copeland,N.G.
  TITLE     New genes involved in cancer identified by retroviral tagging
  JOURNAL   Nat Genet 32 (1), 166-174 (2002)
   PUBMED   12185365
  REMARK    Erratum:[Nat Genet 2002 Oct;32(2):331]
REFERENCE   8  (bases 1 to 2658)
  AUTHORS   Yamamoto,N., Yamamoto,S., Inagaki,F., Kawaichi,M., Fukamizu,A.,
            Kishi,N., Matsuno,K., Nakamura,K., Weinmaster,G., Okano,H. and
            Nakafuku,M.
  TITLE     Role of Deltex-1 as a transcriptional regulator downstream of the
            Notch receptor
  JOURNAL   J Biol Chem 276 (48), 45031-45040 (2001)
   PUBMED   11564735
REFERENCE   9  (bases 1 to 2658)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2658)
  AUTHORS   Kishi,N., Tang,Z., Maeda,Y., Hirai,A., Mo,R., Ito,M., Suzuki,S.,
            Nakao,K., Kinoshita,T., Kadesch,T., Hui,C., Artavanis-Tsakonas,S.,
            Okano,H. and Matsuno,K.
  TITLE     Murine homologs of deltex define a novel gene family involved in
            vertebrate Notch signaling and neurogenesis
  JOURNAL   Int J Dev Neurosci 19 (1), 21-35 (2001)
   PUBMED   11226752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF913708.1, AK012137.1 and BB428288.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012137.1, SRR7345562.3217273.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CF913708.1         1-5
            6-2642              AK012137.1         2-2638
            2643-2658           BB428288.1         272-287
FEATURES             Location/Qualifiers
     source          1..2658
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.64 cM"
     gene            1..2658
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /note="deltex 2, E3 ubiquitin ligase"
                     /db_xref="GeneID:74198"
                     /db_xref="MGI:MGI:1921448"
     exon            1..167
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            168..330
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..673
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..2265
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein deltex-2; mDTX2; probable E3 ubiquitin-protein
                     ligase DTX2; deltex 2 homolog; RING-type E3 ubiquitin
                     transferase DTX2"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase DTX2
                     isoform 1"
                     /protein_id="NP_001243025.1"
                     /db_xref="CCDS:CCDS57389.1"
                     /db_xref="GeneID:74198"
                     /db_xref="MGI:MGI:1921448"
                     /translation="MAMAPSSSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQ
                     HFVRQRGQHFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQNTGTMRSVRRHLFSQ
                     NSAPGQGIVWEWLGDDGSWVAYEARICDYLEQQVARGIQVVDLAPLGYNYTVNYATLT
                     QTNKTSSFCRSVRRQVGPVYPVTSDIAVPRQMGLICFCQQCLHGSGTGPVSGRYRHSM
                     TNLPAYPAPQAPHRTTTVSGAHQAFAPYNKPSLSGARSAPRLNTTNPWAAAPPVAGNQ
                     SLFHSSLSHLGPQLLPSGPSTSSGASASFPSGPSSSSPGSAPTTVPVQMPKASRVQQA
                     LAGMTSVLSAIGLPVCLSRAPRPTGPPASRPASKSHSSVKRLRKMSVKEGAPKPEPEQ
                     VIRKYTEELKVAPEEDCIICMEKLAVASGYSDMTDSKALGPMVVGRLTKCSHAFHLLC
                     LLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVFRFQMSLPGHEDCGTILIVYN
                     IPHGIQGPEHPSPGKPFTARGFPRQCYLPDSPQGRKVLELLKVAWKRRLIFTVGTSST
                     TGETDTVVWNEIHHKTEMDRNVTGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ"
     exon            674..1310
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1414
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1552
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1626
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1785
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1947
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2037
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2658
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="Dtx2"
                     /gene_synonym="2610524D08Rik; Deltex2"
                     /note="major polyA site"
ORIGIN      
        1 tggacatgcg cagcgcggtg cttggaggct gcgacgccga gtttcactcc ggctgcctcc
       61 ggctcggagt cggagacata ctcgagggtt cttcccaggc cgagccggag ctgagcccgg
      121 aggtcggcgg tcctctcaac ctgttccttc tgcttccctc agactcggta cctcggaatc
      181 ggtgtggctg agtcagcaag gcctcagatt tgccgggttc ttgtttgctg ttcctatcaa
      241 gatgggagct cagacaagtt attgcttctg aggatctggt gctttcatca agaagggaca
      301 gtttggtgcc agctcttcag tgaagaggag gtcccccaga ggtgctgggc aatgaacctg
      361 aacctgcaac ccagcgtggt gtgaagtctt cagagaaagc agaagatggc catggcccca
      421 agctcgtctc tgccgcaggt gtaccctagc cacgtggtgg tggctgtgtg ggaatggcag
      481 gatgggcttg gcatttggca cccctacagt gccactgtct gctccttcat tgagcagcat
      541 tttgtccggc agaggggcca gcattttgga ctgggaagcc tggcccacag catcccctta
      601 ggccaagctg acccctcact ggccccttac atcatcgacc tccccagctg gactcagttt
      661 cgccagaaca ctggcaccat gaggtctgtg cgcagacacc tgttctcaca gaattctgcc
      721 ccaggccagg gcatcgtctg ggagtggctg ggcgatgacg gatcctgggt agcctatgaa
      781 gctagaatct gtgactatct ggaacagcaa gtggcccggg gcatccaggt cgtggacttg
      841 gcaccactgg ggtataacta tactgtcaac tatgccaccc taacccaaac caacaagact
      901 tccagcttct gccggagtgt gcgacgccaa gtggggccag tttacccagt gacttcagac
      961 atcgctgttc cacgccaaat gggacttatc tgcttttgcc aacagtgcct ccatggtagc
     1021 ggaactggcc ctgtgtcggg ccgctaccgc cactccatga ccaacctgcc tgcatatcct
     1081 gccccccaag caccccaccg gaccaccact gtctctgggg cccaccaggc ctttgcccca
     1141 tacaataaac cttcactgtc tggggccaga tctgcaccaa ggttgaacac caccaacccc
     1201 tgggctgcag cacctcctgt tgcaggcaac cagtccctgt tccactccag cctctcccac
     1261 ctggggcctc agctcctgcc ctcaggaccg tccacctcca gtggagccag tgcctccttc
     1321 cccagcgggc cctcctccag cagcccaggg agcgccccca ccactgtgcc cgtgcagatg
     1381 ccaaaggcca gcagggtcca gcaggcgctt gcaggcatga cgagtgtgct gtcagccatt
     1441 ggactccctg tgtgtcttag ccgtgcaccc cggcccaccg gccctcccgc ctcccgtccg
     1501 gcctctaaaa gtcacagctc agttaagagg ctgaggaaaa tgtccgtaaa agaaggggcg
     1561 cctaagcccg agccggagca ggtgatcaga aagtacaccg aggagctgaa agtggcccct
     1621 gaagaggact gcattatctg tatggagaaa ctggctgtgg cttctgggta cagtgacatg
     1681 actgacagca aggccctcgg gcccatggtc gtgggccgcc tcaccaagtg cagccatgcc
     1741 ttccacctgc tgtgcctgct ggccatgtat tgcaacggga acaaggacgg gagtcttcag
     1801 tgtccgtcgt gcaaaaccat ctatggggag aagactggga cgcagccctg ggggaagatg
     1861 gaggtgttca ggttccaaat gtccctccca ggccatgaag actgtgggac tatactcatt
     1921 gtttacaaca tccctcatgg catccaggga ccagagcacc ccagccctgg gaagccattc
     1981 actgcccggg gctttccccg gcaatgctac ctgccagata gccctcaggg ccgcaaggtc
     2041 ctggagctcc tgaaggtggc ctggaagagg cgactcattt ttaccgtggg cacttccagc
     2101 accacaggtg agaccgacac cgtggtgtgg aacgagatcc accacaagac cgagatggac
     2161 cgcaacgtga caggccacgg ctatccggac cccaactacc tgcagaatgt gctggctgag
     2221 ctcgctgccc agggagtgac cgaagactgc ctggaacagc agtgacctcg ggcctgcctc
     2281 tgccgacccc acagccctgg gcggggcggg tgggcaggaa ggtgtgcctt cggtgagagg
     2341 caagagtgtg tgttgggttt gtgtagccca ctggggttgc acctcctcct aaaggttggg
     2401 cttcttgcct ctgctgccac catcctgtct gcgccggggt ctgcctggaa aatgggcacc
     2461 ctcctcagta ttgtacttgt ggaagcttaa gctggagcta cctcagtgca cggatgggac
     2521 cggcccttcc agccctgggt gggctggtga cccagcaagg ggtgagcagg gacgatcaca
     2581 ctcccagctt caggtcagct tcttatacct cagattttat ttgcaataaa gatcctatag
     2641 ccaacctgca tctgttgg
//
