LOCUS       NM_001417472            3780 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus deltex 1, E3 ubiquitin ligase (Dtx1), transcript
            variant 1, mRNA.
ACCESSION   NM_001417472 XM_011248180
VERSION     NM_001417472.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3780)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3780)
  AUTHORS   Cao,X., Lu,B., Gu,Y., Li,X., Guo,D. and Xia,F.
  TITLE     miR-210-3p Impairs Pancreatic beta-Cell Function by Targeting Dtx1
            in Gestational Diabetes Mellitus
  JOURNAL   J Environ Pathol Toxicol Oncol 41 (4), 11-23 (2022)
   PUBMED   36374959
  REMARK    GeneRIF: miR-210-3p Impairs Pancreatic beta-Cell Function by
            Targeting Dtx1 in Gestational Diabetes Mellitus.
REFERENCE   3  (bases 1 to 3780)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3780)
  AUTHORS   Choi,D., Park,E., Jung,E., Seong,Y.J., Yoo,J., Lee,E., Hong,M.,
            Lee,S., Ishida,H., Burford,J., Peti-Peterdi,J., Adams,R.H.,
            Srikanth,S., Gwack,Y., Chen,C.S., Vogel,H.J., Koh,C.J., Wong,A.K.
            and Hong,Y.K.
  TITLE     Laminar flow downregulates Notch activity to promote lymphatic
            sprouting
  JOURNAL   J Clin Invest 127 (4), 1225-1240 (2017)
   PUBMED   28263185
REFERENCE   5  (bases 1 to 3780)
  AUTHORS   Hsiao,H.W., Hsu,T.S., Liu,W.H., Hsieh,W.C., Chou,T.F., Wu,Y.J.,
            Jiang,S.T. and Lai,M.Z.
  TITLE     Deltex1 antagonizes HIF-1alpha and sustains the stability of
            regulatory T cells in vivo
  JOURNAL   Nat Commun 6, 6353 (2015)
   PUBMED   25695215
  REMARK    GeneRIF: exerts one level of control on regulatory T-cell stability
            by sustaining the expression of Foxp3 protein
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3780)
  AUTHORS   Mitsiadis,T.A., Gayet,O., Zhang,N. and Carroll,P.
  TITLE     Expression of Deltex1 during mouse embryogenesis: comparison with
            Notch1, 2 and 3 expression
  JOURNAL   Mech Dev 109 (2), 399-403 (2001)
   PUBMED   11731257
REFERENCE   7  (bases 1 to 3780)
  AUTHORS   Yamamoto,N., Yamamoto,S., Inagaki,F., Kawaichi,M., Fukamizu,A.,
            Kishi,N., Matsuno,K., Nakamura,K., Weinmaster,G., Okano,H. and
            Nakafuku,M.
  TITLE     Role of Deltex-1 as a transcriptional regulator downstream of the
            Notch receptor
  JOURNAL   J Biol Chem 276 (48), 45031-45040 (2001)
   PUBMED   11564735
REFERENCE   8  (bases 1 to 3780)
  AUTHORS   Pampeno,C.L., Vallerie,A.M., Choi,J., Meruelo,N.C. and Meruelo,D.
  TITLE     Genomic analysis and localization of murine Deltex, a modulator of
            notch activity, to mouse chromosome 5 and its human homolog to
            chromosome 12
  JOURNAL   DNA Cell Biol 20 (3), 141-148 (2001)
   PUBMED   11313017
REFERENCE   9  (bases 1 to 3780)
  AUTHORS   Kishi,N., Tang,Z., Maeda,Y., Hirai,A., Mo,R., Ito,M., Suzuki,S.,
            Nakao,K., Kinoshita,T., Kadesch,T., Hui,C., Artavanis-Tsakonas,S.,
            Okano,H. and Matsuno,K.
  TITLE     Murine homologs of deltex define a novel gene family involved in
            vertebrate Notch signaling and neurogenesis
  JOURNAL   Int J Dev Neurosci 19 (1), 21-35 (2001)
   PUBMED   11226752
REFERENCE   10 (bases 1 to 3780)
  AUTHORS   Pampeno,C.L. and Meruelo,D.
  TITLE     A novel cDNA transcript expressed in fractionated
            X-irradiation-induced murine thymomas
  JOURNAL   Cell Growth Differ 7 (8), 1113-1123 (1996)
   PUBMED   8853908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115937.14 and AC125183.4.
            
            On Mar 6, 2023 this sequence version replaced XM_011248180.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.392852.1,
                                           SRR7345562.1621918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC115937.14        74847-75023         c
            178-1098            AC125183.4         291-1211
            1099-1801           AC125183.4         16154-16856
            1802-1863           AC125183.4         27518-27579
            1864-2025           AC125183.4         27810-27971
            2026-2087           AC125183.4         28144-28205
            2088-2258           AC125183.4         28528-28698
            2259-2420           AC125183.4         28801-28962
            2421-2510           AC125183.4         29056-29145
            2511-3780           AC125183.4         29794-31063
FEATURES             Location/Qualifiers
     source          1..3780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.64 cM"
     gene            1..3780
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /note="deltex 1, E3 ubiquitin ligase"
                     /db_xref="GeneID:14357"
                     /db_xref="MGI:MGI:1352744"
     exon            1..177
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     exon            178..1098
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     CDS             840..2735
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1;
                     protein deltex-1; mDTX1; FXI-T1; deltex1; fractionated
                     x-irradiation induced transcript 1; RING-type E3 ubiquitin
                     transferase DTX1; E3 ubiquitin-protein ligase DTX1; deltex
                     1 homolog"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DTX1 isoform a"
                     /protein_id="NP_001404401.1"
                     /db_xref="GeneID:14357"
                     /db_xref="MGI:MGI:1352744"
                     /translation="MSRPGQGVMVPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATV
                     CHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSA
                     PGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMN
                     RQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAI
                     LASQRRKAPIAPAAPPAPPPPPPPLPPGGPPGALVVRPSATFAGAALWAAPATGPTEP
                     APPPGVPPRSPSAPNGAPTPGQNNLSRPGPQRSTSVSARASIPPGVPALPVKNLNGTG
                     PVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKH
                     LKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRNKSVRPELVGRLGR
                     CGHMYHLLCLVAMYSNGNKVGHKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLP
                     GFADTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAW
                     ERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGV
                     SEAMAKA"
     exon            1099..1801
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1863
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2025
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2087
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2258
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2420
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2510
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..3780
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3761..3766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /note="hexamer: AATAAA"
     polyA_site      3780
                     /gene="Dtx1"
                     /gene_synonym="Fxit1; mKIAA4160"
                     /note="major polyA site"
ORIGIN      
        1 agcgacgcgt ccgacgcgtc cgcgcgccag gactactgcg tcctcctgtc tgtctgtcta
       61 tccggcggcg ggcgaggtcc gggctggggc aaagcggtgc cctccttccc tccctcccgg
      121 gagccagcgg agaaagagtc agcggggggt gaaaagagcc agcgcgggga gatcacggtc
      181 gcgaacacca gtggggtggg gcgtgcccac ggcccccgcc cctccccagg gtcccccagc
      241 tgcaggtccg gaccgcgatc cccacgctcc gcccccttcc ctgggagatc taccaccact
      301 caggccggcc aggagagggg acaggggtgc aggggtgcag ggagccccgt cgggaggggc
      361 ggacccaagt caccccgaag cgaggcacgg gatctggaaa gcggagccaa gcgcgcaagg
      421 agcagcaggc tggggccagg gcctcctggg tgacaaggcc ctgcgtggcg gacagaagga
      481 acgggagaga agcagggaca ggccggactt agaggggcaa gtgcctcctc actcctgcac
      541 ctgcactgag gggactaagg gattgagatc atgtccccca cctaggacag acattgccta
      601 ccgcgcaccg ctgtgtgcaa cagctgcgct ctgcgggaag gggtcctcgc agcgtctgga
      661 tggccaccca tccccctaac ccaggcctct aggccttgga gacgagccca gctggaaaag
      721 aggccacact cctcgccgcc cgccctggag agggaggacg aagcttcccc ggtgctccca
      781 ggcccaggag gagctgggcc agcaacagtg gggacctggc cccgcaggcg gcagcggcca
      841 tgtcacggcc aggccaaggt gtgatggtgc cggtgaacgg gctgggcttc ccgccgcaga
      901 acgtggccag ggtggtggtg tgggagtggc tcaatgagca cagccgctgg cgaccctaca
      961 cggccaccgt gtgccaccac atcgagaatg ttcttaagga ggatgcccgg ggctctgtgg
     1021 tccttggcca ggtggacgcc cagctggtgc cctacatcat cgacctacaa tccatgcatc
     1081 agttccggca agacacaggt accatgcggc cggtgcgacg caacttctac gatccatcgt
     1141 cggcgccggg caagggcatc gtgtgggaat gggagaacga cggcggggcg tggacggcct
     1201 acgacatgga catctgcatc accatccaga acgcgtacga gaagcagcac ccgtggctcg
     1261 acctctcatc gctcggcttc tgctacctca tctacttcaa cagcatgtcc cagatgaacc
     1321 gccagacgcg ccgccgccgc cgcctgcgcc gtcgcctgga cctggcttac ccgctcactg
     1381 tcggctccat tcccaagtcg caatcctggc ccgtgggagc cagctcgggt cagccctgct
     1441 cctgtcagca gtgcctgctg gtcaacagca cgcgcgccgc ctccaacgcc atcctggcct
     1501 cgcagcgccg caaggctccc attgcgccag ccgcgcctcc agcgccccct ccgcccccgc
     1561 cgccgctgcc acccggagga cctccgggtg cgctcgttgt gcgccccagc gccactttcg
     1621 ccggagctgc gctctgggcc gcacctgcca ccggccccac ggagcctgcg ccgcctccag
     1681 gagttccccc aaggagccct agtgccccca acggagcgcc cacaccgggc caaaacaacc
     1741 tcagtcgacc aggaccacag aggtccacca gcgtcagcgc acgcgcctct atcccgcctg
     1801 gggttccggc gctccccgtg aagaacttga atggcactgg ccctgtccac ccagccttgg
     1861 cagggatgac cgggatcctg ctgtgtgcag cggggctgcc ggtgtgcctg acacgagcac
     1921 ccaaacccat cctgcaccca ccaccagtaa gcaaaagcga cgtgaagcct gtgcctggag
     1981 tgcccggcgt gtgccgcaag accaagaaga aacacctcaa gaaaagcaag aatcctgagg
     2041 atgtggttcg gaggtacatg cagaaggtga aaaacccgcc tgatgaggac tgtaccattt
     2101 gcatggagcg gctggtcaca gcatctggct atgagggcgt gctccgaaac aagagtgtgc
     2161 ggcccgagct tgtgggccgc ctgggccgct gcggccacat gtatcacctg ctctgcctgg
     2221 tggccatgta ctccaatggc aacaaggtgg gccacaagga tggcagcctg cagtgtccaa
     2281 cctgcaaagc catctacggg gagaagacag ggacacagcc accagggaag atggagtttc
     2341 acctcatccc gcactcgctg cctggttttg cagacaccca gacgatccgc atcgtctatg
     2401 acatccccac gggcatccag ggccctgaac atcccaaccc aggcaagaag ttcacagcca
     2461 gaggcttccc tcgccactgc tacctaccca acaatgagaa gggccgaaag gtgctgagat
     2521 tgctcatcac cgcctgggaa cgcagactca tcttcactat cggaacatcc aacaccacgg
     2581 gcgagtcgga caccgtggtg tggaacgaga ttcaccacaa gacggagttt ggttccaacc
     2641 tcactggtca cggctacccc gacgccagct acctagacaa cgtgctggct gagctcaccg
     2701 cccagggggt ttctgaggcc atggccaagg cctgaggcct gagttgcccg ccttcccttt
     2761 tgccttgcct ctagcctggc acatgcctcc ctccgctctc ggcgggagga gccagaagcg
     2821 ctaaggggat ctggctggtg gctgtggggg gggtgatggg agtccaccag gccagctggc
     2881 tccaacctgt ggcttccggc aagagcagca gagataggac caccagcaag ggcgacttcc
     2941 ctatggaaaa cgatggcgct ttgcccttca caccacacac aaacgcacac gtgtcctgtt
     3001 gcacgcacgc actcacgcac gtacaccacg tgcctctcca cttctcccag cttggggaga
     3061 aagagacaga aaggccccca tgacatgtcc tgtggaaata cctgtgtctc cattacatct
     3121 gtataggctc gtccctttcc caggacttga gtcaagcacg ggatagtggg ggggactctg
     3181 taaggcttca aggggtcgct ctgcccctgg gcctcaaccc cttaacccac gtcagcgctg
     3241 ccacctgccc actgagcact gcaaagccaa tggggtagaa accccaggtt attaagtagc
     3301 ttttcgcagg ccactgggga cgaggctatc ttaactttgt gcttgtgtct atctttcccg
     3361 ggaccctgac ttcttcttct tcctgtgtcc atctcttgac ctctgtctat cccaggcaaa
     3421 gacatcgtcc ttgcctctgt accggcttct cccccactaa accgctccgg acatttgaga
     3481 cccacttctg gcttcaggag cgaggggagg aggccttgtt caggctatac acgcatcaag
     3541 ctgagcaggc agcaaagcgt taaacttctc cctgcttgaa agtgggcggt gggcggctga
     3601 tcgtctcagg ccaaccagag gcccgttgcc caggcaactc accagctccg cctctgagga
     3661 ttggctgctg ggatggaagt cagccaagct ttaaagggac gccagcaatt gctcttttgg
     3721 aaaaaaaaaa aaaatctacc agtcccactg tgggtggaga aataaatggt ctttctcctt
//
