LOCUS       NM_025772               1311 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus dystrobrevin binding protein 1 (Dtnbp1), mRNA.
ACCESSION   NM_025772
VERSION     NM_025772.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1311)
  AUTHORS   Bhardwaj,S.K., Nath,M., Wong,T.P. and Srivastava,L.K.
  TITLE     Loss of dysbindin-1 in excitatory neurons in mice impacts
            NMDAR-dependent behaviors, neuronal morphology and synaptic
            transmission in the ventral hippocampus
  JOURNAL   Sci Rep 14 (1), 15239 (2024)
   PUBMED   38956130
  REMARK    GeneRIF: Loss of dysbindin-1 in excitatory neurons in mice impacts
            NMDAR-dependent behaviors, neuronal morphology and synaptic
            transmission in the ventral hippocampus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1311)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1311)
  AUTHORS   Cloutier,M.E., Srivastava,L.K. and Cermakian,N.
  TITLE     Exposure to Circadian Disruption During Adolescence Interacts With
            a Genetic Risk Factor to Modify Schizophrenia-relevant Behaviors in
            a Sex-dependent Manner
  JOURNAL   J Biol Rhythms 37 (6), 655-672 (2022)
   PUBMED   36168739
  REMARK    GeneRIF: Exposure to Circadian Disruption During Adolescence
            Interacts With a Genetic Risk Factor to Modify
            Schizophrenia-relevant Behaviors in a Sex-dependent Manner.
REFERENCE   4  (bases 1 to 1311)
  AUTHORS   Mastrogiacomo,R., Trigilio,G., Devroye,C., Dautan,D., Ferretti,V.,
            Losi,G., Caffino,L., Orso,G., Marotta,R., Maltese,F., Vitali,E.,
            Piras,G., Forgiarini,A., Pacinelli,G., Lia,A., Rothmond,D.A.,
            Waddington,J.L., Drago,F., Fumagalli,F., Luca,M.A., Leggio,G.M.,
            Carmignoto,G., Weickert,C.S., Manago,F. and Papaleo,F.
  TITLE     Dysbindin-1A modulation of astrocytic dopamine and basal ganglia
            dependent behaviors relevant to schizophrenia
  JOURNAL   Mol Psychiatry 27 (10), 4201-4217 (2022)
   PUBMED   35821415
  REMARK    GeneRIF: Dysbindin-1A modulation of astrocytic dopamine and basal
            ganglia dependent behaviors relevant to schizophrenia.
REFERENCE   5  (bases 1 to 1311)
  AUTHORS   Zhao,J., Zhu,H., Duan,K., Petralia,R.S., Wang,Y.X., Gu,Q., Panja,D.
            and Li,Z.
  TITLE     Dysbindin-1 regulates mitochondrial fission and gamma oscillations
  JOURNAL   Mol Psychiatry 26 (9), 4633-4651 (2021)
   PUBMED   33589740
  REMARK    GeneRIF: Dysbindin-1 regulates mitochondrial fission and gamma
            oscillations.
REFERENCE   6  (bases 1 to 1311)
  AUTHORS   Straub,R.E., Jiang,Y., MacLean,C.J., Ma,Y., Webb,B.T.,
            Myakishev,M.V., Harris-Kerr,C., Wormley,B., Sadek,H., Kadambi,B.,
            Cesare,A.J., Gibberman,A., Wang,X., O'Neill,F.A., Walsh,D. and
            Kendler,K.S.
  TITLE     Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of
            the mouse dysbindin gene, is associated with schizophrenia
  JOURNAL   Am J Hum Genet 71 (2), 337-348 (2002)
   PUBMED   12098102
  REMARK    Erratum:[Am J Hum Genet 2002 Oct;72(4):1007]
REFERENCE   7  (bases 1 to 1311)
  AUTHORS   Benson,M.A., Newey,S.E., Martin-Rendon,E., Hawkes,R. and Blake,D.J.
  TITLE     Dysbindin, a novel coiled-coil-containing protein that interacts
            with the dystrobrevins in muscle and brain
  JOURNAL   J Biol Chem 276 (26), 24232-24241 (2001)
   PUBMED   11316798
REFERENCE   8  (bases 1 to 1311)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   9  (bases 1 to 1311)
  AUTHORS   Swank,R.T., Novak,E.K., McGarry,M.P., Rusiniak,M.E. and Feng,L.
  TITLE     Mouse models of Hermansky Pudlak syndrome: a review
  JOURNAL   Pigment Cell Res 11 (2), 60-80 (1998)
   PUBMED   9585243
  REMARK    Review article
REFERENCE   10 (bases 1 to 1311)
  AUTHORS   Swank,R.T., Sweet,H.O., Davisson,M.T., Reddington,M. and Novak,E.K.
  TITLE     Sandy: a new mouse model for platelet storage pool deficiency
  JOURNAL   Genet Res 58 (1), 51-62 (1991)
   PUBMED   1936982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159210.2 and AC166074.3.
            
            On Nov 17, 2006 this sequence version replaced NM_025772.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018350.1, AJ404859.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC159210.2         114376-114555
            181-234             AC159210.2         122734-122787
            235-285             AC159210.2         124403-124453
            286-346             AC159210.2         130377-130437
            347-479             AC159210.2         133599-133731
            480-612             AC159210.2         146294-146426
            613-635             AC159210.2         163278-163300
            636-791             AC166074.3         208280-208435       c
            792-935             AC166074.3         200433-200576       c
            936-1311            AC166074.3         199363-199738       c
FEATURES             Location/Qualifiers
     source          1..1311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 21.73 cM"
     gene            1..1311
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /note="dystrobrevin binding protein 1"
                     /db_xref="GeneID:94245"
                     /db_xref="MGI:MGI:2137586"
     exon            1..180
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1183
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /note="HPS7 protein homolog; hermansky-Pudlak syndrome 7
                     protein homolog; dysbindin-1; sandy; BLOC-1 subunit 8;
                     biogenesis of lysosome-related organelles complex 1
                     subunit 8"
                     /codon_start=1
                     /product="dysbindin"
                     /protein_id="NP_080048.2"
                     /db_xref="CCDS:CCDS36647.1"
                     /db_xref="GeneID:94245"
                     /db_xref="MGI:MGI:2137586"
                     /translation="MLETLRERLLSVQQDFTSGLKTLSDKSREAKVKGKPRTAPRLPK
                     YSAGLELLSRYEDAWAALHRRAKECADAGELVDSEVVMLSAHWEKKRTSLNELQGQLQ
                     QLPALLQDLESLMASLAHLETSFEEVENHLLHLEDLCGQCELERHKQAQAQHLESYKK
                     SKRKELEAFKAELDTEHTQKALEMEHTQQLKLKERQKFFEEAFQQDMEQYLSTGYLQI
                     AERREPMGSMSSMEVNVDVLEQMDLMDISDQEALDVFLNSGGEDNIVMSPGVEMESNP
                     NQNEMSLQIPSPSESASQPPASPSACTDLDTADAPLIQSDEEEVQVDTALVTLHTDRK
                     STPGVSDDSDQCDSTQDI"
     exon            181..234
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     exon            235..285
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     exon            286..346
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     exon            347..479
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     exon            480..612
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     exon            613..635
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     exon            636..791
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     exon            792..935
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1311
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /note="hexamer: AATAAA"
     polyA_site      1311
                     /gene="Dtnbp1"
                     /gene_synonym="5430437B18Rik; Bloc1s8; dysbindin; sdy"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcggcgg ccggggaggc tgcggcggcg gcggcgcggt gaagcgagag ccgacgcgcg
       61 gggcgagggg acgcccgacg gcgtccgagg gcgcggtggc gcgaggcctg agggagggga
      121 cgcgatgctg gagaccctgc gcgagcggct gctgagcgta cagcaggatt tcacctccgg
      181 gctgaagact ttaagtgata agtcaagaga agcaaaagtg aaaggcaaac ccaggactgc
      241 tccacgctta ccgaagtact ctgctggact agaattactt agcaggtatg aggatgcgtg
      301 ggctgcactt cacagaagag ccaaggagtg tgcagacgct ggcgagctgg tggacagcga
      361 ggtggtcatg ctgtctgccc actgggagaa gaagaggacc agcctgaacg agctgcaggg
      421 gcagctgcag cagctgcccg ctctcctgca ggacttggag tctctgatgg caagcctggc
      481 tcatttagag acaagttttg aagaggtaga gaaccatttg ctgcacctgg aggacttgtg
      541 tgggcagtgt gagttagaaa gacacaagca ggcccaggcc caacacctgg agagctacaa
      601 gaaaagtaag aggaaggagc ttgaagcctt caaagctgaa ctcgatacag agcacacaca
      661 gaaggccctg gaaatggagc acacccagca actgaagctg aaggagcggc agaagttctt
      721 cgaggaagcc ttccagcagg acatggaaca gtacctgtcc acgggctacc tgcagatcgc
      781 agagaggcga gagcctatgg gcagcatgtc atccatggaa gtgaatgtgg acgtgctgga
      841 gcagatggac ctgatggaca tctcagacca ggaggctctc gatgtcttcc tgaactccgg
      901 cggagaggac aacattgtga tgtcccctgg tgtggagatg gaatccaacc ccaatcagaa
      961 tgaaatgagt cttcagattc caagtccctc agaatcagca tcccagccac ctgcctcacc
     1021 ctctgcctgc actgacctgg acactgctga tgcccccctc atccagtctg atgaggagga
     1081 ggtacaggtg gacacggcct tggtcacatt acacactgac agaaagtcca ccccaggtgt
     1141 cagtgatgac agtgaccagt gtgactcaac tcaggacatt taagtgactt gtcagctgtg
     1201 cgcagaatcc tcctgcaaag ccaggtgctt agaggttttc aattttacac acttgctaat
     1261 gggatgtaag aaccattaga gaagcgctca caataaagct tatggaataa a
//
