LOCUS       NM_001162465            5027 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus dystrobrevin, beta (Dtnb), transcript variant 1, mRNA.
ACCESSION   NM_001162465
VERSION     NM_001162465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5027)
  AUTHORS   Persiconi I, Cosmi F, Guadagno NA, Lupo G and De Stefano ME.
  TITLE     Dystrophin Is Required for the Proper Timing in Retinal
            Histogenesis: A Thorough Investigation on the mdx Mouse Model of
            Duchenne Muscular Dystrophy
  JOURNAL   Front Neurosci 14, 760 (2020)
   PUBMED   32982660
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5027)
  AUTHORS   Fratini F, Macchia G, Torreri P, Matteucci A, Salzano AM, Crescenzi
            M, Macioce P, Petrucci TC and Ceccarini M.
  TITLE     Phosphorylation on threonine 11 of beta-dystrobrevin alters its
            interaction with kinesin heavy chain
  JOURNAL   FEBS J 279 (22), 4131-4144 (2012)
   PUBMED   22978324
REFERENCE   3  (bases 1 to 5027)
  AUTHORS   Artegiani B, Labbaye C, Sferra A, Quaranta MT, Torreri P, Macchia
            G, Ceccarini M, Petrucci TC and Macioce P.
  TITLE     The interaction with HMG20a/b proteins suggests a potential role
            for beta-dystrobrevin in neuronal differentiation
  JOURNAL   J Biol Chem 285 (32), 24740-24750 (2010)
   PUBMED   20530487
  REMARK    GeneRIF: beta-dystrobrevin interacts with the HMG20 proteins iBRAF
            and BRAF35
REFERENCE   4  (bases 1 to 5027)
  AUTHORS   Lyssand JS, DeFino MC, Tang XB, Hertz AL, Feller DB, Wacker JL,
            Adams ME and Hague C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   5  (bases 1 to 5027)
  AUTHORS   Ceccarini M, Grasso M, Veroni C, Gambara G, Artegiani B, Macchia G,
            Ramoni C, Torreri P, Mallozzi C, Petrucci TC and Macioce P.
  TITLE     Association of dystrobrevin and regulatory subunit of protein
            kinase A: a new role for dystrobrevin as a scaffold for signaling
            proteins
  JOURNAL   J Mol Biol 371 (5), 1174-1187 (2007)
   PUBMED   17610895
REFERENCE   6  (bases 1 to 5027)
  AUTHORS   Wagener R, Kobbe B, Aszodi A, Liu Z, Beier DR and Paulsson M.
  TITLE     Structure and mapping of the mouse matrilin-3 gene (Matn3), a
            member of a gene family containing a U12-type AT-AC intron
  JOURNAL   Mamm Genome 11 (2), 85-90 (2000)
   PUBMED   10656920
REFERENCE   7  (bases 1 to 5027)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 5027)
  AUTHORS   Loh NY, Ambrose HJ, Guay-Woodford LM, DasGupta S, Nawrotzki RA,
            Blake DJ and Davies KE.
  TITLE     Genomic organization and refined mapping of the mouse
            beta-dystrobrevin gene
  JOURNAL   Mamm Genome 9 (11), 857-862 (1998)
   PUBMED   9799833
REFERENCE   9  (bases 1 to 5027)
  AUTHORS   Puca AA, Nigro V, Piluso G, Belsito A, Sampaolo S, Quaderi N, Rossi
            E, Di Iorio G, Ballabio A and Franco B.
  TITLE     Identification and characterization of a novel member of the
            dystrobrevin gene family
  JOURNAL   FEBS Lett 425 (1), 7-13 (1998)
   PUBMED   9540997
REFERENCE   10 (bases 1 to 5027)
  AUTHORS   Blake DJ, Nawrotzki R, Loh NY, Gorecki DC and Davies KE.
  TITLE     beta-dystrobrevin, a member of the dystrophin-related protein
            family
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 241-246 (1998)
   PUBMED   9419360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155273.3, AK043436.1 and CR974568.14.
            
            [WARNING] On May 26, 2023 this sequence was replaced by
            NM_001162465.3.
            
            On Sep 19, 2017 this sequence version replaced NM_001162465.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y15742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC155273.3         97458-97499
            43-2062             AK043436.1         1-2020
            2063-2324           AK043436.1         2098-2359
            2325-5027           CR974568.14        83373-86075         c
FEATURES             Location/Qualifiers
     source          1..5027
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 1.88 cM"
     gene            1..5027
                     /gene="Dtnb"
                     /note="dystrobrevin, beta"
                     /db_xref="GeneID:13528"
                     /db_xref="MGI:MGI:1203728"
     exon            1..257
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            258..325
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..2238
                     /gene="Dtnb"
                     /note="isoform a is encoded by transcript variant 1;
                     DTN-B; mDTN-B; beta-dystrobrevin; mDTN-BDTN-B"
                     /codon_start=1
                     /product="dystrobrevin beta isoform a"
                     /protein_id="NP_001155937.1"
                     /db_xref="CCDS:CCDS49015.1"
                     /db_xref="GeneID:13528"
                     /db_xref="MGI:MGI:1203728"
                     /translation="MIEEGGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFV
                     QKRCNLHLVDIWNMIEAFRDNGLNTLDHSTEISVSRLETVISSIYYQLNKRLPSTHQI
                     SVEQSISLLLNFMVAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYIFSQMSDSNG
                     LMMFGKLDQFLKEALKLPTAVFEGPSFGYTEHAVRTCFPQQKKIMLNMFLDTMMADPP
                     PQCLVWLPLMHRLAHVENVFHPVECSYCHCESMMGFRYRCQQCHNYQLCQNCFWRGHA
                     SGAHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPSREPPHPVFPEQPEKPLDLAHLV
                     PPRPLTNMNDTVVSHMSSGVPTPTKRLQYSQDMPNLLADEHALIASYVARLQHCTRVL
                     DSPSRLDEEHRLIARYAARLAAEAGNMTRPPTDASFNFDANKQQRQLIAELENKNREI
                     LQEIQRLRLEHEQASQPTPEKAQQNPMLLAELRLLRQRKDELEQRMSALQESRRELMV
                     QLEGLMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHGPQDSLSGVGGDVQ
                     EAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSGAEAEEQAGTEKTREGLPPRGTF
                     LSVFLLHTWTKLAGCQTHSTSRERSQAYGKWGGTA"
     exon            326..406
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            407..620
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            621..706
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            707..861
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            862..967
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1134
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1259
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1337
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1427
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1515
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1601
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1715
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1812
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1972
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2062
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..5027
                     /gene="Dtnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcacccgc cctcgccctc gcgccctcgc gccctcgcgc cgggggcggg ctcgctgcgc
       61 gtgccgggcg gggaagcggc gcgagccggc gccgttccgt tcgccgcggg ggcggctccg
      121 gggcctgagt gggcgccgcc gcctcagtcg ctgcttgctg cttcagccgc ctcagccgag
      181 ggggccgggt tggaggaggc tgcggccgcc ggagagccac gcgacggccc ctcagctccg
      241 gccgggaagc gagccaggat gattgaggaa ggcgggaaca agcggaagac catggcggag
      301 aagaggcagc tcttcataga aatgcgtgct cagaattttg atgtcatacg actatcaacg
      361 tacagaacag cttgcaagtt acgatttgta cagaagcgat gcaaccttca tcttgttgat
      421 atctggaata tgatcgaagc tttccgagac aatggcctta acacgctgga ccacagcacg
      481 gagatcagcg tgtcccgcct ggagaccgtc atctcgtcca tctactatca gttgaacaag
      541 cgccttcctt ctactcacca gatcagcgtg gagcagtcca tcagtctcct actcaatttc
      601 atggtcgccg cctacgacag tgagggccga ggcaagttga ccgtgttttc agttaaagct
      661 atgttagcaa ccatgtgtgg tggaaaaatg ctggacaaat tgagatacat tttctcccag
      721 atgtcagatt ccaatggctt aatgatgttt ggaaagcttg accagttcct gaaggaagcc
      781 ctgaagctcc caacagctgt ctttgaaggg ccatcctttg gttacacaga gcatgcagtc
      841 cgtacctgtt ttccgcagca gaagaagata atgctgaata tgtttttaga caccatgatg
      901 gctgatcctc ctccccagtg ccttgtctgg ctacctctca tgcacaggct tgcccatgtt
      961 gagaatgtct tccatcctgt ggaatgctcc tactgtcact gcgagagcat gatgggcttc
     1021 cgataccgat gccagcagtg ccacaactac cagctctgcc agaactgctt ttggcgtggc
     1081 catgccagcg gcgctcacag caaccagcac cagatgaagg agcattcctc ttggaaatcc
     1141 cctgcaaaga agctgagcca tgcaattagt aaatctttgg gatgtgtacc ctccagagaa
     1201 cccccacatc ctgtttttcc tgagcaacca gagaaaccac ttgaccttgc acatctagtt
     1261 cctcctcgcc ctctgaccaa tatgaatgac accgtggtta gtcacatgtc ctctggagtg
     1321 cccactccca ccaagaggtt acagtatagc caagacatgc ccaatctctt ggccgatgag
     1381 catgcgctga tagcctccta tgtggctcgt ctgcaacact gcacacgtgt gctggacagt
     1441 cctagccgac tggatgagga acaccggctt atagcccgct atgctgcccg gctagctgca
     1501 gaggcaggaa acatgactcg tcctcccact gatgccagct tcaactttga tgccaacaaa
     1561 caacagagac agctcattgc agagctggag aacaagaaca gagagatcct gcaggagatc
     1621 cagcgcctgc ggctggagca tgaacaggct tcccagccca cccctgagaa ggctcagcag
     1681 aaccccatgc tgctagcaga gctgcgcttg ctgaggcaaa ggaaagatga gctggagcaa
     1741 aggatgtcag cgctgcagga gagtaggcga gagctgatgg tgcagctgga ggggctgatg
     1801 aagttgctaa aggctcaagc cacagggtca ccacacacat cacccaccca tggaggtggc
     1861 cgccctatgc ccatgcctgt gcgttctaca tctgctggct ccaccccgac ccacggcccg
     1921 caggactcac tgagtggagt tgggggagat gtccaggagg cctttgcaca aggtacgagg
     1981 agaaacctcc gcaatgactt gctggtggct gctgactcca tcaccaacac catgtcctcc
     2041 ctggtgaagg agctccattc aggcgcagag gcggaggagc aagctggcac cgagaagaca
     2101 agggaaggtc ttccccccag aggcacattc ctgtccgtct ttctgctgca cacctggacc
     2161 aagcttgcag gctgccagac tcactcaacc tccagagaga ggagccaagc ctatgggaag
     2221 tggggaggga ctgcctgagg ccgcagctgg tgggcctcct gcatgtacta gcatccgcat
     2281 tcctccctca gggcatggtc tcatctctgc atcaggaatt taccaggaga tggaaaagaa
     2341 cagaaaaagc cctgagcctg tgtgtgttcc ttccggcacc tggccagcat ggagggctct
     2401 ccctagtcct agtgtgtgca catgcagttc tttcctgcct tcgaccttta acaacatttt
     2461 ctgtctatgc aaagaaagct gcaggcctca ttcagttctg cagacattta caccctatcc
     2521 tcagtgctaa aaatagcgac accacccccc cccccttcct ctttgacctg gtgaggaggc
     2581 ttccgcctgc acagtggcgt gaggccctgt tgctgtgtag ccaggaggaa ggcggagaac
     2641 tttaggggcc agtcagtggg gaagcagccc tgatctgtgt gccaagctgg gactggccgc
     2701 cagggggcgc actgcctggg tgctactcat gcatcctgtc ctggggtcct gtggaacatg
     2761 tgatcgccaa gtcccattca cattgatttt cctttttttt ttttttttct tgctccctga
     2821 gctccaggat gttattttta gtagaagagc tattataaat atttataaag ggcagcgaat
     2881 gatgtgagag ggcccacagc tggcactgca gcattcctta cccacctctg cagacccctc
     2941 cctaattctg aggtgtgtgc agagccatgg gttaggtccc atgagagtct cctaaaggaa
     3001 cagtgaaggg agaaggagga atggatactg ttgcagtccg gctccatctg tctctctgcc
     3061 ttcactccca tttctagctg gagtaactca aggctgggag aagggacagg aaccttgctg
     3121 agccaagacc ctcagtgtcc tgggtactta gaatgaaagg caggtgcacc aaggatcact
     3181 gccactgtga gggcaaaaag aaaaatagga gttgggtact agcctctgcc cagctgttgg
     3241 aaaaacactt ggttagcagg caaagctaag gacttggaag gccagcaggg gtttaagact
     3301 gcccactcag ggaaaggaga ttcaggctta tggatggcca gaggggcaaa gatgaacgag
     3361 tccatgtaga gagttctggg gatacactac ataccccagt ggtgaaatgt accccataag
     3421 ggtaagacag cctcacagac atgcgggctg ttctttcccc atcctcaatt ctcacactct
     3481 gtgagactca aggtcgactc ctacctcctg gctcctcaca tgagcttgtt tcctccaaag
     3541 cagcaagaga cagaacagtg agagtaccca gggccacagg gccaaactgt gccctctgcg
     3601 cgtctctggg aggagtgatg ttcacctcac ccctgaccag atggccaagg agagggctgc
     3661 attcattcct ctgatgccag cattagagac acgatgtcac ctttgttaac atcaattctt
     3721 gatttctttt agagctagaa tacccattat tatataaagg ccccttacat ttggtatctg
     3781 ctttctaagt tctgtaccag gatcttgtct ctatgacctg ggacacataa ggccacttta
     3841 tggtgggcac tttcttgtta atttttccat agcaacttag gagcctaatt taatttggac
     3901 tgatgatgtg tggaagacat gcacgggcag atgccctggc tggagagttg aactgcttga
     3961 cagcaccgtg gtctgaattg ctgctttctg tgacagggaa gaaccagatg ctccctgggc
     4021 catcttctgt atgtgctgag ggaagcttga gaccctagct gacccagaac ttgcaatctt
     4081 cctgcctctg tcttgaatgg tcatagacca gatatgtgag attccagaca tgtgccacca
     4141 acctggccat cctgggaagc cactgccctc ctagctttga tgcatgtgca cagctgttct
     4201 gaactgttct tacctggcac tctgaattta ctgcttggct ggtttcctgc attgctggct
     4261 ccctgttccc gatgcccacc agcattagaa aggcacagtt gccatggcaa tactgaagtc
     4321 atctgaattc ctgcagcagt gtctggaaga gaagggctca tgcagagctg ggtggtgggc
     4381 ctcaagcctg gcctcagcta atgtactctt caggggtcaa gtgtttggtt acagctggag
     4441 tgtgggaggt aggcctctgg aagaccctac cctcacagac ttccagaatt ggaggactcc
     4501 cagcaagggt tctcaggcag caccctattc catccagcag tcctcaaact gagcatgcat
     4561 ctgagtctgc tgcaagctta ttaatgcctc cagagtgttt gagcagccac tctgggctgg
     4621 agccagcgct ttgcagtgga gtcccaggac atcttggtac tcagcctgga gcctatattg
     4681 tcaaaaccac tttgagcttc taagaagagg aaacgaatcc cacccatgca gggaacaatt
     4741 tttttagtca ggtagaaaag tctgttgtct gtcctagaag aagaagaggt agagggaacc
     4801 tcaaaaatcc cattgtttcc ctggggtctg gaaaaaggtt atgtgtactg gggctggtga
     4861 cccctatact tcatttgtct ttcttttttt ctttagactt atttttaatt cattctctct
     4921 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctcg tgtgtgtgtg
     4981 tgtgtgtgtg tgatcatata cgaggcatta aaccctaatg agcaata
//
