LOCUS       NM_001285807            3954 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus dystrobrevin alpha (Dtna), transcript variant 1, mRNA.
ACCESSION   NM_001285807
VERSION     NM_001285807.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3954)
  AUTHORS   Malik,S.O., Wierenga,A., Gao,C. and Akaaboune,M.
  TITLE     Plasticity and structural alterations of mitochondria and
            sarcoplasmic organelles in muscles of mice deficient in
            alpha-dystrobrevin, a component of the dystrophin-glycoprotein
            complex
  JOURNAL   Hum Mol Genet 33 (13), 1107-1119 (2024)
   PUBMED   38507070
  REMARK    GeneRIF: Plasticity and structural alterations of mitochondria and
            sarcoplasmic organelles in muscles of mice deficient in
            alpha-dystrobrevin, a component of the dystrophin-glycoprotein
            complex.
REFERENCE   2  (bases 1 to 3954)
  AUTHORS   Babu,V., Bahari,R., Laban,N., Kulaga,J., Abdul,Z., Zakkar,B.,
            Al-Najjar,A., Lesus,J., Al-Rifai,A.A., Sattar,H., Irukulla,S.,
            Gunniya,P., Requena,T. and Lysakowski,A.
  TITLE     RotaRod and acoustic startle reflex performance of two potential
            mouse models for Meniere's disease
  JOURNAL   Eur J Neurosci 58 (3), 2708-2723 (2023)
   PUBMED   37461313
REFERENCE   3  (bases 1 to 3954)
  AUTHORS   Hawkes,C.A., Heath,C.J., Sharp,M.M., Gorecki,D.C. and Carare,R.O.
  TITLE     alpha-Dystrobrevin knockout mice have increased motivation for
            appetitive reward and altered brain cannabinoid receptor 1
            expression
  JOURNAL   Acta Neuropathol Commun 10 (1), 127 (2022)
   PUBMED   36045406
  REMARK    GeneRIF: alpha-Dystrobrevin knockout mice have increased motivation
            for appetitive reward and altered brain cannabinoid receptor 1
            expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3954)
  AUTHORS   Wu,Y., Guo,X., Han,T., Feng,K., Zhang,P., Xu,Y., Yang,Y., Xia,Y.,
            Chen,Y., Xi,J., Yang,H., Wan,X. and Kang,J.
  TITLE     Cmarr/miR-540-3p axis promotes cardiomyocyte maturation transition
            by orchestrating Dtna expression
  JOURNAL   Mol Ther Nucleic Acids 29, 481-497 (2022)
   PUBMED   36035750
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3954)
  AUTHORS   Sharp,M.M., Cassidy,J., Thornton,T., Lyles,J., Keable,A.,
            Gatherer,M., Yasui,M., Abe,Y., Shibata,S., Weller,R.O.,
            Gorecki,D.C. and Carare,R.O.
  TITLE     The alpha-dystrobrevins play a key role in maintaining the
            structure and function of the extracellular matrix-significance for
            protein elimination failure arteriopathies
  JOURNAL   Acta Neuropathol Commun 9 (1), 171 (2021)
   PUBMED   34674769
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3954)
  AUTHORS   Roberts,R.G. and Bobrow,M.
  TITLE     Dystrophins in vertebrates and invertebrates
  JOURNAL   Hum Mol Genet 7 (4), 589-595 (1998)
   PUBMED   9499411
REFERENCE   7  (bases 1 to 3954)
  AUTHORS   Peters,M.F., Adams,M.E. and Froehner,S.C.
  TITLE     Differential association of syntrophin pairs with the dystrophin
            complex
  JOURNAL   J Cell Biol 138 (1), 81-93 (1997)
   PUBMED   9214383
REFERENCE   8  (bases 1 to 3954)
  AUTHORS   Ambrose,H.J., Blake,D.J., Nawrotzki,R.A. and Davies,K.E.
  TITLE     Genomic organization of the mouse dystrobrevin gene: comparative
            analysis with the dystrophin gene
  JOURNAL   Genomics 39 (3), 359-369 (1997)
   PUBMED   9119373
REFERENCE   9  (bases 1 to 3954)
  AUTHORS   Blake,D.J., Nawrotzki,R., Peters,M.F., Froehner,S.C. and
            Davies,K.E.
  TITLE     Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic
            protein
  JOURNAL   J Biol Chem 271 (13), 7802-7810 (1996)
   PUBMED   8631824
REFERENCE   10 (bases 1 to 3954)
  AUTHORS   Madhavan,R. and Jarrett,H.W.
  TITLE     Interactions between dystrophin glycoprotein complex proteins
  JOURNAL   Biochemistry 34 (38), 12204-12209 (1995)
   PUBMED   7547961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127150.1, AC133182.3, AK019477.1, AC111031.8, AC163102.5 and
            BB337232.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY127150.1         2-80
            80-81               AC133182.3         71388-71389         c
            82-420              AK019477.1         2-340
            421-421             AC111031.8         114175-114175
            422-1319            AK019477.1         342-1239
            1320-1320           AC163102.5         95219-95219
            1321-1812           AK019477.1         1241-1732
            1813-1813           AC163102.5         110863-110863
            1814-3941           AK019477.1         1734-3861
            3942-3948           AC163102.5         159424-159430
            3949-3954           BB337232.1         203-208
FEATURES             Location/Qualifiers
     source          1..3954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 12.08 cM"
     gene            1..3954
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /note="dystrobrevin alpha"
                     /db_xref="GeneID:13527"
                     /db_xref="MGI:MGI:106039"
     exon            1..217
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            218..344
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            345..566
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            567..634
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            635..715
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            716..929
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1015
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1170
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1276
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1443
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1568
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1652
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1730
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1823
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1911
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2009
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2123
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2220
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2241
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2401
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2491
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2657
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2790
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2839
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3954
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3926..3931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /note="hexamer: ATTAAA"
     polyA_site      3950
                     /gene="Dtna"
                     /gene_synonym="2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A;
                     Gm19389"
                     /note="major polyA site"
ORIGIN      
        1 gttttcaagt taaagataga cacagtggac gccagaaact ggaagccggg tttttaaact
       61 cctgtctctc cctagaattt cagaattggt tatgatctca ggggtaatta gacaattggc
      121 taaatctgtt ctcccatgaa cgtgatagca atcactgtgt gctctagatg aactggaact
      181 aaaaaggttg aagaaaggat gctgtacctg gtccaggata aataggattt acaagccctt
      241 ggaagcacct gagaagtctt caaatgccac agtcagctgc tatttcaaag aaaacaaaat
      301 agatggttct ggaaagtcca tgctgtctct tcattgaatt ttagctggat tcatcgctgc
      361 catggcaaca gaccacatga tgaggtgtat tggattgctg tgttgaacac aaggggagga
      421 atgaacacag ctttttcttg aagttagagg ttactttgga gtttcttctg gggacgtgtg
      481 taaggtccgg tgcattagcg ttcagcagat ttagtgctcc tgcggaagaa ttagaggcat
      541 gttggtgcgt gaaactacaa aagcagaatg attgaagata gtggaaaaag aggaaacacc
      601 atggcagaaa gaagacagct gtttgcagag atgagggctc aagatctgga tcgcatccga
      661 ctctccacct acagaacagc atgcaagctg agatttgtgc agaagaaatg caatttgcac
      721 ctggtggaca tttggaacgt cattgaagca ttgcgcgaaa acgctttgaa taacctggac
      781 ccaaacatag aactcaacgt ggcccgcctg gaggcggtgc tctccactat tttttaccag
      841 ctcaacaaga ggatgccaac cactcaccaa atccacgtgg agcagtccat cagtctcctg
      901 ctgaacttcc tgctcgcagc ctttgacccg gaaggccatg gaaaaatctc agtatttgct
      961 gtcaaaatgg ctttggctac attgtgtgga ggaaagatca tggacaagtt aagatatatt
     1021 ttctcaatga tctctgactc cagtggagtg atggtatatg gaagatatga ccaattcctt
     1081 cgggaagttc tcaaactacc cacagcagtt tttgaaggtc cttcatttgg ttacacagaa
     1141 cagtcagcca gatcctgttt ctcccaacag aaaaaggtca ccttaaatgg cttcttggac
     1201 acgctcatgt cagaccctcc tccacagtgc ctggtatggc tgcctcttct gcaccgactg
     1261 gcaaatgtag aaaatgtctt ccatccagtt gagtgttcct actgtcacag tgagagcatg
     1321 atgggatttc gataccgatg tcaacagtgt cacaactacc agctttgcca ggactgcttc
     1381 tggaggggcc atgcaggagg ttctcatagc aaccagcacc aaatgaagga gtatacgtcg
     1441 tggaaatcac ctgctaagaa gctaacgaat gcattaagca agtccctgag ctgtgcttca
     1501 agccgtgaac ctttgcaccc catgttccca gaccagcctg aaaagccact caacttggct
     1561 cacatcgtgc ctccgagacc tgtaaccagc atgaacgaca cactcttttc ccactctgtt
     1621 ccctcctcag gaagtccttt catcaccagg agctctcctc ccaaggacag tgaagtagaa
     1681 cagaacaaaa tgctggctag ggctgctccc gcctttctga agggcagagg gatacagtac
     1741 agcctgaatg tggcagacag gctagctgat gaacatgttc tcattgggtt gtatgtcaac
     1801 atgctccgga acaacccacc atgtatgctt gagagttcaa accggcttga tgaagaacac
     1861 aggctgatcg ccaggtacgc cgcacgactg gcagcagaat cctcctcatc acagcccaca
     1921 cagcagagga gtgcccctga catctccttc accatcgatg caaataaaca gcaaaggcag
     1981 ctgattgcag agctagagaa caagaacaga gaaatcttac aagagattca gagacttcgg
     2041 gtagaacatg agcaagcttc ccagcccacg ccagagaaag ctcagcagaa cccaaccttg
     2101 ctggcagaac tccggctcct cagacagcga aaggatgagc tagaacagag aatgtctgct
     2161 ctccaggaga gccggagaga gctgatggtc cagttggaag gtctcatgaa gctcctgaag
     2221 gaagaagaac tgaagcaggg aacccagggg gcaagctccc cacgctcttc ccccagccac
     2281 accatcagca ggccgatccc catgcccatc cgttcagcat ctgcctgtcc cacaccaacg
     2341 cacaccccgc aggactccct cactggggta ggcggagatg tgcaagaggc gtttgcacaa
     2401 agttcgagaa ggaatctaag gagtgacctg ctggtggctg cagactccat caccaatacc
     2461 atgtcctctc tggtgaagga gctgaattca gaggtggcga gtgaaacaga aagtactgtg
     2521 gattccgagt tctcgagacc tcagtttgag gatctggctc catcaccgac ctctgagaag
     2581 gcttttctag cccaaatcca ctcccggaaa cctgggtaca ttcacggtgg agctgcaagt
     2641 accacgcatg gtgacatggt cccggaagat ggggatcctt acacgcaacc cgaggatggc
     2701 aattatgaga acgagtctgt gcggcagctg gagaatgagc tgcagctgga ggagtacctg
     2761 aagcagaagc tgcaggacga ggcctaccag gtcagcttgc aaggttgaat gcaatgccct
     2821 tttctcactc tcctctcaac tccacgtcag cactgagacc agactcaagc acccctgtcc
     2881 tgtagccgag acaaaatggc gtgtgttgtt ttggggtttt gtgattgtcg gtggatttct
     2941 ttccttggct ctccaaattt acttttgggg cctgttctaa atgcaaaccc agcaggtttc
     3001 atccgtctgt ccattctgtt caactgtatc tcacagggat ggttctttct tatcccacca
     3061 tgaattgcac acccacgtct atcgaagctg gtggcctatg aatgagcatt gatctagcac
     3121 agccaagcct ccccacagca ttgtggtcag ggaggtgggt gaaatctact gtataggatt
     3181 caggaactgg ttgtggtttg tcaggatgga agttggggta agtttggttg gtcagaggga
     3241 gacgtgttgg agactatgaa gatggattat cggatgatct ataataaggc agggaaggtt
     3301 catttgtaag tagtaatatg aactgaattg cattaagatt gtggcctttg tgtgatatat
     3361 atactatgta ttttcttata tgcatgagcc aaactgttgc gatataattt agcactgatg
     3421 tctgctctta tttttgacca tcttcgtcca ctgttattag ttcttggctg ttaagtgtag
     3481 atagatactg taaatatggc agccttgggt tgctgagctc acattggttc aattccacgc
     3541 aaggagccac aagcaaagaa ctccactgtg tcctcagaag gtagggcatt tttcctttga
     3601 accaaaaaga aaaagaaaaa agtcacaagc attcattgta ttttgaggct aattaacata
     3661 agacatttta aattgtgact actgtaattt gacctcattt gaaataacca atccagaaac
     3721 actaaagagt tcactatatt catcgttgta acaaaactac tatagtatgt tgttttgttt
     3781 tgttgatatt gctgttaagt attggggtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3841 tggaacctcc tggggacatg ttatattttg aagtgattaa actatttaat tgtgtgtcta
     3901 tattttggaa tggaattatt tcttcattaa aaatgttttt taaaacacta ttat
//
