LOCUS       NM_029766               4221 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus denticleless E3 ubiquitin protein ligase (Dtl),
            transcript variant 1, mRNA.
ACCESSION   NM_029766
VERSION     NM_029766.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4221)
  AUTHORS   Wei,H., Wang,Z., Huang,Y., Gao,L., Wang,W., Liu,S., Sun,Y.L.,
            Liu,H., Weng,Y., Fan,H.Y. and Zhang,M.
  TITLE     DCAF2 regulates the proliferation and differentiation of mouse
            progenitor spermatogonia by targeting p21 and thymine DNA
            glycosylase
  JOURNAL   Cell Prolif 57 (10), e13676 (2024)
   PUBMED   38837535
REFERENCE   2  (bases 1 to 4221)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   3  (bases 1 to 4221)
  AUTHORS   Tian,J., Wen,M., Gao,P., Feng,M. and Wei,G.
  TITLE     RUVBL1 ubiquitination by DTL promotes
            RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ
            pathway and enhances radiation resistance in breast cancer
  JOURNAL   Cell Death Dis 15 (4), 259 (2024)
   PUBMED   38609375
  REMARK    GeneRIF: RUVBL1 ubiquitination by DTL promotes
            RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ
            pathway and enhances radiation resistance in breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4221)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4221)
  AUTHORS   Yang,M., Liu,M., Wang,Z. and Zhang,C.
  TITLE     Mice lacking DCAF2 in placenta die at the gastrulation stage
  JOURNAL   Cell Tissue Res 389 (3), 559-572 (2022)
   PUBMED   35711069
  REMARK    GeneRIF: Mice lacking DCAF2 in placenta die at the gastrulation
            stage.
REFERENCE   6  (bases 1 to 4221)
  AUTHORS   Adeyemi,R.O., Fuller,M.S. and Pintel,D.J.
  TITLE     Efficient parvovirus replication requires CRL4Cdt2-targeted
            depletion of p21 to prevent its inhibitory interaction with PCNA
  JOURNAL   PLoS Pathog 10 (4), e1004055 (2014)
   PUBMED   24699724
  REMARK    GeneRIF: while interaction with PCNA was important for targeting
            p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4221)
  AUTHORS   Liu,C.L., Yu,I.S., Pan,H.W., Lin,S.W. and Hsu,H.C.
  TITLE     L2dtl is essential for cell survival and nuclear division in early
            mouse embryonic development
  JOURNAL   J Biol Chem 282 (2), 1109-1118 (2007)
   PUBMED   17107960
  REMARK    GeneRIF: L2dtl gene expression is essential for very early mouse
            embryonic development
REFERENCE   8  (bases 1 to 4221)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   9  (bases 1 to 4221)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4221)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB841951.1, CF898098.1, AK054412.1, AK133177.1 and AC132830.12.
            
            On Mar 5, 2015 this sequence version replaced NM_029766.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133177.1, BC060208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BB841951.1         1-10
            11-604              CF898098.1         3-596
            605-2390            AK054412.1         565-2350
            2391-3087           AK133177.1         2360-3056
            3088-3088           AC132830.12        109021-109021       c
            3089-3275           AK133177.1         3058-3244
            3276-3276           AC132830.12        108833-108833       c
            3277-3388           AK133177.1         3246-3357
            3389-3389           AC132830.12        108720-108720       c
            3390-4210           AK133177.1         3359-4179
            4211-4221           AC132830.12        107888-107898       c
FEATURES             Location/Qualifiers
     source          1..4221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.44 cM"
     gene            1..4221
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /note="denticleless E3 ubiquitin protein ligase"
                     /db_xref="GeneID:76843"
                     /db_xref="MGI:MGI:1924093"
     exon            1..196
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2334
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /note="isoform 1 is encoded by transcript variant 1; Meth
                     A ramp; lethal(2) denticleless protein homolog; meth A
                     retinoic acid-regulated nuclear matrix-associated protein;
                     denticleless homolog; Sarcoma antigen S35"
                     /codon_start=1
                     /product="denticleless protein homolog isoform 1"
                     /protein_id="NP_084042.1"
                     /db_xref="CCDS:CCDS15621.1"
                     /db_xref="GeneID:76843"
                     /db_xref="MGI:MGI:1924093"
                     /translation="MLFNSVLRQPQLGVLRNGWSSHYPLQSLLSGYQCNCNDEHTSYG
                     ETGVPVPPFGCTFCTAPSMEHILAVANEEGFVRLYNTESQTSKKTCFKEWMAHWNAVF
                     DLAWVPGELKLVTAAGDQTAKFWDVRAGELMGTCKGHQCSLKSVAFPKFQKAVFSTGG
                     RDGNIMIWDTRCNKKDGFYRQVNQISGAHNTADKQTPSKPKKKQNSKGLAPAVDSQQS
                     VTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGTSTRKLGYSS
                     LVLDSTGSTLFANCTDDNIYMFNMTGLKTSPVAVFNGHQNSTFYVKSSLSPDDQFLIS
                     GSSDEAAYIWKVSMPWHPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNR
                     GLEEKPGDKHSIVGWTSQKKKEVKACPVTVPSSQSTPAKAPRAKSSPSISSPSSAACT
                     PSCAGDLPLPSSTPTFSVKTTPATTRSSVSRRGSISSVSPKPLSSFKMSLRNWVTRTP
                     SSSPPVTPPASETKISSPRKALIPVSQKSSQADACSESRNRVKRRLDSSCLESVKQKC
                     VKSCNCVTELDGQAESLRLDLCCLSGTQEVLSQDSEGPTKSSKTEGAGTSISEPPSPV
                     SPYASEGCGPLPLPLRPCGEGSEMVGKENSSPENKNWLLAIAAKRKAENSSPRSPSSQ
                     TPSSRRQSGKTSPGPVTITPSSMRKICTYFRRKTQDDFCSPEHSTEL"
     exon            197..322
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            323..421
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            422..483
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            484..604
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            605..670
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            671..783
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            784..857
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            858..961
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1066
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1179
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1269
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1402
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..2235
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..4221
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4058..4063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /note="hexamer: AATAAA"
     polyA_site      4087
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /note="major polyA site"
     regulatory      4194..4199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /note="hexamer: AATAAA"
     polyA_site      4211
                     /gene="Dtl"
                     /gene_synonym="2810047L02Rik; 5730564G15Rik; L2dtl; Ramp"
                     /note="major polyA site"
ORIGIN      
        1 ggagtttggc ggccggggct cttagtggcg ggagttggag gcgaaaccgc gccgcgttgt
       61 ggagggtgca gacggcggct cctgtggaac ttgggggcga tcttctcggc gttcccctca
      121 gctgagcctt ctcctcaggc ccagatgctc ttcaactcgg tactccgcca gccgcagctc
      181 ggcgtcctga ggaacgggtg gtcttcacat taccctctac aatcccttct aagtggttat
      241 cagtgcaact gtaacgatga acacacgtct tatggagaaa caggagtccc agttcctcct
      301 tttggatgca ccttctgtac cgctcccagt atggagcata tattagcagt tgctaatgaa
      361 gaaggctttg tcagattata taatacagaa tcacaaacta gcaaaaagac atgcttcaag
      421 gagtggatgg ctcactggaa tgctgtcttt gacttggcct gggtccctgg tgaacttaaa
      481 cttgttacag cagccggtga tcagacagcc aaattttggg atgtaagagc tggtgagctg
      541 atggggacat gcaaaggcca ccagtgcagc ctcaagtctg tagcctttcc caagtttcaa
      601 aaagctgtgt tctctacagg ggggagagac ggcaacatta tgatctggga caccaggtgt
      661 aacaaaaaag atggatttta tagacaagtg aatcaaatca gtggagctca caatactgca
      721 gacaagcaaa ccccttcaaa gcccaagaag aaacaaaatt caaaaggact tgctcctgct
      781 gtggattccc agcagagtgt tactgtggtc ctctttcagg atgagaatac attagtctca
      841 gcaggagccg tggatggaat aatcaaagta tgggatttgc gcaagaatta cactgcttat
      901 cgacaagaac ccatagcatc caagtctttc ctgtacccag gtaccagcac tcgaaagcta
      961 ggatactcga gtttggtttt agactctact ggctctactt tatttgctaa ctgcacagat
     1021 gacaacatct atatgttcaa tatgactggc ttaaagactt ctccggtggc tgtcttcaat
     1081 ggacaccaga actctacctt ttatgtaaaa tcaagtctta gtccagatga ccagttttta
     1141 atcagtggtt caagtgatga agctgcctac atttggaagg tttccatgcc atggcatcct
     1201 cctactgtgc tcctgggtca ttctcaagag gtcacgtctg tgtgctggtg tccatcagac
     1261 ttcaccaaga ttgcaacctg ctctgatgat aatacactga aaatctggcg cttgaataga
     1321 ggcctagagg agaaaccagg tgataaacat tccatagtgg gttggacctc tcagaagaaa
     1381 aaagaagtga aagcctgccc agtaacggta ccaagtagcc agagtactcc tgccaaagct
     1441 cccagagcca agagcagtcc atccatctcc tctccttcgt cagcagcttg tactccgagc
     1501 tgtgcaggag acctccctct tccttcaagt acccccacat tctcagtcaa aaccactcct
     1561 gccacgaccc gttcttcagt cagcagaaga ggctccatct cttctgtgtc tcccaagcca
     1621 ctctcatctt tcaagatgtc gcttagaaac tgggtgaccc gaacaccttc ctcatcacca
     1681 cctgtcactc cacctgcttc tgagacaaag atctcatctc caagaaaagc tcttattcct
     1741 gtgagccaga agtcatcaca ggcagatgct tgctctgaat ctagaaatag agtgaagagg
     1801 cgtcttgact caagctgtct ggagagtgtg aaacaaaagt gtgtgaagag ttgcaactgt
     1861 gtcactgagc ttgacggcca agcggagagt cttcgtttgg atctgtgctg cctttccggc
     1921 acccaggaag tccttagcca agactccgag ggtcctacca aatcaagcaa gactgaaggt
     1981 gctggcacaa gcatctcaga acctccttct cctgtcagtc cttatgcttc tgaaggctgt
     2041 ggaccactgc ctcttccttt gagaccttgt ggagaaggat ctgagatggt gggcaaagag
     2101 aatagctctc cagagaataa gaactggttg ttggccatag cagccaaacg caaggcagaa
     2161 aattcatccc caagaagtcc atcatctcag acacccagtt ccaggagaca aagtgggaag
     2221 acgtcaccag gcccggtcac cattactccc agctccatga ggaagatatg tacatacttt
     2281 cgtagaaaga ctcaagatga cttctgcagt cctgaacact caactgaatt atagatgcta
     2341 atctgaagtt cattgaactt gggtctacaa agatttttta aaaaggcttt aaaattctgg
     2401 tctttaagaa aatggtcatc ttttcatttt ggaaaaagtc cttctactct ttagcagacc
     2461 tagtcaggcc ccactgtgta taggcacagc tgcctaggtg agtgctgtct ccagttcccg
     2521 gggcggcttg tcctctgtag tctactctag cagtctgtgg taatcacgtc cagctcgtgg
     2581 atgcaggaat caaggagtgc ttttgtggac agtggagagt gctagtccag cacagggccc
     2641 atccgtgaag gccagtctga agacatcctc tgcagaagat gccttaagca agcgtgagct
     2701 tatttgaaat atatcatttg ttcactatat ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2761 gtgtgtgttt ctcaaactgg ataaaaatgt gatattcact tcgtacattc atattgtctt
     2821 catgtacggt atcaatgtca actctttgga gaatgtagga gaaaacatca gaaagctgag
     2881 tttttgaaag ctgtggaggt cttttctttt tttttaaacc agatttctat tacaaaccag
     2941 catcactcat gagggagcaa ggcactttct tgagagagat gttttataaa atcagtatac
     3001 agtgagacca gggcagttct ctagggtctg tgactttttt taaaatgtca ttagattttt
     3061 aagataaagt aatttcttac ttataaaagt tgatattgct ttaaaaagaa atctagaacc
     3121 tggaaaataa gctttttttt tttttaaaca aaaggcacca gctgtctagt atattggtaa
     3181 gcaaaacata aagagcactt tatctcgaca gttagtgcag aggttgtgtc tgttgactct
     3241 aaattgtatt tgaaatgctg taacttttct ttcccttaaa tgctacatgt tggtcctcat
     3301 gaaatgagca tcatatctcc ctttgcagac tcttagaaag aaactttatg ttggagaaag
     3361 gcgttccctt atagttagaa aagagtttgt ctcattcaaa tctctggggg ctagctaaac
     3421 tttatttcaa ttctcgtgat ttttaaatat tttattaaaa acgtttaagt cctttgagat
     3481 tgtaagttaa gcttataaaa caaaccaaac tgagaaagtt aaataagtgt tgggtttctg
     3541 tagtcattac agtcaaacca cacacacatg cagcagcttt cgctgagcgc tggggagtct
     3601 tcagtgatgt tagctttttg agtagtgggc agtaggaagg aatttttaat gatgtagaac
     3661 tgccaataat gttaaatatc tgctgctttg aaagccagtg gtggtggtca gtaaagcaga
     3721 tgatttgtgt ctctgtgtct ggccacactg ccaagtgaag ctggggtaag tggctgtcag
     3781 aaacttcagg ctctgcttgg aaaacttggt accacaaatg ggtgtcaaag gtcatgtgta
     3841 acaaagtagt aattatccct gccgtgtgac cttgagctga ccctgaataa tcagcctttt
     3901 accttgtctg atattgtcct ttcctatgat ttttttttac agtgacctga aagcaatcta
     3961 cataaaagga agtaatctta gagtcccttt tgcttgcttg tagagtaaaa tgtgttattt
     4021 ccaaaggtat aatctagttc aaactgaaag aggttctaat aaacgtctta cttcatcaaa
     4081 cctcaaatgt ttaagatggc ttgggttact tgctgtgctg ctttaaataa gaatgacccg
     4141 tagtctcata tttgaatgat tgaccactag gaagtggaaa tgtttgaaag gataataaaa
     4201 aaataagtgt ggcctttgtg g
//
