LOCUS       NM_029545               2570 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus D-tyrosyl-tRNA deacylase 2 (Dtd2), transcript variant
            2, mRNA.
ACCESSION   NM_029545 XM_915203
VERSION     NM_029545.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2570)
  AUTHORS   Kuncha,S.K., Mazeed,M., Singh,R., Kattula,B., Routh,S.B. and
            Sankaranarayanan,R.
  TITLE     A chiral selectivity relaxed paralog of DTD for proofreading tRNA
            mischarging in Animalia
  JOURNAL   Nat Commun 9 (1), 511 (2018)
   PUBMED   29410408
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY069987.1 and AK042771.1.
            
            On Nov 26, 2016 this sequence version replaced NM_029545.2.
            
            Transcript Variant: This variant (2) lacks an exon and its 3'
            terminal exon extends past a splice site that is used in variant 1.
            This results in a novel 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (2) is longer and has a distinct
            C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042771.1, AK032228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY069987.1         2-7
            7-2570              AK042771.1         2-2565
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 22.11 cM"
     gene            1..2570
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
                     /note="D-tyrosyl-tRNA deacylase 2"
                     /db_xref="GeneID:328092"
                     /db_xref="MGI:MGI:1923485"
     exon            1..133
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..529
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
                     /EC_number="3.1.1.96"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable D-tyrosyl-tRNA(Tyr) deacylase 2; putative
                     D-tyrosyl-tRNA deacylase 2; putative D-tyrosyl-tRNA(Tyr)
                     deacylase 2; L-alanyl-tRNA deacylase; animalia-specifc
                     tRNA deacylase; D-aminoacyl-tRNA deacylase 2;
                     animalia-specific tRNA deacylase"
                     /codon_start=1
                     /product="D-aminoacyl-tRNA deacylase 2 isoform 2"
                     /protein_id="NP_083821.1"
                     /db_xref="CCDS:CCDS25903.1"
                     /db_xref="GeneID:328092"
                     /db_xref="MGI:MGI:1923485"
                     /translation="MADGGRVAQARALLQQCLHARLQVRPADGDAAAQWVEIRRGLVI
                     YVCFFKGADTDLLPKMVNTLLNVKLSETETGKHVSILDLPGDVLIIPQATLGGRVKGR
                     SMQYHSNSGKEEGSELYSQFVSLCEKAVANNTKSVEAGVAVAHGTYGNRQVLKLDTNG
                     PYTHLIEF"
     exon            134..203
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            204..2570
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1153..1158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1173
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
                     /note="major polyA site"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1920
                     /gene="Dtd2"
                     /gene_synonym="4930578F06Rik; 6530401N04Rik; ATD;
                     B830049N13Rik"
ORIGIN      
        1 atgcgcagtg cggacccgcg ccatggcgga cggtggtcgt gtggcccagg ctcgtgcgct
       61 cctgcagcag tgcctgcacg ctcgcctgca agtgcgcccg gccgatggag acgccgcggc
      121 gcagtgggtg gagattcgga gaggattggt gatctatgtg tgtttcttca agggagctga
      181 cacagacctt ctccccaaaa tggttaatac gctgttaaat gtgaagttaa gcgaaacgga
      241 aaccggcaag cacgtctcca tcctcgatct gcctggcgat gttctgatca tcccgcaagc
      301 caccctcggg ggcagggtga aagggcggag catgcagtac cactctaact ctggaaagga
      361 ggagggctca gaactgtact cccagtttgt gagtctgtgt gaaaaagccg tggccaacaa
      421 caccaagagt gtagaagcgg gggttgcggt ggcgcacggc acgtacggga acaggcaagt
      481 gttaaagctg gacaccaatg gaccctacac gcacctcatt gagttttgaa gaattccgtt
      541 ccacaccgct tcctgtataa aacgacctgg acctttaatt ccagtgctca gggggcagag
      601 gcaagcagat ttcagtgagg tggggaccag cctggtctat gtatcgagtt ctaggacagc
      661 caggactaca cagtgagact ctgactccaa aaaccaaaag ttaagtattt atgctgggca
      721 tagtagtgca cataccttta attccagcac ttgagaggca gaggctggag gatctctgtg
      781 agtttgagga cagcctggtc cacagtgtga gttctaggac aggcagagct acatgtgagc
      841 ccctgtcttg aaaaaacaaa actacataaa taaataaata aatactaaaa ctttaagata
      901 cttttcaaag tgaagaataa atgagcagaa gtagacgtcc gaggagctgc tggcgtctcc
      961 cggtatctca ggatatctta gtctgcgatt ggacgcttta gattccgatt gctcacacac
     1021 cccaaaatcc ctcttttttt tttttttttt atagctttcc tactgttcta ttttgaaact
     1081 taagaatcaa taacttgagc tcattgtcct tagcttttgt tttattgatt cacaatacag
     1141 ttgttgaaat gtaataaact attcataagc ttagaaactc cagtttttct taaagcctct
     1201 ccaaggacat gtatatgcct ttcaaaaaag actacattac ttcctttgca tcactttgac
     1261 tttgtgctcg ggtgaaatgc tgactcacag cccagatatg gctcaagcca ttctcctcac
     1321 agaaatcgcc tgagacactt gaggagagtg gcactgcaag cgcgaggggg gttgttcctt
     1381 agatatgaca gcagataggg aagaaacagg aaaaagagta ggctgggact aacttcagtt
     1441 tagcttccag catacacaca tactttacct tcaacgctct agtgaggacc gcactgtaag
     1501 aagcaagaca agtcatttct gcaagtcatc ctattcggca gactcatctc tgtcctctaa
     1561 catgagacct gttgaaatta accttgatag agggtctgct tctctccttg ccaataattg
     1621 ctttatttac taaacgaggc acaagctgaa ttgcccctaa cgtggatgcc cagaggctcc
     1681 cctggagctg gcattacagg tggttgtgtc tgctgtgggt gccaggaatc caactgaggc
     1741 ccacttaagt aagcagtgtg tgctcttaac caccaagcca tctctccacc acccagaagt
     1801 gtcttttaat ctttcagttt cgaaactggg aaccacttgt agcaaatact ctatgtaagg
     1861 tggaacatgc agttttgatg tcttgaacac attcctataa agtaaaatgg gggaactgga
     1921 gaggctggtc agtggttccg agaatgttac tcttaaagga gaggcgttca gctctcagca
     1981 ccaacatcag gcaattgaca gcatcctggt gctccagctc caggtctgta ccccgcgcac
     2041 acacatacgc atatgcgcat gctttttttt tttttttttg atcttaaaaa aagcagcatg
     2101 aatcacacct ttatcctccc ttcattgctt catgttataa aagaaggcat gctgtcacag
     2161 aggctgccca tcgggggagg agccatacat cagaccctgt gtagtatctt ccctaaacat
     2221 gagcagcagc agccctgagt tgggggtggg acaataggat tggctcccta aattacagcc
     2281 ctacattcta catagcactg tcatatgtct gctaaactca gggaccctac tctctaacta
     2341 aggtcagaga cctctcccct cctctctaag gtccagaaat gtcagaattc cctgttctgc
     2401 tggtccctgt taggtctctc agcccagcct cccccattgt gaatggcagc tttactaaag
     2461 gtatttcccc agagagaaaa aaaaaaagac ataccattta agaataatat ctatgctaat
     2521 gatcttttgg ctctatggtg aaggaataaa cattattgaa tatcaatatc
//
