LOCUS       NM_172516               6385 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus dual serine/threonine and tyrosine protein kinase
            (Dstyk), mRNA.
ACCESSION   NM_172516
VERSION     NM_172516.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6385)
  AUTHORS   Kelam,N., Racetin,A., Katsuyama,Y., Vukojevic,K. and Kostic,S.
  TITLE     Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and
            HIP2 in Developing and Postnatal Kidneys of Dab1-/- (yotari) Mice
  JOURNAL   Int J Mol Sci 23 (4), 2025 (2022)
   PUBMED   35216141
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6385)
  AUTHORS   Li,K., Liu,J.W., Zhu,Z.C., Wang,H.T., Zu,Y., Liu,Y.J., Yang,Y.H.,
            Xiong,Z.Q., Shen,X., Chen,R., Zheng,J. and Hu,Z.L.
  TITLE     DSTYK kinase domain ablation impaired the mice capabilities of
            learning and memory in water maze test
  JOURNAL   Int J Clin Exp Pathol 7 (10), 6486-6492 (2014)
   PUBMED   25400726
  REMARK    GeneRIF: DSTYK homozygous knockout mice show impaired capabilities
            of learning and memory.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6385)
  AUTHORS   Sanna-Cherchi,S., Sampogna,R.V., Papeta,N., Burgess,K.E.,
            Nees,S.N., Perry,B.J., Choi,M., Bodria,M., Liu,Y., Weng,P.L.,
            Lozanovski,V.J., Verbitsky,M., Lugani,F., Sterken,R., Paragas,N.,
            Caridi,G., Carrea,A., Dagnino,M., Materna-Kiryluk,A.,
            Santamaria,G., Murtas,C., Ristoska-Bojkovska,N., Izzi,C., Kacak,N.,
            Bianco,B., Giberti,S., Gigante,M., Piaggio,G., Gesualdo,L.,
            Vukic,D.K., Vukojevic,K., Saraga-Babic,M., Saraga,M., Gucev,Z.,
            Allegri,L., Latos-Bielenska,A., Casu,D., State,M., Scolari,F.,
            Ravazzolo,R., Kiryluk,K., Al-Awqati,Q., D'Agati,V.D.,
            Drummond,I.A., Tasic,V., Lifton,R.P., Ghiggeri,G.M. and
            Gharavi,A.G.
  TITLE     Mutations in DSTYK and dominant urinary tract malformations
  JOURNAL   N Engl J Med 369 (7), 621-629 (2013)
   PUBMED   23862974
REFERENCE   4  (bases 1 to 6385)
  AUTHORS   Peng,J., Dong,W., Chen,Y., Mo,R., Cheng,J.F., Hui,C.C., Mohandas,N.
            and Huang,C.H.
  TITLE     Dusty protein kinases: primary structure, gene evolution, tissue
            specific expression and unique features of the catalytic domain
  JOURNAL   Biochim Biophys Acta 1759 (11-12), 562-572 (2006)
   PUBMED   17123648
REFERENCE   5  (bases 1 to 6385)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 6385)
  AUTHORS   Zha,J., Zhou,Q., Xu,L.G., Chen,D., Li,L., Zhai,Z. and Shu,H.B.
  TITLE     RIP5 is a RIP-homologous inducer of cell death
  JOURNAL   Biochem Biophys Res Commun 319 (2), 298-303 (2004)
   PUBMED   15178406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ110290.1, AK132119.1, AK083696.1, AK050542.1, AK082904.1,
            BB749395.1 and AK082434.1.
            
            On Jan 31, 2007 this sequence version replaced NM_172516.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY429676.1, AK172954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               CJ110290.1         3-130
            129-256             AK132119.1         3-130
            257-1838            AK083696.1         155-1736
            1839-3204           AK132119.1         1714-3079
            3205-5339           AK050542.1         1451-3585
            5340-6135           AK082904.1         517-1312
            6136-6153           BB749395.1         425-442
            6154-6385           AK082434.1         1233-1464
FEATURES             Location/Qualifiers
     source          1..6385
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.24 cM"
     gene            1..6385
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /note="dual serine/threonine and tyrosine protein kinase"
                     /db_xref="GeneID:213452"
                     /db_xref="MGI:MGI:1925064"
     exon            1..418
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2937
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /EC_number="2.7.12.1"
                     /note="receptor interacting protein kinase 5; dusty
                     protein kinase; dusty PK; receptor-interacting
                     serine/threonine-protein kinase 5"
                     /codon_start=1
                     /product="dual serine/threonine and tyrosine protein
                     kinase"
                     /protein_id="NP_766104.2"
                     /db_xref="CCDS:CCDS15285.1"
                     /db_xref="GeneID:213452"
                     /db_xref="MGI:MGI:1925064"
                     /translation="MEADGQSWAGESVSGPGPGGGGMIRELCRGFSRYRRYLGRLRQN
                     LRETQKFFRDIKCSHSHSCPSSPAGGGAAELGPAGDVAEAPLPAGQLSCISFPPMEET
                     YLQQLVDRLPCILILGQDCNAKCQLLNLLLGVQVLPTLKLDSDESCKLRRLRFTYGTR
                     TRVSLALPGQYELVHTLASHQDNWETIPEEDLEVQEDSEDAAHVLADLEVTMHHALLQ
                     EVDIVVAPCPSHRPSVDVLSDLANDFLPVITYALHKDELSERGEQELREVRQYFSFPM
                     FFFKVPKLEIISSSSGRAESERSPLYGQLVDLGYLSSSHRNCVPSDQDCKAQSMLVEQ
                     SEKLKQLSTFSHQLLQNRLVDAAKALNVVHSHCLDIFINQAFDMQRDLQITPKRLEYT
                     RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVIVPENGETI
                     GTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSV
                     HITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKV
                     AQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVR
                     KDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVV
                     PPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLY
                     TGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK
                     PEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASK
                     DHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLRSIMDRLCKC
                     SSEQPNRGLDDST"
     exon            419..807
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1471
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1704
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1788
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1965
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2095
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2252
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2385
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2499
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2614
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2749
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..6385
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6120..6125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /note="hexamer: AATAAA"
     regulatory      6133..6138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /note="hexamer: AACAAA"
     polyA_site      6149
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
     polyA_site      6155
                     /gene="Dstyk"
                     /gene_synonym="A930019K20Rik; C430014H23Rik; C820013G01;
                     Ripk5"
                     /note="major polyA site"
ORIGIN      
        1 gctgctcagc cgcggcagtg acggaggctg gaggccgcgc ggagcgccgg caggggcgtc
       61 gggaggcgga ttccgccttc tctgagcgct agggggcggg aggagggggc cgggccagcg
      121 gctcagccag ccgcgaagac agctggctga gcgatggagg ccgacgggca gtcatgggcc
      181 ggcgagtccg tgtcgggccc gggtcccgga ggcggcggaa tgatccgcga gctgtgccgg
      241 ggcttcagcc gctaccgccg ctacctggga cggctgcggc agaacctgcg agagacccag
      301 aagttcttcc gcgacatcaa gtgctcccac agccacagtt gtccctcctc ccccgcgggc
      361 ggcggagcgg ccgagcttgg ccctgccggc gacgtcgccg aagccccgct gccggcgggc
      421 cagctgagct gcatttcctt cccacccatg gaagagacgt atctgcagca gcttgtggac
      481 cgccttccct gtatactgat cctcggccag gactgcaacg ccaagtgcca gctgctgaac
      541 ctgctgttgg gggtgcaggt gcttcccacc ctcaagctgg acagtgatga gagctgtaag
      601 cttcgtcgcc tccgcttcac ctatgggact cggactcggg tcagcttggc gctccccggt
      661 cagtatgaac tagtgcacac gctagcttca catcaggaca actgggagac tatccctgag
      721 gaggacctgg aggttcaaga agacagtgag gacgctgctc atgtgctagc tgacctcgag
      781 gtgacaatgc atcatgctct cctgcaggaa gtggacattg tggtggcacc gtgcccgagc
      841 caccggccct cagtagatgt tctgagtgac ttggcaaatg acttcttgcc tgtgataacc
      901 tatgcacttc acaaggatga actctctgag cggggtgagc aagagcttcg ggaagttaga
      961 cagtatttct ccttccccat gttctttttc aaagtaccca agctggagat aatcagctct
     1021 tccagtggga gagcagagag tgaaaggtca ccactgtatg gacagctggt ggacctgggc
     1081 tacctgagca gcagtcacag gaactgtgtg ccctctgacc aggactgtaa agctcagagc
     1141 atgttggtgg agcaaagtga gaagctgaaa caactgagta cattttctca ccagctgcta
     1201 cagaaccgcc tagtggatgc agccaaggcc ctgaatgtgg tgcacagcca ctgccttgac
     1261 atctttatta accaggcttt tgacatgcag cgggacctgc agattactcc caaacgccta
     1321 gaatatacta gaaaaaagga gaatgaattg tatgaatcgt tgatgaatat tgccaaccga
     1381 aagcaagagg aaatgaagga tatgattgtt gagacactta acaccatgaa agaggaactt
     1441 ctggatgatg ctgccaacat ggagtttaaa gatgtcattg tccctgagaa tggagaaaca
     1501 atcgggacca gggagatcaa atcctgcatc cgccagatcc aggagctcat catctccagg
     1561 ctcaatcagg ccgtggccaa caagctgatc agctcagtgg actacctgcg ggaaagcttt
     1621 gttgggaccc tggagcggtg tctgcagagc cttgaaaaat cacaggatgt ctcagttcat
     1681 attaccagca actatctcaa acagatctta aatgccgctt accatgttga ggtcactttt
     1741 cactcgggat cctcagttac tcggatgctt tgggaacaaa tcaagcagat catccagcgt
     1801 atcacatggg tgaacccacc caccatcact ctagagtgga agaggaaggt ggcccaggaa
     1861 gccatcgaca gcctcagcgc ctccaagttg gccaagagca tttgcagcca gttccgcacg
     1921 cggctcaata gttctcatga ggcgtttgca gcctccttga ggcagctgga agctggccat
     1981 tctggccgtc tggagaaaac tgaagatctg tggctaaagg ttcgaaaaga tcacgcccct
     2041 cgtctggccc gcctttcgct agagagccgg tctttacagg atgtcttgct tcaccgtaaa
     2101 cctaaattag gacaggaact aggccggggc caatatggtg tggtatacct gtgtgacaac
     2161 tgggggggac acttcccttg tgccctcaaa tcagttgttc ctccagatga gaagcactgg
     2221 aacgatctgg cattggagtt tcattacatg aggtctctgc caaagcatga gcggctggtc
     2281 gatcttcatg gctcagtcat tgactacaac tatggtggcg gctccagcgt tgctgtactg
     2341 cttatcatgg agcggctaca ccgggacctc tacacagggc tgaaggctgg gctgaccctg
     2401 gagacacgtt tgcaaatagc tctggatgtg gtggagggaa tccgctttct gcacagccag
     2461 gggcttgttc atcgggatat caaactgaaa aatgtgctgc tggacaaaca aaaccgtgcc
     2521 aagatcaccg acttaggatt ctgtaaacca gaagctatga tgtcaggcag cattgtgggg
     2581 acaccaatcc atatggcccc tgaacttttc acaggaaagt atgataactc tgtggacgtc
     2641 tatgcttttg ggatcctttt ttggtatatc tgctccggct ctatcaagct ccctgaggca
     2701 tttgagaggt gtgctagcaa agaccatctc tggaataatg tgcgcagagg gacccgtcca
     2761 gagcgtcttc ctgtgtttga tgaggagtgc tggcagttga tggaggcgtg ttgggatggt
     2821 gaccccttga agaggcccct cttgggcatc gtgcagccta tgctccgaag cattatggac
     2881 cggctctgca agtgcagctc tgaacaacca aacagaggac tagacgattc tacttgaaga
     2941 caaaaccctt tctcttccac tctgttcctt ccttccctct caccttttgg ccatggggag
     3001 aatttgtcat ttgttcatta aggaggctcc caagggaact ggtgcttggt ggcaactcga
     3061 agccttcctg ggtagggatg gctcctgggc agtgaagaag tcagtggctg tttagtgttc
     3121 acactacctt acactgcctc tttggcaaaa gactgtctca gatgtttaaa agctgaagaa
     3181 tgtgatgttc tggcctcaga actgaaaagg agacaactgt taccactgtc tgctcgctgt
     3241 gtgtcactaa aacaagacag gcttgcagtg cagggcatca gtccagcggt agagaccact
     3301 tagaaacatg accttagttc cagattgtat ggtcataaag gcaaaaacca aaccaaccta
     3361 gccagataga cctgaggttg tctggttctt ggtctttata gccaggatct caggttgtta
     3421 cagtcaaaga cccaggaggc agttagacat gaagctgtct gtcctcacaa cccagtgtgt
     3481 ttacatttcc agggccaggg agccctggtt tctgtggggc agagctaacc cagaacagaa
     3541 tctgtttgat tcttgtgtct ttccccaccc tctacccttc tttttcctca aaaaagaaag
     3601 gagggaataa accagataac atggtacttg ggcttgagca tctagtcaga aataggctat
     3661 aattttgttg tttttaatgg gatgtagccc aggctagcct taagtcatcc atatgctacc
     3721 atgcatagct tctaactata taactcgctc ctttcttctt ccgtgctagg gatcaatccc
     3781 actgctcaga tattgctggt aagcactctc ccatgggcta tgctccagct ccatatagct
     3841 ttccaagttc actttgaaca ctctgcacca tgaactctga taattgtgca gttgagcatg
     3901 gtggtctaca cactcacagc tcttcagaaa cgccaggtaa tgctttctac atgcaaactg
     3961 gaatggacaa gtggcgggcc attgtctttg ggttccttgg ctctggttca ttttggcaga
     4021 atgcttagtc tagcttttag aattttaaca cctactcaac tatacttagt tactctactc
     4081 tgagggttaa catgttgctc tctggagaca gtaggacgta caggaagcca aggagtcagg
     4141 agggaagaaa tgagtcgtct cagcttgtta ggtctgtggt gcgtgaaacc tgagatcttg
     4201 tgtagttaga agactgctga ccctgctctt gagtctagct gtaataaaga ggcggtagct
     4261 ccagtatgga actatattcc taacattctt tggaccactt agcccacact cagactccta
     4321 agtggaggtt agagttttgt tccctcattc agagtctctt tttcgtctcc tgtcagatta
     4381 caggttcctt cttttaattt taaaaagcca gttttcatca ttttctgctc agtgggagga
     4441 gcagagagat taatgcctta gggaaaggag gaggagttgt atagttcatt cattagagta
     4501 gccgagcaag gcccacgata gtcctgagag tatccgggca agccaaaggc cacattgggg
     4561 gtatttggtg ttggtatttc aatgctcagc gggctgagta tgtgaacaca tatgtctaat
     4621 ttgtgtgtgt tgtacttcat aacattgtaa gctatttttt gattctgtgg tttttggcat
     4681 ctactattat ttcagcgata aaatgccacg aaatgtactg tattgtatat cacttgggaa
     4741 gacactaggc ggtcagagaa gtgtggtggc acttgggtag tacagggctt gacagggcca
     4801 aagttttgaa gatttacctc tgggctgagt gaggaagaag ggtggcatga agagtgccat
     4861 ccttcaaaac agttgccaca gctccagccc agcactgaca cccggctgct tctcgggagc
     4921 tcaaagtctg gcctcagaat ggagtgacag gcctttctgc agagcaatca gaaaaaatgc
     4981 cggcagagtc tgagcccaag agctgtatct gaggcccaga tgactggctt cttgactgag
     5041 caatctttca gtgttctcag gaagaggact atcctagttg ttgccagacc aaagagagtc
     5101 acttctgact ctgtcaagtt taagggacag ggctaggcag ccatgttaac actaatgctc
     5161 aagaaaacca aggaaaggct gcaatgctgt tacagccaga gcaggagaat gggaaactga
     5221 acacctggca gctcccagga tgcttttctg tatttttgct tgagctgtca aacaggttgg
     5281 agcactcagg gtagaatgtg cttagcctgc acatggcctt gggttcagtg tctagaacca
     5341 aaaaaaaaaa aaaaaaaagc cacaaaggtc aaaggggttg gaatgttttt cctgacagca
     5401 gtggcctggg gtagtagggc tgcacagtga caactgcact aaatgacact ttattattgt
     5461 cttatttagc actgagaagc ccgggggata ggtgagtaca gtcacttagt aaactgaggc
     5521 accctttggt cttgtcctag agagatgcca tctttgatct agcttcctgg gagacctgcc
     5581 aagcccatgt tctccaggat ggagtagcgg ccttggtaaa gtgtatccca aagagggagc
     5641 tgctttaggt gttcagaact agcattttgt attgggtcaa acagtccaca tattccttaa
     5701 aagaaaacga ggacttagtt ttctaaatgt tggggtgtga gatggagctg atataatatt
     5761 agactgtatc aggaaggggt ggccttaaac aacacctgtg ctgcaaactc ccctagaagt
     5821 ttcaggtagt actgtccttc ttaagagttt tatttttaac ttcatgtgct ttattagcat
     5881 ctagtgtgat tgtcatggtg gtgaagaatg tatatctgac atcatcggac agaccaagta
     5941 gcctggagag ttgacaagaa gattgtctgg atggcctgct gggttttgct ttttgggttt
     6001 ttggggggtg gggtggggaa ggagttggct tttttttttg tctttatgta atgtttttgt
     6061 tttaaaggac taatgtttat tacagtgtta tataaaagtg taacatatta agtgtataga
     6121 ataaagggca ataacaaaaa tttactcgac accaatttta gccgctatac cctcctttct
     6181 tgtgcagtgt ggttctttcc atggcattgt tacagtggga ccattttatt tgtttgtttg
     6241 ttgtttgttt tgtttttgag agttgcagcc cttgcttttg tcttagtata gcctgaatgg
     6301 ctgcactagg tttgtggagt ctcctggaag ctgttaggat atggatacca ggtgtgctgc
     6361 gtaataaaaa ccacgttcat gttcc
//
