LOCUS       NM_019771               1918 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus destrin (Dstn), mRNA.
ACCESSION   NM_019771 XM_991857
VERSION     NM_019771.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1918)
  AUTHORS   Khudayberdiev,S., Weiss,K., Heinze,A., Colombaretti,D., Trausch,N.,
            Linne,U. and Rust,M.B.
  TITLE     The actin-binding protein CAP1 represses MRTF-SRF-dependent gene
            expression in mouse cerebral cortex
  JOURNAL   Sci Signal 17 (835), eadj0032 (2024)
   PUBMED   38713765
REFERENCE   2  (bases 1 to 1918)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1918)
  AUTHORS   Liao,K.A., Rangarajan,K.V., Bai,X., Taylor,J.M. and Mack,C.P.
  TITLE     The actin depolymerizing factor destrin serves as a negative
            feedback inhibitor of smooth muscle cell differentiation
  JOURNAL   Am J Physiol Heart Circ Physiol 321 (5), H893-H904 (2021)
   PUBMED   34559579
  REMARK    GeneRIF: The actin depolymerizing factor destrin serves as a
            negative feedback inhibitor of smooth muscle cell differentiation.
REFERENCE   4  (bases 1 to 1918)
  AUTHORS   McGrath,J., Tung,C.Y., Liao,X., Belyantseva,I.A., Roy,P.,
            Chakraborty,O., Li,J., Berbari,N.F., Faaborg-Andersen,C.C.,
            Barzik,M., Bird,J.E., Zhao,B., Balakrishnan,L., Friedman,T.B. and
            Perrin,B.J.
  TITLE     Actin at stereocilia tips is regulated by mechanotransduction and
            ADF/cofilin
  JOURNAL   Curr Biol 31 (6), 1141-1153 (2021)
   PUBMED   33400922
REFERENCE   5  (bases 1 to 1918)
  AUTHORS   Tedeschi,A., Dupraz,S., Curcio,M., Laskowski,C.J., Schaffran,B.,
            Flynn,K.C., Santos,T.E., Stern,S., Hilton,B.J., Larson,M.J.E.,
            Gurniak,C.B., Witke,W. and Bradke,F.
  TITLE     ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in
            the Adult CNS
  JOURNAL   Neuron 103 (6), 1073-1085 (2019)
   PUBMED   31400829
  REMARK    GeneRIF: Actin depolymerizing factor (ADF)/cofilin controls actin
            turnover to sustain axon regeneration after spinal cord injury
            through its actin-severing activity. This pinpoints ADF/cofilin as
            a key regulator of axon growth competence, irrespective of
            developmental stage.
REFERENCE   6  (bases 1 to 1918)
  AUTHORS   Vartiainen,M.K., Mustonen,T., Mattila,P.K., Ojala,P.J.,
            Thesleff,I., Partanen,J. and Lappalainen,P.
  TITLE     The three mouse actin-depolymerizing factor/cofilins evolved to
            fulfill cell-type-specific requirements for actin dynamics
  JOURNAL   Mol Biol Cell 13 (1), 183-194 (2002)
   PUBMED   11809832
REFERENCE   7  (bases 1 to 1918)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   8  (bases 1 to 1918)
  AUTHORS   Wang,I., Kao,C.W., Liu,C., Saika,S., Nishina,P.M., Sundberg,J.P.,
            Smith,R.S. and Kao,W.W.
  TITLE     Characterization of Corn1 mice: Alteration of epithelial and
            stromal cell gene expression
  JOURNAL   Mol Vis 7, 20-26 (2001)
   PUBMED   11182022
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1918)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   10 (bases 1 to 1918)
  AUTHORS   Smith,R.S., Hawes,N.L., Kuhlmann,S.D., Heckenlively,J.R., Chang,B.,
            Roderick,T.H. and Sundberg,J.P.
  TITLE     Corn1: a mouse model for corneal surface disease and
            neovascularization
  JOURNAL   Invest Ophthalmol Vis Sci 37 (2), 397-404 (1996)
   PUBMED   8603845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF123977.1 and AB025406.1.
            
            On Nov 18, 2008 this sequence version replaced NM_019771.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025406.1, SRR1660813.268616.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               BF123977.1         12-418
            408-1406            AB025406.1         128-1126
            1407-1918           AB025406.1         1128-1639
FEATURES             Location/Qualifiers
     source          1..1918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 70.89 cM"
     gene            1..1918
                     /gene="Dstn"
                     /gene_synonym="2610043P17Rik; ADF; corn1; Dsn; sid23p"
                     /note="destrin"
                     /db_xref="GeneID:56431"
                     /db_xref="MGI:MGI:1929270"
     exon            1..317
                     /gene="Dstn"
                     /gene_synonym="2610043P17Rik; ADF; corn1; Dsn; sid23p"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..812
                     /gene="Dstn"
                     /gene_synonym="2610043P17Rik; ADF; corn1; Dsn; sid23p"
                     /note="sid 23; actin-depolymerizing factor; corneal
                     disease 1"
                     /codon_start=1
                     /product="destrin"
                     /protein_id="NP_062745.1"
                     /db_xref="CCDS:CCDS16812.1"
                     /db_xref="GeneID:56431"
                     /db_xref="MGI:MGI:1929270"
                     /translation="MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADK
                     KCIVVEEGKEILVGDVGATITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFF
                     LWAPEQAPLKSKMIYASSKDAIKKKFPGIKHEYQANGPEDLNRTCIAEKLGGSLIVAF
                     EGSPV"
     exon            318..625
                     /gene="Dstn"
                     /gene_synonym="2610043P17Rik; ADF; corn1; Dsn; sid23p"
                     /inference="alignment:Splign:2.1.0"
     exon            626..702
                     /gene="Dstn"
                     /gene_synonym="2610043P17Rik; ADF; corn1; Dsn; sid23p"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1900
                     /gene="Dstn"
                     /gene_synonym="2610043P17Rik; ADF; corn1; Dsn; sid23p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dstn"
                     /gene_synonym="2610043P17Rik; ADF; corn1; Dsn; sid23p"
                     /note="hexamer: ATTAAA"
     polyA_site      1029
                     /gene="Dstn"
                     /gene_synonym="2610043P17Rik; ADF; corn1; Dsn; sid23p"
                     /note="major polyA site"
ORIGIN      
        1 cagcccgggc gctcctctgg gcggggaacc catgcactcc ccttaactgg agaggggttt
       61 ccagttgtct ggagactatt gggactcctg ggtggggcct gtctggggag gccggcctgt
      121 tgcgtagcaa cggtgggcgg agcgaggggc gcgcgcagcc gcagtctggc tggaactcgt
      181 gcccgccctt aataagctcg agctgccgcg tccgccctgc gcctgctctc ctgcttttgc
      241 tacccggagg acgaaggtgc acagactttg ccgtcaggct cctagctctc ctcccgaagt
      301 ccgccccagc gaacatggcc tcaggagttc aggttgcgga tgaagtatgt cgcattttct
      361 acgacatgaa agttcggaaa tgttccacac cagaagaaat caagaaaaga aagaaggctg
      421 tcattttctg tctcagtgca gacaaaaagt gcatagtcgt tgaagaaggc aaagagatct
      481 tggtgggaga tgttggcgcc accataactg atcctttcaa gcattttgtc ggaatgcttc
      541 ctgaaaaaga ttgtcgctat gctttgtatg acgccagctt tgagaccaag gagtccagga
      601 aagaagagct gatgttcttc ctgtgggcac cagaacaagc acctctgaaa agtaaaatga
      661 tctatgcaag ctcgaaggat gccatcaaga agaaatttcc aggtataaag catgagtatc
      721 aagcaaatgg gccagaagac ctcaatcgga cctgtattgc tgaaaagcta ggtggctcct
      781 taattgtagc ctttgaagga tcccctgtgt agaccgccag tcagtgccac gagttgaaag
      841 cttccatact gaacactatc ctttcactat ataagtaaag caaatatatt aggccaggat
      901 ctcactgagg aatttgtctt gtcatctttt agagtaaact aaaaattgta tagtgtctgc
      961 aaacactacc ctacctaaat ccagcctcta aggtctcact ggtgtggaat taaactctta
     1021 ttggccaaat gcctgttttc atgaggtgac ttgtaaagat tttgttaagc tcaggatttt
     1081 taataacaca gttcacaaaa cagtacaagg cagtatgacg agaactcatc tttgctaacc
     1141 tcagcagtta ctttgtttct tttgtttaga aaagtgattg caatccgtgt attttgacca
     1201 aagttctcta tttttccttg actaaaacaa gataatgaga cataattttc tttataatgt
     1261 gtacaacacc taatatacac taacagcagt aagactaagc caggcagtct taaaaaattc
     1321 tatcagatgt gtcatgagac tgtttcagac tcatgtctgc ttaaaattca cgctgacctt
     1381 gcagagcacc agagcatggg gctggcatgc aggaagtgcc ctgtatctgc agcaggaggc
     1441 tctgggctgg gacatggctt agagtgactt tctgtcttag aaatcatggt atatcctcag
     1501 gagaatgttc cgtgtctcgc aacaactaat tatattgcaa attattaggg cttcattgta
     1561 atctacttta ttaatgaaaa atgacaaagc agtgtactga taagccaagg tgcttttgat
     1621 ctgtaatttc ttctctaaaa ctgctgcatc tggtacagta gactgtggaa ggtgttgatt
     1681 atgtttcctc tggggcctgg taggatgcta atccctagag cagtttacca gctatgtgtg
     1741 aaattgaagc aggtaccatg gatgacacgg gactgcccaa caacacttgg aaatgattgt
     1801 taacatcaca ggcatggcac cgaacactgt agagatgcac agtcagttga acttagtagc
     1861 aacgctggct ttgtgtaata aaggaagcat ttgtaactta aaaaaaaaaa aaaaaaaa
//
